Decylubiquinone (BioDeep_00000010743)

 

Secondary id: BioDeep_00001871560

human metabolite blood metabolite


代谢物信息卡片


2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

化学式: C19H30O4 (322.2144)
中文名称: 癸基泛醌(2,3-Dmdb)
谱图信息: 最多检出来源 Homo sapiens(blood) 52.59%

分子结构信息

SMILES: CCCCCCCCCCC1=C(C(=O)C(=C(C1=O)OC)OC)C
InChI: InChI=1S/C19H30O4/c1-5-6-7-8-9-10-11-12-13-15-14(2)16(20)18(22-3)19(23-4)17(15)21/h5-13H2,1-4H3



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CASP3, CDH1, LIMK1, SLC9A1, XIAP
Peripheral membrane protein 2 HSD17B6, NDUFA5
Endosome membrane 1 CLCN5
Nucleus 5 CASP3, CDH1, DDX53, LIMK1, XIAP
cytosol 7 CASP3, CDH1, CLCN5, DDX53, DHODH, LIMK1, XIAP
dendrite 2 ADGRB1, MT-ND1
mitochondrial membrane 1 MT-ND1
trans-Golgi network 1 CDH1
nucleoplasm 8 ATP2B1, CASP3, CD2, CDH1, DDX53, DHODH, SLC9A1, XIAP
Cell membrane 7 ADGRB1, ATP2B1, CD2, CDH1, CLCN5, GPRC5A, SLC9A1
lamellipodium 3 CDH1, LIMK1, SLC9A1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 8 ADGRB1, ATP2B1, CLCN5, COQ2, GPRC5A, MT-CYB, MT-ND1, SLC9A1
Golgi apparatus membrane 1 CLCN5
Synapse 1 ATP2B1
cell junction 1 CDH1
cell surface 2 CD2, SLC9A1
glutamatergic synapse 4 ATP2B1, CASP3, CDH1, LIMK1
Golgi apparatus 3 CD2, CDH1, CLCN5
Golgi membrane 1 CLCN5
lysosomal membrane 1 CLCN5
mitochondrial inner membrane 7 ATP5ME, COQ2, DHODH, MT-CYB, MT-ND1, NDUFA5, SQOR
neuronal cell body 2 CASP3, MT-ND1
postsynapse 2 CDH1, LIMK1
presynaptic membrane 1 ATP2B1
synaptic vesicle 1 CLCN5
endosome 1 CDH1
plasma membrane 7 ADGRB1, ATP2B1, CD2, CDH1, CLCN5, GPRC5A, SLC9A1
synaptic vesicle membrane 1 ATP2B1
Membrane 9 ADGRB1, ATP2B1, CDH1, CLCN5, COQ2, DHODH, LIMK1, MT-CYB, SLC9A1
apical plasma membrane 1 SLC9A1
basolateral plasma membrane 2 ATP2B1, SLC9A1
extracellular exosome 4 ATP2B1, CDH1, GPRC5A, SLC9A1
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 1 ADGRB1
perinuclear region of cytoplasm 3 ADGRB1, CDH1, SLC9A1
adherens junction 1 CDH1
intercalated disc 1 SLC9A1
mitochondrion 9 ATP5ME, COQ2, DHODH, MT-CYB, MT-ND1, NDUFA5, SLC9A1, SQOR, SUOX
protein-containing complex 1 CD2
intracellular membrane-bounded organelle 4 ATP2B1, DDX53, GPRC5A, HSD17B6
Microsome membrane 1 HSD17B6
postsynaptic density 2 ADGRB1, CASP3
Single-pass type I membrane protein 2 CD2, CDH1
extracellular region 2 CD2, CDH1
cytoplasmic side of plasma membrane 2 CD2, CDH1
Single-pass membrane protein 1 DHODH
mitochondrial matrix 1 SUOX
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 CDH1
external side of plasma membrane 1 CD2
actin cytoskeleton 1 CDH1
dendritic spine 1 ADGRB1
T-tubule 1 SLC9A1
nucleolus 2 DDX53, GPRC5A
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
cell-cell junction 2 ADGRB1, CD2
vesicle 1 GPRC5A
Cell projection, lamellipodium 1 LIMK1
Mitochondrion inner membrane 5 COQ2, DHODH, MT-CYB, MT-ND1, NDUFA5
Matrix side 2 COQ2, NDUFA5
Membrane raft 1 SLC9A1
Cell junction, focal adhesion 1 ADGRB1
Cytoplasm, cytoskeleton 1 LIMK1
focal adhesion 3 ADGRB1, LIMK1, SLC9A1
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
Cell projection, dendritic spine 1 ADGRB1
Mitochondrion intermembrane space 1 SUOX
mitochondrial intermembrane space 1 SUOX
lateral plasma membrane 2 ATP2B1, CDH1
nuclear speck 1 LIMK1
receptor complex 1 GPRC5A
neuron projection 1 LIMK1
Cell projection, phagocytic cup 1 ADGRB1
cell projection 1 ATP2B1
phagocytic cup 1 ADGRB1
cytoskeleton 1 LIMK1
Golgi apparatus, trans-Golgi network 1 CDH1
Basolateral cell membrane 2 ATP2B1, SLC9A1
Cytoplasmic vesicle membrane 1 GPRC5A
Presynaptic cell membrane 1 ATP2B1
respiratory chain complex I 2 MT-ND1, NDUFA5
male germ cell nucleus 1 LIMK1
anaphase-promoting complex 1 CDH1
[Vasculostatin-120]: Secreted 1 ADGRB1
[Vasculostatin-40]: Secreted 1 ADGRB1
immunological synapse 1 ATP2B1
respiratory chain complex III 1 MT-CYB
[Isoform 2]: Nucleus 1 CDH1
death-inducing signaling complex 1 CASP3
apical junction complex 1 CDH1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
proton-transporting ATP synthase complex 1 ATP5ME
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
photoreceptor ribbon synapse 1 ATP2B1
cation-transporting ATPase complex 1 SLC9A1


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Leonardo Borges Murad, Marcela Rodrigues Moreira Guimarães, Lucia Marques Vianna. Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP. BioFactors (Oxford, England). 2007; 30(1):13-8. doi: 10.1002/biof.5520300102. [PMID: 18198397]
  • Yasser Ahmed Mahmmoud, Henrik Vorum, Flemming Cornelius. Interaction of FXYD10 (PLMS) with Na,K-ATPase from shark rectal glands. Close proximity of Cys74 of FXYD10 to Cys254 in the a domain of the alpha-subunit revealed by intermolecular thiol cross-linking. The Journal of biological chemistry. 2005 Jul; 280(30):27776-82. doi: 10.1074/jbc.m503150200. [PMID: 15919665]
  • Nicholas Fisher, C Kate Castleden, Ingrid Bourges, Gael Brasseur, Genevieve Dujardin, Brigitte Meunier. Human disease-related mutations in cytochrome b studied in yeast. The Journal of biological chemistry. 2004 Mar; 279(13):12951-8. doi: 10.1074/jbc.m313866200. [PMID: 14718526]
  • Xiaokang Ge, Ya-Min Fu, Yi-Qi Li, Gary G Meadows. Activation of caspases and cleavage of Bid are required for tyrosine and phenylalanine deficiency-induced apoptosis of human A375 melanoma cells. Archives of biochemistry and biophysics. 2002 Jul; 403(1):50-8. doi: 10.1016/s0003-9861(02)00211-4. [PMID: 12061801]
  • G Lenaz, G Parenti Castelli, Fato, M D'Aurelio, C Bovina, G Formiggini, M Marchetti, E Estornell, H Rauchova. Coenzyme Q deficiency in mitochondria: kinetic saturation versus physical saturation. Molecular aspects of medicine. 1997; 18 Suppl(?):S25-31. doi: 10.1016/s0098-2997(97)00029-0. [PMID: 9266503]
  • G Pollakis, R W Grady, H A Dieck, A B Clarkson. Competition between inhibitors of the trypanosome alternative oxidase (TAO) and reduced coenzyme Q9. Biochemical pharmacology. 1995 Oct; 50(8):1207-10. doi: 10.1016/0006-2952(95)00259-3. [PMID: 7488235]
  • . . . . doi: . [PMID: 10491195]