Diosgenin (BioDeep_00000000107)

 

Secondary id: BioDeep_00000000533, BioDeep_00000171853

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2R,4S,5R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5,6a,8a,9-Tetramethyl-1,3,3,4,4,5,5,6,6a,6b,6,7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2,1:4,5]indeno[2,1-b]furan-10,2-pyran]-4-ol

化学式: C27H42O3 (414.3134)
中文名称: 薯芋皂苷配基, 薯蓣皂苷元, 薯蓣皂素, 薯芋皂素, 地奥配质, 薯蓣皂甙元
谱图信息: 最多检出来源 Viridiplantae(plant) 9.53%

分子结构信息

SMILES: C1[C@H](O)CC2[C@@](C)([C@@]3([H])CC[C@]4(C)[C@H]5[C@@H]([C@]6(O[C@H]5C[C@@]4([H])[C@]3([H])CC=2)CC[C@@H](C)CO6)C)C1
InChI: InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3

描述信息

Diosgenin is a sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone. It has a role as an apoptosis inducer, an antiviral agent, an antineoplastic agent and a metabolite. It is a 3beta-sterol, a spiroketal, a hexacyclic triterpenoid and a sapogenin. It derives from a hydride of a spirostan.
Diosgenin is a natural product found in Ophiopogon intermedius, Dracaena draco, and other organisms with data available.
A spirostan found in DIOSCOREA and other plants. The 25S isomer is called yamogenin. Solasodine is a natural derivative formed by replacing the spiro-ring with a nitrogen, which can rearrange to SOLANINE.
See also: Fenugreek seed (part of); Dioscorea polystachya tuber (part of).
A sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.
Diosgenin is a member of the class of compounds known as triterpenoids. Triterpenoids are terpene molecules containing six isoprene units. Diosgenin is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Diosgenin can be found in a number of food items such as carrot, wild carrot, yam, and bitter gourd, which makes diosgenin a potential biomarker for the consumption of these food products. Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone) product of such hydrolysis, diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products .
Bottle Name:Diosgenin; Origin: Plant; Formula(Parent): C27H42O3; PRIME Parent Name:Diosgenin; PRIME in-house No.:T0108; SubCategory_DNP: The sterols, Cholestanes
Origin: Plant; Formula(Parent): C27H42O3; Bottle Name:Diosgenin; PRIME Parent Name:Diosgenin; PRIME in-house No.:T0108; SubCategory_DNP: The sterols, Cholestanes
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2260
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression[5].
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression[5].

同义名列表

42 个代谢物同义名

(2R,4S,5R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5,6a,8a,9-Tetramethyl-1,3,3,4,4,5,5,6,6a,6b,6,7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2,1:4,5]indeno[2,1-b]furan-10,2-pyran]-4-ol; (1S,2R,2S,4S,5R,7S,8R,9S,12S,13R,16S)-5,7,9,13-tetramethyl-5-oxaspiro[oxane-2,6-pentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan]-18-en-16-ol; (25R)-5-Spirosten-3(1/4)?-ol ; 3(1/4)?-Hydroxy-5-spirostene; Diosgenin, European Pharmacopoeia (EP) Reference Standard; (2R,5R)-5-tetramethylspiro[[?]-2,2-tetrahydropyran]ol; DIOSGENIN (CONSTITUENT OF FENUGREEK SEED) [DSC]; 5-19-03-00030 (Beilstein Handbook Reference); DIOSGENIN (CONSTITUENT OF FENUGREEK SEED); (25R)-14beta,17beta-spirost-5-en-3beta-ol; Spirost-5-en-3-ol, (3-beta,25R)-; (3.BETA.,25R)-SPIROST-5-EN-3-OL; Spirost-5-en-3-ol, (3beta,25R)-; (20R,25R)-Spirost-5-en-3beta-ol; Spirost-5-en-3-beta-ol, (25R)-; Spirost-5-en-3beta-ol, (25R)-; 22alpha-Spirost-5-en-3beta-ol; (25R)-spirost-5-en-3beta-diol; (3beta,25R)-spirost-5-en-3-ol; Spirost-5-en-3-ol, (3b,25R)-; WQLVFSAGQJTQCK-VKROHFNGSA-N; (25R)-Spirost-5-en-3beta-ol; 3beta-Hydroxy-5-spirostene; (25R)-5-Spirosten-3beta-ol; 3A-Hydroxy-5-spirostene; (25R)-5-Spirosten-3A-ol; Dioscorea sapogenin; DIOSGENIN [WHO-DD]; Diosgenin, >=93\\%; DIOSGENIN [INCI]; UNII-K49P2K8WLX; DIOSGENIN [MI]; Diosgenin,(S); nitrogen in; ST 27:3;O3; K49P2K8WLX; Diosgenin; Nitogenin; DISOGENIN; SP 37; YUV; NCGC00386027-01_C27H42O3_Spirost-5-en-3-ol, (3beta,25R)-; Diosgenin



数据库引用编号

56 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

446 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 17 AKT1, BCL2, CASP3, CASP8, CASP9, ESR1, FASN, MAPK8, MTOR, PIK3CA, PPARG, PRKAA2, PTGS2, STAT3, TLR4, TP53, VEGFA
Peripheral membrane protein 3 ESR1, MTOR, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 4 BCL2, HMGCR, MTOR, PTGS2
Nucleus 13 AKT1, BCL2, CASP3, CASP8, CASP9, ESR1, MAPK8, MTOR, PPARG, PRKAA2, STAT3, TP53, VEGFA
cytosol 14 AKT1, BCL2, CASP3, CASP8, CASP9, ESR1, FASN, MAPK8, MTOR, PIK3CA, PPARG, PRKAA2, STAT3, TP53
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 1 TP53
nucleoplasm 10 AKT1, CASP3, CASP8, ESR1, MAPK8, MTOR, PPARG, PRKAA2, STAT3, TP53
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 3 AKT1, ESR1, TLR4
Cytoplasmic side 2 ESR1, MTOR
lamellipodium 3 AKT1, CASP8, PIK3CA
Multi-pass membrane protein 1 HMGCR
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 TLR4, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 4 ESR1, FASN, PRKAA2, VEGFA
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, PRKAA2
postsynapse 1 AKT1
Lysosome 1 MTOR
plasma membrane 6 AKT1, ESR1, FASN, PIK3CA, STAT3, TLR4
Membrane 10 AKT1, BCL2, ESR1, FASN, HMGCR, MTOR, PRKAA2, TLR4, TP53, VEGFA
axon 2 MAPK8, PRKAA2
caveola 1 PTGS2
extracellular exosome 1 FASN
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 BCL2, HMGCR, PTGS2, TP53, VEGFA
extracellular space 3 IL4, INS, VEGFA
perinuclear region of cytoplasm 3 PIK3CA, PPARG, TLR4
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CASP8, CASP9, TP53
protein-containing complex 7 AKT1, BCL2, CASP8, CASP9, ESR1, PTGS2, TP53
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 3 IL4, INS, VEGFA
extracellular region 3 IL4, INS, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, CASP8, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 ESR1, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TLR4
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
Early endosome 1 TLR4
cell-cell junction 1 AKT1
vesicle 1 AKT1
Cell projection, lamellipodium 1 CASP8
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
spindle 1 AKT1
extracellular matrix 1 VEGFA
peroxisomal membrane 1 HMGCR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 PPARG, TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 4 ESR1, PPARG, STAT3, TP53
phagocytic cup 1 TLR4
cytoskeleton 1 CASP8
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
Melanosome 1 FASN
cytoplasmic stress granule 1 PRKAA2
euchromatin 1 ESR1
cell body 1 CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
Peroxisome membrane 1 HMGCR
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 CASP9
[Isoform 1]: Nucleus 2 ESR1, TP53
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
glycogen granule 1 FASN
caspase complex 1 CASP9


文献列表

  • Liwei Fan, Runfeng Ni, Haijin Wang, Le Zhang, Aidi Wang, Baoshan Liu. Dioscin alleviates aplastic anemia through regulatory T cells promotion. Hematology (Amsterdam, Netherlands). 2024 Dec; 29(1):2326389. doi: 10.1080/16078454.2024.2326389. [PMID: 38466633]
  • Xinyu Zhou, Duanna Zhang, Jieting Lei, Jixia Ren, Bo Yang, Zhixing Cao, Chuanjie Guo, Yuzhi Li. Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation. Journal of natural medicines. 2024 Jun; 78(3):618-632. doi: 10.1007/s11418-024-01811-4. [PMID: 38668832]
  • Ya-Xin Shi, Li Xu, Xin Wang, Ke-Ke Zhang, Cheng-Yuan Zhang, Hong-Yun Liu, Ping-Ping Ding, Wei Shi, Zhi-Yong Liu. Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155461. doi: 10.1016/j.phymed.2024.155461. [PMID: 38452697]
  • Shuli Man, Xinghao Zhang, Lu Xie, Yaxue Zhou, Genbei Wang, Ruijia Hao, Wenyuan Gao. A new insight into material basis of rhizoma Paridis saponins in alleviating pain. Journal of ethnopharmacology. 2024 Apr; 323(?):117642. doi: 10.1016/j.jep.2023.117642. [PMID: 38151180]
  • Chang Junli, Zhao Fulai, Sun Xingyuan, M A Xiaoping, Zhao Peng, Zhou Chujie, Shi Binhao, G U Wenchao, Wang Yongjun, Yang Yanping. Polyphyllin I enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth downregulating the Wnt/β-catenin pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Apr; 44(2):251-259. doi: 10.19852/j.cnki.jtcm.2024.02.002. [PMID: 38504531]
  • Jia Liu, Honglin Liu, Liangyan Deng, Tao Wang, Luyao Li, Yuanyuan Chen, Liping Qu, Wenjun Zou. Protective Role of Dioscin against Doxorubicin-Induced Chronic Cardiotoxicity: Insights from Nrf2-GPX4 Axis-Mediated Cardiac Ferroptosis. Biomolecules. 2024 Mar; 14(4):. doi: 10.3390/biom14040422. [PMID: 38672439]
  • Shangni Dang, Jiang Geng, Ran Wang, Yumei Feng, Youzhi Han, Runmei Gao. Isolation of endophytes from Dioscorea nipponica Makino for stimulating diosgenin production and plant growth. Plant cell reports. 2024 Mar; 43(4):95. doi: 10.1007/s00299-024-03164-4. [PMID: 38472393]
  • Parul Tyagi, Mrinalini Prasad, Shivangi Mathur, Rajiv Ranjan. Diosgenin biosynthesis investigation in medicinal herb (Tribulus terrestris) by transcriptome analysis. Gene. 2024 Jan; 893(?):147937. doi: 10.1016/j.gene.2023.147937. [PMID: 38381509]
  • Juliana Caroline Santos Santana, Gelson Dos Santos Difante, Jéssica Gomes Rodrigues, Marislayne de Gusmão Pereira, Henrique Jorge Fernandes, Camila Celeste Brandão Ferreira Ítavo, Vanessa Zirondi Longhini, Alexandre Menezes Dias, Luís Carlos Vinhas Ítavo. Mathematical models for predicting protodioscin in tropical forage grasses. Toxicon : official journal of the International Society on Toxinology. 2024 Jan; 240(?):107628. doi: 10.1016/j.toxicon.2024.107628. [PMID: 38278421]
  • Mehdi Arabasadi, Amin Ebrahimi, Mohammad-Reza Amerian, Ehsan Ebrahimibasabi, Elham Azadvari. The amelioration of salt stress-induced damage in fenugreek through the application of cold plasma and melatonin. Plant physiology and biochemistry : PPB. 2024 Jan; 207(?):108382. doi: 10.1016/j.plaphy.2024.108382. [PMID: 38271864]
  • Mengyao Yan, Yixin Zhao, Shuli Man, Yujie Dai, Long Ma, Wenyuan Gao. Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 125(?):155299. doi: 10.1016/j.phymed.2023.155299. [PMID: 38301301]
  • Mengfei Wang, Chenyue Yuan, Zong Wu, Meng Xu, Ziqi Chen, Jialiang Yao, Zujun Que, Jianhui Tian, Elaine Lai-Han Leung, Ziliang Wang. Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis. International journal of biological sciences. 2024; 20(7):2454-2475. doi: 10.7150/ijbs.91861. [PMID: 38725854]
  • Yan Lin, Qiuyan Hu, Qiang Ye, Haohua Zhang, Ziyu Bao, Yongping Li, Luo Jian Mo. Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L. PeerJ. 2024; 12(?):e16702. doi: 10.7717/peerj.16702. [PMID: 38282859]
  • Haoyang Gao, Ze Wang, Danlin Zhu, Linlin Zhao, Weihua Xiao. Dioscin: Therapeutic potential for diabetes and complications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116051. doi: 10.1016/j.biopha.2023.116051. [PMID: 38154275]
  • Shirong Feng, Lintao Pan, Quanshun Li, Yi Zhang, Fangyuan Mou, Zhao Liu, Yuanyuan Zhang, Longfei Duan, Baofu Qin, Zhongqiu Hu. The Isolation, Identification and Immobilization Method of Three Novel Enzymes with Diosgenin-Producing Activity Derived from an Aspergillus flavus. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417611. [PMID: 38139441]
  • Yifan Cui, Yingzhuo Zhou, Yan Li, Jieying Wang, Daotong Li, Fang Chen. Chinese Yam and Its Active Components Regulate the Structure of Gut Microbiota and Indole-like Metabolites in Anaerobic Fermentation In Vitro. Nutrients. 2023 Dec; 15(24):. doi: 10.3390/nu15245112. [PMID: 38140371]
  • Su-Wen Chen, Guo-Liang Yin, Chao-Yuan Song, De-Cheng Meng, Wen-Fei Yu, Xin Zhang, Ya-Nan Feng, Peng-Peng Liang, Feng-Xia Zhang. [Diosgenin alleviates NAFLD induced by a high-fat diet in rats via mTOR/SREBP-1c/HSP60/MCAD/SCAD signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Oct; 48(19):5304-5314. doi: 10.19540/j.cnki.cjcmm.20230601.705. [PMID: 38114120]
  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Yang Liu, Weitao Zhang, Haoyan Zhou, Jun Chen. Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis. Biochemical and biophysical research communications. 2023 09; 673(?):51-58. doi: 10.1016/j.bbrc.2023.06.062. [PMID: 37356145]
  • Pei-Lu Chen, Guang-Hui Xu, Ming Li, Jia-Yuan Zhang, Jie Cheng, Cheng-Fu Li, Li-Tao Yi. Yamogenin Exhibits Antidepressant-like Effects via Inhibition of ER Stress and Microglial Activation in LPS-Induced Mice. ACS chemical neuroscience. 2023 Aug; ?(?):. doi: 10.1021/acschemneuro.3c00306. [PMID: 37579249]
  • Yi Xiao, Fang Liu, Qinyi Wu, Xinting Zhu, Changyan Yu, Nian Jiang, Sanhua Li, Yun Liu. Dioscin activates endoplasmic reticulum UPR for defense against pathogen bacteria in Caenorhabditis elegans via IRE-1/XBP-1 pathway. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad294. [PMID: 37499184]
  • Min He, Si-Yuan Guo, Yan Yin, Chi Zhang, Xia-Nan Zhang. [Gene clone and functional identification of sterol glycosyltransferases from Paris polyphylla var. yunnanensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jul; 48(14):3774-3785. doi: 10.19540/j.cnki.cjcmm.20230413.101. [PMID: 37475069]
  • Weiyi Shen, Wentao Shao, Qihan Wang, Bo Wang, Gang Zhao, Aihua Gu, Zhaoyan Jiang, Hai Hu. Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice. Journal of biomedical science. 2023 Jun; 30(1):44. doi: 10.1186/s12929-023-00933-3. [PMID: 37370162]
  • Michael Yu-Chih Chen, Bruce Chi-Kang Tsai, Wei-Wen Kuo, Chia-Hua Kuo, Yueh-Min Lin, Dennis Jine-Yuan Hsieh, Pei-Ying Pai, Shih-Chieh Liao, Shang-En Huang, Shin-Da Lee, Chih-Yang Huang. Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K/Akt and ERK Axes. The American journal of Chinese medicine. 2023 Jun; ?(?):1-22. doi: 10.1142/s0192415x23500556. [PMID: 37335210]
  • Suwen Chen, Shangwen Sun, Yanan Feng, Xiu Li, Guoliang Yin, Pengpeng Liang, Wenfei Yu, Decheng Meng, Xin Zhang, Hongshuai Liu, Fengxia Zhang. Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway. European journal of pharmacology. 2023 May; ?(?):175808. doi: 10.1016/j.ejphar.2023.175808. [PMID: 37263401]
  • Weipeng Wang, Lixiu Hou, Song Li, Jiaru Li. The Functional Characterization of DzCYP72A12-4 Related to Diosgenin Biosynthesis and Drought Adaptability in Dioscorea zingiberensis. International journal of molecular sciences. 2023 May; 24(9):. doi: 10.3390/ijms24098430. [PMID: 37176134]
  • Shahla Sheikhi, Amin Ebrahimi, Parviz Heidari, Mohamad Reza Amerian, Sajad Rashidi-Monfared, Hadi Alipour. Exogenous 24-epibrassinolide ameliorates tolerance to high-temperature by adjusting the biosynthesis of pigments, enzymatic, non-enzymatic antioxidants, and diosgenin content in fenugreek. Scientific reports. 2023 Apr; 13(1):6661. doi: 10.1038/s41598-023-33913-6. [PMID: 37095206]
  • Xinxin Zhang, Yu Zhang, Yuting Guo, Peiyun Xue, Zhaowei Xue, Yan Zhang, Hong Zhang, Yoichiro Ito, Jianwei Dou, Zengjun Guo. Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics. Steroids. 2023 04; 192(?):109181. doi: 10.1016/j.steroids.2023.109181. [PMID: 36642106]
  • Yanjie Li, Chengyu Zhang, Kexin Kong, Xiaohui Yan. Characterization and Biological Activities of Four Biotransformation Products of Diosgenin from Rhodococcus erythropolis. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28073093. [PMID: 37049855]
  • Joan Candice Ondevilla, Shinya Hanashima, Akane Mukogawa, Darcy Garza Miyazato, Yuichi Umegawa, Michio Murata. Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids. Biochimica et biophysica acta. Biomembranes. 2023 Mar; 1865(5):184145. doi: 10.1016/j.bbamem.2023.184145. [PMID: 36914020]
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  • Xu-Bo Wu, Chin-Hu Lai, Ying-Jui Ho, Chia-Hua Kuo, Pei-Fang Lai, Ching-Yi Tasi, Guohua Jin, Minqian Wei, Marthandam Asokan Shibu, Chih-Yang Huang, Shin-Da Lee. Anti-apoptotic effects of diosgenin on ovariectomized hearts. Steroids. 2022 03; 179(?):108980. doi: 10.1016/j.steroids.2022.108980. [PMID: 35157911]
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  • Prabhakar Semwal, Sakshi Painuli, Tareq Abu-Izneid, Abdur Rauf, Anshu Sharma, Sevgi Durna Daştan, Manoj Kumar, Mohammed M Alshehri, Yasaman Taheri, Rajib Das, Saikat Mitra, Talha Bin Emran, Javad Sharifi-Rad, Daniela Calina, William C Cho. Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives. Oxidative medicine and cellular longevity. 2022; 2022(?):1035441. doi: 10.1155/2022/1035441. [PMID: 35677108]
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  • Lixiu Hou, Xincheng Yuan, Song Li, Yi Li, Zihao Li, Jiaru Li. Genome-Wide Identification of CYP72A Gene Family and Expression Patterns Related to Jasmonic Acid Treatment and Steroidal Saponin Accumulation in Dioscorea zingiberensis. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222010953. [PMID: 34681613]
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  • Paulo Vinicius Moreira da Costa Menezes, Adriano Antonio Silva, Márcio Shigueaki Mito, Gislaine Cristiane Mantovanelli, Gabriel Felipe Stulp, Ana Luiza Wagner, Rodrigo Polimeni Constantin, Débora Cristina Baldoqui, Raísa Gonçales Silva, Amanda Aparecida Oliveira do Carmo, Luíz Antonio de Souza, Rubem Silvério de Oliveira Junior, Fabrizio Araniti, Maria Rosa Abenavoli, Emy Luiza Ishii-Iwamoto. Morphogenic responses and biochemical alterations induced by the cover crop Urochloa ruziziensis and its component protodioscin in weed species. Plant physiology and biochemistry : PPB. 2021 Sep; 166(?):857-873. doi: 10.1016/j.plaphy.2021.06.040. [PMID: 34237604]
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