Kynurenic acid (BioDeep_00000001106)

 

Secondary id: BioDeep_00000398532, BioDeep_00000412666

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin BioNovoGene_Lab2019


代谢物信息卡片


InChI=1/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)

化学式: C10H7NO3 (189.0426)
中文名称: 1,4-二氢-4-氧喹啉-2-羧酸, 犬尿胺酸, 犬尿喹啉酸
谱图信息: 最多检出来源 Homo sapiens(feces) 19.97%

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Kynurenic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/kynurenic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001106). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O
InChI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)

描述信息

Kynurenic acid is a quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4. It has a role as a G-protein-coupled receptor agonist, a NMDA receptor antagonist, a nicotinic antagonist, a neuroprotective agent, a human metabolite and a Saccharomyces cerevisiae metabolite. It is a monohydroxyquinoline and a quinolinemonocarboxylic acid. It is a conjugate acid of a kynurenate.
Kynurenic Acid is under investigation in clinical trial NCT02340325 (FS2 Safety and Tolerability Study in Healthy Volunteers).
Kynurenic acid is a natural product found in Ephedra foeminea, Ephedra intermedia, and other organisms with data available.
Kynurenic acid is a uremic toxin. Uremic toxins can be subdivided into three major groups based upon their chemical and physical characteristics: 1) small, water-soluble, non-protein-bound compounds, such as urea; 2) small, lipid-soluble and/or protein-bound compounds, such as the phenols and 3) larger so-called middle-molecules, such as beta2-microglobulin. Chronic exposure of uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease. Kynurenic acid (KYNA) is a well-known endogenous antagonist of the glutamate ionotropic excitatory amino acid receptors N-methyl-D-aspartate (NMDA), alphaamino-3-hydroxy-5-methylisoxazole-4-propionic acid and kainate receptors and of the nicotine cholinergic subtype alpha 7 receptors. KYNA neuroprotective and anticonvulsive activities have been demonstrated in animal models of neurodegenerative diseases. Because of KYNAs neuromodulatory character, its involvement has been speculatively linked to the pathogenesis of a number of neurological conditions including those in the ageing process. Different patterns of abnormalities in various stages of KYNA metabolism in the CNS have been reported in Alzheimers disease, Parkinsons disease and Huntingtons disease. In HIV-1-infected patients and in patients with Lyme neuroborreliosis a marked rise of KYNA metabolism was seen. In the ageing process KYNA metabolism in the CNS of rats shows a characteristic pattern of changes throughout the life span. A marked increase of the KYNA content in the CNS occurs before the birth, followed by a dramatic decline on the day of birth. A low activity was seen during ontogenesis, and a slow and progressive enhancement occurs during maturation and ageing. This remarkable profile of KYNA metabolism alterations in the mammalian brain has been suggested to result from the development of the organisation of neuronal connections and synaptic plasticity, development of receptor recognition sites, maturation and ageing. There is significant evidence that KYNA can improve cognition and memory, but it has also been demonstrated that it interferes with working memory. Impairment of cognitive function in various neurodegenerative disorders is accompanied by profound reduction and/or elevation of KYNA metabolism. The view that enhancement of CNS KYNA levels could underlie cognitive decline is supported by the increased KYNA metabolism in Alzheimers disease, by the increased KYNA metabolism in downs syndrome and the enhancement of KYNA function during the early stage of Huntingtons disease. Kynurenic acid is the only endogenous N-methyl-D-aspartate (NMDA) receptor antagonist identified up to now, that mediates glutamatergic hypofunction. Schizophrenia is a disorder of dopaminergic neurotransmission, but modulation of the dopaminergic system by glutamatergic neurotransmission seems to play a key role. Despite the NMDA receptor antagonism, kynurenic acid also blocks, in lower doses, the nicotinergic acetycholine receptor, i.e., increased kynurenic acid levels can explain psychotic symptoms and cognitive deterioration. Kynurenic acid levels are described to be higher in the cerebrospinal fluid (CSF) and in critical central nervous system (CNS) regions of schizophrenics as compared to controls. (A3279, A3280)....
Kynurenic acid (KYNA) is a well-known endogenous antagonist of the glutamate ionotropic excitatory amino acid receptors N-methyl-D-aspartate (NMDA), alphaamino-3-hydroxy-5-methylisoxazole-4-propionic acid and kainate receptors and of the nicotine cholinergic subtype alpha 7 receptors. KYNA neuroprotective and anticonvulsive activities have been demonstrated in animal models of neurodegenerative diseases. Because of KYNAs neuromodulatory character, its involvement has been speculatively linked to the pathogenesis of a number of neurological conditions including those in the ageing process. Different patterns of abnormalities in various stages of KYNA metabolism in the CNS have been reported in Alzheimers disease, Parkinsons disease and Huntingtons disease. In HIV-1-infected patients and in patients with Lyme neuroborreliosis a marked rise of KYNA metabolism was seen. In the ageing process KYNA metabolism in the CNS of rats shows a characteristic pattern of changes throughout the life span. A marked increase of the KYNA content in the CNS occurs before the birth, followed by a dramatic decline on the day of birth. A low activity was seen during ontogenesis, and a slow and progressive enhancement occurs during maturation and ageing. This remarkable profile of KYNA metabolism alterations in the mammalian brain has been suggested to result from the development of the organisation of neuronal connections and synaptic plasticity, development of receptor recognition sites, maturation and ageing. There is significant evidence that KYNA can improve cognition and memory, but it has also been demonstrated that it interferes with working memory. Impairment of cognitive function in various neurodegenerative disorders is accompanied by profound reduction and/or elevation of KYNA metabolism. The view that enhancement of CNS KYNA levels could underlie cognitive decline is supported by the increased KYNA metabolism in Alzheimers disease, by the increased KYNA metabolism in downs syndrome and the enhancement of KYNA function during the early stage of Huntingtons disease. Kynurenic acid is the only endogenous N-methyl-D-aspartate (NMDA) receptor antagonist identified up to now, that mediates glutamatergic hypofunction. Schizophrenia is a disorder of dopaminergic neurotransmission, but modulation of the dopaminergic system by glutamatergic neurotransmission seems to play a key role. Despite the NMDA receptor antagonism, kynurenic acid also blocks, in lower doses, the nicotinergic acetycholine receptor, i.e., increased kynurenic acid levels can explain psychotic symptoms and cognitive deterioration. Kynurenic acid levels are described to be higher in the cerebrospinal fluid (CSF) and in critical central nervous system (CNS) regions of schizophrenics as compared to controls. (PMID: 17062375 , 16088227). KYNA has also been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821).
Kynurenic acid (KYNA) is a well-known endogenous antagonist of the glutamate ionotropic excitatory amino acid receptors N-methyl-D-aspartate (NMDA), alphaamino-3-hydroxy-5-methylisoxazole-4-propionic acid and kainate receptors and of the nicotine cholinergic subtype alpha 7 receptors. KYNA neuroprotective and anticonvulsive activities have been demonstrated in animal models of neurodegenerative diseases. Because of KYNAs neuromodulatory character, its involvement has been speculatively linked to the pathogenesis of a number of neurological conditions including those in the ageing process. Different patterns of abnormalities in various stages of KYNA metabolism in the CNS have been reported in Alzheimers disease, Parkinsons disease and Huntingtons disease. In HIV-1-infected patients and in patients with Lyme neuroborreliosis a marked rise of KYNA metabolism was seen. In the ageing process KYNA metabolism in the CNS of rats shows a characteristic pattern of changes throughout the life span. A marked increase of the KYNA content in the CNS occurs before the birth, followed by a dramatic decline on the day of birth. A low activity was seen during ontogenesis, and a slow and progressive enhancement occurs during maturation and ageing. This remarkable profile of KYNA metabolism alterations in the mammalian brain has been suggested to result from the development of the organisation of neuronal connections and synaptic plasticity, development of receptor recognition sites, maturation and ageing. There is significant evidence that KYNA can improve cognition and memory, but it has also been demonstrated that it interferes with working memory. Impairment of cognitive function in various neurodegenerative disorders is accompanied by profound reduction and/or elevation of KYNA metabolism. The view that enhancement of CNS KYNA levels could underlie cognitive decline is supported by the increased KYNA metabolism in Alzheimers disease, by the increased KYNA metabolism in downs syndrome and the enhancement of KYNA function during the early stage of Huntingtons disease. Kynurenic acid is the only endogenous N-methyl-D-aspartate (NMDA) receptor antagonist identified up to now, that mediates glutamatergic hypofunction. Schizophrenia is a disorder of dopaminergic neurotransmission, but modulation of the dopaminergic system by glutamatergic neurotransmission seems to play a key role. Despite the NMDA receptor antagonism, kynurenic acid also blocks, in lower doses, the nicotinergic acetycholine receptor, i.e., increased kynurenic acid levels can explain psychotic symptoms and cognitive deterioration. Kynurenic acid levels are described to be higher in the cerebrospinal fluid (CSF) and in critical central nervous system (CNS) regions of schizophrenics as compared to controls. (PMID: 17062375, 16088227) [HMDB]
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.

[Raw Data] CBA11_Kynurenic-acid_pos_30eV_1-3_01_673.txt
[Raw Data] CBA11_Kynurenic-acid_pos_50eV_1-3_01_675.txt
[Raw Data] CBA11_Kynurenic-acid_pos_40eV_1-3_01_674.txt
[Raw Data] CBA11_Kynurenic-acid_neg_30eV_1-3_01_726.txt
[Raw Data] CBA11_Kynurenic-acid_pos_20eV_1-3_01_672.txt
[Raw Data] CBA11_Kynurenic-acid_pos_10eV_1-3_01_671.txt
[Raw Data] CBA11_Kynurenic-acid_neg_20eV_1-3_01_725.txt
[Raw Data] CBA11_Kynurenic-acid_neg_50eV_1-3_01_728.txt
[Raw Data] CBA11_Kynurenic-acid_neg_40eV_1-3_01_727.txt
[Raw Data] CBA11_Kynurenic-acid_neg_10eV_1-3_01_724.txt
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.

同义名列表

61 个代谢物同义名

InChI=1/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14); 4-Oxo-1,4-dihydro-quinoline-2-carboxylic acid; 1,4-Dihydro-4-oxoquinoline-2-carboxylic acid; 4-oxo-1,4-dihydroquinoline-2-carboxylic acid; 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLICACID; 4-oxo-1,4-dihydroquinoline-2-carboxylicacid; 2-Quinolinecarboxylic acid, 4-hydroxy-; 4-Hydroxy-quinoline-2-carboxylic acid; 6F535706-B297-4930-A3FC-7A2823830118; 4-oxo-1H-quinoline-2-carboxylic acid; 4-Hydroxy-2-quinolinecarboxylic acid; 4-Hydroxyquinoline-2-carboxylic acid; 4-Hydroxy-2-quinolincarboxylic acid; 4-Hydroxyquinoline-2-carboxylicacid; 4-hydroxyquinolinium-2-carboxylate; 4-hydroxyquinoline-2-carboxylate; 4-Hydroxy-2-chinolincarbonsaeure; 4-Hydroxy-2-quinolinecarboxylate; 2-Carboxy-4-hydroxyquinoline; Quinaldic acid, 4-hydroxy-; HCZHHEIFKROPDY-UHFFFAOYSA-; Quinurenic acid|Kynurenate; 4-Hydroxyquinaldinic acid; 4-hydroxy-Quinaldic acid; 4-Hydroxyquinaldic acid; Kynurenic acid, >=98\\%; 4-Hydroxyquinaldinate; 4-hydroxy-Quinaldate; 4-Hydroxyquinaldate; KYNURENIC ACID [MI]; Spectrum5_001318; Spectrum3_001390; Spectrum4_000814; Spectrum2_001342; Acid, Kynurenic; Quinurenic acid; Kynurenic acid; Kynuronic acid; Kinurenic acid; kynurenic-acid; Lopac0_000716; BPBio1_001350; DivK1c_000309; Oprea1_032085; Kynurensaeure; PDSP2_000131; KBio2_004164; Tox21_500716; KBio3_002200; KBio2_006732; PDSP1_000132; KBio1_000309; KBio2_001596; SMP1_000172; Transtorine; IDI1_000309; Kynurenate; KYNA; KYA; 4-Hydroxy-2-quinolinecarboxylic acid; Kynurenate



数据库引用编号

47 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(8)

BioCyc(0)

PlantCyc(0)

代谢反应

55 个相关的代谢反应过程信息。

Reactome(48)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AHR, BDNF, CA3, DAO, HTT, IDO1, KYAT1, KYNU
Peripheral membrane protein 1 DAO
Endosome membrane 1 HTT
Nucleus 2 AHR, HTT
autophagosome 1 HTT
cytosol 8 AHR, CA3, DAO, HTT, IDO1, KMO, KYAT1, KYNU
dendrite 2 BDNF, HTT
nucleoplasm 3 AHR, HTT, KYNU
Cell membrane 6 DAO, GPR35, GPRC5A, GRID1, HTT, TNF
Multi-pass membrane protein 6 GPR35, GPRC5A, GRID1, HTT, KMO, SLC22A6
Synapse 1 HTT
cell surface 1 TNF
glutamatergic synapse 1 GRID1
Golgi apparatus 1 HTT
Golgi membrane 1 INS
neuronal cell body 1 TNF
presynaptic membrane 1 HTT
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 4 DAO, IDO1, KYAT1, KYNU
plasma membrane 8 DAO, GPR35, GPRC5A, GRID1, HTT, IFNLR1, SLC22A6, TNF
presynaptic active zone 1 DAO
Membrane 4 BDNF, IFNLR1, KMO, SLC22A6
axon 2 BDNF, HTT
basolateral plasma membrane 1 SLC22A6
caveola 1 SLC22A6
extracellular exosome 4 DAO, GPRC5A, GRID1, SLC22A6
endoplasmic reticulum 1 HTT
extracellular space 8 BDNF, CRP, DAO, IL10, IL6, INS, KMO, TNF
perinuclear region of cytoplasm 2 BDNF, HTT
bicellular tight junction 1 DAO
mitochondrion 4 AADAT, KMO, KYAT1, KYNU
protein-containing complex 3 AHR, HTT, SLC22A6
intracellular membrane-bounded organelle 1 GPRC5A
Single-pass type I membrane protein 1 IFNLR1
Secreted 6 BDNF, CRP, DAO, IL10, IL6, INS
extracellular region 7 BDNF, CRP, DAO, IL10, IL6, INS, TNF
Mitochondrion outer membrane 1 KMO
mitochondrial outer membrane 1 KMO
mitochondrial matrix 1 AADAT
Extracellular side 1 DAO
transcription regulator complex 1 AHR
external side of plasma membrane 1 TNF
nucleolus 1 GPRC5A
Early endosome 1 HTT
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 GPRC5A
postsynaptic membrane 2 GRID1, HTT
Membrane raft 2 HTT, TNF
Cell junction, focal adhesion 1 HTT
focal adhesion 1 HTT
GABA-ergic synapse 1 GRID1
Peroxisome 1 DAO
Peroxisome matrix 1 DAO
peroxisomal matrix 1 DAO
Postsynaptic cell membrane 1 GRID1
Late endosome 1 HTT
receptor complex 1 GPRC5A
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
chromatin 1 AHR
stereocilium bundle 1 IDO1
cell projection 1 DAO
phagocytic cup 1 TNF
centriole 1 HTT
Secreted, extracellular space 1 DAO
Basolateral cell membrane 1 SLC22A6
Endomembrane system 1 HTT
endosome lumen 1 INS
aryl hydrocarbon receptor complex 1 AHR
Cytoplasmic vesicle membrane 2 GPRC5A, HTT
basal plasma membrane 1 SLC22A6
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, IL6, INS
specific granule lumen 1 DAO
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
Basal cell membrane 1 SLC22A6
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 HTT
interleukin-6 receptor complex 1 IL6
smooth muscle contractile fiber 1 IDO1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
nuclear aryl hydrocarbon receptor complex 1 AHR
serotonergic synapse 1 HTT
cytosolic aryl hydrocarbon receptor complex 1 AHR
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Magdalena Wróbel-Kwiatkowska, Waldemar Turski, Grażyna Silska, Magdalena Rakicka-Pustułka, Lucyna Dymińska, Waldemar Rymowicz. Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081702. [PMID: 38675522]
  • Ádám Juhász, Ditta Ungor, Norbert Varga, Gábor Katona, György T Balogh, Edit Csapó. Lipid-Based Nanocarriers for Delivery of Neuroprotective Kynurenic Acid: Preparation, Characterization, and BBB Transport. International journal of molecular sciences. 2023 Sep; 24(18):. doi: 10.3390/ijms241814251. [PMID: 37762551]
  • Xiaoli Qi, Keyi Fu, Mingyuan Yue, Na Shou, Xuefeng Yuan, Xi Chen, Chunyu He, Yunfeng Yang, Zunji Shi. Kynurenic acid mediates bacteria-algae consortium in resisting environmental cadmium toxicity. Journal of hazardous materials. 2023 02; 444(Pt A):130397. doi: 10.1016/j.jhazmat.2022.130397. [PMID: 36403444]
  • Magdalena Matusiewicz, Magdalena Wróbel-Kwiatkowska, Tomasz Niemiec, Wiesław Świderek, Iwona Kosieradzka, Aleksandra Rosińska, Anna Niwińska, Magdalena Rakicka-Pustułka, Tomasz Kocki, Waldemar Rymowicz, Waldemar A Turski. Effect of Yarrowia lipolytica yeast biomass with increased kynurenic acid content on selected metabolic indicators in mice. PeerJ. 2023; 11(?):e15833. doi: 10.7717/peerj.15833. [PMID: 37780388]
  • Yanpo Si, Wenjun Wei, Xiaohui Chen, Xiaolong Xie, Tao Guo, Yohei Sasaki, Youbo Zhang, Lili Wang, Fei Zhang, Shuying Feng. A comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p-chlorphenylalanine induced insomnia rats. Pharmaceutical biology. 2022 Dec; 60(1):131-143. doi: 10.1080/13880209.2021.2019283. [PMID: 34978949]
  • Yanmei Chen, Jiahui Zhang, Yueying Yang, Ke Xiang, Hua Li, Dejuan Sun, Lixia Chen. Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression. Journal of cellular physiology. 2022 12; 237(12):4339-4355. doi: 10.1002/jcp.30876. [PMID: 36088660]
  • Liying Cheng, Liming Wang, Biying Chen, Chenxi Wang, Mengxi Wang, Jie Li, Xiumei Gao, Zhu Zhang, Lifeng Han. A multiple-metabolites model to predict preliminary renal injury induced by iodixanol based on UHPLC/Q-Orbitrap-MS and 1H-NMR. Metabolomics : Official journal of the Metabolomic Society. 2022 10; 18(11):85. doi: 10.1007/s11306-022-01942-3. [PMID: 36307737]
  • Wenhua Ding, Fengchun Wu, Sumiao Zhou, Hehua Li, Runhua Wang, Yuping Ning. Increased plasma level of kynurenic acid in drug-free patients with first-episode schizophrenia compared to patients with chronic schizophrenia and healthy controls: preliminary data. Nordic journal of psychiatry. 2022 Aug; 76(6):451-456. doi: 10.1080/08039488.2021.1992647. [PMID: 34928781]
  • Petra Majerova, Dominika Olesova, Greta Golisova, Martina Buralova, Alena Michalicova, Jozef Vegh, Juraj Piestansky, Mangesh Bhide, Jozef Hanes, Andrej Kovac. Analog of kynurenic acid decreases tau pathology by modulating astrogliosis in rat model for tauopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113257. doi: 10.1016/j.biopha.2022.113257. [PMID: 35714514]
  • Melike Kucukkarapinar, Aysegul Yay-Pence, Yesim Yildiz, Merve Buyukkoruk, Gizem Yaz-Aydin, Tuba S Deveci-Bulut, Ozlem Gulbahar, Esin Senol, Selcuk Candansayar. Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress. Journal of neural transmission (Vienna, Austria : 1996). 2022 08; 129(8):1077-1089. doi: 10.1007/s00702-022-02525-1. [PMID: 35796878]
  • Huan Wang, Jian Li, Zheng Wang, Yanfeng Tian, Chunlei Li, Feng Jin, Jia Li, Lanfeng Wang. Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-eNOS pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113040. doi: 10.1016/j.biopha.2022.113040. [PMID: 35658210]
  • Duygu Eryavuz Onmaz, Dilek Tezcan, Sedat Abusoglu, Abdullah Sivrikaya, Menekse Kuzu, Fatma Humeyra Yerlikaya, Sema Yilmaz, Ali Unlu. Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease. Amino acids. 2022 Jun; 54(6):877-887. doi: 10.1007/s00726-022-03170-4. [PMID: 35604497]
  • Johann Steiner, Henrik Dobrowolny, Paul C Guest, Hans-Gert Bernstein, Dietmar Fuchs, Julien Roeser, Paul Summergrad, Gregory Oxenkrug. Gender-specific elevation of plasma anthranilic acid in schizophrenia: Protection against glutamatergic hypofunction?. Schizophrenia research. 2022 05; 243(?):483-485. doi: 10.1016/j.schres.2022.01.048. [PMID: 35151533]
  • Ebru Nur Ay, Şeyda Demirkol, Mehmet Tolgahan Hakan, Cem Horozoğlu, Soykan Arıkan, Mehmet Baki Doğan, Filiz Akyüz, Ceylan Özsoy Hepokur, İlhan Yaylım. Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer. Scandinavian journal of clinical and laboratory investigation. 2022 05; 82(3):185-191. doi: 10.1080/00365513.2022.2040050. [PMID: 35452343]
  • Qiufen Li, Hua Zhou, Jingxin Ouyang, Shuaipeng Guo, Jun Zheng, Guanhong Li. Effects of dietary tryptophan supplementation on body temperature, hormone, and cytokine levels in broilers exposed to acute heat stress. Tropical animal health and production. 2022 Apr; 54(3):164. doi: 10.1007/s11250-022-03161-3. [PMID: 35435494]
  • Fabiana Russo, Francesco Tolomeo, Maria Angela Vandelli, Giuseppe Biagini, Roberta Paris, Flavia Fulvio, Aldo Laganà, Anna Laura Capriotti, Luigi Carbone, Giuseppe Gigli, Giuseppe Cannazza, Cinzia Citti. Kynurenine and kynurenic acid: Two human neuromodulators found in Cannabis sativa L. Journal of pharmaceutical and biomedical analysis. 2022 Mar; 211(?):114636. doi: 10.1016/j.jpba.2022.114636. [PMID: 35124451]
  • Elisabeth R Paul, Lilly Schwieler, Sophie Erhardt, Sandra Boda, Ada Trepci, Robin Kämpe, Anna Asratian, Lovisa Holm, Adam Yngve, Robert Dantzer, Markus Heilig, J Paul Hamilton, Martin Samuelsson. Peripheral and central kynurenine pathway abnormalities in major depression. Brain, behavior, and immunity. 2022 03; 101(?):136-145. doi: 10.1016/j.bbi.2022.01.002. [PMID: 34999196]
  • Murat Cihan, Özlem Doğan, Ceyhan Ceran Serdar, Arzu Altunçekiç Yıldırım, Celali Kurt, Muhittin A Serdar. Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis. Journal of clinical laboratory analysis. 2022 Mar; 36(3):e24257. doi: 10.1002/jcla.24257. [PMID: 35092710]
  • Mary Kimmel, Wanting Jin, Kai Xia, Kun Lun, Andrea Azcarate-Peril, Anna Plantinga, Michael Wu, Shirin Ataei, Hannah Rackers, Ian Carroll, Samantha Meltzer-Brody, Emma Fransson, Rebecca Knickmeyer. Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition. Behavioural brain research. 2022 02; 418(?):113635. doi: 10.1016/j.bbr.2021.113635. [PMID: 34755640]
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