Aconitine (BioDeep_00000000133)

   

Toxin


代谢物信息卡片


(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-4-yl benzoate

化学式: C34H47NO11 (645.3148952)
中文名称: 乌头碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.44%

分子结构信息

SMILES: CCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)OC(=O)C)OC)OC)O)COC
InChI: InChI=1S/C34H47NO11/c1-7-35-15-31(16-41-3)20(37)13-21(42-4)33-19-14-32(40)28(45-30(39)18-11-9-8-10-12-18)22(19)34(46-17(2)36,27(38)29(32)44-6)23(26(33)35)24(43-5)25(31)33/h8-12,19-29,37-38,40H,7,13-16H2,1-6H3/t19-,20-,21+,22-,23+,24+,25-,26+,27+,28-,29+,31+,32-,33+,34-/m1/s1

描述信息

D049990 - Membrane Transport Modulators > D062687 - Sodium Channel Agonists > D061585 - Voltage-Gated Sodium Channel Agonists
D007155 - Immunologic Factors
Aconitine is a diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively. It is functionally related to an aconitane.
Aconitine is a natural product found in Aconitum anthora, Aconitum napellus, and other organisms with data available.
Aconitine is a plant toxin found in species of wolfsbane (Aconitum genus). It is a neurotoxin previously used as an antipyretic and analgesic, and still has some limited application in herbal medicine. (L1235). The toxic effects of Aconitine have been tested in a variety of different test animals, including mammals (dog, cat, guinea pig, mouse, rat and rabbit), frogs and pigeons. Depending on the route of exposure, the observed toxic effects were: local anesthetic effect, diarrhea, convulsions, arrhythmias or death. According to a review of different reports of aconite poisoning in humans the following clinical features were observed: Neurological, Cardiovascular, Ventricular arrhythmias, Gastrointestinal.
A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.
See also: Aconitum coreanum root (part of).
Origin: Plant; SubCategory_DNP: Terpenoid alkaloids, Diterpene alkaloid, Aconitum alkaloid
Annotation level-1
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2309

同义名列表

17 个代谢物同义名

2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-3,8,13,14,15-pentol deriv.; Aconitine; (1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-4-yl benzoate; [(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-; (1alpha,3alpha,6alpha,14.ALPHA,15alpha,16beta)-20-ETHYL-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITANE-3,8,13,14,15-PENTOL 8-ACETATE 14-BENZOATE; (1Alpha,3Alpha,6Alpha,14Alpha,15Alpha,16Beta)-20-Ethyl-1,6,16-Trimethoxy-4-(Methoxymethyl)Aconitane-3,8,13,14,15-Pentol 8-Acetate 14-Benzoate; 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diyl 8-acetate 14-benzoate; 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate; Acetylbenzoyl-aconine; Acetylbenzoyl aconine; Acetylbenzoylaconine; NCI60_004380; Aconitinum; Aconitin; [(1S,4R,5R,6S,7S,8R,9R,10R,13R,14R,16S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; [(1S,2R,3R,4R,5R,6S,7S,8R,9R,10S,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate



数据库引用编号

60 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yixin Rui, Xiumeng Zhang, Xinran Min, Hongxiao Xie, Xiuying Ma, Funeng Geng, Rong Liu. Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury. International immunopharmacology. 2024 May; 133(?):112170. doi: 10.1016/j.intimp.2024.112170. [PMID: 38691919]
  • Cuihan Zhang, Huan Hou, Changhong Shen, Qian Ran, Fang Cheng, Ziqing Yao, Ruoqi Zhang, Cheng Peng. Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling. Toxicon : official journal of the International Society on Toxinology. 2024 May; 242(?):107693. doi: 10.1016/j.toxicon.2024.107693. [PMID: 38519012]
  • Tong Xu, Zengnan Wu, Hongren Yao, Yingrui Zhang, Shiyu Chen, Yuxuan Li, Xian-Li Meng, Yi Zhang, Jin-Ming Lin. Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device. Chemical communications (Cambridge, England). 2024 May; 60(37):4898-4901. doi: 10.1039/d4cc00396a. [PMID: 38629248]
  • Bhanu Kumar, Ankita Misra, Poonam Rawat, Priyanka Agnihotri, Sharad Srivastava. Anti-rheumatic potential vis-à-vis aconitine and hypaconitine content analysis in different Aconitum spp. from Sikkim Himalayas (India). Chemistry & biodiversity. 2024 Jan; ?(?):e202301656. doi: 10.1002/cbdv.202301656. [PMID: 38217357]
  • Yan Xiao, Meng Han, Ying Chen, Yu-Zhu Li, Yin-Yong Zhang, Lin Chen, Shuai Huang, Xian-Li Zhou. In vitro and in vivo biological evaluation of Lappaconitine derivatives as potential anti-inflammatory agents. Chemistry & biodiversity. 2023 Dec; ?(?):e202301761. doi: 10.1002/cbdv.202301761. [PMID: 38117633]
  • Natasha L Goumeniouk, Davis N Maclean, Joshua S Howie, Jason E Waechter, Philippe Couillard, Jeffrey A Shaw, Scott N Lucyk. Stir Fry with a Side of Extracorporeal Membrane Oxygen: Management of Cardiogenic Shock Secondary to Unintentional Aconitine Ingestion. Wilderness & environmental medicine. 2023 Nov; ?(?):. doi: 10.1016/j.wem.2023.09.006. [PMID: 37923684]
  • Chen Jiang, Jun Shen, Chun Wang, Yongjie Huang, Linbo Wang, Yiran Yang, Wen Hu, Ping Li, Haiying Wu. Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU. Toxicology letters. 2023 Jul; 384(?):86-95. doi: 10.1016/j.toxlet.2023.07.014. [PMID: 37506855]
  • Kirill P Cheremnykh, Arkadiy O Bryzgalov, Dmitry S Baev, Sergey A Borisov, Yulia S Sotnikova, Victor A Savelyev, Tatyana G Tolstikova, Shamansur S Sagdullaev, Elvira E Shults. Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine-1,5-Benzodiazepine Hybrids. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28104234. [PMID: 37241973]
  • Ning Ding, Shu Wang, Yan Xiao, Shuai Huang, Lin Chen, Jiang Xie, Xian-Li Zhou. Four New C19 -Diterpenoid Alkaloids from Aconitum nagarum Stapf. Chemistry & biodiversity. 2023 May; 20(5):e202300058. doi: 10.1002/cbdv.202300058. [PMID: 36944592]
  • Yu-Jie Wang, Yan Wang, Pei Tao. Structural characterization, in vivo toxicity and biological activity of two new pyro-type diterpenoid alkaloids derived from 3-acetylaconitine. Journal of integrative medicine. 2023 Apr; ?(?):. doi: 10.1016/j.joim.2023.04.001. [PMID: 37080800]
  • Catalina Mares, Ana-Maria Udrea, Catalin Buiu, Angela Staicu, Speranta Avram. Therapeutic Potentials of Aconite-like Alkaloids - Bioinformatics and Experimental Approaches. Mini reviews in medicinal chemistry. 2023 Mar; ?(?):. doi: 10.2174/1389557523666230328153417. [PMID: 36994982]
  • Xiaocui Li, Weiqing Hou, Tingting Lin, Jiadong Ni, Huawei Qiu, Yu Fu, Zhongxiang Zhao, Caihua Yang, Na Li, Hua Zhou, Rong Zhang, Zhongqiu Liu, Ling Fu, Lijun Zhu. Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: In vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations. Journal of ethnopharmacology. 2023 Mar; 303(?):115879. doi: 10.1016/j.jep.2022.115879. [PMID: 36370966]
  • Xiang Jin, Jiafei Cheng, Qing Zhang, Haiwang Ji, Chan Zhu, Yan Yang, Yuan Zhou, Guang Yu, Changming Wang, Zongxiang Tang. Aconitine - A promising candidate for treating cold and mechanical allodynia in cancer induced bone pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 161(?):114284. doi: 10.1016/j.biopha.2023.114284. [PMID: 36868017]
  • Qiuju Li, Fu Peng, Xiaoyu Yan, Yan Chen, Jie Zhou, Shuangyue Wu, Wanyanhan Jiang, Xuhui Jin, Jie Liang, Cheng Peng, Xiaoqi Pan. Inhibition of SLC7A11-GPX4 signal pathway is involved in aconitine-induced ferroptosis in vivo and in vitro. Journal of ethnopharmacology. 2023 Mar; 303(?):116029. doi: 10.1016/j.jep.2022.116029. [PMID: 36503029]
  • Xianfeng Liu, Honglin Tao, Ruimin Tian, Wenge Huang, Tao Zhang, Yue Liu, Yi Zhang, Xianli Meng. Hezi inhibits Tiebangchui-induced cardiotoxicity and preserves its anti-rheumatoid arthritis effects by regulating the pharmacokinetics of aconitine and deoxyaconitine. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115915. doi: 10.1016/j.jep.2022.115915. [PMID: 36375646]
  • Jiang Hu, Qiong Wu, Qiang Li, Tao Lv, Tian-Feng Peng, Si Yin, Hong-Zhou Jin. Antinociceptive diterpenoid alkaloids from the roots of Aconitum austroyunnanense. Journal of Asian natural products research. 2023 Feb; 25(2):132-138. doi: 10.1080/10286020.2022.2070483. [PMID: 35574919]
  • Tao Song, Yuanyuan Hao, Mingye Wang, Tongtong Li, Chi Zhao, Jiajia Li, Yunlong Hou. Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 112(?):154688. doi: 10.1016/j.phymed.2023.154688. [PMID: 36738478]
  • Jiao Song, Wei Liao, Xuan Deng, Dingkun Zhang, Junzhi Lin, Runchun Xu, Li Han. Analysis of the pharmacodynamic difference between Xiaojin Pills taken with Chinese Baijiu and water based on serum pharmacochemistry and pharmacokinetics. Journal of ethnopharmacology. 2023 Jan; 300(?):115723. doi: 10.1016/j.jep.2022.115723. [PMID: 36115600]
  • Youwei Gu, Jieru Wang, Mengting Li, Fei Zhong, Jie Xiang, Zhengxin Xu. Inhibitory Effects of Nobiletin on Voltage-Gated Na+ Channel in Rat Ventricular Myocytes Based on Electrophysiological Analysis and Molecular Docking Method. International journal of molecular sciences. 2022 Dec; 23(23):. doi: 10.3390/ijms232315175. [PMID: 36499507]
  • Gokhan Yilmaz, Mustafa Boz, Alper B Iskit. The Effects of Lipopolysaccharide Derivatives in Rodent Models of Cardiac Arrhythmia. Anatolian journal of cardiology. 2022 12; 26(12):886-892. doi: 10.5152/anatoljcardiol.2022.1524. [PMID: 35949121]
  • Ashwani Punia, Robin Joshi, Rajiv Kumar. Identification and quantification of eight alkaloids in Aconitum heterophyllum using UHPLC-DAD-QTOF-IMS: A valuable tool for quality control. Phytochemical analysis : PCA. 2022 Oct; 33(7):1121-1134. doi: 10.1002/pca.3164. [PMID: 35794832]
  • Qi Wang, Jing Peng, Yang Liu, Yang Tian, Jie Li, Yao-Yao Ren, Jian Gu, Rui Tan. [Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4715-4722. doi: 10.19540/j.cnki.cjcmm.20220207.704. [PMID: 36164879]
  • Fei Gao, Fei Zhou, Shuai Gan, Ya-Lan Chen, Shu Fu, Mei-Si Lin, Chao-Mei Fu. [Comparative study on intestinal absorption kinetics of main active components in Sini Decoction and its separated recipes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):5064-5070. doi: 10.19540/j.cnki.cjcmm.20220421.701. [PMID: 36164916]
  • Xin Xu, Xiao-Fang Xie, Yan-Hong Dong, Hui-Qiong Zhang, Cheng Peng. Ginsenoside Rg1 Reduces Cardiotoxicity While Increases Cardiotonic Effect of Aconitine in vitro. Chinese journal of integrative medicine. 2022 Aug; 28(8):693-701. doi: 10.1007/s11655-022-3509-0. [PMID: 35723815]
  • Liuying Li, Limin Zhang, Tingting Liao, Chuantao Zhang, Keling Chen, Qun Huang. Advances on pharmacology and toxicology of aconitine. Fundamental & clinical pharmacology. 2022 Aug; 36(4):601-611. doi: 10.1111/fcp.12761. [PMID: 35060168]
  • Yabin Gao, Hang Fan, Anzheng Nie, Kang Yang, Haiyan Xing, Zhiqing Gao, Liujie Yang, Zheng Wang, Linqi Zhang. Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification. Journal of ethnopharmacology. 2022 Jul; 293(?):115270. doi: 10.1016/j.jep.2022.115270. [PMID: 35405250]
  • Qian Chen, Kai Zhang, Mingjie Jiao, Jiakang Jiao, Dongling Chen, Yihui Yin, Jia Zhang, Fei Li. Study on the Mechanism of Mesaconitine-Induced Hepatotoxicity in Rats Based on Metabonomics and Toxicology Network. Toxins. 2022 07; 14(7):. doi: 10.3390/toxins14070486. [PMID: 35878224]
  • Shiling Li, Liqiong Yu, Qian Shi, Yue Liu, Yi Zhang, Shaohui Wang, Xianrong Lai. An insight into current advances on pharmacology, pharmacokinetics, toxicity and detoxification of aconitine. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113115. doi: 10.1016/j.biopha.2022.113115. [PMID: 35605296]
  • Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu, Mingfeng Xiong. Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats. BMC complementary medicine and therapies. 2022 Jun; 22(1):160. doi: 10.1186/s12906-022-03632-y. [PMID: 35710396]
  • Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Apr; 80(?):105324. doi: 10.1016/j.tiv.2022.105324. [PMID: 35101544]
  • Hui Wang, Yanbing Liu, Ziyu Guo, Kexin Wu, Yunhao Zhang, Yanan Tian, Baoyu Zhao, Hao Lu. Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line. Research in veterinary science. 2022 Mar; 143(?):124-133. doi: 10.1016/j.rvsc.2022.01.001. [PMID: 35026629]
  • Yang Xin, Kaichen Yu, Yang Yu, Haijun Wang. Filtration and qualification for target biomarkers of traditional Chinese medicine formula "fuzi lizhong decoction" acting on stomach ulcer by UPLC/Q-TOF MS. Pakistan journal of pharmaceutical sciences. 2022 Mar; 35(2):519-528. doi: . [PMID: 35642408]
  • Yu-Feng Huang, Fan He, Hao Cui, Yan-Yu Zhang, Hua-Yi Yang, Zong-Suo Liang, Wei Dai, Chun-Song Cheng, Ying Xie, Liang Liu, Zhong-Qiu Liu, Hua Zhou. Systematic investigation on the distribution of four hidden toxic Aconitum alkaloids in commonly used Aconitum herbs and their acute toxicity. Journal of pharmaceutical and biomedical analysis. 2022 Jan; 208(?):114471. doi: 10.1016/j.jpba.2021.114471. [PMID: 34814080]
  • Lulu Ni, Ping Miao, Jian Jiang, Fang Wan, Jiangan Li, Min Ai, Lingzhong Kong, Su Tu. Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure. PloS one. 2022; 17(6):e0270069. doi: 10.1371/journal.pone.0270069. [PMID: 35759460]
  • Y Y Jin, C H Qin, B L Duan, Y Q Huang, K Ma. [Clinical efficacy of bulleyaconitine A combined with gabapentin on postherpetic neuralgia]. Zhonghua yi xue za zhi. 2021 Nov; 101(43):3575-3580. doi: 10.3760/cma.j.cn112137-20210817-01867. [PMID: 34808751]
  • Hui-Xia Zhou, Huan Liu, Xue Han, Sheng-Jie Nie, Rong-Ping Zhang, Jian-Yun Yu, Shu-Hua Li. Application of UPLC-QTOF-MS in Analysis of Non-targeted Urine Metabolomics in Rats with Yunaconitine Poisoning. Fa yi xue za zhi. 2021 Oct; 37(5):653-660. doi: 10.12116/j.issn.1004-5619.2020.301003. [PMID: 35187917]
  • Ya Li, Jun Zeng, Yu-Hua Tian, Yanan Hou, Honghong Da, Jianguo Fang, Kun Gao. Isolation, identification, and activity evaluation of diterpenoid alkaloids from Aconitum sinomontanum. Phytochemistry. 2021 Oct; 190(?):112880. doi: 10.1016/j.phytochem.2021.112880. [PMID: 34311277]
  • Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura, Tsuyoshi Akiyama, Masaru Sugimachi. Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats. Cardiovascular drugs and therapy. 2021 10; 35(5):877-888. doi: 10.1007/s10557-020-07062-1. [PMID: 32860618]
  • Yang Ya, Zhang Zhixiang, Liu Chao, Zhao Wei, Wang Zhiyong, Cheng Huafeng, Zhu Shaohua, Xu Hongfei. Reflections on the aconitine poisoning. Journal of forensic sciences. 2021 Sep; 66(5):2035-2040. doi: 10.1111/1556-4029.14766. [PMID: 34235734]
  • Liang Yang, Yan Chen, Jie Zhou, Jiayi Sun, Wanyanhan Jiang, Tianyu Liu, Chaolong Rao, Xiaoqi Pan. Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells. Toxicology letters. 2021 Sep; 347(?):36-44. doi: 10.1016/j.toxlet.2021.04.020. [PMID: 33945864]
  • A Michel, I Siebe, V Auwärter, D Regul, M Hermanns-Clausen. [Aconitine poisoning due to confusion of aconite leaves with lovage]. Der Anaesthesist. 2021 08; 70(8):633-638. doi: 10.1007/s00101-021-01002-w. [PMID: 34251482]
  • Wei Zhou, Hong Liu, Li-Zhen Qiu, Lan-Xin Yue, Guang-Jie Zhang, Hui-Fang Deng, Yu-Hao Ni, Yue Gao. Cardiac efficacy and toxicity of aconitine: A new frontier for the ancient poison. Medicinal research reviews. 2021 05; 41(3):1798-1811. doi: 10.1002/med.21777. [PMID: 33512023]
  • Fei Yao, Guo-Rong Jiang, Guo-Qiang Liang, Qin Yuan, Yang Zhu, Min Liu, Lu-Rong Zhang. The antitumor effect of the combination of aconitine and crude monkshood polysaccharide on hepatocellular carcinoma. Pakistan journal of pharmaceutical sciences. 2021 May; 34(3):971-979. doi: . [PMID: 34602421]
  • Ning-Ning Wang, Huan-Hua Xu, Wei Zhou, Hong-Xing Yang, Jia Wang, Zeng-Chun Ma, Yue Gao. Aconitine attenuates mitochondrial dysfunction of cardiomyocytes via promoting deacetylation of cyclophilin-D mediated by sirtuin-3. Journal of ethnopharmacology. 2021 Apr; 270(?):113765. doi: 10.1016/j.jep.2020.113765. [PMID: 33418031]
  • Shu-Shong Hsu, Wei-Zhe Liang. Cytotoxic Effects of Mesaconitine, the Aconitum carmichaelii Debx Bioactive Compound, on HBEC-5i Human Brain Microvascular Endothelial Cells: Role of Ca2+ Signaling-Mediated Pathway. Neurotoxicity research. 2021 Apr; 39(2):256-265. doi: 10.1007/s12640-020-00249-2. [PMID: 32588354]
  • Yana Shi, Yi Zhao, Junxiang Qian, Zhiyuan Dong, Guosong Wen, Dake Zhao, Edward J Kennelly. Aconitum Diterpenoid Alkaloid Profiling to Distinguish between the Official Traditional Chinese Medicine (TCM) Fuzi and Adulterant Species Using LC-qToF-MS with Chemometrics. Journal of natural products. 2021 03; 84(3):570-587. doi: 10.1021/acs.jnatprod.0c00851. [PMID: 33496169]
  • Zemin Yang, Yanke Lin, Chong Su, Shuai Wang, Lu Gao, Jingpan Lin, Zhigang Wang, Baojian Wu. Pharmacokinetics-based chronoefficacy of Fuzi against chronic kidney disease. The Journal of pharmacy and pharmacology. 2021 Mar; 73(4):535-544. doi: 10.1093/jpp/rgaa060. [PMID: 33793835]
  • Min Wang, Ruiying Wang, Hong Sun, Guibo Sun, Xiaobo Sun. Ginsenoside Rb1 ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Mar; 83(?):153468. doi: 10.1016/j.phymed.2021.153468. [PMID: 33513559]
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