Neosaxitoxin (BioDeep_00000011595)
Secondary id: BioDeep_00001869469
human metabolite Endogenous Marine Natural Products
代谢物信息卡片
化学式: C10H17N7O5 (315.1291)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(not specific) 40.91%
分子结构信息
SMILES: C1CN2C(=N)N(C(C3C2(C1(O)O)NC(=N3)N)COC(=O)N)O
InChI: InChI=1S/C10H17N7O5/c11-6-14-5-4(3-22-8(13)18)17(21)7(12)16-2-1-9(19,20)10(5,16)15-6/h4-5,12,19-21H,1-3H2,(H2,13,18)(H3,11,14,15)/t4-,5-,10-/m0/s1
描述信息
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
Neosaxitoxin is produced by Protogonyaulax and found in shellfis
D009676 - Noxae > D011042 - Poisons > D008978 - Mollusk Venoms
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
D009676 - Noxae > D011042 - Poisons > D014688 - Venoms
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
同义名列表
11 个代谢物同义名
[(4R,10aS,10bS)-2-amino-5,10,10-trihydroxy-6-imino-3H,4H,5H,6H,8H,9H,10H,10bH-pyrrolo[1,2-c]purin-4-yl]methyl carbamate; [(4R,10aS,10bS)-2-amino-5,10,10-trihydroxy-6-imino-3H,4H,8H,9H,10bH-pyrrolo[1,2-c]purin-4-yl]methyl carbamate; [(3AS,4R,10as)-5,10,10-trihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamic acid; [(3AS,4R,10as)-5,10,10-trihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate; Unii-6yrl8bwd9H; Neosaxitoxina; Neosaxitoxin; NeoSTX; NSTX; Neosaxitoxin; NeoSTX; Neosaxitoxin
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:181363
- ChEBI: CHEBI:167561
- KEGG: C17208
- PubChem: 135562690
- PubChem: 21117946
- PubChem: 4255631
- PubChem: 104753
- HMDB: HMDB0029369
- Metlin: METLIN71608
- DrugBank: DB12989
- ChEMBL: CHEMBL4297307
- Wikipedia: Neosaxitoxin
- KNApSAcK: C00055233
- foodb: FDB000438
- chemspider: 19975931
- CAS: 64296-20-4
- PMhub: MS000044311
- PMhub: MS000025657
- PubChem: 135626097
- KNApSAcK: 167561
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
11 个相关的物种来源信息
- 2926 - Alexandrium tamarense:
- 1175 - Aphanizomenon:
- 1176 - Aphanizomenon flos-aquae:
- 6848 - Carcinoscorpius rotundicauda: 10.1016/0041-0101(88)90064-5
- 6848 - Carcinoscorpius rotundicauda: 10.2331/SUISAN.53.261
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-021-01798-Z
- 6549 - Mytilus californianus: 10.1016/0041-0101(85)90159-X
- 1129274 - Saxidomus nuttalli: 10.1016/0041-0101(85)90159-X
- 903796 - Zosimus aeneus: 10.1016/0041-0101(84)90171-5
- 903796 - Zosimus aeneus: 10.1016/S0021-9673(01)88193-0
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yang Liu, Fan-Zhou Kong, Xiao-Gang Xun, Li Dai, Hui-Xia Geng, Xiao-Li Hu, Ren-Cheng Yu, Zhen-Min Bao, Ming-Jiang Zhou. Biokinetics and biotransformation of paralytic shellfish toxins in different tissues of Yesso scallops, Patinopecten yessoensis.
Chemosphere.
2020 Dec; 261(?):128063. doi:
10.1016/j.chemosphere.2020.128063. [PMID: 33113659] - Miguel Del Campo, Néstor Lagos, Hernán Lara. In vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats.
The Journal of endocrinology.
2020 03; 244(3):523-533. doi:
10.1530/joe-19-0545. [PMID: 31958316] - R M Coleman, G Ojeda-Torres, W Bragg, D Fearey, P McKinney, L Castrodale, D Verbrugge, K Stryker, E DeHart, M Cooper, E Hamelin, J Thomas, R C Johnson. Saxitoxin Exposure Confirmed by Human Urine and Food Analysis.
Journal of analytical toxicology.
2018 Sep; 42(7):e61-e64. doi:
10.1093/jat/bky031. [PMID: 29800291] - Xiao-Min Xu, Bai-Fen Huang, Jiao-Jiao Xu, Zeng-Xuan Cai, Jing Zhang, Qing Chen, Jian-Long Han. Fast and quantitative determination of saxitoxin and neosaxitoxin in urine by ultra performance liquid chromatography-triple quadrupole mass spectrometry based on the cleanup of solid phase extraction with hydrophilic interaction mechanism.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jan; 1072(?):267-272. doi:
10.1016/j.jchromb.2017.11.032. [PMID: 29195146] - P Eangoor, A S Indapurkar, M Vakkalanka, J S Yeh, J S Knaack. Rapid and Sensitive ELISA Screening Assay for Several Paralytic Shellfish Toxins in Human Urine.
Journal of analytical toxicology.
2017 Nov; 41(9):755-759. doi:
10.1093/jat/bkx072. [PMID: 28977469] - Roy W A Peake, Victoria Y Zhang, Nina Azcue, Christina E Hartigan, Aida Shkreta, Jasmina Prabhakara, Charles B Berde, Mark D Kellogg. Measurement of neosaxitoxin in human plasma using liquid-chromatography tandem mass spectrometry: Proof of concept for a pharmacokinetic application.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Nov; 1036-1037(?):42-49. doi:
10.1016/j.jchromb.2016.09.043. [PMID: 27710889] - Kimberly Lobo, Carolina Donado, Laura Cornelissen, Joseph Kim, Rebeca Ortiz, Roy W A Peake, Mark Kellogg, Mark E Alexander, David Zurakowski, Katherine E Kurgansky, James Peyton, Aykut Bilge, Karen Boretsky, Mary Ellen McCann, Charles B Berde, Joseph Cravero. A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2\% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia.
Anesthesiology.
2015 Oct; 123(4):873-85. doi:
10.1097/aln.0000000000000831. [PMID: 26275090] - William A Bragg, Sharon W Lemire, Rebecca M Coleman, Elizabeth I Hamelin, Rudolph C Johnson. Detection of human exposure to saxitoxin and neosaxitoxin in urine by online-solid phase extraction-liquid chromatography-tandem mass spectrometry.
Toxicon : official journal of the International Society on Toxinology.
2015 Jun; 99(?):118-24. doi:
10.1016/j.toxicon.2015.03.017. [PMID: 25817003] - De Lu Zhang, Si Yi Liu, Jing Zhang, Chun Xiang Hu, Dun Hai Li, Yong Ding Liu. Antioxidative responses in zebrafish liver exposed to sublethal doses Aphanizomenon flos-aquae DC-1 aphantoxins.
Ecotoxicology and environmental safety.
2015 Mar; 113(?):425-32. doi:
10.1016/j.ecoenv.2014.12.029. [PMID: 25544652] - Rudolph C Johnson, Yingtao Zhou, Kristen Statler, Jerry Thomas, Frederick Cox, Sherwood Hall, John R Barr. Quantification of saxitoxin and neosaxitoxin in human urine utilizing isotope dilution tandem mass spectrometry.
Journal of analytical toxicology.
2009 Jan; 33(1):8-14. doi:
10.1093/jat/33.1.8. [PMID: 19161664] - Alberto J Rodriguez-Navarro, Nestor Lagos, Marcelo Lagos, Italo Braghetto, Attila Csendes, James Hamilton, Cristian Figueroa, Dominique Truan, Carlos Garcia, Andres Rojas, Veronica Iglesias, Luis Brunet, Francisco Alvarez. Neosaxitoxin as a local anesthetic: preliminary observations from a first human trial.
Anesthesiology.
2007 Feb; 106(2):339-45. doi:
10.1097/00000542-200702000-00023. [PMID: 17264729] - T Uemura, G Sakaguchi, T Ito, K Okazawa, S Sakai. Experimental diarrhea in cynomolgus monkeys by oral administration with Clostridium perfringens type A viable cells or enterotoxin.
Japanese journal of medical science & biology.
1975 Jun; 28(3):165-77. doi:
10.7883/yoken1952.28.165. [PMID: 525]
