Hypaconitine (BioDeep_00000000388)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(3S,6S,6aS,7R,7aR,8R,9R,10S,11S,11aR,12R,13R,14R)-11a-acetoxy-9,11-dihydroxy-6,10,13-trimethoxy-3-(methoxymethyl)-1-methyltetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-8-yl benzoate

化学式: C33H45NO10 (615.3043)
中文名称: 次乌头碱, 海帕乌头碱, 下乌头碱, 高乌头碱, 次乌碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 81.82%

分子结构信息

SMILES: C(C562)([H])(N7C)C(C(C([H])5C(C7)(CCC6OC)COC)OC)(C(C31[H])(OC(C)=O)C(C(OC)C(C(OC(=O)c(c4)cccc4)3)(O)CC12[H])O)[H]
InChI: InChI=1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21-,22+,23+,24-,25+,26+,27-,28+,30+,31-,32+,33-/m1/s1

描述信息

Hypaconitine is a diterpenoid.
Hypaconitine is a natural product found in Aconitum japonicum, Aconitum firmum, and other organisms with data available.
Annotation level-1
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. IC50 value: Target: In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1]. In vivo:
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. IC50 value: Target: In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1]. In vivo:

同义名列表

12 个代谢物同义名

Hypaconitine; CID 4526188; (3S,6S,6aS,7R,7aR,8R,9R,10S,11S,11aR,12R,13R,14R)-11a-acetoxy-9,11-dihydroxy-6,10,13-trimethoxy-3-(methoxymethyl)-1-methyltetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-8-yl benzoate; [(1S,2R,3R,4R,5R,6S,7S,8R,9R,13S,16S,17R,18R)-8-acetyloxy-5,7-dihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; 8-(Acetyloxy)-13,15-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-20-methylaconitan-14-yl benzoate; hypaconitine hydrobromide; Deoxymesaconitine; Japaconitine C1; Japaconitine B1; Japaconitine C; [(1S,2R,3R,4R,5R,6S,7S,8R,9R,10S,13S,16S,17R,18R)-8-acetyloxy-5,7-dihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; Hypaconitine



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

72 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, ANXA5, BMAL1, CYP2E1, CYP3A4, FGF2, NOS3, RB1, VEGFA, XDH
Peripheral membrane protein 3 ANXA5, CYP1B1, CYP2E1
Endoplasmic reticulum membrane 5 CYP1A2, CYP1B1, CYP2E1, CYP3A4, HSP90B1
Mitochondrion membrane 1 ABCG2
Nucleus 8 BMAL1, FGF2, HSP90B1, MPO, NOS3, RB1, RBL2, VEGFA
cytosol 7 ANXA5, HSP90B1, NOS3, RB1, RBL2, TNNT2, XDH
mitochondrial membrane 1 ABCG2
nucleoplasm 6 ABCG2, BMAL1, MPO, NOS3, RB1, RBL2
Cell membrane 4 ABCB1, ABCG2, KCNH2, TNF
Multi-pass membrane protein 4 ABCB1, ABCC2, ABCG2, KCNH2
cell surface 5 ABCB1, ABCC2, KCNH2, TNF, VEGFA
Golgi apparatus 2 NOS3, VEGFA
Golgi membrane 1 NOS3
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 1 TNF
sarcolemma 1 ANXA5
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 1 MPO
plasma membrane 6 ABCB1, ABCC2, ABCG2, KCNH2, NOS3, TNF
Membrane 9 ABCB1, ABCC2, ABCG2, ANXA5, CYP1B1, CYP3A4, HSP90B1, KCNH2, VEGFA
apical plasma membrane 3 ABCB1, ABCC2, ABCG2
caveola 1 NOS3
extracellular exosome 5 ABCB1, ANXA5, HSP90B1, MPO, RBL2
endoplasmic reticulum 2 HSP90B1, VEGFA
extracellular space 5 FGF2, MPO, TNF, VEGFA, XDH
perinuclear region of cytoplasm 3 HSP90B1, KCNH2, NOS3
adherens junction 1 VEGFA
intercellular canaliculus 1 ABCC2
mitochondrion 1 CYP1B1
protein-containing complex 1 HSP90B1
intracellular membrane-bounded organelle 6 BMAL1, CYP1A2, CYP1B1, CYP2E1, CYP3A4, MPO
Microsome membrane 4 CYP1A2, CYP1B1, CYP2E1, CYP3A4
Secreted 2 FGF2, VEGFA
extracellular region 6 ANXA5, FGF2, HSP90B1, MPO, TNF, VEGFA
transcription regulator complex 2 BMAL1, RBL2
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 RBL2
midbody 1 HSP90B1
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 3 ABCB1, ABCC2, ABCG2
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 2 ABCG2, TNF
focal adhesion 2 ANXA5, HSP90B1
spindle 1 RB1
extracellular matrix 1 VEGFA
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
Nucleus, PML body 1 BMAL1
PML body 2 BMAL1, RB1
collagen-containing extracellular matrix 2 ANXA5, HSP90B1
secretory granule 2 MPO, VEGFA
sarcomere 1 TNNT2
Zymogen granule membrane 1 ANXA5
chromatin 3 BMAL1, RB1, RBL2
phagocytic cup 1 TNF
Chromosome 1 RBL2
cytoskeleton 1 NOS3
brush border membrane 1 ABCG2
monoatomic ion channel complex 1 KCNH2
aryl hydrocarbon receptor complex 1 BMAL1
Melanosome 1 HSP90B1
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
sperm plasma membrane 1 HSP90B1
azurophil granule 1 MPO
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 1 KCNH2
endoplasmic reticulum lumen 1 HSP90B1
platelet alpha granule lumen 1 VEGFA
chromatoid body 1 BMAL1
CLOCK-BMAL transcription complex 1 BMAL1
endocytic vesicle membrane 1 NOS3
azurophil granule lumen 1 MPO
SWI/SNF complex 1 RB1
vesicle membrane 1 ANXA5
Sarcoplasmic reticulum lumen 1 HSP90B1
phagocytic vesicle lumen 1 MPO
external side of apical plasma membrane 2 ABCB1, ABCG2
endocytic vesicle lumen 1 HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cardiac myofibril 1 TNNT2
troponin complex 1 TNNT2
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
endoplasmic reticulum chaperone complex 1 HSP90B1
endothelial microparticle 1 ANXA5
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cardiac Troponin complex 1 TNNT2
striated muscle thin filament 1 TNNT2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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  • Bhanu Kumar, Ankita Misra, Poonam Rawat, Priyanka Agnihotri, Sharad Srivastava. Anti-rheumatic potential vis-à-vis aconitine and hypaconitine content analysis in different Aconitum spp. from Sikkim Himalayas (India). Chemistry & biodiversity. 2024 Jan; ?(?):e202301656. doi: 10.1002/cbdv.202301656. [PMID: 38217357]
  • Hongyan Luo, Fangfang Zan, Jin Cui. Effect of microneedle roller on promoting transdermal absorption of crossbow-medicine liquid via transdermal administration of Traditional Chinese Medicine and the safety of crossbow-medicine needle therapy: An experimental study. Journal of ethnopharmacology. 2023 Jun; ?(?):116751. doi: 10.1016/j.jep.2023.116751. [PMID: 37295573]
  • Fei Gao, Fei Zhou, Shuai Gan, Ya-Lan Chen, Shu Fu, Mei-Si Lin, Chao-Mei Fu. [Comparative study on intestinal absorption kinetics of main active components in Sini Decoction and its separated recipes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):5064-5070. doi: 10.19540/j.cnki.cjcmm.20220421.701. [PMID: 36164916]
  • Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu, Mingfeng Xiong. Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats. BMC complementary medicine and therapies. 2022 Jun; 22(1):160. doi: 10.1186/s12906-022-03632-y. [PMID: 35710396]
  • Yana Shi, Yi Zhao, Junxiang Qian, Zhiyuan Dong, Guosong Wen, Dake Zhao, Edward J Kennelly. Aconitum Diterpenoid Alkaloid Profiling to Distinguish between the Official Traditional Chinese Medicine (TCM) Fuzi and Adulterant Species Using LC-qToF-MS with Chemometrics. Journal of natural products. 2021 03; 84(3):570-587. doi: 10.1021/acs.jnatprod.0c00851. [PMID: 33496169]
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  • Suyun Yu, Can Li, Yushi Ding, Shuai Huang, Wei Wang, Yuanyuan Wu, Fangxu Wang, Aiyun Wang, Yuexia Han, Zhiguang Sun, Yin Lu, Ning Gu. Exploring the 'cold/hot' properties of traditional Chinese medicine by cell temperature measurement. Pharmaceutical biology. 2020 Dec; 58(1):208-218. doi: 10.1080/13880209.2020.1732429. [PMID: 32114881]
  • Jiaojiao Cong, Yiling Ruan, Qinglin Lyu, Xiaohui Qin, Xinming Qi, Wenyuan Liu, Lifeng Kang, Junying Zhang, Chunyong Wu. A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids. Journal of ethnopharmacology. 2020 Apr; 252(?):112581. doi: 10.1016/j.jep.2020.112581. [PMID: 31968215]
  • Zemin Yang, Yanke Lin, Lu Gao, Ziyue Zhou, Shuai Wang, Dong Dong, Baojian Wu. Circadian clock regulates metabolism and toxicity of Fuzi(lateral root of Aconitum carmichaeli Debx) in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Feb; 67(?):153161. doi: 10.1016/j.phymed.2019.153161. [PMID: 31911401]
  • Yufei He, Zihong Wei, Xiaoyan Ci, Ying Xie, Xiulin Yi, Yong Zeng, Yazhuo Li, Changxiao Liu. Effects of liquorice on pharmacokinetics of aconitine in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Dec; 49(12):1485-1493. doi: 10.1080/00498254.2019.1579007. [PMID: 30741588]
  • Haolong Liu, Feng Qiu, Haiyu Zhao, Baolin Bian, Lei Wang. Simultaneous high-performance liquid chromatography with tandem mass spectrometry quantification of six bioactive components in rat plasma after oral administration of Yougui pill. Journal of separation science. 2019 May; 42(10):1867-1877. doi: 10.1002/jssc.201800772. [PMID: 30868717]
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  • Shuilin Xie, Ying Jia, Aiming Liu, Renke Dai, Lizhen Huang. Hypaconitine-induced QT prolongation mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs. Journal of ethnopharmacology. 2015 May; 166(?):375-9. doi: 10.1016/j.jep.2015.03.023. [PMID: 25800797]
  • Bing Yu, Yi Cao, Yao-Kang Xiong. Pharmacokinetics of aconitine-type alkaloids after oral administration of Fuzi (Aconiti Lateralis Radix Praeparata) in rats with chronic heart failure by microdialysis and ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of ethnopharmacology. 2015 May; 165(?):173-9. doi: 10.1016/j.jep.2015.01.057. [PMID: 25708163]
  • Wen Zhang, Hai Zhang, Sen Sun, Feng-Feng Sun, Jun Chen, Liang Zhao, Guo-Qing Zhang. Comparative pharmacokinetics of hypaconitine after oral administration of pure hypaconitine, Aconitum carmichaelii extract and Sini Decoction to rats. Molecules (Basel, Switzerland). 2015 Jan; 20(1):1560-70. doi: 10.3390/molecules20011560. [PMID: 25603501]
  • Shuai Song, Qingfa Tang, Huiling Huo, Hancheng Li, Xuefeng Xing, Jiabo Luo. Simultaneous quantification and pharmacokinetics of alkaloids in Herba Ephedrae-Radix Aconiti Lateralis extracts. Journal of analytical toxicology. 2015 Jan; 39(1):58-68. doi: 10.1093/jat/bku113. [PMID: 25324527]
  • Yogini Jaiswal, Zhitao Liang, Alan Ho, LaiLai Wong, Peng Yong, Hubiao Chen, Zhongzhen Zhao. Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC-QTOF MS and LC-MS/MS techniques. Phytochemistry. 2014 Nov; 107(?):155-74. doi: 10.1016/j.phytochem.2014.07.026. [PMID: 25172517]
  • Yu V Nesterova, T N Povet'yeva, N I Suslov, G N Zyuz'kov, S V Pushkarskii, S G Aksinenko, E E Schultz, S S Kravtsova, A V Krapivin. Analgesic activity of diterpene alkaloids from Aconitum baikalensis. Bulletin of experimental biology and medicine. 2014 Aug; 157(4):488-91. doi: 10.1007/s10517-014-2598-6. [PMID: 25110090]
  • Wen-Wen Peng, Wen Li, Jun-Song Li, Xiao-Bing Cui, Yong-xin Zhang, Guang-Ming Yang, Hong-Mei Wen, Bao-Chang Cai. The effects of Rhizoma Zingiberis on pharmacokinetics of six Aconitum alkaloids in herb couple of Radix Aconiti Lateralis-Rhizoma Zingiberis. Journal of ethnopharmacology. 2013 Jul; 148(2):579-86. doi: 10.1016/j.jep.2013.04.056. [PMID: 23707213]
  • Jin-Ming Zhang, Wan Liao, Yu-xin He, Yao He, Dong Yan, Chao-Mei Fu. Study on intestinal absorption and pharmacokinetic characterization of diester diterpenoid alkaloids in precipitation derived from fuzi-gancao herb-pair decoction for its potential interaction mechanism investigation. Journal of ethnopharmacology. 2013 May; 147(1):128-35. doi: 10.1016/j.jep.2013.02.019. [PMID: 23506993]
  • Hong Shen, Jie Wu, Liu-Qing Di, Ling-Ying Zhu, Jun Xu, Ru Yan, Song-Lin Li. Enhancement by Glycyrrhizae Radix of hepatic metabolism of hypaconitine, a major bioactive and toxic component of Aconiti Laterlis Radix, evaluated by HPLC-TQ-MS/MS analysis. Biomedical chromatography : BMC. 2013 May; 27(5):556-62. doi: 10.1002/bmc.2825. [PMID: 23027546]
  • Ling Ye, Xiaoshan Yang, Zhen Yang, Song Gao, Taijun Yin, Wei Liu, Feng Wang, Ming Hu, Zhongqiu Liu. The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicology letters. 2013 Feb; 216(2-3):86-99. doi: 10.1016/j.toxlet.2012.11.011. [PMID: 23200901]
  • Rui-Qing Wen, Dong-Hui Li, Xin Zhao, Jia-Bo Wang, Yan-Ling Zhao, Ping Zhang, Zhi-Yong Sun, Dan Yan, Xiao-He Xiao, Yu-Zhen Ren, Fei Li, Jie Du, Hai-Yan Zhou. [Rationality of the processing methods of aconiti lateralis radix (Fuzi) based on chemical analysis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Feb; 48(2):286-90. doi: ". [PMID: 23672028]
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  • Mingjing Yi, Wei Peng, Xiaomin Chen, Junjun Wang, Yong Chen. Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac muscle in vivo. The Journal of pharmacy and pharmacology. 2012 Nov; 64(11):1654-8. doi: 10.1111/j.2042-7158.2012.01532.x. [PMID: 23058053]
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  • Na Li, Rong Tsao, Zhigang Sui, Jingwei Ma, Zhiqiang Liu, Zhongying Liu. Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. Planta medica. 2012 May; 78(7):692-7. doi: 10.1055/s-0031-1298368. [PMID: 22411726]
  • Hong-Fei Zhang, Yan-Ping Shi. Preparation of Fe3O4 nanoparticle enclosure hydroxylated multi-walled carbon nanotubes for the determination of aconitines in human serum samples. Analytica chimica acta. 2012 Apr; 724(?):54-60. doi: 10.1016/j.aca.2012.02.039. [PMID: 22483209]
  • Yu V Nesterova, T N Povetieva, N I Suslov, V V Zhdanov, T Yu Hrichkova, E V Udut, A S Chaykovskiy, N N Gaydamovich, T I Andreeva, A M Dygai. Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense. Bulletin of experimental biology and medicine. 2012 Feb; 152(4):439-43. doi: 10.1007/s10517-012-1548-4. [PMID: 22803106]
  • Jing Zhang, Zhi Hai Huang, Xiao Hui Qiu, Yi Ming Yang, Da Yuan Zhu, Wen Xu. Neutral fragment filtering for rapid identification of new diester-diterpenoid alkaloids in roots of Aconitum carmichaeli by ultra-high-pressure liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry. PloS one. 2012; 7(12):e52352. doi: 10.1371/journal.pone.0052352. [PMID: 23285005]
  • Xin Dong, Shu-Min Wang, Xiao-Ming Li, Feng-Rui Song, Zhi-Qiang Liu, Shu-Ying Liu. [Determination of content changes of three diester-diterpenoid alkaloids in compatibility of radix aconiti laterlis preparata and Rhizoma pinelliae, Fructus trichosanthis, Bulbus fritillariae, Radix ampelopsis, Rhizoma bletillae by HPLC]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Dec; 34(12):1891-4. doi: ". [PMID: 22500426]
  • Zhuo Liu, Xing Yan, Chun-Xia Xu, Da-Bin Hou, Xiao-Hong Yuan. [Extraction technology of diester-type alkaloids from Radix Aconiti lateralis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Nov; 34(11):1781-4. doi: ". [PMID: 22506406]
  • Hong Shen, Ling-ying Zhu, Nan Yao, Jie Wu. [The effect of the compatibility of Radix Aconiti Laterlis and radix glycyrrhizae on pharmacokinatic of aconitine, mesaconitine and hypacmitine in rat plasma]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Jun; 34(6):937-42. doi: . [PMID: 22017011]
  • Yi Bao, Fan Yang, Xiurong Yang. CE-electrochemiluminescence with ionic liquid for the facile separation and determination of diester-diterpenoid aconitum alkaloids in traditional Chinese herbal medicine. Electrophoresis. 2011 Jun; 32(12):1515-21. doi: 10.1002/elps.201100040. [PMID: 21692082]
  • Yang Xin, Zifeng Pi, Fengrui Song, Zhiqiang Liu, Shuying Liu. [Comparison of intracorporal absorption of hypaconitine in Heishunpian decoction and its compound recipe decoction by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry]. Se pu = Chinese journal of chromatography. 2011 May; 29(5):389-93. doi: 10.3724/sp.j.1123.2011.00389. [PMID: 21847970]
  • Ligang Zhao, Liang Fang, Yan Li, Ni Zheng, Yongnan Xu, Jinghua Wang, Zhonggui He. Effect of (E)-2-isopropyl-5-methylcyclohexyl octadec-9-enoate on transdermal delivery of Aconitum alkaloids. Drug development and industrial pharmacy. 2011 Mar; 37(3):290-9. doi: 10.3109/03639045.2010.510141. [PMID: 21054218]
  • Min Zhang, Yin Long, Yang Sun, Yukun Wang, Qian Li, Huanjie Wu, Zhenjun Guo, Yuhua Li, Yinbo Niu, Chen Li, Li Liu, Qibing Mei. Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid. European journal of pharmacology. 2011 Jan; 651(1-3):187-96. doi: 10.1016/j.ejphar.2010.10.030. [PMID: 20969848]
  • Yang Yang, Juan Chen, Yan-Ping Shi. Determination of aconitine, hypaconitine and mesaconitine in urine using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Oct; 878(28):2811-6. doi: 10.1016/j.jchromb.2010.08.032. [PMID: 20846913]
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