Hypaconitine (BioDeep_00000000388)

   

PANOMIX_OTCML-2023 Volatile Flavor Compounds natural product


代谢物信息卡片


(3S,6S,6aS,7R,7aR,8R,9R,10S,11S,11aR,12R,13R,14R)-11a-acetoxy-9,11-dihydroxy-6,10,13-trimethoxy-3-(methoxymethyl)-1-methyltetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-8-yl benzoate

化学式: C33H45NO10 (615.304331)
中文名称: 次乌头碱, 海帕乌头碱, 下乌头碱, 高乌头碱, 次乌碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.7%

分子结构信息

SMILES: C(C562)([H])(N7C)C(C(C([H])5C(C7)(CCC6OC)COC)OC)(C(C31[H])(OC(C)=O)C(C(OC)C(C(OC(=O)c(c4)cccc4)3)(O)CC12[H])O)[H]
InChI: InChI=1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21-,22+,23+,24-,25+,26+,27-,28+,30+,31-,32+,33-/m1/s1

描述信息

Hypaconitine is a diterpenoid.
Hypaconitine is a natural product found in Aconitum japonicum, Aconitum firmum, and other organisms with data available.
Annotation level-1
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. IC50 value: Target: In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1]. In vivo:
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. IC50 value: Target: In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1]. In vivo:

同义名列表

12 个代谢物同义名

Hypaconitine; CID 4526188; (3S,6S,6aS,7R,7aR,8R,9R,10S,11S,11aR,12R,13R,14R)-11a-acetoxy-9,11-dihydroxy-6,10,13-trimethoxy-3-(methoxymethyl)-1-methyltetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-8-yl benzoate; [(1S,2R,3R,4R,5R,6S,7S,8R,9R,13S,16S,17R,18R)-8-acetyloxy-5,7-dihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; 8-(Acetyloxy)-13,15-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-20-methylaconitan-14-yl benzoate; hypaconitine hydrobromide; Deoxymesaconitine; Japaconitine C1; Japaconitine B1; Japaconitine C; [(1S,2R,3R,4R,5R,6S,7S,8R,9R,10S,13S,16S,17R,18R)-8-acetyloxy-5,7-dihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; Hypaconitine



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

72 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gelin Xiang, Sa Guo, Jing Qin, Huimin Gao, Yi Zhang, Shaohui Wang. Comprehensive insight into the pharmacology, pharmacokinetics, toxicity, detoxification and extraction of hypaconitine from Aconitum plants. Journal of ethnopharmacology. 2024 Mar; 321(?):117505. doi: 10.1016/j.jep.2023.117505. [PMID: 38016573]
  • Bhanu Kumar, Ankita Misra, Poonam Rawat, Priyanka Agnihotri, Sharad Srivastava. Anti-rheumatic potential vis-à-vis aconitine and hypaconitine content analysis in different Aconitum spp. from Sikkim Himalayas (India). Chemistry & biodiversity. 2024 Jan; ?(?):e202301656. doi: 10.1002/cbdv.202301656. [PMID: 38217357]
  • Hongyan Luo, Fangfang Zan, Jin Cui. Effect of microneedle roller on promoting transdermal absorption of crossbow-medicine liquid via transdermal administration of Traditional Chinese Medicine and the safety of crossbow-medicine needle therapy: An experimental study. Journal of ethnopharmacology. 2023 Jun; ?(?):116751. doi: 10.1016/j.jep.2023.116751. [PMID: 37295573]
  • Fei Gao, Fei Zhou, Shuai Gan, Ya-Lan Chen, Shu Fu, Mei-Si Lin, Chao-Mei Fu. [Comparative study on intestinal absorption kinetics of main active components in Sini Decoction and its separated recipes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):5064-5070. doi: 10.19540/j.cnki.cjcmm.20220421.701. [PMID: 36164916]
  • Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu, Mingfeng Xiong. Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats. BMC complementary medicine and therapies. 2022 Jun; 22(1):160. doi: 10.1186/s12906-022-03632-y. [PMID: 35710396]
  • Yana Shi, Yi Zhao, Junxiang Qian, Zhiyuan Dong, Guosong Wen, Dake Zhao, Edward J Kennelly. Aconitum Diterpenoid Alkaloid Profiling to Distinguish between the Official Traditional Chinese Medicine (TCM) Fuzi and Adulterant Species Using LC-qToF-MS with Chemometrics. Journal of natural products. 2021 03; 84(3):570-587. doi: 10.1021/acs.jnatprod.0c00851. [PMID: 33496169]
  • Zemin Yang, Yanke Lin, Chong Su, Shuai Wang, Lu Gao, Jingpan Lin, Zhigang Wang, Baojian Wu. Pharmacokinetics-based chronoefficacy of Fuzi against chronic kidney disease. The Journal of pharmacy and pharmacology. 2021 Mar; 73(4):535-544. doi: 10.1093/jpp/rgaa060. [PMID: 33793835]
  • Suyun Yu, Can Li, Yushi Ding, Shuai Huang, Wei Wang, Yuanyuan Wu, Fangxu Wang, Aiyun Wang, Yuexia Han, Zhiguang Sun, Yin Lu, Ning Gu. Exploring the 'cold/hot' properties of traditional Chinese medicine by cell temperature measurement. Pharmaceutical biology. 2020 Dec; 58(1):208-218. doi: 10.1080/13880209.2020.1732429. [PMID: 32114881]
  • Jiaojiao Cong, Yiling Ruan, Qinglin Lyu, Xiaohui Qin, Xinming Qi, Wenyuan Liu, Lifeng Kang, Junying Zhang, Chunyong Wu. A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids. Journal of ethnopharmacology. 2020 Apr; 252(?):112581. doi: 10.1016/j.jep.2020.112581. [PMID: 31968215]
  • Zemin Yang, Yanke Lin, Lu Gao, Ziyue Zhou, Shuai Wang, Dong Dong, Baojian Wu. Circadian clock regulates metabolism and toxicity of Fuzi(lateral root of Aconitum carmichaeli Debx) in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Feb; 67(?):153161. doi: 10.1016/j.phymed.2019.153161. [PMID: 31911401]
  • Yufei He, Zihong Wei, Xiaoyan Ci, Ying Xie, Xiulin Yi, Yong Zeng, Yazhuo Li, Changxiao Liu. Effects of liquorice on pharmacokinetics of aconitine in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Dec; 49(12):1485-1493. doi: 10.1080/00498254.2019.1579007. [PMID: 30741588]
  • Haolong Liu, Feng Qiu, Haiyu Zhao, Baolin Bian, Lei Wang. Simultaneous high-performance liquid chromatography with tandem mass spectrometry quantification of six bioactive components in rat plasma after oral administration of Yougui pill. Journal of separation science. 2019 May; 42(10):1867-1877. doi: 10.1002/jssc.201800772. [PMID: 30868717]
  • Weiming Xu, Min Zhang, Hongwu Liu, Kun Wei, Ming He, Xiangyang Li, Deyu Hu, Song Yang, Yuguo Zheng. Antiviral activity of aconite alkaloids from Aconitum carmichaelii Debx. Natural product research. 2019 May; 33(10):1486-1490. doi: 10.1080/14786419.2017.1416385. [PMID: 29271255]
  • Xingxing Zong, Xiaojing Yan, Jian-Lin Wu, Zhongqiu Liu, Hua Zhou, Na Li, Liang Liu. Potentially Cardiotoxic Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii. Journal of natural products. 2019 04; 82(4):980-989. doi: 10.1021/acs.jnatprod.8b01039. [PMID: 30892884]
  • Shuilin Xie, Ying Jia, Aiming Liu, Renke Dai, Lizhen Huang. Hypaconitine-induced QT prolongation mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs. Journal of ethnopharmacology. 2015 May; 166(?):375-9. doi: 10.1016/j.jep.2015.03.023. [PMID: 25800797]
  • Bing Yu, Yi Cao, Yao-Kang Xiong. Pharmacokinetics of aconitine-type alkaloids after oral administration of Fuzi (Aconiti Lateralis Radix Praeparata) in rats with chronic heart failure by microdialysis and ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of ethnopharmacology. 2015 May; 165(?):173-9. doi: 10.1016/j.jep.2015.01.057. [PMID: 25708163]
  • Wen Zhang, Hai Zhang, Sen Sun, Feng-Feng Sun, Jun Chen, Liang Zhao, Guo-Qing Zhang. Comparative pharmacokinetics of hypaconitine after oral administration of pure hypaconitine, Aconitum carmichaelii extract and Sini Decoction to rats. Molecules (Basel, Switzerland). 2015 Jan; 20(1):1560-70. doi: 10.3390/molecules20011560. [PMID: 25603501]
  • Shuai Song, Qingfa Tang, Huiling Huo, Hancheng Li, Xuefeng Xing, Jiabo Luo. Simultaneous quantification and pharmacokinetics of alkaloids in Herba Ephedrae-Radix Aconiti Lateralis extracts. Journal of analytical toxicology. 2015 Jan; 39(1):58-68. doi: 10.1093/jat/bku113. [PMID: 25324527]
  • Yogini Jaiswal, Zhitao Liang, Alan Ho, LaiLai Wong, Peng Yong, Hubiao Chen, Zhongzhen Zhao. Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC-QTOF MS and LC-MS/MS techniques. Phytochemistry. 2014 Nov; 107(?):155-74. doi: 10.1016/j.phytochem.2014.07.026. [PMID: 25172517]
  • Yu V Nesterova, T N Povet'yeva, N I Suslov, G N Zyuz'kov, S V Pushkarskii, S G Aksinenko, E E Schultz, S S Kravtsova, A V Krapivin. Analgesic activity of diterpene alkaloids from Aconitum baikalensis. Bulletin of experimental biology and medicine. 2014 Aug; 157(4):488-91. doi: 10.1007/s10517-014-2598-6. [PMID: 25110090]
  • Wen-Wen Peng, Wen Li, Jun-Song Li, Xiao-Bing Cui, Yong-xin Zhang, Guang-Ming Yang, Hong-Mei Wen, Bao-Chang Cai. The effects of Rhizoma Zingiberis on pharmacokinetics of six Aconitum alkaloids in herb couple of Radix Aconiti Lateralis-Rhizoma Zingiberis. Journal of ethnopharmacology. 2013 Jul; 148(2):579-86. doi: 10.1016/j.jep.2013.04.056. [PMID: 23707213]
  • Jin-Ming Zhang, Wan Liao, Yu-xin He, Yao He, Dong Yan, Chao-Mei Fu. Study on intestinal absorption and pharmacokinetic characterization of diester diterpenoid alkaloids in precipitation derived from fuzi-gancao herb-pair decoction for its potential interaction mechanism investigation. Journal of ethnopharmacology. 2013 May; 147(1):128-35. doi: 10.1016/j.jep.2013.02.019. [PMID: 23506993]
  • Hong Shen, Jie Wu, Liu-Qing Di, Ling-Ying Zhu, Jun Xu, Ru Yan, Song-Lin Li. Enhancement by Glycyrrhizae Radix of hepatic metabolism of hypaconitine, a major bioactive and toxic component of Aconiti Laterlis Radix, evaluated by HPLC-TQ-MS/MS analysis. Biomedical chromatography : BMC. 2013 May; 27(5):556-62. doi: 10.1002/bmc.2825. [PMID: 23027546]
  • Ling Ye, Xiaoshan Yang, Zhen Yang, Song Gao, Taijun Yin, Wei Liu, Feng Wang, Ming Hu, Zhongqiu Liu. The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicology letters. 2013 Feb; 216(2-3):86-99. doi: 10.1016/j.toxlet.2012.11.011. [PMID: 23200901]
  • Rui-Qing Wen, Dong-Hui Li, Xin Zhao, Jia-Bo Wang, Yan-Ling Zhao, Ping Zhang, Zhi-Yong Sun, Dan Yan, Xiao-He Xiao, Yu-Zhen Ren, Fei Li, Jie Du, Hai-Yan Zhou. [Rationality of the processing methods of aconiti lateralis radix (Fuzi) based on chemical analysis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Feb; 48(2):286-90. doi: ". [PMID: 23672028]
  • Kohei Kazuma, Motoyoshi Satake, Katsuhiro Konno. [Case of fatal aconite poisoning, and its background]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 2013; 54(6):419-25. doi: 10.3358/shokueishi.54.419. [PMID: 24389474]
  • Mingjing Yi, Wei Peng, Xiaomin Chen, Junjun Wang, Yong Chen. Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac muscle in vivo. The Journal of pharmacy and pharmacology. 2012 Nov; 64(11):1654-8. doi: 10.1111/j.2042-7158.2012.01532.x. [PMID: 23058053]
  • Ping Cui, Han Han, Rui Wang, Li Yang. Identification and determination of Aconitum alkaloids in Aconitum herbs and Xiaohuoluo pill using UPLC-ESI-MS. Molecules (Basel, Switzerland). 2012 Aug; 17(9):10242-57. doi: 10.3390/molecules170910242. [PMID: 22926305]
  • Na Li, Rong Tsao, Zhigang Sui, Jingwei Ma, Zhiqiang Liu, Zhongying Liu. Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. Planta medica. 2012 May; 78(7):692-7. doi: 10.1055/s-0031-1298368. [PMID: 22411726]
  • Hong-Fei Zhang, Yan-Ping Shi. Preparation of Fe3O4 nanoparticle enclosure hydroxylated multi-walled carbon nanotubes for the determination of aconitines in human serum samples. Analytica chimica acta. 2012 Apr; 724(?):54-60. doi: 10.1016/j.aca.2012.02.039. [PMID: 22483209]
  • Yu V Nesterova, T N Povetieva, N I Suslov, V V Zhdanov, T Yu Hrichkova, E V Udut, A S Chaykovskiy, N N Gaydamovich, T I Andreeva, A M Dygai. Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense. Bulletin of experimental biology and medicine. 2012 Feb; 152(4):439-43. doi: 10.1007/s10517-012-1548-4. [PMID: 22803106]
  • Jing Zhang, Zhi Hai Huang, Xiao Hui Qiu, Yi Ming Yang, Da Yuan Zhu, Wen Xu. Neutral fragment filtering for rapid identification of new diester-diterpenoid alkaloids in roots of Aconitum carmichaeli by ultra-high-pressure liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry. PloS one. 2012; 7(12):e52352. doi: 10.1371/journal.pone.0052352. [PMID: 23285005]
  • Xin Dong, Shu-Min Wang, Xiao-Ming Li, Feng-Rui Song, Zhi-Qiang Liu, Shu-Ying Liu. [Determination of content changes of three diester-diterpenoid alkaloids in compatibility of radix aconiti laterlis preparata and Rhizoma pinelliae, Fructus trichosanthis, Bulbus fritillariae, Radix ampelopsis, Rhizoma bletillae by HPLC]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Dec; 34(12):1891-4. doi: ". [PMID: 22500426]
  • Zhuo Liu, Xing Yan, Chun-Xia Xu, Da-Bin Hou, Xiao-Hong Yuan. [Extraction technology of diester-type alkaloids from Radix Aconiti lateralis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Nov; 34(11):1781-4. doi: ". [PMID: 22506406]
  • Hong Shen, Ling-ying Zhu, Nan Yao, Jie Wu. [The effect of the compatibility of Radix Aconiti Laterlis and radix glycyrrhizae on pharmacokinatic of aconitine, mesaconitine and hypacmitine in rat plasma]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Jun; 34(6):937-42. doi: . [PMID: 22017011]
  • Yi Bao, Fan Yang, Xiurong Yang. CE-electrochemiluminescence with ionic liquid for the facile separation and determination of diester-diterpenoid aconitum alkaloids in traditional Chinese herbal medicine. Electrophoresis. 2011 Jun; 32(12):1515-21. doi: 10.1002/elps.201100040. [PMID: 21692082]
  • Yang Xin, Zifeng Pi, Fengrui Song, Zhiqiang Liu, Shuying Liu. [Comparison of intracorporal absorption of hypaconitine in Heishunpian decoction and its compound recipe decoction by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry]. Se pu = Chinese journal of chromatography. 2011 May; 29(5):389-93. doi: 10.3724/sp.j.1123.2011.00389. [PMID: 21847970]
  • Ligang Zhao, Liang Fang, Yan Li, Ni Zheng, Yongnan Xu, Jinghua Wang, Zhonggui He. Effect of (E)-2-isopropyl-5-methylcyclohexyl octadec-9-enoate on transdermal delivery of Aconitum alkaloids. Drug development and industrial pharmacy. 2011 Mar; 37(3):290-9. doi: 10.3109/03639045.2010.510141. [PMID: 21054218]
  • Min Zhang, Yin Long, Yang Sun, Yukun Wang, Qian Li, Huanjie Wu, Zhenjun Guo, Yuhua Li, Yinbo Niu, Chen Li, Li Liu, Qibing Mei. Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid. European journal of pharmacology. 2011 Jan; 651(1-3):187-96. doi: 10.1016/j.ejphar.2010.10.030. [PMID: 20969848]
  • Yang Yang, Juan Chen, Yan-Ping Shi. Determination of aconitine, hypaconitine and mesaconitine in urine using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Oct; 878(28):2811-6. doi: 10.1016/j.jchromb.2010.08.032. [PMID: 20846913]
  • Chao Wang, Yu-guang Wang, Qian-de Liang, Wei-qing Rang, Yue Gao. [Analysis of chemical composition in the combination of monkshood and pinellia by UPLC/Q-TOFMS with multivariate statistical analysis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Oct; 45(10):1301-6. doi: . [PMID: 21348310]
  • Yuan Yang, Jianmei Huang, Xiaoqing Liu, Meirong Bai, Changhua Ma, Bing Zhang. [Difference of hypaconitine concentration in serum between cold-deficiency and normal mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Aug; 35(15):2008-11. doi: 10.4268/cjcmm20101521. [PMID: 20931857]
  • Hai-Yan Zhou, Lan Sun, Run-Huai Zhao, Lei Zhang, Yong Yang, Qi Chang. [Evaluation of the accumulation of dry substance and active componentsevaluation of the accumulation of dry substance and active components of Radix Aconiti Lateralis Praeparata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Apr; 33(4):487-9. doi: ". [PMID: 20845771]
  • Jing-Zheng Song, Quan-Bin Han, Chun-Feng Qiao, Paul Pui-Hay But, Hong-Xi Xu. Development and validation of a rapid capillary zone electrophoresis method for the determination of aconite alkaloids in aconite roots. Phytochemical analysis : PCA. 2010 Mar; 21(2):137-43. doi: 10.1002/pca.1168. [PMID: 19810124]
  • Bo Sun, Ling Li, Shengming Wu, Qi Zhang, Haijing Li, Hebing Chen, Famei Li, Fangting Dong, Xianzhong Yan. Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography/time-of-flight mass spectrometry. Analytical biochemistry. 2009 Dec; 395(2):125-33. doi: 10.1016/j.ab.2009.08.014. [PMID: 19683504]
  • Lei-ping He, Bin Di, Ying-xiang Du, Fang Yan, Meng-xiang Su, Hua-qing Liu, Lin-jun You. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the rapid simultaneous quantification of aconitine, mesaconitine, and hypaconitine in rat plasma after oral administration of Sini decoction. Journal of analytical toxicology. 2009 Nov; 33(9):588-94. doi: 10.1093/jat/33.9.588. [PMID: 20040133]
  • Wei Liu, Min Shen, Zhi-Qiang Qin. [Distribution of aconitum alkaloids in the corpse died of acute aconite intoxication]. Fa yi xue za zhi. 2009 Jun; 25(3):176-8. doi: NULL. [PMID: 19697773]
  • Huitao Liu, Yingying Wen, Feng Luan, Yuan Gao. Application of experimental design and radial basis function neural network to the separation and determination of active components in traditional Chinese medicines by capillary electrophoresis. Analytica chimica acta. 2009 Apr; 638(1):88-93. doi: 10.1016/j.aca.2009.02.006. [PMID: 19298884]
  • Fan Zhang, Ming-Hai Tang, Li-Juan Chen, Rui Li, Xian-Huo Wang, Jun-Guo Duan, Xia Zhao, Yu-Quan Wei. Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetics evaluation of "SHEN-FU" injectable powder. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Oct; 873(2):173-9. doi: 10.1016/j.jchromb.2008.08.008. [PMID: 18778973]
  • Yang-qing He, Zhan-ying Ma, Qian Yang, Bing-hua Yao, Li-ming Gao. A new norditerpenoid alkaloid from Aconitum taipaicum. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Sep; 43(9):934-7. doi: . [PMID: 19048785]
  • Fang Liu, Xiang-Hong Yu, Fei Li, Yu-Yuan Tan, Yan-Jiang Qiao. [Determination of three kind of diester diterpenoid alkaloids (DDAs) in Aconitum carmichaeli and its processed products by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Jul; 31(14):1160-2. doi: ". [PMID: 17048584]
  • Rina Kaneko, Satoshi Hattori, Shiho Furuta, Makoto Hamajima, Yukari Hirata, Kanako Watanabe, Hiroshi Seno, Akira Ishii. Sensitive analysis of aconitine, hypaconitine, mesaconitine and jesaconitine in human body fluids and Aconitum tubers by LC/ESI-TOF-MS. Journal of mass spectrometry : JMS. 2006 Jun; 41(6):810-4. doi: 10.1002/jms.1038. [PMID: 16770829]
  • Zhaohong Wang, Jiao Wen, Junbo Xing, Ye He. Quantitative determination of diterpenoid alkaloids in four species of Aconitum by HPLC. Journal of pharmaceutical and biomedical analysis. 2006 Mar; 40(4):1031-4. doi: 10.1016/j.jpba.2005.08.012. [PMID: 16181762]
  • Haihua Shu, Hideko Arita, Masakazu Hayashida, Hiroshi Sekiyama, Kazuo Hanaoka. Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine. Journal of ethnopharmacology. 2006 Feb; 103(3):398-405. doi: 10.1016/j.jep.2005.08.017. [PMID: 16169697]
  • Zhi-Hong Jiang, Ying Xie, Hua Zhou, Jing-Rong Wang, Zhong-Qiu Liu, Yuen-Fan Wong, Xiong Cai, Hong-Xi Xu, Liang Liu. Quantification of Aconitum alkaloids in aconite roots by a modified RP-HPLC method. Phytochemical analysis : PCA. 2005 Nov; 16(6):415-21. doi: 10.1002/pca.861. [PMID: 16315485]
  • Wen-Dong Li, Chen Ma. Tissue distribution of Aconitum alkaloids extracted from Radix aconiti preparata after oral administration to rats. Yao xue xue bao = Acta pharmaceutica Sinica. 2005 Jun; 40(6):539-43. doi: NULL. [PMID: 16144321]
  • Zhao Hong Wang, Dean Guo, Yi He, Chunhua Hu, Jizong Zhang. Quantitative determination of Aconitum alkaloids in blood and urine samples by high-performance liquid chromatography. Phytochemical analysis : PCA. 2004 Jan; 15(1):16-20. doi: 10.1002/pca.736. [PMID: 14979521]
  • Sang Hee Shim, Ju Sun Kim, Sam Sik Kang, Kun Ho Son, KiHwan Bae. Alkaloidal constituents from Aconitum jaluense. Archives of pharmacal research. 2003 Sep; 26(9):709-15. doi: 10.1007/bf02976678. [PMID: 14560917]
  • Yan-fang Chen, Wei He, Feng-chi Zhu. [Determination of aconitine alkaloids in a pesticide--0.25\% aconitine alkaloids mixed with emulsion by high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2002 May; 20(3):253-5. doi: ". [PMID: 12541949]
  • A Sun, D Chen, P Bi. [Determination of the aconitine alkaloids in traditional Chinese medicine chuanwu and caowu by high performance capillary electrophoresis(HPCE)]. Se pu = Chinese journal of chromatography. 1999 Jan; 17(1):67-9. doi: ". [PMID: 12548834]
  • S Mao, X Li, L Cheng, C Zhang, M Fu, Q Ke, L Wu, Z Lu, D Zhu, Z Ye, J Wang. [Optimization of technical parameters for processing radix Aconiti coreani]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1997 Oct; 22(10):595-8, 639. doi: ". [PMID: 11038925]
  • M Fu, C Zhang, S Mao. [Influence of processing on the content of hypaconitine in the roots of Aconitnum coreanum (Lévl.) Rapaics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1997 May; 22(5):280-1, 319. doi: ". [PMID: 11038959]
  • H Ohta, Y Seto, N Tsunoda. Determination of Aconitum alkaloids in blood and urine samples. I. High-performance liquid chromatographic separation, solid-phase extraction and mass spectrometric confirmation. Journal of chromatography. B, Biomedical sciences and applications. 1997 Apr; 691(2):351-6. doi: 10.1016/s0378-4347(96)00471-9. [PMID: 9174271]
  • N Yoshioka, K Gonmori, A Tagashira, O Boonhooi, M Hayashi, Y Saito, M Mizugaki. A case of aconitine poisoning with analysis of aconitine alkaloids by GC/SIM. Forensic science international. 1996 Aug; 81(2-3):117-23. doi: 10.1016/s0379-0738(96)01980-9. [PMID: 8837486]
  • T Y Chan, B Tomlinson, L K Tse, J C Chan, W W Chan, J A Critchley. Aconitine poisoning due to Chinese herbal medicines: a review. Veterinary and human toxicology. 1994 Oct; 36(5):452-5. doi: . [PMID: 7839574]