Mannopine (BioDeep_00000011350)

   

natural product


代谢物信息卡片


AGN-PC-0OKTBE

化学式: C11H22N2O8 (310.1376)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)N)C(C(=O)O)NCC(C(C(C(CO)O)O)O)O
InChI: InChI=1S/C11H22N2O8/c12-8(17)2-1-5(11(20)21)13-3-6(15)9(18)10(19)7(16)4-14/h5-7,9-10,13-16,18-19H,1-4H2,(H2,12,17)(H,20,21)/t5-,6+,7+,9+,10+/m0/s1

描述信息

A hexitol derivative that is D-mannitol in which the hydroxy group at position 1 is replaced by the alpha-amino group of L-glutamine. It is produced in crown gall tumours induced in a wide range of dicotyledenous plants by Agrobacterium tumefaciens.

同义名列表

3 个代谢物同义名

Mannopine; AGN-PC-0OKTBE; Mannopine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CHIA, DHFR, G6PD, SLC9A1, TUBB4B
Peripheral membrane protein 3 COQ10A, G6PD, HSD17B6
Endoplasmic reticulum membrane 2 HSP90B1, SERINC1
Nucleus 3 GGH, HSP90B1, TUBB4B
cytosol 4 DHFR, G6PD, HSP90B1, TUBB4B
nucleoplasm 1 SLC9A1
Cell membrane 4 MAS1, SERINC3, SLC9A1, TRB
lamellipodium 1 SLC9A1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 4 MAS1, SERINC1, SERINC3, SLC9A1
Golgi apparatus membrane 1 SERINC3
cell surface 3 MAS1, SLC9A1, TRB
Golgi membrane 1 SERINC3
mitochondrial inner membrane 1 COQ10A
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 G6PD
Lysosome 1 GGH
plasma membrane 5 MAS1, SERINC1, SERINC3, SLC9A1, TRB
Membrane 6 G6PD, HSP90B1, SERINC1, SERINC3, SLC9A1, TRB
apical plasma membrane 1 SLC9A1
basolateral plasma membrane 1 SLC9A1
extracellular exosome 5 G6PD, GGH, HSP90B1, SLC9A1, TUBB4B
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, HSP90B1
extracellular space 2 CHIA, GGH
perinuclear region of cytoplasm 3 HSP90B1, SERINC3, SLC9A1
intercalated disc 1 SLC9A1
mitochondrion 3 COQ10A, DHFR, SLC9A1
protein-containing complex 1 HSP90B1
intracellular membrane-bounded organelle 2 G6PD, HSD17B6
Microsome membrane 1 HSD17B6
extracellular region 4 CHIA, GGH, HSP90B1, TUBB4B
cytoplasmic side of plasma membrane 1 G6PD
centriolar satellite 1 G6PD
Extracellular vesicle 1 TUBB4B
T-tubule 1 SLC9A1
microtubule cytoskeleton 1 TUBB4B
midbody 1 HSP90B1
Cytoplasm, perinuclear region 1 SERINC3
Mitochondrion inner membrane 1 COQ10A
Matrix side 1 COQ10A
Membrane raft 1 SLC9A1
Cytoplasm, cytoskeleton 1 TUBB4B
focal adhesion 2 HSP90B1, SLC9A1
microtubule 1 TUBB4B
collagen-containing extracellular matrix 1 HSP90B1
mitotic spindle 1 TUBB4B
cytoskeleton 1 TUBB4B
Secreted, extracellular space 1 GGH
Basolateral cell membrane 1 SLC9A1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
Melanosome 2 GGH, HSP90B1
sperm plasma membrane 1 HSP90B1
endoplasmic reticulum lumen 1 HSP90B1
specific granule lumen 1 GGH
tertiary granule lumen 1 GGH
azurophil granule lumen 2 GGH, TUBB4B
Sarcoplasmic reticulum lumen 1 HSP90B1
Vacuole 1 GGH
endocytic vesicle lumen 1 HSP90B1
T cell receptor complex 1 TRB
alpha-beta T cell receptor complex 1 TRB
endoplasmic reticulum chaperone complex 1 HSP90B1
cation-transporting ATPase complex 1 SLC9A1


文献列表

  • Rosa Padilla, Vincent Gaillard, Thao Nhi Le, Floriant Bellvert, David Chapulliot, Xavier Nesme, Yves Dessaux, Ludovic Vial, Céline Lavire, Isabelle Kerzaon. Development and validation of a UHPLC-ESI-QTOF mass spectrometry method to analyze opines, plant biomarkers of crown gall or hairy root diseases. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jan; 1162(?):122458. doi: 10.1016/j.jchromb.2020.122458. [PMID: 33383499]
  • Armelle Vigouroux, Jeanne Doré, Loïc Marty, Magali Aumont-Nicaise, Pierre Legrand, Yves Dessaux, Ludovic Vial, Solange Moréra. Import pathways of the mannityl-opines into the bacterial pathogen Agrobacterium tumefaciens: structural, affinity and in vivo approaches. The Biochemical journal. 2020 02; 477(3):615-628. doi: 10.1042/bcj20190886. [PMID: 31922182]
  • Loïc Marty, Armelle Vigouroux, Magali Aumont-Nicaise, Franck Pelissier, Thibault Meyer, Céline Lavire, Yves Dessaux, Solange Moréra. Structural basis for two efficient modes of agropinic acid opine import into the bacterial pathogen Agrobacterium tumefaciens. The Biochemical journal. 2019 01; 476(1):165-178. doi: 10.1042/bcj20180861. [PMID: 30552142]
  • Loïc Marty, Armelle Vigouroux, Magali Aumont-Nicaise, Yves Dessaux, Denis Faure, Solange Moréra. Structural Basis for High Specificity of Amadori Compound and Mannopine Opine Binding in Bacterial Pathogens. The Journal of biological chemistry. 2016 Oct; 291(43):22638-22649. doi: 10.1074/jbc.m116.745562. [PMID: 27609514]
  • P M Oger, H Mansouri, X Nesme, Y Dessaux. Engineering root exudation of Lotus toward the production of two novel carbon compounds leads to the selection of distinct microbial populations in the rhizosphere. Microbial ecology. 2004 Jan; 47(1):96-103. doi: 10.1007/s00248-003-2012-9. [PMID: 15259274]
  • H-P Shi, S Kintzios. Genetic transformation of Pueraria phaseoloides with Agrobacterium rhizogenes and puerarin production in hairy roots. Plant cell reports. 2003 Jul; 21(11):1103-7. doi: 10.1007/s00299-003-0633-6. [PMID: 12836005]
  • Chang-Ho Baek, Stephen K Farrand, Ko-Eun Lee, Dae-Kyun Park, Jeong Kug Lee, Kun-Soo Kim. Convergent evolution of Amadori opine catabolic systems in plasmids of Agrobacterium tumefaciens. Journal of bacteriology. 2003 Jan; 185(2):513-24. doi: 10.1128/jb.185.2.513-524.2003. [PMID: 12511498]
  • Hounayda Mansouri, Annik Petit, Phil Oger, Yves Dessaux. Engineered rhizosphere: the trophic bias generated by opine-producing plants is independent of the opine type, the soil origin, and the plant species. Applied and environmental microbiology. 2002 May; 68(5):2562-6. doi: 10.1128/aem.68.5.2562-2566.2002. [PMID: 11976135]
  • Y Ogawa, M Mii. Ti- and cryptic-plasmid-borne virulence of wild-type Agrobacterium tumefaciens strain CNI5 isolated from chrysanthemum (Dendranthema grandiflora Tzvelev). Archives of microbiology. 2001 Nov; 176(5):315-22. doi: 10.1007/s002030100331. [PMID: 11702072]
  • K S Kim, C H Baek, J K Lee, J M Yang, S K Farrand. Intracellular accumulation of mannopine, an opine produced by crown gall tumors, transiently inhibits growth of Agrobacterium tumefaciens. Molecular plant-microbe interactions : MPMI. 2001 Jun; 14(6):793-803. doi: 10.1094/mpmi.2001.14.6.793. [PMID: 11386375]
  • H T Lei, J J Song, J J Qi, Y L Zhang, J S Yang, Z G Guo. [Genetic transformation of hairy roots in Trichosanthes kirilowii Maxim. by Ti and Ri plasmids]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2001 Mar; 26(3):162-5. doi: ". [PMID: 12525033]
  • P Oger, H Mansouri, Y Dessaux. Effect of crop rotation and soil cover on alteration of the soil microflora generated by the culture of transgenic plants producing opines. Molecular ecology. 2000 Jul; 9(7):881-90. doi: 10.1046/j.1365-294x.2000.00940.x. [PMID: 10886651]
  • Y Ogawa, K Ishikawa, M Mii. Highly tumorigenic Agrobacterium tumefaciens strain from crown gall tumors of chrysanthemum. Archives of microbiology. 2000 Apr; 173(4):311-5. doi: 10.1007/s002030000146. [PMID: 10816052]
  • C Fründt, A D Meyer, T Ichikawa, F Meins. A tobacco homologue of the Ri-plasmid orf13 gene causes cell proliferation in carrot root discs. Molecular & general genetics : MGG. 1998 Oct; 259(6):559-68. doi: 10.1007/s004380050849. [PMID: 9819048]
  • P Oger, K S Kim, R L Sackett, K R Piper, S K Farrand. Octopine-type Ti plasmids code for a mannopine-inducible dominant-negative allele of traR, the quorum-sensing activator that regulates Ti plasmid conjugal transfer. Molecular microbiology. 1998 Jan; 27(2):277-88. doi: 10.1046/j.1365-2958.1998.00671.x. [PMID: 9484884]
  • J Zhu, S C Winans. Activity of the quorum-sensing regulator TraR of Agrobacterium tumefaciens is inhibited by a truncated, dominant defective TraR-like protein. Molecular microbiology. 1998 Jan; 27(2):289-97. doi: 10.1046/j.1365-2958.1998.00672.x. [PMID: 9484885]
  • P Oger, A Petit, Y Dessaux. Genetically engineered plants producing opines alter their biological environment. Nature biotechnology. 1997 Apr; 15(4):369-72. doi: 10.1038/nbt0497-369. [PMID: 9094140]
  • K S Kim, S K Farrand. Ti plasmid-encoded genes responsible for catabolism of the crown gall opine mannopine by Agrobacterium tumefaciens are homologs of the T-region genes responsible for synthesis of this opine by the plant tumor. Journal of bacteriology. 1996 Jun; 178(11):3275-84. doi: 10.1128/jb.178.11.3275-3284.1996. [PMID: 8655509]
  • K S Kim, W S Chilton, S K Farrand. A Ti plasmid-encoded enzyme required for degradation of mannopine is functionally homologous to the T-region-encoded enzyme required for synthesis of this opine in crown gall tumors. Journal of bacteriology. 1996 Jun; 178(11):3285-92. doi: 10.1128/jb.178.11.3285-3292.1996. [PMID: 8655510]
  • S B Hong, S K Farrand. Functional role of the Ti plasmid-encoded catabolic mannopine cyclase in mannityl opine catabolism by Agrobacterium spp. Journal of bacteriology. 1994 Jun; 176(12):3576-83. doi: 10.1128/jb.176.12.3576-3583.1994. [PMID: 8206835]
  • I Hwang, S K Farrand. A novel gene tag for identifying microorganisms released into the environment. Applied and environmental microbiology. 1994 Mar; 60(3):913-20. doi: 10.1128/aem.60.3.913-920.1994. [PMID: 8161184]
  • M F van Wordragen, G Honée, H J Dons. Insect-resistant chrysanthemum calluses by introduction of a Bacillus thuringiensis crystal protein gene. Transgenic research. 1993 May; 2(3):170-80. doi: 10.1007/bf01972611. [PMID: 8353535]
  • S B Hong, Y Dessaux, W S Chilton, S K Farrand. Organization and regulation of the mannopine cyclase-associated opine catabolism genes in Agrobacterium tumefaciens 15955. Journal of bacteriology. 1993 Jan; 175(2):401-10. doi: 10.1128/jb.175.2.401-410.1993. [PMID: 8380402]
  • C Peach, J Velten. Transgene expression variability (position effect) of CAT and GUS reporter genes driven by linked divergent T-DNA promoters. Plant molecular biology. 1991 Jul; 17(1):49-60. doi: 10.1007/bf00036805. [PMID: 1907871]
  • S K Farrand, J Tempé, Y Dessaux. Localization and characterization of the region encoding catabolism of mannopinic acid from the octopine-type Ti plasmid pTi15955. Molecular plant-microbe interactions : MPMI. 1990 Jul; 3(4):259-67. doi: 10.1094/mpmi-3-259. [PMID: 1966675]
  • V J DiRita, S B Gelvin. Deletion analysis of the mannopine synthase gene promoter in sunflower crown gall tumors and Agrobacterium tumefaciens. Molecular & general genetics : MGG. 1987 May; 207(2-3):233-41. doi: 10.1007/bf00331583. [PMID: 3039293]
  • D Ursic. Eight DNA insertion events of Agrobacterium tumefaciens Ti-plasmids in isogenic sunflower genomes are all distinct. Biochemical and biophysical research communications. 1985 Aug; 131(1):152-9. doi: 10.1016/0006-291x(85)91783-8. [PMID: 3929775]