Talatizamine (BioDeep_00000000196)

 

Secondary id: BioDeep_00000184121

PANOMIX_OTCML-2023


代谢物信息卡片


(3S,6S,6aS,8S,9S,10S,11aS,12S)-1-ethyl-6,10-dimethoxy-3-(methoxymethyl)tetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocine-8,11a-diol

化学式: C24H39NO5 (421.2828)
中文名称: 它拉乌头胺, 塔技乌头胺, 塔拉萨敏, 塔拉乌头胺
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 53.48%

分子结构信息

SMILES: CCN1CC2(CCC(C34C2CC(C31)C5(CC(C6CC4C5C6O)OC)O)OC)COC
InChI: InChI=1S/C24H39NO5/c1-5-25-11-22(12-28-2)7-6-18(30-4)24-14-8-13-16(29-3)10-23(27,19(14)20(13)26)15(21(24)25)9-17(22)24/h13-21,26-27H,5-12H2,1-4H3

描述信息

Talatizamine is a diterpenoid.
Origin: Plant; SubCategory_DNP: Terpenoid alkaloids, Diterpene alkaloid, Aconitum alkaloid
Talatisamine, a aconitum alkaloid, is specific K+ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons[1].
Talatisamine, a aconitum alkaloid, is specific K+ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons[1].

同义名列表

6 个代谢物同义名

(1S,2R,3R,4S,5S,6S,8S,9S,13S,16S,17R)-11-ethyl-6,16-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,8-diol; 20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol; Talatizamine; Talatisamine; (3S,6S,6aS,8S,9S,10S,11aS,12S)-1-ethyl-6,10-dimethoxy-3-(methoxymethyl)tetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocine-8,11a-diol; Talatizamine



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 BCL2, CASP3, CASP9, RB1, STMN4
Endoplasmic reticulum membrane 1 BCL2
Nucleus 5 BCL2, CASP3, CASP9, RB1, RBL2
cytosol 5 BCL2, CASP3, CASP9, RB1, RBL2
nucleoplasm 3 CASP3, RB1, RBL2
Cell membrane 2 PECAM1, TNF
Cell projection, axon 1 STMN4
Cell projection, growth cone 1 STMN4
Multi-pass membrane protein 1 RYR2
cell junction 1 PECAM1
cell surface 1 TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 1 STMN4
growth cone 1 STMN4
neuronal cell body 2 CASP3, TNF
sarcolemma 1 RYR2
smooth endoplasmic reticulum 1 RYR2
plasma membrane 4 F2, PECAM1, RYR2, TNF
Membrane 2 BCL2, RYR2
extracellular exosome 3 F2, PECAM1, RBL2
endoplasmic reticulum 1 BCL2
extracellular space 5 F2, IGF1, IL6, PECAM1, TNF
mitochondrion 2 BCL2, CASP9
protein-containing complex 4 BCL2, CASP9, PECAM1, RYR2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 PECAM1
Secreted 3 F2, IGF1, IL6
extracellular region 4 F2, IGF1, IL6, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 1 RBL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 PECAM1, TNF
Z disc 1 RYR2
nucleolus 1 RBL2
cell-cell junction 1 PECAM1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 PECAM1, TNF
pore complex 1 BCL2
spindle 1 RB1
sarcoplasmic reticulum 1 RYR2
PML body 1 RB1
collagen-containing extracellular matrix 1 F2
neuron projection 1 STMN4
chromatin 2 RB1, RBL2
phagocytic cup 1 TNF
Chromosome 1 RBL2
blood microparticle 1 F2
myelin sheath 1 BCL2
exocytic vesicle 1 IGF1
secretory granule membrane 1 PECAM1
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 F2, IL6
platelet alpha granule lumen 1 IGF1
Sarcoplasmic reticulum membrane 1 RYR2
SWI/SNF complex 1 RB1
apoptosome 1 CASP9
calcium channel complex 1 RYR2
junctional sarcoplasmic reticulum membrane 1 RYR2
death-inducing signaling complex 1 CASP3
[Isoform Long]: Cell membrane 1 PECAM1
platelet alpha granule membrane 1 PECAM1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
interleukin-6 receptor complex 1 IL6
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
BAD-BCL-2 complex 1 BCL2
[Isoform Delta15]: Cell junction 1 PECAM1
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Shuai Huang, Yang Lv, Jian-Zhu Wang, Mei-Zhen Ye, Rui-Jie Lu, Lin Chen, Jiang Xie, Feng Gao, Xian-Li Zhou. Metabolite Profiling of Talatisamine in Heart Tissue After Oral Administration and Analysis of Cardiac Bioactivities. Planta medica. 2023 Jan; ?(?):. doi: 10.1055/a-1956-7542. [PMID: 36202094]
  • Mengchun Chen, Yijie Chen, Xianqin Wang, Yunfang Zhou. Quantitative determination of talatisamine and its pharmacokinetics and bioavailability in mouse plasma by UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):180-187. doi: 10.1016/j.jchromb.2019.06.015. [PMID: 31207562]
  • Ahmatbeck Samanbay, Bo Zhao, Haji Akber Aisa. A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang. Natural product research. 2018 Oct; 32(19):2319-2324. doi: 10.1080/14786419.2017.1410814. [PMID: 29212360]
  • Zhi-jun Guo, Zhu-ya Yang, Wen-hong Tan, Zhi-hong Zhou, Xiao-xia Ma. [Chemical Constituents from Processed Products of Aconitum Vilmoriniani Radix]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 May; 38(5):988-91. doi: . [PMID: 26767293]
  • Zhi Long Liu, Jie Cao, Hai Min Zhang, Li Li Lin, Hui Juan Liu, Shu Shan Du, Ligang Zhou, Zhi Wei Deng. Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. Journal of agricultural and food chemistry. 2011 Apr; 59(8):3701-6. doi: 10.1021/jf104879h. [PMID: 21417277]
  • Feng Gao, Qiao-Hong Chen, Feng-Peng Wang. C19-diterpenoid alkaloids from Aconitum hemsleyanum var. circinatum. Journal of natural products. 2007 May; 70(5):876-9. doi: 10.1021/np0700117. [PMID: 17432903]
  • Le Cai, Dong-Lin Chen, Shuang-Yong Liu, Feng-Peng Wang. New C19-diterpenoid alkaloids from Aconitum piepunense. Chemical & pharmaceutical bulletin. 2006 Jun; 54(6):779-81. doi: 10.1248/cpb.54.779. [PMID: 16755043]
  • Shan-Hao Jiang, Pei-Ming Yang, Hui Zhou, Da-Yuan Zhu. Two norditerpenoid ester alkaloids from Aconitum bulleyanum. Planta medica. 2002 Dec; 68(12):1147-9. doi: 10.1055/s-2002-36359. [PMID: 12494351]