Complestatin (BioDeep_00000010842)

   


代谢物信息卡片


Chloropeptin II

化学式: C61H45Cl6N7O15 (1325.1105)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C(=O)C(c2cc(Cl)c(O)c(Cl)c2)NC(=O)C2NC(=O)C(c3cc(Cl)c(O)c(Cl)c3)NC(=O)C(NC(=O)C(=O)c3cc(Cl)c(O)c(Cl)c3)Cc3c[nH]c4cc(ccc34)-c3cc2cc(c3O)Oc2ccc(cc2)CC1C(=O)NC(C(=O)O)c1ccc(O)cc1
InChI: InChI=1S/C61H45Cl6N7O15/c1-74-44(56(82)73-49(61(87)88)25-4-7-32(75)8-5-25)12-24-2-9-33(10-3-24)89-45-22-27-13-35(51(45)77)26-6-11-34-31(23-68-42(34)20-26)21-43(69-59(85)50(76)30-18-40(66)54(80)41(67)19-30)55(81)70-47(28-14-36(62)52(78)37(63)15-28)57(83)71-46(27)58(84)72-48(60(74)86)29-16-38(64)53(79)39(65)17-29/h2-11,13-20,22-23,43-44,46-49,68,75,77-80H,12,21H2,1H3,(H,69,85)(H,70,81)(H,71,83)(H,72,84)(H,73,82)(H,87,88)/t43-,44+,46-,47-,48-,49-/m1/s1

描述信息

A heterodetic cyclic peptide consisting of N-acylated trytophan, 3,5-dichloro-4-hydroxyphenylglycine, 4-hydroxyphenylglycine, 3,5-dichloro-4-hydroxyphenylglycyl, tyrosine and 4-hydroxyphenylglycine residues joined in sequence and in which the side-chain of the central 4-hydroxyphenylglycine residue is attached to the side-chain of the tryptophan via a C3-C6 bond and to the side-chain of the tyrosine via an ether bond from C5. It is isolated from the culture broth of Streptomyces and has anti-HIV-1 activity.

同义名列表

4 个代谢物同义名

Chloropeptin II; Complestatin; Isocomplestatin; Complestatin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE2, ANG, CASP3, HTT
Peripheral membrane protein 2 CYP1B1, MBP
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 2 CD4, CYP1B1
Nucleus 4 ANG, CASP3, HTT, MBP
autophagosome 1 HTT
cytosol 5 ANG, CASP3, GYPA, HTT, MBP
dendrite 2 C4B, HTT
nucleoplasm 3 CASP3, GYPA, HTT
Cell membrane 5 ACE2, C5AR1, CD4, GYPA, HTT
Cytoplasmic side 1 MBP
Cell projection, axon 1 C4B
Multi-pass membrane protein 2 C5AR1, HTT
Synapse 3 C4B, HTT, MBP
cell surface 5 ACE2, C3, MBP, PLG, SERPINF2
glutamatergic synapse 3 CASP3, ICAM5, PLG
Golgi apparatus 1 HTT
growth cone 1 ANG
neuronal cell body 3 ANG, CASP3, MBP
postsynapse 1 ICAM5
presynaptic membrane 1 HTT
plasma membrane 10 ACE2, C3, C4B, C5AR1, CD4, GYPA, HTT, ICAM5, MBP, PLG
Membrane 4 ACE2, CYP1B1, GYPA, ICAM5
apical plasma membrane 1 ACE2
axon 2 C4B, HTT
basolateral plasma membrane 1 C5AR1
extracellular exosome 6 ACE2, C3, C4B, MBP, PLG, SERPINF2
endoplasmic reticulum 1 HTT
extracellular space 7 ACE2, ANG, C3, C4B, LPA, PLG, SERPINF2
perinuclear region of cytoplasm 1 HTT
Schaffer collateral - CA1 synapse 1 PLG
mitochondrion 1 CYP1B1
protein-containing complex 3 C3, HTT, MBP
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 1 CYP1B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 4 ACE2, CD4, GYPA, ICAM5
Secreted 5 ACE2, ANG, C3, C4B, PLG
extracellular region 8 ACE2, ANG, C3, C4B, LPA, MBP, PLG, SERPINF2
Single-pass membrane protein 1 GYPA
Cell projection, cilium 1 ACE2
external side of plasma membrane 2 CD4, PLG
actin cytoskeleton 1 ANG
cytoplasmic vesicle 1 C5AR1
nucleolus 1 ANG
Early endosome 2 CD4, HTT
apical part of cell 1 C5AR1
postsynaptic membrane 1 HTT
Apical cell membrane 1 ACE2
Membrane raft 3 ACE2, CD4, HTT
Cell junction, focal adhesion 1 HTT
focal adhesion 1 HTT
basement membrane 1 ANG
collagen-containing extracellular matrix 3 MBP, PLG, SERPINF2
Late endosome 1 HTT
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
cilium 1 ACE2
cell periphery 1 MBP
Chromosome 1 ANG
[Isoform 3]: Nucleus 1 MBP
centriole 1 HTT
brush border membrane 1 ACE2
Nucleus, nucleolus 1 ANG
blood microparticle 4 C3, C4B, PLG, SERPINF2
Endomembrane system 1 HTT
Cytoplasmic vesicle membrane 1 HTT
Cell projection, dendrite 1 C4B
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
myelin sheath 1 MBP
ficolin-1-rich granule lumen 1 MBP
secretory granule lumen 1 C3
secretory granule membrane 1 C5AR1
endoplasmic reticulum lumen 3 ACE2, C3, CD4
platelet alpha granule lumen 2 PLG, SERPINF2
endocytic vesicle membrane 1 ACE2
endocytic vesicle 1 ANG
transport vesicle 1 MBP
azurophil granule lumen 1 C3
clathrin-coated endocytic vesicle membrane 1 CD4
death-inducing signaling complex 1 CASP3
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
T cell receptor complex 1 CD4
fibrinogen complex 1 SERPINF2
compact myelin 1 MBP
internode region of axon 1 MBP
ankyrin-1 complex 1 GYPA
angiogenin-PRI complex 1 ANG
inclusion body 1 HTT
plasma lipoprotein particle 1 LPA
symbiont cell surface 1 C4B
[Bone marrow proteoglycan]: Secreted 1 MBP
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
Myelin membrane 1 MBP
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • K Tachikawa, K Hasumi, A Endo. Enhancement of plasminogen binding and fibrinolysis by chloropeptin I. Thrombosis research. 1997 Sep; 87(6):571-6. doi: 10.1016/s0049-3848(97)00186-2. [PMID: 9330439]