Blasticidin S (BioDeep_00001028330)
Main id: BioDeep_00000003361
代谢物信息卡片
化学式: C17H26N8O5 (422.2026)
中文名称: 布拉叶斯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N
InChI: InChI=1S/C17H26N8O5/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29)/t9-,10-,13+,14-/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
A blasticidin that is an antibiotic obtained from Streptomyces griseochromogene.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:15353
- ChEBI: CHEBI:182497
- KEGG: C02010
- PubChem: 170012
- PubChem: 439625
- ChEMBL: CHEMBL476894
- CAS: 2079-00-7
- MetaboLights: MTBLC15353
- PubChem: 5106
- KNApSAcK: C00016063
- PDB-CCD: BLS
- NIKKAJI: J9.250I
- RefMet: Blasticidin S
- KNApSAcK: 15353
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yixin Ge, Jae Hoon Lee, Baishi Hu, Youfu Zhao. Loss-of-Function Mutations in the Dpp and Opp Permeases Render Erwinia amylovora Resistant to Kasugamycin and Blasticidin S.
Molecular plant-microbe interactions : MPMI.
2018 08; 31(8):823-832. doi:
10.1094/mpmi-01-18-0007-r. [PMID: 29474798] - Jack R Davison, Katheryn M Lohith, Xiaoning Wang, Kostyantyn Bobyk, Sivakoteswara R Mandadapu, Su-Lin Lee, Regina Cencic, Justin Nelson, Scott Simpkins, Karen M Frank, Jerry Pelletier, Chad L Myers, Jeff Piotrowski, Harold E Smith, Carole A Bewley. A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter.
Antimicrobial agents and chemotherapy.
2017 06; 61(6):. doi:
10.1128/aac.02635-16. [PMID: 28373194] - Anthony L Shiver, Hendrik Osadnik, George Kritikos, Bo Li, Nevan Krogan, Athanasios Typas, Carol A Gross. A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S.
PLoS genetics.
2016 06; 12(6):e1006124. doi:
10.1371/journal.pgen.1006124. [PMID: 27355376] - Shohei Sakuda, Tomoya Yoshinari, Tomohiro Furukawa, Usuma Jermnak, Keiko Takagi, Kurin Iimura, Toshiyoshi Yamamoto, Michio Suzuki, Hiromichi Nagasawa. Search for aflatoxin and trichothecene production inhibitors and analysis of their modes of action.
Bioscience, biotechnology, and biochemistry.
2016; 80(1):43-54. doi:
10.1080/09168451.2015.1086261. [PMID: 26376763] - Clarissa C Lee, Elizaveta Freinkman, David M Sabatini, Hidde L Ploegh. The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.
The Journal of biological chemistry.
2014 Jun; 289(24):17124-31. doi:
10.1074/jbc.m114.571257. [PMID: 24782309] - D Engelmeier, F Hadacek, O Hofer, G Lutz-Kutschera, M Nagl, G Wurz, H Greger. Antifungal 3-butylisocoumarins from Asteraceae-Anthemideae.
Journal of natural products.
2004 Jan; 67(1):19-25. doi:
10.1021/np0301339. [PMID: 14738379] - Denny G Mellersh, Inge V Foulds, Verna J Higgins, Michele C Heath. H2O2 plays different roles in determining penetration failure in three diverse plant-fungal interactions.
The Plant journal : for cell and molecular biology.
2002 Feb; 29(3):257-68. doi:
10.1046/j.0960-7412.2001.01215.x. [PMID: 11844104] - Makoto Kimura, Makio Furuichi, Masaki Yamamoto, Takashi Kumasaka, Hiroshi Mizuno, Masashi Miyano, Isamu Yamaguchi. The flexible C-terminal region of Aspergillus terreus blasticidin S deaminase: identification of its functional roles with deletion enzymes.
Biochemical and biophysical research communications.
2002 Jan; 290(1):421-6. doi:
10.1006/bbrc.2001.6184. [PMID: 11779186] - D Engelmeier, F Hadacek, T Pacher, S Vajrodaya, H Greger. Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea).
Journal of agricultural and food chemistry.
2000 Apr; 48(4):1400-4. doi:
10.1021/jf990509h. [PMID: 10775404] - K Tamura, M Kimura, I Yamaguchi. Blasticidin S deaminase gene (BSD): a new selection marker gene for transformation of Arabidopsis thaliana and Nicotiana tabacum.
Bioscience, biotechnology, and biochemistry.
1995 Dec; 59(12):2336-8. doi:
10.1271/bbb.59.2336. [PMID: 8611760] - T Kitagawa, T Kawasaki, H Munechika. Enzyme immunoassay of blasticidin S with high sensitivity: a new and convenient method for preparation of immunogenic (hapten-protein) conjugates.
Journal of biochemistry.
1982 Aug; 92(2):585-90. doi:
10.1093/oxfordjournals.jbchem.a133967. [PMID: 6752134] - K T HUANG, T MISATO, H ASUYAMA. EFFECT OF BLASTICIDIN S ON PROTEIN SYNTHESIS OF PIRICULARIA ORYZAE.
The Journal of antibiotics.
1964 Mar; 17(?):65-70. doi:
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