Tomentosin (BioDeep_00000001040)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2H-Cyclohepta(b)furan-2-one, 3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-(3-oxobutyl)-, (3aR,7S,8aR)-

化学式: C15H20O3 (248.1412)
中文名称:
谱图信息: 最多检出来源 Pteris henryi Christ(not specific) 50%

分子结构信息

SMILES: C=C1C(=O)OC2CC(C)C(CCC(C)=O)=CCC12
InChI: InChI=1S/C15H20O3/c1-9-8-14-13(11(3)15(17)18-14)7-6-12(9)5-4-10(2)16/h6,9,13-14H,3-5,7-8H2,1-2H3/t9-,13+,14+/m0/s1



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

94 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ANXA5, BCL2, CASP3, CAT, CCND1, CDKN1A, MAPK14, NLRP3, NOS2, PIK3CA, PTGS2, TLR4
Peripheral membrane protein 3 ANXA5, GORASP1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 9 BCL2, CASP3, CCND1, CDKN1A, MAPK14, MPO, NLRP3, NOS2, PARP1
cytosol 12 ANXA5, BCL2, CASP3, CAT, CCND1, CDKN1A, GHR, MAPK14, NLRP3, NOS2, PARP1, PIK3CA
nuclear body 2 CDKN1A, PARP1
centrosome 1 CCND1
nucleoplasm 7 CASP3, CCND1, CDKN1A, MAPK14, MPO, NOS2, PARP1
Cell membrane 3 GHR, TLR4, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 PIK3CA
Golgi apparatus membrane 2 GORASP1, NLRP3
cell surface 3 GHR, TLR4, TNF
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 1 GORASP1
Golgi membrane 3 GORASP1, INS, NLRP3
lysosomal membrane 1 GAA
neuronal cell body 3 CASP3, GHR, TNF
sarcolemma 1 ANXA5
Cytoplasm, cytosol 3 NLRP3, NOS2, PARP1
Lysosome 2 GAA, MPO
plasma membrane 6 GAA, GHR, NOS2, PIK3CA, TLR4, TNF
Membrane 8 ANXA5, BCL2, CAT, GAA, GHR, NLRP3, PARP1, TLR4
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CAT, GAA, MPO
Lysosome membrane 1 GAA
endoplasmic reticulum 3 BCL2, NLRP3, PTGS2
extracellular space 5 GHR, IL6, INS, MPO, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 4 CDKN1A, NOS2, PIK3CA, TLR4
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CAT, MAPK14, NLRP3, PARP1
protein-containing complex 5 BCL2, CAT, CDKN1A, PARP1, PTGS2
intracellular membrane-bounded organelle 3 CAT, GAA, MPO
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 GHR, TLR4
Secreted 5 GAA, GHR, IL6, INS, NLRP3
extracellular region 10 ANXA5, CAT, GAA, GHR, IL6, INS, MAPK14, MPO, NLRP3, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
transcription regulator complex 1 PARP1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 4 ANXA5, GHR, TLR4, TNF
nucleolus 2 CDKN1A, PARP1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 2 ANXA5, CAT
cis-Golgi network 1 GORASP1
Peroxisome 2 CAT, NOS2
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 MPO
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 GHR, TLR4
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 1 PARP1
phagocytic cup 2 TLR4, TNF
Chromosome 1 PARP1
cytoplasmic ribonucleoprotein granule 1 GHR
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
[Isoform 2]: Cell membrane 1 GHR
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
tertiary granule membrane 1 GAA
myelin sheath 1 BCL2
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
transcription repressor complex 1 CCND1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
vesicle membrane 1 ANXA5
phagocytic vesicle lumen 1 MPO
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDKN1A
growth hormone receptor complex 1 GHR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Growth hormone-binding protein]: Secreted 1 GHR
cyclin D1-CDK4 complex 1 CCND1
PCNA-p21 complex 1 CDKN1A
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yu-Xi Di, Yu-Jie Bao, Zhi-Qi Zhu, Shan-Liang Sun, Feng-Xiang Tian, Fu-Rong Wang, Ge Yu, Ming-Fei Zhang, Jing Han, Ling-Ling Zhou. Tomentosin suppressed M1 polarization via increasing MERTK activation mediated by regulation of GAS6. Journal of ethnopharmacology. 2023 Apr; ?(?):116429. doi: 10.1016/j.jep.2023.116429. [PMID: 37011736]
  • Tuba Aydin, Ruya Saglamtas, Busra Dogan, Evin Kostekci, Rukiye Durmus, Ahmet Cakir. A new specific method for isolation of tomentosin with a high yield from Inula viscosa (L.) and determination of its bioactivities. Phytochemical analysis : PCA. 2022 Jun; 33(4):612-618. doi: 10.1002/pca.3114. [PMID: 35243708]
  • Yunhu Fan, M Maghimaa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Sardar Hussain, Thamaraiselvan Rengarajan. Tomentosin Reduces Behavior Deficits and Neuroinflammatory Response in MPTP-Induced Parkinson's Disease in Mice. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2021; 40(1):75-84. doi: 10.1615/jenvironpatholtoxicoloncol.v40.i1.70. [PMID: 33639075]
  • Qinghao Jin, Jin Woo Lee, Hari Jang, Ji Eun Choi, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells. Journal of natural products. 2016 06; 79(6):1548-53. doi: 10.1021/acs.jnatprod.5b01106. [PMID: 27276091]
  • Lin-fen Ding, Kou Wang, Hai-yin Wang, Wen-chao Tu, Zhen-tao Deng, Yue Zhou, Liu-dong Song. [Chemical Constituents of Inula japonica]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jun; 39(6):1296-9. doi: . [PMID: 30156801]
  • Chunfeng Xie, Lingmei Sun, Linghao Meng, Meicheng Wang, Jing Xu, Mark Bartlam, Yuanqiang Guo. Sesquiterpenes from Carpesium macrocephalum inhibit Candida albicans biofilm formation and dimorphism. Bioorganic & medicinal chemistry letters. 2015 Nov; 25(22):5409-11. doi: 10.1016/j.bmcl.2015.09.013. [PMID: 26394911]
  • Mette G Hyldgaard, Stig Purup, Andrew D Bond, Xavier C Fretté, Haiyan Qu, Katrine T Jensen, Lars P Christensen. Guaianolides and a seco-Eudesmane from the Resinous Exudates of Cushion Bush (Leucophyta brownii) and Evaluation of Their Cytostatic and Anti-inflammatory Activity. Journal of natural products. 2015 Aug; 78(8):1877-85. doi: 10.1021/acs.jnatprod.5b00208. [PMID: 26218649]
  • Xiangrong Cheng, Qi Zeng, Jie Ren, Jiangjiang Qin, Shoude Zhang, Yunheng Shen, Jiaxian Zhu, Fei Zhang, Ruijie Chang, Yan Zhu, Weidong Zhang, Huizi Jin. Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents. European journal of medicinal chemistry. 2011 Nov; 46(11):5408-15. doi: 10.1016/j.ejmech.2011.08.047. [PMID: 21924800]
  • Xu-Wen Li, Liang Weng, Xue Gao, Yun Zhao, Fei Pang, Jian-Hui Liu, Hong-Feng Zhang, Jin-Feng Hu. Antiproliferative and apoptotic sesquiterpene lactones from Carpesium faberi. Bioorganic & medicinal chemistry letters. 2011 Jan; 21(1):366-72. doi: 10.1016/j.bmcl.2010.10.138. [PMID: 21109433]
  • Sharon Rozenblat, Shlomo Grossman, Margalit Bergman, Hugo Gottlieb, Yigal Cohen, Sara Dovrat. Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines. Biochemical pharmacology. 2008 Jan; 75(2):369-82. doi: 10.1016/j.bcp.2007.08.024. [PMID: 17919456]
  • C Cafarchia, N De Laurentis, M A Milillo, V Losacco, V Puccini. [Fungistatic activity of a sesquiterpene lactone (tomentosin) isolated from fresh Inula viscosa (Asteraceae) flowers from the Puglia region]. Parassitologia. 2001 Sep; 43(3):117-21. doi: ". [PMID: 11921538]