Xanthosine (BioDeep_00000001710)

 

Secondary id: BioDeep_00000398755

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purine-2,6-diol

化学式: C10H12N4O6 (284.0757)
中文名称: 黄嘌呤核苷, 黄苷, 黄嘌呤
谱图信息: 最多检出来源 Homo sapiens(plant) 9.68%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Xanthosine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/xanthosine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001710). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c2[nH]c(=O)[nH]c3=O)O1)O)O)O
InChI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)

描述信息

Xanthosine, also known as xanthine riboside, belongs to the class of organic compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine exists in all living species, ranging from bacteria to plants to humans. In plants xanthosine is the biosynthetic precursor to 7-methylxanthosine which is produced by the action of the enzyme known as 7-methylxanthosine synthase. 7-Methylxanthosine in turn is the precursor to theobromine (the active alkaloid in chocolate), which in turn is the precursor to caffeine, the active alkaloid in coffee and tea. Within humans, xanthosine participates in a number of enzymatic reactions. In particular, xanthosine can be biosynthesized from xanthylic acid; which is catalyzed by the enzyme cytosolic purine 5-nucleotidase. In addition, xanthosine can be converted into xanthine and ribose 1-phosphate; which is mediated by the enzyme purine nucleoside phosphorylase. Xanthosine monophosphate (XMP) is an intermediate in purine metabolism, formed from IMP (inosine monophosphate).
Biological Source: Production by guanine-free mutants of bacteria e.g. Bacillus subtilis, Aerobacter aerogenesand is also reported from seeds of Trifolium alexandrinum Physical Description: Prismatic cryst. (H2O) (Chemnetbase) The deamination product of guanosine; Xanthosine monophosphate is an intermediate in purine metabolism, formed from IMP, and forming GMP.; Xanthylic acid can be used in quantitative measurements of the Inosine monophosphate dehydrogenase enzyme activities in purine metabolism, as recommended to ensure optimal thiopurine therapy for children with acute lymphoblastic leukaemia (ALL). (PMID: 16725387). Xanthosine is found in many foods, some of which are calabash, rambutan, apricot, and pecan nut.
Acquisition and generation of the data is financially supported in part by CREST/JST.
CONFIDENCE standard compound; INTERNAL_ID 126
COVID info from COVID-19 Disease Map
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Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats[1].
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats[1].
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats[1].

同义名列表

24 个代谢物同义名

9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purine-2,6-diol; 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine-2,6-diol; 3,9-Dihydro-9-beta-delta-ribofuranosyl-1H-purine-2,6-dione; 9-beta-D-Ribofuranosyl-3,9-dihydro-1H-purine-2,6-dione; 3,9-Dihydro-9-delta-ribofuranosyl-1H-purine-2,6-dione; 3,9-Dihydro-9-b-D-ribofuranosyl-1H-purine-2,6-dione; 9-Β-D-ribofuranosyl-3,9-dihydro-1H-purine-2,6-dione; 9-b-D-Ribofuranosyl-3,9-dihydro-1H-purine-2,6-dione; 3,9-Dihydro-9-D-ribofuranosyl-1H-purine-2,6-dione; 9-beta-delta-Ribofuranosylxanthine; Xanthine 9-beta-D-ribofuranoside; 9-beta-D-Ribofuranosylxanthine; 9 beta-D-Ribofuranosylxanthine; Xanthine 9-β-D-ribofuranoside; Xanthine 9-b-D-ribofuranoside; 9-delta-Ribofuranosylxanthine; 9-Β-D-ribofuranosylxanthine; 9-b-D-Ribofuranosylxanthine; 9-D-Ribofuranosylxanthine; Xanthine riboside; Xanthosine; Xanthosine; Xanthosine; Xanthosine



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(7)

代谢反应

701 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(117)

WikiPathways(3)

Plant Reactome(3)

INOH(2)

PlantCyc(527)

COVID-19 Disease Map(2)

PathBank(47)

PharmGKB(0)

76 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ADA, AKT1, ALDH1A1, ALDH3B1, APRT, CSN2, DGUOK, EGFR, EMP2, NT5C2, PNP, XDH
Peripheral membrane protein 1 ADA
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 1 EGFR
Nucleus 7 ADK, AKT1, CSN2, DGUOK, EGFR, EMP2, FABP3
cytosol 13 ADA, ADK, AKT1, ALDH1A1, ALDH3B1, APRT, CSN2, DGUOK, FABP3, GDA, NT5C2, PNP, XDH
nucleoplasm 4 ADK, AKT1, APRT, CSN2
Cell membrane 5 ADA, AKT1, ALDH3B1, EGFR, EMP2
Lipid-anchor 1 ALDH3B1
lamellipodium 1 AKT1
ruffle membrane 1 EGFR
Cell projection, axon 1 ALDH1A1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 EMP2, GDA
Golgi apparatus membrane 1 EMP2
Synapse 1 ALDH1A1
cell cortex 1 AKT1
cell junction 2 ADA, EGFR
cell surface 3 ADA, EGFR, EMP2
glutamatergic synapse 2 AKT1, EGFR
Golgi apparatus 1 EMP2
Golgi membrane 4 EGFR, EMP2, INS, LALBA
mitochondrial inner membrane 1 GDA
postsynapse 1 AKT1
Cytoplasm, cytosol 2 ALDH1A1, NT5C2
Lysosome 1 ADA
endosome 1 EGFR
plasma membrane 7 ADA, ADK, AKT1, ALDH3B1, EGFR, EMP2, GCG
Membrane 5 ADA, AKT1, EGFR, EMP2, FNDC3B
apical plasma membrane 2 EGFR, EMP2
axon 1 ALDH1A1
basolateral plasma membrane 1 EGFR
extracellular exosome 5 ALDH1A1, ALDH3B1, APRT, FABP3, PNP
extracellular space 8 CSN2, EGFR, FABP3, GCG, INS, LALBA, PNP, XDH
perinuclear region of cytoplasm 2 EGFR, EMP2
mitochondrion 2 DGUOK, GDA
protein-containing complex 3 AKT1, EGFR, LALBA
Single-pass type I membrane protein 1 EGFR
Secreted 5 CSN2, GCG, INS, LALBA, PNP
extracellular region 5 APRT, CSN2, GCG, INS, PNP
Single-pass membrane protein 1 FNDC3B
mitochondrial matrix 1 DGUOK
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
nuclear membrane 1 EGFR
external side of plasma membrane 1 ADA
cytoplasmic vesicle 1 EMP2
microtubule cytoskeleton 1 AKT1
apical part of cell 1 EMP2
cell-cell junction 1 AKT1
vesicle 2 AKT1, ALDH3B1
Apical cell membrane 1 EMP2
Cytoplasm, perinuclear region 1 EMP2
Mitochondrion inner membrane 1 GDA
Membrane raft 2 EGFR, EMP2
focal adhesion 1 EGFR
spindle 1 AKT1
Peroxisome 1 XDH
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 XDH
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
receptor complex 1 EGFR
ciliary basal body 1 AKT1
COP9 signalosome 1 CSN2
endosome lumen 1 INS
specific granule membrane 1 ALDH3B1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 PNP
secretory granule lumen 4 APRT, GCG, INS, PNP
secretory granule membrane 1 ALDH3B1
Golgi lumen 2 INS, LALBA
endoplasmic reticulum lumen 2 GCG, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 1 ADK
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 ADK
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Glucagon-like peptide 1]: Secreted 1 GCG


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