(4-Aminobutyl)guanidine (BioDeep_00000001287)
Secondary id: BioDeep_00000400211
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
N-(Aminoiminomethyl)-1,4-butanediamine
化学式: C5H14N4 (130.1218404)
中文名称: (4-氨基丁基)胍, 胍丁胺
谱图信息:
最多检出来源 Homo sapiens(blood) 0.11%
Reviewed
Last reviewed on 2024-09-14.
Cite this Page
(4-Aminobutyl)guanidine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/(4-aminobutyl)guanidine (retrieved
2024-09-17) (BioDeep RN: BioDeep_00000001287). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CCN=C(N)N)CN
InChI: InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9)
描述信息
Agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)) is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is a putative neurotransmitter. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. Agmatine binds to 2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Treatment with exogenous agmatine exerts neuroprotective effects in animal models of neurotrauma. -- Wikipedia; Agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)) is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is discussed as a putative neurotransmitter. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. Agmatine binds to ?2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Agmatine is found in many foods, some of which are fruits, kohlrabi, carob, and burdock.
Agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)) is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is a putative neurotransmitter. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. Agmatine binds to 2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Treatment with exogenous agmatine exerts neuroprotective effects in animal models of neurotrauma.
Agmatine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=306-60-5 (retrieved 2024-07-01) (CAS RN: 306-60-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
同义名列表
16 个代谢物同义名
N-(Aminoiminomethyl)-1,4-butanediamine; 1 Amino 4 guanidinobutane; 1-(4-Aminobutyl)guanidine; 1-Amino-4-guanidinobutane; N-(4-Aminobutyl)guanidine; (4-Aminobutyl) guanidine; (4-Aminobutyl)-guanidine; 4-Guanidino-1-butanamine; N-4-Aminobutylguanidine; 1-Amino-4-guanidobutane; 4-(Aminobutyl)guanidine; (4-Aminobutyl)guanidine; Agmatine sulfate salt; Agmatinium; Argmatine; Agmatine
数据库引用编号
34 个数据库交叉引用编号
- ChEBI: CHEBI:17431
- KEGG: C00179
- PubChem: 199
- HMDB: HMDB0001432
- Metlin: METLIN3523
- DrugBank: DB08838
- ChEMBL: CHEMBL58343
- Wikipedia: Agmatine
- MeSH: Agmatine
- MetaCyc: AGMATHINE
- KNApSAcK: C00001400
- foodb: FDB008310
- chemspider: 194
- CAS: 306-60-5
- MoNA: PS066001
- MoNA: PS011403
- MoNA: PS066002
- MoNA: PS066003
- MoNA: AU510707
- MoNA: KO002257
- MoNA: PR100066
- MoNA: KO002253
- MoNA: PS011401
- MoNA: PR100307
- MoNA: AU510701
- MoNA: KO002256
- MoNA: PS011402
- MoNA: KO002255
- MoNA: KO002254
- PMhub: MS000000267
- PDB-CCD: AG2
- 3DMET: B00052
- NIKKAJI: J11.608D
- RefMet: Agmatine
分类词条
相关代谢途径
Reactome(0)
BioCyc(3)
PlantCyc(0)
代谢反应
335 个相关的代谢反应过程信息。
Reactome(12)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of polyamines:
GAA + SAM ⟶ CRET + H+ + SAH - Agmatine biosynthesis:
AGM + H2O ⟶ Putrescine + Urea - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of polyamines:
GAA + SAM ⟶ CRET + H+ + SAH - Agmatine biosynthesis:
L-Arg ⟶ AGM + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of polyamines:
GAA + SAM ⟶ CRET + H+ + SAH - Agmatine biosynthesis:
L-Arg ⟶ AGM + carbon dioxide
BioCyc(10)
- superpathway of polyamine biosynthesis I:
H2O + agmatine ⟶ putrescine + urea - putrescine biosynthesis I:
H2O + agmatine ⟶ putrescine + urea - arginine degradation III (arginine decarboxylase/agmatinase pathway):
H2O + agmatine ⟶ putrescine + urea - superpathway of arginine and ornithine degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ γ-glutamyl-γ-aminobutyraldehyde + ammonium + hydrogen peroxide - superpathway of arginine, putrescine, and 4-aminobutyrate degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ γ-glutamyl-γ-aminobutyraldehyde + ammonium + hydrogen peroxide - superpathway of polyamine biosynthesis I:
H2O + agmatine ⟶ putrescine + urea - superpathway of arginine and polyamine biosynthesis:
N-acetyl-L-ornithine + H2O ⟶ L-ornithine + acetate - putrescine biosynthesis I:
H2O + agmatine ⟶ putrescine + urea - superpathway of polyamine biosynthesis II:
N-carbamoylputrescine + H2O + H+ ⟶ CO2 + ammonia + putrescine - putrescine biosynthesis II:
N-carbamoylputrescine + H2O + H+ ⟶ CO2 + ammonia + putrescine
WikiPathways(0)
Plant Reactome(311)
- Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amine and polyamine biosynthesis:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
H2O + N-Carbamoylputrescine ⟶ Putrescine + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amine and polyamine biosynthesis:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia - Putrescine biosynthesis I:
L-Arg ⟶ AGM + carbon dioxide - Putrescine biosynthesis II:
AGM + H2O ⟶ N-Carbamoylputrescine + ammonia
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Arginine Metabolism:
N-Acetylornithine + Water ⟶ Acetic acid + Ornithine - Arginine Metabolism:
N-Acetylornithine + Water ⟶ Acetic acid + Ornithine
PharmGKB(0)
34 个相关的物种来源信息
- 9606 Homo sapiens:
- 654 Aeromonas veronii: 10.3389/FCIMB.2020.00044
- 29760 Vitis vinifera: 10.1016/J.DIB.2020.106469
- 442941 Lyallia kerguelensis: 10.1016/S0031-9422(99)00191-0
- 119431 Hippospongia communis: 10.1515/BCHM2.1960.322.1.198
- 54801 Nuphar japonica: 10.1139/B97-175
- 182803 Araneus ventricosus: 10.1016/0305-0491(91)90393-R
- 3824 Canavalia gladiata: 10.1016/0031-9422(90)85449-P
- 3908 Vicia sativa: 10.1016/0031-9422(91)83201-U
- 3888 Pisum sativum: 10.1016/0031-9422(90)85450-T
- 3891 Psophocarpus tetragonolobus: 10.1016/0031-9422(90)85450-T
- 3847 Glycine max: 10.1016/0031-9422(90)85450-T
- 3860 Lathyrus sativus: 10.1016/0031-9422(74)85020-X
- 148819 Anadara broughtonii: 10.1021/JF60216A038
- 244452 Pseudopleuronectes herzensteini: 10.1021/JF60216A038
- 6573 Mizuhopecten yessoensis: 10.1021/JF60216A038
- 9606 Homo sapiens:
- 654 Aeromonas veronii: 10.3389/FCIMB.2020.00044
- 29760 Vitis vinifera: 10.1016/J.DIB.2020.106469
- 442941 Lyallia kerguelensis: 10.1016/S0031-9422(99)00191-0
- 119431 Hippospongia communis: 10.1515/BCHM2.1960.322.1.198
- 54801 Nuphar japonica: 10.1139/B97-175
- 182803 Araneus ventricosus: 10.1016/0305-0491(91)90393-R
- 3824 Canavalia gladiata: 10.1016/0031-9422(90)85449-P
- 3908 Vicia sativa: 10.1016/0031-9422(91)83201-U
- 3888 Pisum sativum: 10.1016/0031-9422(90)85450-T
- 3891 Psophocarpus tetragonolobus: 10.1016/0031-9422(90)85450-T
- 3847 Glycine max: 10.1016/0031-9422(90)85450-T
- 3860 Lathyrus sativus: 10.1016/0031-9422(74)85020-X
- 148819 Anadara broughtonii: 10.1021/JF60216A038
- 244452 Pseudopleuronectes herzensteini: 10.1021/JF60216A038
- 6573 Mizuhopecten yessoensis: 10.1021/JF60216A038
- 9606 Homo sapiens: -
- 569774 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Karen Rodríguez-Núñez, Alejandra Cortés-Monroy, Marcela Serey, Yunus Ensari, Mehdi D Davari, Claudia Bernal, Ronny Martinez. Modulating Substrate Specificity of Rhizobium sp. Histamine Dehydrogenase through Protein Engineering for Food Quality Applications.
Molecules (Basel, Switzerland).
2023 Apr; 28(9):. doi:
10.3390/molecules28093748. [PMID: 37175158] - Madhura P Dixit, Shivkumar S Sammeta, Mrunali D Dhokne, Shubhada Mangrulkar, Manoj A Upadhya, Milind J Umekar, Brijesh G Taksande, Nandkishor R Kotagale. Chronic agmatine treatment prevents olanzapine-induced obesity and metabolic dysregulation in female rats.
Brain research bulletin.
2022 12; 191(?):69-77. doi:
10.1016/j.brainresbull.2022.10.013. [PMID: 36272666] - Donatella Coradduzza, Tatiana Solinas, Emanuela Azara, Nicola Culeddu, Sara Cruciani, Angelo Zinellu, Serenella Medici, Margherita Maioli, Massimo Madonia, Ciriaco Carru. Plasma Polyamine Biomarker Panels: Agmatine in Support of Prostate Cancer Diagnosis.
Biomolecules.
2022 03; 12(4):. doi:
10.3390/biom12040514. [PMID: 35454104] - Katarina Milosevic, Ivana Stevanovic, Iva D Bozic, Ana Milosevic, Marija M Janjic, Danijela Laketa, Ivana Bjelobaba, Irena Lavrnja, Danijela Savic. Agmatine Mitigates Inflammation-Related Oxidative Stress in BV-2 Cells by Inducing a Pre-Adaptive Response.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073561. [PMID: 35408922] - Dan Zhang, Jinzhao Li, Tianzhu Li. Agmatine mitigates palmitate (PA)-induced mitochondrial and metabolic dysfunction in microvascular endothelial cells.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221110857. doi:
10.1177/09603271221110857. [PMID: 35747990] - Anna Wiśniewska, Aneta Stachowicz, Katarzyna Kuś, Magdalena Ulatowska-Białas, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Mariusz Gajda, Jacek Jawień, Rafał Olszanecki. Inhibition of Atherosclerosis and Liver Steatosis by Agmatine in Western Diet-Fed apoE-Knockout Mice Is Associated with Decrease in Hepatic De Novo Lipogenesis and Reduction in Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio.
International journal of molecular sciences.
2021 Oct; 22(19):. doi:
10.3390/ijms221910688. [PMID: 34639029] - Yanpei Zhang, Shuqiao Yuan, Tuanjie Che, Jinchun He. Agmatine and glycolipid metabolism.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2021 Aug; 46(8):889-893. doi:
10.11817/j.issn.1672-7347.2021.200351. [PMID: 34565735] - Patrick M Honore, Sebastien Redant, Keitiane Kaefer, Leonel Barreto Gutierrez, Luc Kugener, Rachid Attou, Andrea Gallerani, David De Bels. Serum Agmatine Levels Were Negatively Correlated With the Severity of Sepsis: Beware of Potential Confounders!.
Critical care medicine.
2021 08; 49(8):e810-e811. doi:
10.1097/ccm.0000000000004980. [PMID: 34261941] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Nanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-Cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-Ping Ge. Using arterial-venous analysis to characterize cancer metabolic consumption in patients.
Nature communications.
2020 06; 11(1):3169. doi:
10.1038/s41467-020-16810-8. [PMID: 32576825] - Wanwan Wang, Zhuoxian Yu, Jinpeng Meng, Pengyong Zhou, Ting Luo, Jin Zhang, Jun Wu, Yonggen Lou. Rice phenolamindes reduce the survival of female adults of the white-backed planthopper Sogatella furcifera.
Scientific reports.
2020 04; 10(1):5778. doi:
10.1038/s41598-020-62752-y. [PMID: 32238850] - Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Bibiana Beckmann, Björn Redfors. Synthesis of homoagmatine and GC-MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat.
Amino acids.
2020 Feb; 52(2):235-245. doi:
10.1007/s00726-019-02808-0. [PMID: 31776762] - Takahiro Sugiura, Yasushi Hirasawa, Tohru Toyoshi, Yasuo Matsumura. Effects of Agmatine on Contrast-Induced Nephropathy in Rats and Rabbits.
Biological & pharmaceutical bulletin.
2020; 43(10):1556-1561. doi:
10.1248/bpb.b20-00405. [PMID: 32999165] - Arisoy Ozden, Halaris Angelos, Aricioglu Feyza, Wild Elizabeth, Piletz John. Altered plasma levels of arginine metabolites in depression.
Journal of psychiatric research.
2020 01; 120(?):21-28. doi:
10.1016/j.jpsychires.2019.10.004. [PMID: 31629205] - Xuanfei Li, Junyu Zhu, Lixing Tian, Xiaoyuan Ma, Xia Fan, Li Luo, Jing Yu, Yu Sun, Xue Yang, Wanqi Tang, Wei Ma, Jun Yan, Xiang Xu, Huaping Liang. Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-κB Signaling Pathway.
Critical care medicine.
2020 01; 48(1):e40-e47. doi:
10.1097/ccm.0000000000004065. [PMID: 31634234] - Laura Barrientos-Moreno, María Antonia Molina-Henares, Marta Pastor-García, María Isabel Ramos-González, Manuel Espinosa-Urgel. Arginine Biosynthesis Modulates Pyoverdine Production and Release in Pseudomonas putida as Part of the Mechanism of Adaptation to Oxidative Stress.
Journal of bacteriology.
2019 11; 201(22):. doi:
10.1128/jb.00454-19. [PMID: 31451546] - Rosina Pryor, Povilas Norvaisas, Georgios Marinos, Lena Best, Louise B Thingholm, Leonor M Quintaneiro, Wouter De Haes, Daniela Esser, Silvio Waschina, Celia Lujan, Reuben L Smith, Timothy A Scott, Daniel Martinez-Martinez, Orla Woodward, Kevin Bryson, Matthias Laudes, Wolfgang Lieb, Riekelt H Houtkooper, Andre Franke, Liesbet Temmerman, Ivana Bjedov, Helena M Cochemé, Christoph Kaleta, Filipe Cabreiro. Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
Cell.
2019 09; 178(6):1299-1312.e29. doi:
10.1016/j.cell.2019.08.003. [PMID: 31474368] - David H Bergin, Yu Jing, Gail Williams, Bruce G Mockett, Hu Zhang, Wickliffe C Abraham, Ping Liu. Safety and neurochemical profiles of acute and sub-chronic oral treatment with agmatine sulfate.
Scientific reports.
2019 09; 9(1):12669. doi:
10.1038/s41598-019-49078-0. [PMID: 31481723] - Daqing Xu, Lirong Zhang. Increasing Agmatine Production in Escherichia coli through Metabolic Engineering.
Journal of agricultural and food chemistry.
2019 Jul; 67(28):7908-7915. doi:
10.1021/acs.jafc.9b03038. [PMID: 31268314] - Emine Yılmaz, M Ramazan Şekeroğlu, Ekrem Yılmaz, Erdem Çokluk. Evaluation of plasma agmatine level and its metabolic pathway in patients with bipolar disorder during manic episode and remission period.
International journal of psychiatry in clinical practice.
2019 Jun; 23(2):128-133. doi:
10.1080/13651501.2019.1569237. [PMID: 31081413] - Beyazit Garip, Hakan Kayir, Ozcan Uzun. l-Arginine metabolism before and after 10 weeks of antipsychotic treatment in first-episode psychotic patients.
Schizophrenia research.
2019 04; 206(?):58-66. doi:
10.1016/j.schres.2018.12.015. [PMID: 30587428] - V Selakovic, Lj Arsenijevic, M Jovanovic, S Sivcev, N Jovanovic, M Leontijevic, M Stojanovic, M Radenkovic, P Andjus, L Radenovic. Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models.
Brain research bulletin.
2019 03; 146(?):201-212. doi:
10.1016/j.brainresbull.2019.01.005. [PMID: 30641119] - E K El-Sayed, Aae Ahmed, Em El Morsy, S Nofal. Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson's disease.
Human & experimental toxicology.
2019 Feb; 38(2):173-184. doi:
10.1177/0960327118788139. [PMID: 30001633] - Nishat Ahmed, Naif Aljuhani, Hind S Al-Hujaili, Manar A Al-Hujaili, Mohamed A Elkablawy, Magdy M Noah, Hany Abo-Haded, Dina S El-Agamy. Agmatine protects against sodium valproate-induced hepatic injury in mice via modulation of nuclear factor-κB/inducible nitric oxide synthetase pathway.
Journal of biochemical and molecular toxicology.
2018 Dec; 32(12):e22227. doi:
10.1002/jbt.22227. [PMID: 30273971] - Ana C Guerra de Souza, Cinara L Gonçalves, Viviane de Souza, Juliana M Hartwig, Marcelo Farina, Rui D Prediger. Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid β (Aβ1-40) administration in mice.
Behavioural brain research.
2018 11; 353(?):51-56. doi:
10.1016/j.bbr.2018.06.032. [PMID: 29964071] - Lusliany J Rondón, M C Farges, N Davin, B Sion, A M Privat, M P Vasson, A Eschalier, C Courteix. L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration.
European journal of nutrition.
2018 Oct; 57(7):2353-2363. doi:
10.1007/s00394-017-1508-x. [PMID: 28725942] - Maha H Sharawy, Rehab S Abdelrahman, Dalia H El-Kashef. Agmatine attenuates rhabdomyolysis-induced acute kidney injury in rats in a dose dependent manner.
Life sciences.
2018 Sep; 208(?):79-86. doi:
10.1016/j.lfs.2018.07.019. [PMID: 30009822] - Jinbo Li, Kaixuan Zhang, Yu Meng, Jianping Hu, Mengqi Ding, Jiahui Bian, Mingli Yan, Jianming Han, Meiliang Zhou. Jasmonic acid/ethylene signaling coordinates hydroxycinnamic acid amides biosynthesis through ORA59 transcription factor.
The Plant journal : for cell and molecular biology.
2018 08; 95(3):444-457. doi:
10.1111/tpj.13960. [PMID: 29752755] - Yusuke Kitada, Koji Muramatsu, Hirokazu Toju, Ryoko Kibe, Yoshimi Benno, Shin Kurihara, Mitsuharu Matsumoto. Bioactive polyamine production by a novel hybrid system comprising multiple indigenous gut bacterial strategies.
Science advances.
2018 06; 4(6):eaat0062. doi:
10.1126/sciadv.aat0062. [PMID: 29963630] - Erman Esnafoglu, İlhan İrende. Decreased plasma agmatine levels in autistic subjects.
Journal of neural transmission (Vienna, Austria : 1996).
2018 04; 125(4):735-740. doi:
10.1007/s00702-017-1836-2. [PMID: 29302750] - S Tommasi, D J Elliot, M Da Boit, S R Gray, B C Lewis, A A Mangoni. Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance.
Scientific reports.
2018 02; 8(1):3697. doi:
10.1038/s41598-018-22099-x. [PMID: 29487337] - Inci Turan, Hale Sayan Ozacmak, V Haktan Ozacmak, Figen Barut, Mehmet Araslı. Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats.
Life sciences.
2017 Nov; 189(?):23-28. doi:
10.1016/j.lfs.2017.08.032. [PMID: 28893640] - Mohammed S El-Awady, Manar A Nader, Maha H Sharawy. The inhibition of inducible nitric oxide synthase and oxidative stress by agmatine attenuates vascular dysfunction in rat acute endotoxemic model.
Environmental toxicology and pharmacology.
2017 Oct; 55(?):74-80. doi:
10.1016/j.etap.2017.08.009. [PMID: 28837867] - Anna Wiśniewska, Rafał Olszanecki, Justyna Totoń-Żurańska, Katarzyna Kuś, Aneta Stachowicz, Maciej Suski, Anna Gębska, Mariusz Gajda, Jacek Jawień, Ryszard Korbut. Anti-Atherosclerotic Action of Agmatine in ApoE-Knockout Mice.
International journal of molecular sciences.
2017 Aug; 18(8):. doi:
10.3390/ijms18081706. [PMID: 28777310] - Nitin B Gawali, Vipin D Bulani, Malvika S Gursahani, Padmini S Deshpande, Pankaj S Kothavade, Archana R Juvekar. Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway.
Brain research.
2017 05; 1663(?):66-77. doi:
10.1016/j.brainres.2017.03.004. [PMID: 28302445] - Fatemeh Yarmohmmadi, Nastaran Rahimi, Hedyeh Faghir-Ghanesefat, Nina Javadian, Alireza Abdollahi, Parvin Pasalar, Farahnaz Jazayeri, Shahram Ejtemaeemehr, Ahmad Reza Dehpour. Protective effects of agmatine on doxorubicin-induced chronic cardiotoxicity in rat.
European journal of pharmacology.
2017 Feb; 796(?):39-44. doi:
10.1016/j.ejphar.2016.12.022. [PMID: 27993640] - Brijesh G Taksande, Dinesh Y Gawande, Chandrabhan T Chopde, Milind J Umekar, Nandkishor R Kotagale. Agmatine ameliorates adjuvant induced arthritis and inflammatory cachexia in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Feb; 86(?):271-278. doi:
10.1016/j.biopha.2016.12.039. [PMID: 28006753] - Eun-Jeong Kwon, Moon-Moo Kim. Agmatine modulates melanogenesis via MITF signaling pathway.
Environmental toxicology and pharmacology.
2017 Jan; 49(?):124-130. doi:
10.1016/j.etap.2016.12.008. [PMID: 27988355] - Nagla A El-Sherbeeny, Manar A Nader, Ghalia M Attia, Hayam Ateyya. Agmatine protects rat liver from nicotine-induced hepatic damage via antioxidative, antiapoptotic, and antifibrotic pathways.
Naunyn-Schmiedeberg's archives of pharmacology.
2016 Dec; 389(12):1341-1351. doi:
10.1007/s00210-016-1284-9. [PMID: 27638633] - Andréia S Cunha, Filipe C Matheus, Morgana Moretti, Tuane B Sampaio, Anicleto Poli, Danúbia B Santos, Dirleise Colle, Mauricio P Cunha, Carlos H Blum-Silva, Louis P Sandjo, Flávio H Reginatto, Ana Lúcia S Rodrigues, Marcelo Farina, Rui D Prediger. Agmatine attenuates reserpine-induced oral dyskinesia in mice: Role of oxidative stress, nitric oxide and glutamate NMDA receptors.
Behavioural brain research.
2016 10; 312(?):64-76. doi:
10.1016/j.bbr.2016.06.014. [PMID: 27306571] - Yavuz Sami Salihoglu, Tarik Elri, Kanat Gulle, Murat Can, Mustafa Aras, Hale Sayan Ozacmak, Mehmet Cabuk. Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C.
Renal failure.
2016 Oct; 38(9):1496-1502. doi:
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Macromolecular bioscience.
2016 10; 16(10):1533-1544. doi:
10.1002/mabi.201600061. [PMID: 27282336] - M A Nader, N M Gamiel, H El-Kashef, M S Zaghloul. Effect of agmatine on experimental vascular endothelial dysfunction.
Human & experimental toxicology.
2016 May; 35(5):573-82. doi:
10.1177/0960327115597311. [PMID: 26424770] - Dalia H El-Kashef, Asmaa E El-Kenawi, Mona Abdel Rahim, Ghada M Suddek, Hatem A Salem. Agmatine improves renal function in gentamicin-induced nephrotoxicity in rats.
Canadian journal of physiology and pharmacology.
2016 Mar; 94(3):278-86. doi:
10.1139/cjpp-2015-0321. [PMID: 26641937] - Jia Deng, Lixing Tian, Xiaoyuan Ma, Xia Fan, Fengyan Hou, Huaping Liang, Yan Luo. [The effects of agmatine on acute peritoneal inflammatory injury and neutrophil infiltration induced by zymosan in mice].
Zhonghua wei zhong bing ji jiu yi xue.
2016 Mar; 28(3):225-9. doi:
NULL. [PMID: 29916686] - Nitin B Gawali, Amrita A Chowdhury, Pankaj S Kothavade, Vipin D Bulani, Dnyaneshwar M Nagmoti, Archana R Juvekar. Involvement of nitric oxide in anticompulsive-like effect of agmatine on marble-burying behaviour in mice.
European journal of pharmacology.
2016 Jan; 770(?):165-71. doi:
10.1016/j.ejphar.2015.11.044. [PMID: 26593708] - Bruno Ramos-Molina, Andrés J López-Contreras, Ana Lambertos, Christophe Dardonville, Asunción Cremades, Rafael Peñafiel. Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells.
Amino acids.
2015 May; 47(5):1025-34. doi:
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AJNR. American journal of neuroradiology.
2015 Feb; 36(2):283-8. doi:
10.3174/ajnr.a4113. [PMID: 25273536] - Zheng Liu, Fengyan Hou, He Jin, Ya Xiao, Xia Fan, Xue Yang, Jun Yan, Huaping Liang. [Effects of agmatine on excessive inflammatory reaction and proliferation of splenic cells in mice with trauma].
Zhonghua wei zhong bing ji jiu yi xue.
2015 Feb; 27(2):110-4. doi:
10.3760/cma.j.issn.2095-4352.2015.02.007. [PMID: 25665609] - Tomasz Hura, Michał Dziurka, Katarzyna Hura, Agnieszka Ostrowska, Kinga Dziurka. Free and Cell Wall-Bound Polyamines under Long-Term Water Stress Applied at Different Growth Stages of ×Triticosecale Wittm.
PloS one.
2015; 10(8):e0135002. doi:
10.1371/journal.pone.0135002. [PMID: 26247474] - Gad M Gilad, Varda H Gilad. Long-term (5 years), high daily dosage of dietary agmatine--evidence of safety: a case report.
Journal of medicinal food.
2014 Nov; 17(11):1256-9. doi:
10.1089/jmf.2014.0026. [PMID: 25247837] - Zhongli Qiu, Ying Lin, Zhili Xiong, Jianwei Xie. [Determination of endogenous agmatine in rat plasma by isotope dilution-gas chromatography-mass spectrometry].
Se pu = Chinese journal of chromatography.
2014 Jul; 32(7):779-83. doi:
10.3724/sp.j.1123.2014.03030. [PMID: 25255573] - D S El-Agamy, M H Sharawy, E M Ammar. Agmatine attenuates silica-induced pulmonary fibrosis.
Human & experimental toxicology.
2014 Jun; 33(6):650-60. doi:
10.1177/0960327114521047. [PMID: 24505053] - Dina S El-Agamy, Mirhan N Makled, Nareman M Gamil. Protective effects of agmatine against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice.
Inflammopharmacology.
2014 Jun; 22(3):187-94. doi:
10.1007/s10787-013-0188-2. [PMID: 23989863] - Mohammed S El-Awady, Ghada M Suddek. Agmatine ameliorates atherosclerosis progression and endothelial dysfunction in high cholesterol-fed rabbits.
The Journal of pharmacy and pharmacology.
2014 Jun; 66(6):835-43. doi:
10.1111/jphp.12204. [PMID: 24393128] - Andiara E Freitas, Luis E B Bettio, Vivian B Neis, Danúbia B Santos, Camille M Ribeiro, Priscila B Rosa, Marcelo Farina, Ana Lúcia S Rodrigues. Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2014 Apr; 50(?):143-50. doi:
10.1016/j.pnpbp.2013.12.012. [PMID: 24370459] - Gulay Bayramoglu, M Yakup Arica. P(HPMA/EGDMA) beads grafted with fibrous chains by SI-ATRP method: agmatine functionalized affinity beads for selective separation of serum albumin.
Bioprocess and biosystems engineering.
2014 Feb; 37(2):205-15. doi:
10.1007/s00449-013-0987-2. [PMID: 23754324] - Xuan -fei Li, Xia Fan, Zhi-hua Zheng, Xue Yang, Zheng Liu, Jian-ping Gong, Hua-ping Liang. [Protective effects of agmatine on lipopolysaccharide -induced acute hepatic injury in mice].
Zhonghua wei zhong bing ji jiu yi xue.
2013 Dec; 25(12):720-4. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 Dec; 62(?):758-62. doi:
10.1016/j.fct.2013.10.005. [PMID: 24140462] - Brijesh G Taksande, Dharmesh S Faldu, Madhura P Dixit, Jay N Sakaria, Manish M Aglawe, Milind J Umekar, Nandkishor R Kotagale. Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice.
European journal of pharmacology.
2013 Nov; 720(1-3):115-20. doi:
10.1016/j.ejphar.2013.10.041. [PMID: 24183973] - Tayfun Uzbay, Gokhan Goktalay, Hakan Kayir, Salih S Eker, Asli Sarandol, Sema Oral, Levent Buyukuysal, Gokhan Ulusoy, Selcuk Kirli. Increased plasma agmatine levels in patients with schizophrenia.
Journal of psychiatric research.
2013 Aug; 47(8):1054-60. doi:
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Pharmaceutical research.
2013 Feb; 30(2):362-76. doi:
10.1007/s11095-012-0876-4. [PMID: 23054087] - Arthur S Brecher, Anum H Riaz. Polyamines detoxify the anticoagulant effect of acetaldehyde on prothrombin time.
Journal of cardiovascular pharmacology.
2012 Jul; 60(1):1-7. doi:
10.1097/fjc.0b013e318251f98d. [PMID: 22407337] - Wenkai Ren, Yulong Yin, Gang Liu, Xinglong Yu, Yinghui Li, Guan Yang, Teijun Li, Guoyao Wu. Effect of dietary arginine supplementation on reproductive performance of mice with porcine circovirus type 2 infection.
Amino acids.
2012 Jun; 42(6):2089-94. doi:
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Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2012 May; 84(3):55-62. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2012 Apr; 37(1):96-105. doi:
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PloS one.
2012; 7(5):e37859. doi:
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PLoS pathogens.
2012; 8(5):e1002724. doi:
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Pharmacology, biochemistry, and behavior.
2012 Jan; 100(3):464-73. doi:
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Current topics in membranes.
2012; 70(?):1-28. doi:
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PloS one.
2012; 7(2):e32048. doi:
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Pharmacology, biochemistry, and behavior.
2012 Jan; 100(3):398-403. doi:
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BMC plant biology.
2011 Nov; 11(?):163. doi:
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2011 Nov; 23(11):665-8. doi:
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The British journal of nutrition.
2011 Oct; 106 Suppl 1(?):S187-90. doi:
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PLoS pathogens.
2011 Sep; 7(9):e1002266. doi:
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Yao xue xue bao = Acta pharmaceutica Sinica.
2011 Aug; 46(8):936-41. doi:
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PLoS genetics.
2011 May; 7(5):e1002064. doi:
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The Plant cell.
2011 Apr; 23(4):1231-48. doi:
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American journal of medical genetics. Part C, Seminars in medical genetics.
2011 Feb; 157C(1):45-53. doi:
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Molecular pharmaceutics.
2011 Feb; 8(1):133-42. doi:
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PloS one.
2011; 6(5):e19847. doi:
10.1371/journal.pone.0019847. [PMID: 21625437] - Francois Blachier, Anne Marie Davila, Robert Benamouzig, Daniel Tome. Channelling of arginine in NO and polyamine pathways in colonocytes and consequences.
Frontiers in bioscience (Landmark edition).
2011 01; 16(4):1331-43. doi:
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BMC plant biology.
2010 Dec; 10(?):289. doi:
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Protoplasma.
2010 Oct; 246(1-4):65-72. doi:
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PloS one.
2010 Aug; 5(8):e12489. doi:
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Analytical chemistry.
2010 Aug; 82(15):6526-33. doi:
10.1021/ac100858u. [PMID: 20586417] - Dagmar Kolb, Maria Müller, Günther Zellnig, Bernd Zechmann. Cadmium induced changes in subcellular glutathione contents within glandular trichomes of Cucurbita pepo L.
Protoplasma.
2010 Jul; 243(1-4):87-94. doi:
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Plant physiology and biochemistry : PPB.
2010 Jul; 48(7):496-505. doi:
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Journal of experimental botany.
2010 Mar; 61(5):1321-35. doi:
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Molecular pharmaceutics.
2010 Feb; 7(1):138-45. doi:
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Metabolic syndrome and related disorders.
2010 Feb; 8(1):21-4. doi:
10.1089/met.2009.0032. [PMID: 19929601] - Chin-Hong Chang, Hung-Tsung Wu, Kai-Chun Cheng, Hung-Jung Lin, Juei-Tang Cheng. Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of rats.
Neuroscience letters.
2010 Jan; 468(3):297-9. doi:
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BMC pharmacology.
2010 Jan; 10(?):1. doi:
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Molecular plant-microbe interactions : MPMI.
2009 Dec; 22(12):1588-600. doi:
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Planta.
2009 Aug; 230(3):517-27. doi:
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International journal of molecular sciences.
2009 Jul; 10(7):3012-3032. doi:
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Neuroscience letters.
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Journal of chromatography. A.
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