Eldelin (BioDeep_00000000315)

 

Secondary id: BioDeep_00000410578

PANOMIX_OTCML-2023


代谢物信息卡片


[(1R,2S,3S,4S,5R,6S,8R,12S,16R,19S,20R,21S)-14-ethyl-2-hydroxy-4,6,19-trimethoxy-16-methyl-9,11-dioxa-14-azaheptacyclo[10.7.2.12,5.01,13.03,8.08,12.016,20]docosan-21-yl] acetate

化学式: C27H41NO8 (507.28320260000004)
中文名称: 德尔塔林
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.04%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Eldelin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/eldelin (retrieved 2024-11-08) (BioDeep RN: BioDeep_00000000315). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCN1CC2(C)CCC(OC)C34C2C(OC(C)=O)C2(OCOC25CC(OC)C2CC3(O)C5C2OC)C14
InChI: InChI=1S/C27H41NO8/c1-7-28-12-23(3)9-8-17(32-5)26-20(23)21(36-14(2)29)27(22(26)28)25(34-13-35-27)11-16(31-4)15-10-24(26,30)19(25)18(15)33-6/h15-22,30H,7-13H2,1-6H3/t15-,16+,17+,18+,19+,20-,21+,22?,23+,24+,25-,26-,27-/m1/s1

描述信息

Deltaline is a diterpene alkaloid, a tertiary alcohol, a tertiary amino compound, an acetate ester, a cyclic acetal and an organic polycyclic compound. It derives from a hydride of an aconitane.
Deltaline is a natural product found in Delphinium cheilanthum, Delphinium andersonii, and other organisms with data available.

Deltaline. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=6836-11-9 (retrieved 2024-07-09) (CAS RN: 6836-11-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Deltaline is a diterpenoid alkaloid and isolated from plants of the genus Delphinium delavayi Franch. Deltaline itself has analgesic properties, and plants of the genus Delphinium delavayi Franch have also been therapeutically used to treat rheumaticpain, paralysis due to stroke, rheumatoid arthritis[1].
Deltaline is a diterpenoid alkaloid and isolated from plants of the genus Delphinium delavayi Franch. Deltaline itself has analgesic properties, and plants of the genus Delphinium delavayi Franch have also been therapeutically used to treat rheumaticpain, paralysis due to stroke, rheumatoid arthritis[1].

同义名列表

10 个代谢物同义名

[(1R,2S,3S,4S,5R,6S,8R,12S,16R,19S,20R,21S)-14-ethyl-2-hydroxy-4,6,19-trimethoxy-16-methyl-9,11-dioxa-14-azaheptacyclo[10.7.2.12,5.01,13.03,8.08,12.016,20]docosan-21-yl] acetate; Aconitane-6,10-diol, 20-ethyl-4-methyl-7,8-(methylenebis(oxy))-, 1,14,16-trimethoxy-, 6-acetate, (1-alpha,6-beta,14-alpha,16-beta)-; 20-ethyl-10-hydroxy-1alpha,14alpha,16beta-trimethoxy-4-methyl-7,8-[methylenebis(oxy)]aconitan-6beta-yl acetate; Deltamine 6-acetate; Prestwick3_000673; BPBio1_000843; Delphelatine; Deltaline; Eldeline; Eldelin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qi Hu, Yusi Bu, Ruiqi Cao, Gao Zhang, Xiaoyu Xie, Sicen Wang. Stability Designs of Cell Membrane Cloaked Magnetic Carbon Nanotubes for Improved Life Span in Screening Drug Leads. Analytical chemistry. 2019 10; 91(20):13062-13070. doi: 10.1021/acs.analchem.9b03268. [PMID: 31512859]
  • Clinton A Stonecipher, Stephen T Lee, Benedict T Green, Daniel Cook, Kevin D Welch, James A Pfister, Dale R Gardner. Evaluation of noninvasive specimens to diagnose livestock exposure to toxic larkspur (Delphinium spp.). Toxicon : official journal of the International Society on Toxinology. 2019 Apr; 161(?):33-39. doi: 10.1016/j.toxicon.2019.02.013. [PMID: 30826472]
  • Benedict T Green, John W Keele, Dale R Gardner, Kevin D Welch, Gary L Bennett, Daniel Cook, James A Pfister, T Zane Davis, Clint A Stonecipher, Stephen T Lee, Bryan L Stegelmeier. Sex-dependent differences for larkspur (Delphinium barbeyi) toxicosis in yearling Angus cattle1. Journal of animal science. 2019 Mar; 97(3):1424-1432. doi: 10.1093/jas/skz002. [PMID: 30772914]
  • K D Welch, D R Gardner, C A Stonecipher, B T Green, J A Pfister. Serum toxicokinetics after intravenous and oral dosing of larkspur toxins in goats. Toxicon : official journal of the International Society on Toxinology. 2017 Jul; 133(?):91-94. doi: 10.1016/j.toxicon.2017.05.008. [PMID: 28479311]
  • K D Welch, C A Stonecipher, B T Green, D R Gardner, D Cook, J A Pfister. Administering multiple doses of a non N-(methylsuccinimido) anthranoyllycoctonine (MSAL)-containing tall larkspur (Delphinium occidentale) to cattle. Toxicon : official journal of the International Society on Toxinology. 2017 Mar; 128(?):46-49. doi: 10.1016/j.toxicon.2017.01.020. [PMID: 28153491]
  • Kevin D Welch, James A Pfister, Flavia G Lima, Benedict T Green, Dale R Gardner. Effect of α₇ nicotinic acetylcholine receptor agonists and antagonists on motor function in mice. Toxicology and applied pharmacology. 2013 Feb; 266(3):366-74. doi: 10.1016/j.taap.2012.11.024. [PMID: 23219611]
  • Benedict T Green, Kevin D Welch, Dale R Gardner, Bryan L Stegelmeier, James A Pfister, Daniel Cook, T Zane Davis. A toxicokinetic comparison of norditerpenoid alkaloids from Delphinium barbeyi and D. glaucescens in cattle. Journal of applied toxicology : JAT. 2011 Jan; 31(1):20-6. doi: 10.1002/jat.1563. [PMID: 20635330]
  • Benedict T Green, Kevin D Welch, Dale R Gardner, Bryan L Stegelmeier, T Zane Davis, Daniel Cook, Stephen T Lee, James A Pfister, Kip E Panter. Serum elimination profiles of methyllycaconitine and deltaline in cattle following oral administration of larkspur (Delphinium barbeyi). American journal of veterinary research. 2009 Jul; 70(7):926-31. doi: 10.2460/ajvr.70.7.926. [PMID: 19566479]
  • K D Welch, K E Panter, D R Gardner, B T Green, J A Pfister, D Cook, B L Stegelmeier. The effect of 7,8-methylenedioxylycoctonine-type diterpenoid alkaloids on the toxicity of methyllycaconitine in mice. Journal of animal science. 2008 Oct; 86(10):2761-70. doi: 10.2527/jas.2008-1025. [PMID: 18539831]
  • G D Manners, K E Panter, S W Pelletier. Structure-activity relationships of norditerpenoid alkaloids occurring in toxic larkspur (Delphinium) species. Journal of natural products. 1995 Jun; 58(6):863-9. doi: 10.1021/np50120a007. [PMID: 7673930]
  • J H Becker, J S Willis. Properties of Na-K pump in primary cultures of kidney cells. Journal of cellular physiology. 1979 Jun; 99(3):427-39. doi: 10.1002/jcp.1040990317. [PMID: 222786]
  • L A Barness. Safety considerations with high ascorbic acid dosage. Annals of the New York Academy of Sciences. 1975 Sep; 258(?):523-8. doi: 10.1111/j.1749-6632.1975.tb29311.x. [PMID: 946]