Aconitine (BioDeep_00000000133)

   

Toxin natural product


代谢物信息卡片


(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-4-yl benzoate

化学式: C34H47NO11 (645.3149)
中文名称: 乌头碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 87.24%

分子结构信息

SMILES: CCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)OC(=O)C)OC)OC)O)COC
InChI: InChI=1S/C34H47NO11/c1-7-35-15-31(16-41-3)20(37)13-21(42-4)33-19-14-32(40)28(45-30(39)18-11-9-8-10-12-18)22(19)34(46-17(2)36,27(38)29(32)44-6)23(26(33)35)24(43-5)25(31)33/h8-12,19-29,37-38,40H,7,13-16H2,1-6H3/t19-,20-,21+,22-,23+,24+,25-,26+,27+,28-,29+,31+,32-,33+,34-/m1/s1

描述信息

D049990 - Membrane Transport Modulators > D062687 - Sodium Channel Agonists > D061585 - Voltage-Gated Sodium Channel Agonists
D007155 - Immunologic Factors
Aconitine is a diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively. It is functionally related to an aconitane.
Aconitine is a natural product found in Aconitum anthora, Aconitum napellus, and other organisms with data available.
Aconitine is a plant toxin found in species of wolfsbane (Aconitum genus). It is a neurotoxin previously used as an antipyretic and analgesic, and still has some limited application in herbal medicine. (L1235). The toxic effects of Aconitine have been tested in a variety of different test animals, including mammals (dog, cat, guinea pig, mouse, rat and rabbit), frogs and pigeons. Depending on the route of exposure, the observed toxic effects were: local anesthetic effect, diarrhea, convulsions, arrhythmias or death. According to a review of different reports of aconite poisoning in humans the following clinical features were observed: Neurological, Cardiovascular, Ventricular arrhythmias, Gastrointestinal.
A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.
See also: Aconitum coreanum root (part of).
Origin: Plant; SubCategory_DNP: Terpenoid alkaloids, Diterpene alkaloid, Aconitum alkaloid
Annotation level-1
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2309

同义名列表

18 个代谢物同义名

2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-3,8,13,14,15-pentol deriv.; Aconitine; (1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-4-yl benzoate; [(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-; (1alpha,3alpha,6alpha,14.ALPHA,15alpha,16beta)-20-ETHYL-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITANE-3,8,13,14,15-PENTOL 8-ACETATE 14-BENZOATE; (1Alpha,3Alpha,6Alpha,14Alpha,15Alpha,16Beta)-20-Ethyl-1,6,16-Trimethoxy-4-(Methoxymethyl)Aconitane-3,8,13,14,15-Pentol 8-Acetate 14-Benzoate; 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diyl 8-acetate 14-benzoate; 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate; Acetylbenzoyl-aconine; Acetylbenzoyl aconine; Acetylbenzoylaconine; NCI60_004380; Aconitinum; Aconitin; [(1S,4R,5R,6S,7S,8R,9R,10R,13R,14R,16S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; [(1S,2R,3R,4R,5R,6S,7S,8R,9R,10S,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; Aconitine



数据库引用编号

62 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

115 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, AKT1, AXIN2, BCL2, CA1, CASP3, PIK3CA, PRKAA2, PTGS2
Peripheral membrane protein 2 CYP1B1, PTGS2
Endoplasmic reticulum membrane 4 BCL2, CD4, CYP1B1, PTGS2
Mitochondrion membrane 1 ABCG2
Nucleus 5 AKT1, AXIN2, BCL2, CASP3, PRKAA2
cytosol 9 AKT1, AXIN2, BCL2, CA1, CASP3, KCNN4, PIK3CA, PRKAA2, PRKCQ
dendrite 1 PRKAA2
mitochondrial membrane 1 ABCG2
centrosome 1 AXIN2
nucleoplasm 6 ABCG2, AKT1, CASP3, PRKAA2, SCN5A, SCNN1G
Cell membrane 7 ABCB1, ABCG2, AKT1, CD4, KCNN4, SCN5A, TNF
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 1 KCNN4
Multi-pass membrane protein 7 ABCB1, ABCG2, CACNA1I, KCNN4, RYR2, SCN5A, SCNN1G
cell cortex 1 AKT1
cell junction 1 SCN5A
cell surface 3 ABCB1, SCN5A, TNF
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 1 PRKAA2
neuronal cell body 4 CASP3, KCNN4, PRKAA2, TNF
postsynapse 1 AKT1
sarcolemma 2 RYR2, SCN5A
smooth endoplasmic reticulum 1 RYR2
plasma membrane 13 ABCB1, ABCG2, AKT1, AXIN2, CACNA1I, CD4, KCNN4, PIK3CA, PRKCQ, RYR2, SCN5A, SCNN1G, TNF
Membrane 10 ABCB1, ABCG2, AKT1, BCL2, CACNA1I, CYP1B1, KCNN4, PRKAA2, RYR2, SCN5A
apical plasma membrane 3 ABCB1, ABCG2, SCNN1G
axon 1 PRKAA2
caveola 2 PTGS2, SCN5A
extracellular exosome 3 ABCB1, CA1, SCNN1G
endoplasmic reticulum 3 BCL2, PTGS2, SCN5A
extracellular space 2 IL6, TNF
perinuclear region of cytoplasm 2 PIK3CA, SCN5A
intercalated disc 2 PIK3CA, SCN5A
mitochondrion 2 BCL2, CYP1B1
protein-containing complex 4 AKT1, BCL2, PTGS2, RYR2
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 CD4
Secreted 1 IL6
extracellular region 2 IL6, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
centriolar satellite 1 PRKCQ
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 CD4, SCNN1G, TNF
T-tubule 1 SCN5A
Z disc 2 RYR2, SCN5A
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 AKT1
nucleolus 1 SCN5A
Early endosome 1 CD4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, KCNN4
Apical cell membrane 3 ABCB1, ABCG2, SCNN1G
Cell projection, ruffle membrane 1 KCNN4
Cytoplasm, perinuclear region 1 SCN5A
Membrane raft 3 ABCG2, CD4, TNF
pore complex 1 BCL2
spindle 1 AKT1
sarcoplasmic reticulum 1 RYR2
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
lateral plasma membrane 1 SCN5A
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 KCNN4, PTGS2
ciliary basal body 1 AKT1
phagocytic cup 1 TNF
brush border membrane 1 ABCG2
sodium channel complex 1 SCNN1G
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 BCL2
Cell membrane, sarcolemma, T-tubule 1 SCN5A
voltage-gated potassium channel complex 1 KCNN4
endoplasmic reticulum lumen 3 CD4, IL6, PTGS2
voltage-gated calcium channel complex 1 CACNA1I
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Sarcoplasmic reticulum membrane 1 RYR2
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 CD4
calcium channel complex 1 RYR2
junctional sarcoplasmic reticulum membrane 1 RYR2
external side of apical plasma membrane 2 ABCB1, ABCG2
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
voltage-gated sodium channel complex 1 SCN5A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yixin Rui, Xiumeng Zhang, Xinran Min, Hongxiao Xie, Xiuying Ma, Funeng Geng, Rong Liu. Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury. International immunopharmacology. 2024 May; 133(?):112170. doi: 10.1016/j.intimp.2024.112170. [PMID: 38691919]
  • Cuihan Zhang, Huan Hou, Changhong Shen, Qian Ran, Fang Cheng, Ziqing Yao, Ruoqi Zhang, Cheng Peng. Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling. Toxicon : official journal of the International Society on Toxinology. 2024 May; 242(?):107693. doi: 10.1016/j.toxicon.2024.107693. [PMID: 38519012]
  • Tong Xu, Zengnan Wu, Hongren Yao, Yingrui Zhang, Shiyu Chen, Yuxuan Li, Xian-Li Meng, Yi Zhang, Jin-Ming Lin. Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device. Chemical communications (Cambridge, England). 2024 May; 60(37):4898-4901. doi: 10.1039/d4cc00396a. [PMID: 38629248]
  • Bhanu Kumar, Ankita Misra, Poonam Rawat, Priyanka Agnihotri, Sharad Srivastava. Anti-rheumatic potential vis-à-vis aconitine and hypaconitine content analysis in different Aconitum spp. from Sikkim Himalayas (India). Chemistry & biodiversity. 2024 Jan; ?(?):e202301656. doi: 10.1002/cbdv.202301656. [PMID: 38217357]
  • Yan Xiao, Meng Han, Ying Chen, Yu-Zhu Li, Yin-Yong Zhang, Lin Chen, Shuai Huang, Xian-Li Zhou. In vitro and in vivo biological evaluation of Lappaconitine derivatives as potential anti-inflammatory agents. Chemistry & biodiversity. 2023 Dec; ?(?):e202301761. doi: 10.1002/cbdv.202301761. [PMID: 38117633]
  • Natasha L Goumeniouk, Davis N Maclean, Joshua S Howie, Jason E Waechter, Philippe Couillard, Jeffrey A Shaw, Scott N Lucyk. Stir Fry with a Side of Extracorporeal Membrane Oxygen: Management of Cardiogenic Shock Secondary to Unintentional Aconitine Ingestion. Wilderness & environmental medicine. 2023 Nov; ?(?):. doi: 10.1016/j.wem.2023.09.006. [PMID: 37923684]
  • Chen Jiang, Jun Shen, Chun Wang, Yongjie Huang, Linbo Wang, Yiran Yang, Wen Hu, Ping Li, Haiying Wu. Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU. Toxicology letters. 2023 Jul; 384(?):86-95. doi: 10.1016/j.toxlet.2023.07.014. [PMID: 37506855]
  • Kirill P Cheremnykh, Arkadiy O Bryzgalov, Dmitry S Baev, Sergey A Borisov, Yulia S Sotnikova, Victor A Savelyev, Tatyana G Tolstikova, Shamansur S Sagdullaev, Elvira E Shults. Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine-1,5-Benzodiazepine Hybrids. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28104234. [PMID: 37241973]
  • Ning Ding, Shu Wang, Yan Xiao, Shuai Huang, Lin Chen, Jiang Xie, Xian-Li Zhou. Four New C19 -Diterpenoid Alkaloids from Aconitum nagarum Stapf. Chemistry & biodiversity. 2023 May; 20(5):e202300058. doi: 10.1002/cbdv.202300058. [PMID: 36944592]
  • Yu-Jie Wang, Yan Wang, Pei Tao. Structural characterization, in vivo toxicity and biological activity of two new pyro-type diterpenoid alkaloids derived from 3-acetylaconitine. Journal of integrative medicine. 2023 Apr; ?(?):. doi: 10.1016/j.joim.2023.04.001. [PMID: 37080800]
  • Catalina Mares, Ana-Maria Udrea, Catalin Buiu, Angela Staicu, Speranta Avram. Therapeutic Potentials of Aconite-like Alkaloids - Bioinformatics and Experimental Approaches. Mini reviews in medicinal chemistry. 2023 Mar; ?(?):. doi: 10.2174/1389557523666230328153417. [PMID: 36994982]
  • Xiaocui Li, Weiqing Hou, Tingting Lin, Jiadong Ni, Huawei Qiu, Yu Fu, Zhongxiang Zhao, Caihua Yang, Na Li, Hua Zhou, Rong Zhang, Zhongqiu Liu, Ling Fu, Lijun Zhu. Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: In vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations. Journal of ethnopharmacology. 2023 Mar; 303(?):115879. doi: 10.1016/j.jep.2022.115879. [PMID: 36370966]
  • Xiang Jin, Jiafei Cheng, Qing Zhang, Haiwang Ji, Chan Zhu, Yan Yang, Yuan Zhou, Guang Yu, Changming Wang, Zongxiang Tang. Aconitine - A promising candidate for treating cold and mechanical allodynia in cancer induced bone pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 161(?):114284. doi: 10.1016/j.biopha.2023.114284. [PMID: 36868017]
  • Qiuju Li, Fu Peng, Xiaoyu Yan, Yan Chen, Jie Zhou, Shuangyue Wu, Wanyanhan Jiang, Xuhui Jin, Jie Liang, Cheng Peng, Xiaoqi Pan. Inhibition of SLC7A11-GPX4 signal pathway is involved in aconitine-induced ferroptosis in vivo and in vitro. Journal of ethnopharmacology. 2023 Mar; 303(?):116029. doi: 10.1016/j.jep.2022.116029. [PMID: 36503029]
  • Xianfeng Liu, Honglin Tao, Ruimin Tian, Wenge Huang, Tao Zhang, Yue Liu, Yi Zhang, Xianli Meng. Hezi inhibits Tiebangchui-induced cardiotoxicity and preserves its anti-rheumatoid arthritis effects by regulating the pharmacokinetics of aconitine and deoxyaconitine. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115915. doi: 10.1016/j.jep.2022.115915. [PMID: 36375646]
  • Jiang Hu, Qiong Wu, Qiang Li, Tao Lv, Tian-Feng Peng, Si Yin, Hong-Zhou Jin. Antinociceptive diterpenoid alkaloids from the roots of Aconitum austroyunnanense. Journal of Asian natural products research. 2023 Feb; 25(2):132-138. doi: 10.1080/10286020.2022.2070483. [PMID: 35574919]
  • Tao Song, Yuanyuan Hao, Mingye Wang, Tongtong Li, Chi Zhao, Jiajia Li, Yunlong Hou. Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 112(?):154688. doi: 10.1016/j.phymed.2023.154688. [PMID: 36738478]
  • Jiao Song, Wei Liao, Xuan Deng, Dingkun Zhang, Junzhi Lin, Runchun Xu, Li Han. Analysis of the pharmacodynamic difference between Xiaojin Pills taken with Chinese Baijiu and water based on serum pharmacochemistry and pharmacokinetics. Journal of ethnopharmacology. 2023 Jan; 300(?):115723. doi: 10.1016/j.jep.2022.115723. [PMID: 36115600]
  • Youwei Gu, Jieru Wang, Mengting Li, Fei Zhong, Jie Xiang, Zhengxin Xu. Inhibitory Effects of Nobiletin on Voltage-Gated Na+ Channel in Rat Ventricular Myocytes Based on Electrophysiological Analysis and Molecular Docking Method. International journal of molecular sciences. 2022 Dec; 23(23):. doi: 10.3390/ijms232315175. [PMID: 36499507]
  • Gokhan Yilmaz, Mustafa Boz, Alper B Iskit. The Effects of Lipopolysaccharide Derivatives in Rodent Models of Cardiac Arrhythmia. Anatolian journal of cardiology. 2022 12; 26(12):886-892. doi: 10.5152/anatoljcardiol.2022.1524. [PMID: 35949121]
  • Ashwani Punia, Robin Joshi, Rajiv Kumar. Identification and quantification of eight alkaloids in Aconitum heterophyllum using UHPLC-DAD-QTOF-IMS: A valuable tool for quality control. Phytochemical analysis : PCA. 2022 Oct; 33(7):1121-1134. doi: 10.1002/pca.3164. [PMID: 35794832]
  • Qi Wang, Jing Peng, Yang Liu, Yang Tian, Jie Li, Yao-Yao Ren, Jian Gu, Rui Tan. [Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4715-4722. doi: 10.19540/j.cnki.cjcmm.20220207.704. [PMID: 36164879]
  • Fei Gao, Fei Zhou, Shuai Gan, Ya-Lan Chen, Shu Fu, Mei-Si Lin, Chao-Mei Fu. [Comparative study on intestinal absorption kinetics of main active components in Sini Decoction and its separated recipes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):5064-5070. doi: 10.19540/j.cnki.cjcmm.20220421.701. [PMID: 36164916]
  • Xin Xu, Xiao-Fang Xie, Yan-Hong Dong, Hui-Qiong Zhang, Cheng Peng. Ginsenoside Rg1 Reduces Cardiotoxicity While Increases Cardiotonic Effect of Aconitine in vitro. Chinese journal of integrative medicine. 2022 Aug; 28(8):693-701. doi: 10.1007/s11655-022-3509-0. [PMID: 35723815]
  • Liuying Li, Limin Zhang, Tingting Liao, Chuantao Zhang, Keling Chen, Qun Huang. Advances on pharmacology and toxicology of aconitine. Fundamental & clinical pharmacology. 2022 Aug; 36(4):601-611. doi: 10.1111/fcp.12761. [PMID: 35060168]
  • Yabin Gao, Hang Fan, Anzheng Nie, Kang Yang, Haiyan Xing, Zhiqing Gao, Liujie Yang, Zheng Wang, Linqi Zhang. Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification. Journal of ethnopharmacology. 2022 Jul; 293(?):115270. doi: 10.1016/j.jep.2022.115270. [PMID: 35405250]
  • Qian Chen, Kai Zhang, Mingjie Jiao, Jiakang Jiao, Dongling Chen, Yihui Yin, Jia Zhang, Fei Li. Study on the Mechanism of Mesaconitine-Induced Hepatotoxicity in Rats Based on Metabonomics and Toxicology Network. Toxins. 2022 07; 14(7):. doi: 10.3390/toxins14070486. [PMID: 35878224]
  • Shiling Li, Liqiong Yu, Qian Shi, Yue Liu, Yi Zhang, Shaohui Wang, Xianrong Lai. An insight into current advances on pharmacology, pharmacokinetics, toxicity and detoxification of aconitine. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113115. doi: 10.1016/j.biopha.2022.113115. [PMID: 35605296]
  • Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu, Mingfeng Xiong. Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats. BMC complementary medicine and therapies. 2022 Jun; 22(1):160. doi: 10.1186/s12906-022-03632-y. [PMID: 35710396]
  • Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Apr; 80(?):105324. doi: 10.1016/j.tiv.2022.105324. [PMID: 35101544]
  • Hui Wang, Yanbing Liu, Ziyu Guo, Kexin Wu, Yunhao Zhang, Yanan Tian, Baoyu Zhao, Hao Lu. Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line. Research in veterinary science. 2022 Mar; 143(?):124-133. doi: 10.1016/j.rvsc.2022.01.001. [PMID: 35026629]
  • Yang Xin, Kaichen Yu, Yang Yu, Haijun Wang. Filtration and qualification for target biomarkers of traditional Chinese medicine formula "fuzi lizhong decoction" acting on stomach ulcer by UPLC/Q-TOF MS. Pakistan journal of pharmaceutical sciences. 2022 Mar; 35(2):519-528. doi: . [PMID: 35642408]
  • Yu-Feng Huang, Fan He, Hao Cui, Yan-Yu Zhang, Hua-Yi Yang, Zong-Suo Liang, Wei Dai, Chun-Song Cheng, Ying Xie, Liang Liu, Zhong-Qiu Liu, Hua Zhou. Systematic investigation on the distribution of four hidden toxic Aconitum alkaloids in commonly used Aconitum herbs and their acute toxicity. Journal of pharmaceutical and biomedical analysis. 2022 Jan; 208(?):114471. doi: 10.1016/j.jpba.2021.114471. [PMID: 34814080]
  • Lulu Ni, Ping Miao, Jian Jiang, Fang Wan, Jiangan Li, Min Ai, Lingzhong Kong, Su Tu. Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure. PloS one. 2022; 17(6):e0270069. doi: 10.1371/journal.pone.0270069. [PMID: 35759460]
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