denudatine (BioDeep_00000000508)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(1S,5R,8R,10S,11R,13R,14S,15S,16R)-7-Ethyl-5-methyl-12-methylidene-7-azahexacyclo[7.6.2.210,13.01,8.05,16.010,15]nonadecane-11,14-diol

化学式: C22H33NO2 (343.2511)
中文名称: 光翠雀碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 77.84%

分子结构信息

SMILES: C=C1C2CCC3(C1O)C1CC4C5(C)CCCC4(C1N(CC)C5)C3C2O
InChI: InChI=1S/C22H33NO2/c1-4-23-11-20(3)7-5-8-22-15(20)10-14(18(22)23)21-9-6-13(12(2)19(21)25)16(24)17(21)22/h13-19,24-25H,2,4-11H2,1,3H3/t13-,14?,15-,16+,17-,18-,19-,20+,21+,22+/m1/s1

描述信息

Denudatine is a diterpenoid. It derives from a hydride of an atisane.
CID 441729 is a natural product found in Aconitum kusnezoffii and Aconitum carmichaelii with data available.

同义名列表

5 个代谢物同义名

(1S,5R,8R,10S,11R,13R,14S,15S,16R)-7-Ethyl-5-methyl-12-methylidene-7-azahexacyclo[7.6.2.210,13.01,8.05,16.010,15]nonadecane-11,14-diol; 21-Ethyl-4-methyl-7,20-cycloatid-16-ene-11,15-diol; denudatine; CID 441729; Denudatine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 NLRP3, P2RX7, PTGS2
Peripheral membrane protein 3 ACHE, GORASP1, PTGS2
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 2 ACHE, NLRP3
cytosol 1 NLRP3
dendrite 1 PDYN
Cell membrane 4 ACHE, OPRD1, P2RX7, TNF
Cytoplasmic side 1 GORASP1
Multi-pass membrane protein 2 OPRD1, P2RX7
Golgi apparatus membrane 3 GORASP1, MGAT1, NLRP3
Synapse 2 ACHE, PDYN
cell surface 2 ACHE, TNF
Golgi apparatus 3 ACHE, GORASP1, MGAT1
Golgi membrane 3 GORASP1, MGAT1, NLRP3
neuromuscular junction 2 ACHE, P2RX7
neuronal cell body 3 P2RX7, PDYN, TNF
postsynapse 1 P2RX7
presynaptic membrane 1 OPRD1
Cytoplasm, cytosol 1 NLRP3
Presynapse 1 P2RX7
plasma membrane 6 ACHE, F2, OPRD1, P2RX7, PDYN, TNF
synaptic vesicle membrane 1 OPRD1
Membrane 5 ACHE, MGAT1, NLRP3, OPRD1, P2RX7
caveola 1 PTGS2
extracellular exosome 2 F2, MGAT1
endoplasmic reticulum 2 NLRP3, PTGS2
extracellular space 3 ACHE, F2, TNF
perinuclear region of cytoplasm 2 ACHE, MGAT1
mitochondrion 2 NLRP3, P2RX7
protein-containing complex 1 PTGS2
Microsome membrane 1 PTGS2
Secreted 4 ACHE, F2, NLRP3, PDYN
extracellular region 6 ACHE, DNAH9, F2, NLRP3, PDYN, TNF
hippocampal mossy fiber to CA3 synapse 1 PDYN
Extracellular side 1 ACHE
motile cilium 1 DNAH9
external side of plasma membrane 2 P2RX7, TNF
Extracellular vesicle 1 MGAT1
cell-cell junction 1 P2RX7
recycling endosome 1 TNF
Single-pass type II membrane protein 2 MGAT1, TNF
Cytoplasm, perinuclear region 1 MGAT1
Membrane raft 1 TNF
microtubule 1 DNAH9
cis-Golgi network 1 GORASP1
basement membrane 1 ACHE
collagen-containing extracellular matrix 1 F2
axoneme 1 DNAH9
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 OPRD1, PTGS2
phagocytic cup 1 TNF
blood microparticle 1 F2
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
Lipid-anchor, GPI-anchor 1 ACHE
Endomembrane system 1 NLRP3
microtubule organizing center 1 NLRP3
side of membrane 1 ACHE
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 F2, PTGS2
axon terminus 2 OPRD1, PDYN
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, MGAT1
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 2 OPRD1, PDYN
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
synaptic cleft 1 ACHE
dendrite membrane 1 OPRD1
bleb 1 P2RX7
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform H]: Cell membrane 1 ACHE
spine apparatus 1 OPRD1
outer dynein arm 1 DNAH9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
distal portion of axoneme 1 DNAH9


文献列表

  • Shuhan Liu, Na Che, Wen Ou, Meichen Yan, Yajin Liao, Yong Cheng. Bullatine A exerts anti-inflammatory effects by inhibiting the ROS/JNK/NF-κB pathway and attenuating systemic inflammatory responses in mice. Pharmaceutical biology. 2022 Dec; 60(1):1840-1849. doi: 10.1080/13880209.2022.2121410. [PMID: 36200648]
  • Hui Liu, Shuai Shao, Huan Xia, Yu-Zhuo Wu, Cheng-Gen Zhu, Cheng-Bo Xu, Tian-Tai Zhang, Qing-Lan Guo, Jian-Gong Shi. Denudatine-type diterpenoid alkaloids from an aqueous extract of the lateral root of Aconitum carmichaelii. Journal of Asian natural products research. 2021 Jul; 23(7):615-626. doi: 10.1080/10286020.2021.1931141. [PMID: 34080502]
  • Ahmatbeck Samanbay, Bo Zhao, Haji Akber Aisa. A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang. Natural product research. 2018 Oct; 32(19):2319-2324. doi: 10.1080/14786419.2017.1410814. [PMID: 29212360]
  • Li-Guo Yang, Ying-Jie Zhang, Jia-Ying Xie, Wei-Jun Xia, Hai-Yuan Zhang, Meng-Yun Tang, Shuang-Xi Mei, Tao Cui, Jing-Kun Wang, Zhao-Yun Zhu. Diterpenoid alkaloids from the roots of Aconitum brachypodum Diels. Journal of Asian natural products research. 2016 Sep; 18(9):908-12. doi: 10.1080/10286020.2016.1173677. [PMID: 27268073]
  • Hong-Yan Tang, Xiao-Lan Chen, Yu-Mei Wu, Wen-Zhen Wei, Ya-Jie Dai. [In vitro recovery rate of bullatine A microdialysis probe]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Jul; 41(13):2538-2542. doi: 10.4268/cjcmm20161328. [PMID: 28905582]
  • Tian-Peng Yin, Le Cai, Yun Xing, Jing Yu, Xue-Jiao Li, Rui-Feng Mei, Zhong-Tao Ding. Alkaloids with antioxidant activities from Aconitum handelianum. Journal of Asian natural products research. 2016 Jun; 18(6):603-10. doi: 10.1080/10286020.2015.1114473. [PMID: 26744060]
  • Yu-Mei Wu, Xiao-Lan Chen, Wen Liu, Fang-Fang Yang, Hong-Yan Tang, Ya-Jie Dai. [Pharmacokinetics of bullatine A in Aconitum brachypodum total alkaloids gel in transdermal delivery]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Apr; 41(8):1530-1534. doi: 10.4268/cjcmm20160827. [PMID: 28884551]
  • Shi-Yong Teng, Si-Xi Zhang, Kai Niu, Li-Jie Zhai, Shi-Ji Wang. Development and validation of an LC-MS/MS method for the determination of bullatine A in rat plasma: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2015 Dec; 29(12):1798-804. doi: 10.1002/bmc.3498. [PMID: 26033334]
  • G Q Han, S M Li, C L Li, J P Springer, S B Hwang, M N Chang. [Neolignans from Piper hancei Maxim]. Yao xue xue bao = Acta pharmaceutica Sinica. 1986 May; 21(5):361-5. doi: ". [PMID: 3776545]