3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acid (BioDeep_00000010801)

 

Secondary id: BioDeep_00001871577

human metabolite blood metabolite


代谢物信息卡片


2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetic acid

化学式: C33H31ClF3NO3 (581.1944441999999)
中文名称: 3-[3-[[[2-氯-3-(三氟甲基)苯基]甲基](2,2-联苯基乙基)氨基]丙氧基]苯乙酸盐酸盐
谱图信息: 最多检出来源 Homo sapiens(blood) 97.78%

分子结构信息

SMILES: C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4
InChI: InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)

描述信息

同义名列表

7 个代谢物同义名

2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetic acid; 2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetate; 3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acid; C33H31ClF3NO3; GW 3965; GW3965; GW 3965



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • YuChen Jiang, LiShuang Hou, JiaYi Dou, MeiYan Xuan, ZhenYu Cui, LiHua Lian, JiXing Nan, YanLing Wu. Sesamol as a potential candidate for the treatment of hepatic fibrosis, based on its regulation of FXR/LXR axis-mediated inhibition of autophagy through crosstalk between hepatic cells and macrophage. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155145. doi: 10.1016/j.phymed.2023.155145. [PMID: 37976698]
  • Fenfang Yu, Lin Gao, Ke Xu, Xiaobing Yang, Junran Zhang, Yu Tang, Zhifei Ma, Wei Gu, Bining Wu, Ying Shi. Protective effect of liver X receptor on cigarette smoke and lipopolysaccharide induced airway inflammation and emphysema in mice. Experimental lung research. 2024; 50(1):53-64. doi: 10.1080/01902148.2024.2329436. [PMID: 38509754]
  • Sheetal Uppal, Olga Postnikova, Rafael Villasmil, Igor B Rogozin, Alexander V Bocharov, Thomas L Eggerman, Eugenia Poliakov, T Michael Redmond. Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells. International journal of molecular sciences. 2023 Jul; 24(14):. doi: 10.3390/ijms241411860. [PMID: 37511618]
  • Ruiyi Zhang, Yifei Dong, Yang Liu, Dorsa Moezzi, Samira Ghorbani, Reza Mirzaei, Brian M Lozinski, Jeff F Dunn, V Wee Yong, Mengzhou Xue. Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages. Stroke and vascular neurology. 2023 May; ?(?):. doi: 10.1136/svn-2023-002331. [PMID: 37137522]
  • Lara Bideyan, Wenxin Fan, Karolina Elżbieta Kaczor-Urbanowicz, Christina Priest, David Casero, Peter Tontonoz. Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver. Proceedings of the National Academy of Sciences of the United States of America. 2022 02; 119(7):. doi: 10.1073/pnas.2122683119. [PMID: 35145035]
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  • Peng Wang, Xingjiang Mu, Hongyan Zhao, Yutian Li, Lu Wang, Vivian Wolfe, Shu-Nan Cui, Xiaohong Wang, Tianqing Peng, Basilia Zingarelli, Chunting Wang, Guo-Chang Fan. Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis. Frontiers in immunology. 2021; 12(?):647070. doi: 10.3389/fimmu.2021.647070. [PMID: 33679812]
  • Tao Zhang, Zhikun Zhan, Yulian Chen, Jianwu Chen, Weichao Han, Zhi Liang, Qiuyue Liu, Shuwen Liu, Lan Tang. Regulation of cytochrome P450 4F11 expression by liver X receptor alpha. International immunopharmacology. 2021 Jan; 90(?):107240. doi: 10.1016/j.intimp.2020.107240. [PMID: 33310663]
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  • Yong Huang, Ke Ning, Wen-Wen Li, Ge Lin, Cui-Lan Hou, Ming-Jie Wang, Yi-Chun Zhu. Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells. American journal of physiology. Cell physiology. 2020 12; 319(6):C1082-C1096. doi: 10.1152/ajpcell.00244.2019. [PMID: 32938225]
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  • Mirko E Minniti, Matteo Pedrelli, Lise-Lotte Vedin, Anne-Sophie Delbès, Raphaël G P Denis, Katariina Öörni, Claudia Sala, Chiara Pirazzini, Divya Thiagarajan, Harri J Nurmi, Markus Grompe, Kevin Mills, Paolo Garagnani, Ewa C S Ellis, Stephen C Strom, Serge H Luquet, Elizabeth M Wilson, John Bial, Knut R Steffensen, Paolo Parini. Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans. Hepatology (Baltimore, Md.). 2020 08; 72(2):656-670. doi: 10.1002/hep.31052. [PMID: 31785104]
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  • Deolinda Santinha, Anna Klopot, Igor Marques, Ewa Ellis, Carl Jorns, Helene Johansson, Tânia Melo, Per Antonson, Tomas Jakobsson, Vítor Félix, Jan-Åke Gustafsson, Maria Rosário Domingues, Agneta Mode, Luisa A Helguero. Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine. The Journal of steroid biochemistry and molecular biology. 2020 04; 198(?):105558. doi: 10.1016/j.jsbmb.2019.105558. [PMID: 31783151]
  • Dorothy Moseti, Alemu Regassa, Chongxiao Chen, Karmin O, Woo Kyun Kim. 25-Hydroxycholesterol Inhibits Adipogenic Differentiation of C3H10T1/2 Pluripotent Stromal Cells. International journal of molecular sciences. 2020 Jan; 21(2):. doi: 10.3390/ijms21020412. [PMID: 31936485]
  • Tomofumi Fujino, Kouta Sugizaki, Rei Kato, Masaki Beppu, Satoshi Murakami, Hyunjung Lee, Toshiyuki Oshima, Makio Hayakawa. Farnesoid X receptor and liver X receptors regulate Oct3/4 expression by multiple feedback regulating system in normal renal-derived cells and renal adenocarcinoma cells. The Journal of toxicological sciences. 2020; 45(1):25-35. doi: 10.2131/jts.45.25. [PMID: 31932555]
  • Matteo Curtarello, Martina Tognon, Carolina Venturoli, Micol Silic-Benussi, Angela Grassi, Martina Verza, Sonia Minuzzo, Marica Pinazza, Valentina Brillo, Giovanni Tosi, Ruggero Ferrazza, Graziano Guella, Egidio Iorio, Adrien Godfroid, Nor Eddine Sounni, Alberto Amadori, Stefano Indraccolo. Rewiring of Lipid Metabolism and Storage in Ovarian Cancer Cells after Anti-VEGF Therapy. Cells. 2019 12; 8(12):. doi: 10.3390/cells8121601. [PMID: 31835444]
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  • Priscila Calle, Selene Torrico, Angeles Muñoz, Georgina Hotter. CPT1a downregulation protects against cholesterol-induced fibrosis in tubular epithelial cells by downregulating TGFβ-1 and inflammasome. Biochemical and biophysical research communications. 2019 10; 517(4):715-721. doi: 10.1016/j.bbrc.2019.07.121. [PMID: 31405564]
  • Xin Han, Zhen-Yu Cui, Jian Song, Hui-Qing Piao, Li-Hua Lian, Li-Shuang Hou, Ge Wang, Shuang Zheng, Xiu-Xiu Dong, Ji-Xing Nan, Yan-Ling Wu. Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR/LXRs-dependent manner. Chemico-biological interactions. 2019 Sep; 311(?):108794. doi: 10.1016/j.cbi.2019.108794. [PMID: 31421115]
  • Zizhen Zhang, Hao Chen, Ziyang Chen, Peng Ding, Yingchen Ju, Qiong Gu, Jun Xu, Huihao Zhou. Identify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay. European journal of medicinal chemistry. 2019 Sep; 178(?):458-467. doi: 10.1016/j.ejmech.2019.06.011. [PMID: 31202993]
  • Nur Banu Bal, Sevtap Han, Suzan Emel Usanmaz, Saba Kiremitci, Gökhan Sadi, Orhan Uludag, Emine Demirel-Yilmaz. Activation of Liver X Receptors by GW3965 Attenuated Deoxycorticosterone Acetate-Salt Hypertension-Induced Cardiac Functional and Structural Changes. Journal of cardiovascular pharmacology. 2019 08; 74(2):105-117. doi: 10.1097/fjc.0000000000000693. [PMID: 31397742]
  • Tibor Sághy, Krisztina Köröskényi, Krisztina Hegedűs, Miklós Antal, Csaba Bankó, Zsolt Bacsó, Attila Papp, Rinke Stienstra, Zsuzsa Szondy. Loss of transglutaminase 2 sensitizes for diet-induced obesity-related inflammation and insulin resistance due to enhanced macrophage c-Src signaling. Cell death & disease. 2019 06; 10(6):439. doi: 10.1038/s41419-019-1677-z. [PMID: 31165747]
  • Diego Y Grinman, Valeria P Careaga, Elizabeth A Wellberg, María V Dansey, Edith C Kordon, Steven M Anderson, Marta S Maier, Gerardo Burton, Paul S MacLean, Michael C Rudolph, Adali Pecci. Liver X receptor-α activation enhances cholesterol secretion in lactating mammary epithelium. American journal of physiology. Endocrinology and metabolism. 2019 06; 316(6):E1136-E1145. doi: 10.1152/ajpendo.00548.2018. [PMID: 30964702]
  • Ming-Xiang Cheng, Ping Huang, Qiang He, Yong Chen, Jin-Zheng Li. Liver X Receptors Activation Attenuates Ischemia Reperfusion Injury of Liver Graft in Rats. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2019 Jun; 32(4):298-303. doi: 10.1080/08941939.2017.1412543. [PMID: 29286833]
  • Chuanwei Li, Zhangxue Hu, Wen Zhang, Junyi Yu, Yang Yang, Zaicheng Xu, Hao Luo, Xiaoli Liu, Yukai Liu, Caiyu Chen, Yue Cai, Xuewei Xia, Xiaoqun Zhang, Da-Zhi Wang, Gengze Wu, Chunyu Zeng. Regulation of Cholesterol Homeostasis by a Novel Long Non-coding RNA LASER. Scientific reports. 2019 05; 9(1):7693. doi: 10.1038/s41598-019-44195-2. [PMID: 31118464]
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  • Tianpeng Zhang, Jiangyan Duan, Lei Zhang, Zhuoyu Li, Clifford J Steer, Guiqin Yan, Guisheng Song. LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression. Hepatology (Baltimore, Md.). 2019 04; 69(4):1488-1503. doi: 10.1002/hep.30301. [PMID: 30281809]
  • Celio Ferreira, Ramona Meyer, Henriette E Meyer Zu Schwabedissen. The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1. Biochimica et biophysica acta. Gene regulatory mechanisms. 2019 04; 1862(4):447-456. doi: 10.1016/j.bbagrm.2019.02.007. [PMID: 30831268]
  • Leonore Wigger, Cristina Casals-Casas, Michaël Baruchet, Khanh B Trang, Sylvain Pradervand, Aurélien Naldi, Béatrice Desvergne. System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells. PloS one. 2019; 14(8):e0220894. doi: 10.1371/journal.pone.0220894. [PMID: 31437187]
  • Sevtap Han, Nur Banu Bal, Gökhan Sadi, Suzan Emel Usanmaz, Mecit Orhan Uludag, Emine Demirel-Yilmaz. The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta. Life sciences. 2018 Nov; 213(?):287-293. doi: 10.1016/j.lfs.2018.10.042. [PMID: 30366037]
  • Guohui Zhang, Jin Zhou, Wen Huang, Luting Yu, Yuanzhen Zhang, Hui Wang. Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats. Toxicology letters. 2018 Oct; 296(?):31-38. doi: 10.1016/j.toxlet.2018.07.022. [PMID: 30036686]
  • Chaitanya K Gavini, Angie L Bookout, Raiza Bonomo, Laurent Gautron, Syann Lee, Virginie Mansuy-Aubert. Liver X Receptors Protect Dorsal Root Ganglia from Obesity-Induced Endoplasmic Reticulum Stress and Mechanical Allodynia. Cell reports. 2018 10; 25(2):271-277.e4. doi: 10.1016/j.celrep.2018.09.046. [PMID: 30304667]
  • Ju-Hee Lee, Su Youn Baek, Eun Jeong Jang, Sae Kwang Ku, Kyu Min Kim, Sung Hwan Ki, Chang-Eop Kim, Kwang Il Park, Sang Chan Kim, Young Woo Kim. Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase. Chemico-biological interactions. 2018 Jun; 289(?):68-74. doi: 10.1016/j.cbi.2018.04.023. [PMID: 29702089]
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  • Teerasak Wongwan, Suticha Kittayaruksakul, Nithi Asavapanumas, Varanuj Chatsudthipong, Sunhapas Soodvilai. Activation of liver X receptor inhibits OCT2-mediated organic cation transport in renal proximal tubular cells. Pflugers Archiv : European journal of physiology. 2017 11; 469(11):1471-1481. doi: 10.1007/s00424-017-2033-8. [PMID: 28741179]
  • Mikyung Yu, Jaume Amengual, Arjun Menon, Nazila Kamaly, Felix Zhou, Xiaoding Xu, Phei Er Saw, Seung-Joo Lee, Kevin Si, Carleena Angelica Ortega, Won Il Choi, In-Hyun Lee, Yazan Bdour, Jinjun Shi, Morteza Mahmoudi, Sangyong Jon, Edward A Fisher, Omid C Farokhzad. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice. Advanced healthcare materials. 2017 Oct; 6(20):. doi: 10.1002/adhm.201700313. [PMID: 28730752]
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