Trazodone (BioDeep_00000001964)

 

Secondary id: BioDeep_00000406049

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one

化学式: C19H22ClN5O (371.1512792)
中文名称: 曲唑酮
谱图信息: 最多检出来源 Homo sapiens(blood) 1.72%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Trazodone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/trazodone (retrieved 2024-11-25) (BioDeep RN: BioDeep_00000001964). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1ccn2c(c1)nn(c2=O)CCCN3CCN(CC3)c4cccc(c4)Cl
InChI: InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2

描述信息

A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
CONFIDENCE standard compound; INTERNAL_ID 712; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7040; ORIGINAL_PRECURSOR_SCAN_NO 7038
CONFIDENCE standard compound; INTERNAL_ID 712; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6960; ORIGINAL_PRECURSOR_SCAN_NO 6956
CONFIDENCE standard compound; INTERNAL_ID 712; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7037; ORIGINAL_PRECURSOR_SCAN_NO 7034
CONFIDENCE standard compound; INTERNAL_ID 712; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6996; ORIGINAL_PRECURSOR_SCAN_NO 6993
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
CONFIDENCE standard compound; INTERNAL_ID 2271
D049990 - Membrane Transport Modulators
Trazodone (AF-1161 free base) is a serotonin receptor antagonist and reuptake inhibitor. Trazodone can be used for the research of major depressive disorder. Trazodone also has potential for sleep disorder research[1].

同义名列表

50 个代谢物同义名

2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one; 2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; Bristol myers squibb brand OF trazodone hydrochloride; Boehringer ingelheim brand OF trazodone hydrochloride; Bristol-myers squibb brand OF trazodone hydrochloride; Aventis pharma brand OF trazodone hydrochloride; Pharmascience brand OF trazodone hydrochloride; Farma lepori brand OF trazodone hydrochloride; Neuraxpharm brand OF trazodone hydrochloride; Ratiopharm brand OF trazodone hydrochloride; Novopharm brand OF trazodone hydrochloride; Apothecon brand OF trazodone hydrochloride; Nu pharm brand OF trazodone hydrochloride; Genpharm brand OF trazodone hydrochloride; Nu-pharm brand OF trazodone hydrochloride; Sidmark brand OF trazodone hydrochloride; Aventis brand OF trazodone hydrochloride; Apotex brand OF trazodone hydrochloride; Searle brand OF trazodone hydrochloride; Hexal brand OF trazodone hydrochloride; trazodone hydrochloride; Trazodon neuraxpharm; Trazodon-neuraxpharm; TrazodonNeuraxpharm; Ratio-trazodone; Ratio trazodone; Novo-trazodone; Novo trazodone; RatioTrazodone; Trazodon hexal; Apo-trazodone; PMS Trazodone; Gen trazodone; Gen-trazodone; Apo trazodone; PMS-Trazodone; Nu-trazodone; Nu trazodone; Trazodonum; Molipaxin; Trazodona; trazodone; Tradozone; Trittico; Thombran; Desyrel; Trazon; Deprax; AF-1161 (free base); Trazodone



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review. Medicine. 2024 Mar; 103(11):e37612. doi: 10.1097/md.0000000000037612. [PMID: 38489675]
  • Marta Balog, Allison Anderson, Thiago C Genaro-Mattos, Zeljka Korade, Karoly Mirnics. Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain. Journal of lipid research. 2022 08; 63(8):100249. doi: 10.1016/j.jlr.2022.100249. [PMID: 35839864]
  • Marianna Mazza, Emanuele Caroppo, Giuseppe Marano, Georgios D Kotzalidis, Carla Avallone, Giovanni Camardese, Delfina Janiri, Lorenzo Moccia, Alessio Simonetti, Luigi Janiri, Gabriele Sani. Trazodone Prolonged-Release Monotherapy in Cannabis Dependent Patients during Lockdown Due to COVID-19 Pandemic: A Case Series. International journal of environmental research and public health. 2022 06; 19(12):. doi: 10.3390/ijerph19127397. [PMID: 35742646]
  • Jing Ding, Yan Zhang, Xiaohua Cui, Caiping Zhao, Suo Zhang. Development of a Novel Analytical Method for Determining Trazodone in Human Plasma by Liquid Chromatography Coupled With Mass Spectrometry Coupled With Automatic 2-Dimensional Liquid Chromatograph-Mass Spectrometer Coupler 9500 and Its Application to Therapeutic Drug Monitoring. Therapeutic drug monitoring. 2022 06; 44(3):465-473. doi: 10.1097/ftd.0000000000000921. [PMID: 34469419]
  • Udo Bonnet, Georg Juckel. COVID-19 Outcomes: Does the Use of Psychotropic Drugs Make a Difference? Accumulating Evidence of a Beneficial Effect of Antidepressants-A Scoping Review. Journal of clinical psychopharmacology. 2022 May; 42(3):284-292. doi: 10.1097/jcp.0000000000001543. [PMID: 35420565]
  • Isabel Seguro, Patrícia Rebelo, João G Pacheco, Cristina Delerue-Matos. Electropolymerized, Molecularly Imprinted Polymer on a Screen-Printed Electrode-A Simple, Fast, and Disposable Voltammetric Sensor for Trazodone. Sensors (Basel, Switzerland). 2022 Apr; 22(7):. doi: 10.3390/s22072819. [PMID: 35408433]
  • Basar Cenik, Jayme M Palka, Bonne M Thompson, Jeffrey G McDonald, Carol A Tamminga, Can Cenik, E Sherwood Brown. Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone. Translational psychiatry. 2022 04; 12(1):139. doi: 10.1038/s41398-022-01903-3. [PMID: 35379782]
  • Sun-A Kim, Michelle R Borchardt, Kyuyoung Lee, Elizabeth A Stelow, Melissa J Bain. Effects of trazodone on behavioral and physiological signs of stress in dogs during veterinary visits: a randomized double-blind placebo-controlled crossover clinical trial. Journal of the American Veterinary Medical Association. 2022 03; 260(8):876-883. doi: 10.2460/javma.20.10.0547. [PMID: 35333743]
  • Gauthier Nendumba, Lidvine Boland, Vincent Haufroid, Pierre-François Laterre, Philippe Hantson. Intravenous Lipid Emulsion in a Case of Trazodone Overdose. The primary care companion for CNS disorders. 2022 03; 24(2):. doi: 10.4088/pcc.21cr02994. [PMID: 35768021]
  • Naglaa F Khedr, Rehab H Werida. l-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity. Life sciences. 2022 Feb; 290(?):120025. doi: 10.1016/j.lfs.2021.120025. [PMID: 34637798]
  • Jumpei Saito, Mariko Ishii, Asako Mito, Naho Yakuwa, Hiroyo Kawasaki, Yoshiyuki Tachibana, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Trazodone Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine. 2021 11; 16(11):922-925. doi: 10.1089/bfm.2021.0191. [PMID: 34348038]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Zeljka Korade, Luke B Allen, Allison Anderson, Keri A Tallman, Thiago C Genaro-Mattos, Ned A Porter, Karoly Mirnics. Trazodone effects on developing brain. Translational psychiatry. 2021 02; 11(1):85. doi: 10.1038/s41398-021-01217-w. [PMID: 33526772]
  • Alexandra L Moss, Rachel L Hritz, Rachel C Hector, Kathryn L Wotman. Investigation of the effects of orally administered trazodone on intraocular pressure, pupil diameter, physical examination variables, and sedation level in healthy equids. American journal of veterinary research. 2021 Feb; 82(2):138-143. doi: 10.2460/ajvr.82.2.138. [PMID: 33480276]
  • Alessandro Ruggieri, Rossella Picollo, Alessandra Del Vecchio, Fabrizio Calisti, Patrizia Dragone, Alessandro Comandini, Maria T Rosignoli, Agnese Cattaneo, Frank Donath, Ralph-Steven Wedemeyer, Marina Todorova-Sanjari, André Warnke, Henning H Blume. Investigations on dose proportionality and drug-drug interaction for a fixed-dose combination of trazodone and gabapentin. International journal of clinical pharmacology and therapeutics. 2021 Jan; 59(1):71-86. doi: 10.5414/cp203845. [PMID: 33040841]
  • Fitri Fareez Ramli, Muhammad Hasif Azizi, Syed Alhafiz Syed Hashim. Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis. International journal of medical sciences. 2021; 18(11):2372-2380. doi: 10.7150/ijms.57641. [PMID: 33967614]
  • Yasmeen Prud'homme, Shannon T Ferrell, Francis Beaudry, Guy Beauchamp, Sylvain Nichols, Marion Desmarchelier. PHARMACOKINETICS AND CLINICAL EFFECTS OF A SINGLE ORAL DOSE OF TRAZODONE IN THE DOMESTIC GOAT (CAPRA HIRCUS) AS A MODEL FOR WILD RUMINANTS. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2021 Jan; 51(4):896-904. doi: 10.1638/2019-0242. [PMID: 33480570]
  • Magdalene M Assimon, Jennifer E Flythe. Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis. Clinical journal of the American Society of Nephrology : CJASN. 2020 12; 16(1):88-97. doi: 10.2215/cjn.10070620. [PMID: 33355192]
  • Valeria Tellone, Maria Teresa Rosignoli, Rossella Picollo, Patrizia Dragone, Alessandra Del Vecchio, Alessandro Comandini, Milko Radicioni, Chiara Leuratti, Fabrizio Calisti. Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects. Journal of clinical pharmacology. 2020 11; 60(11):1483-1495. doi: 10.1002/jcph.1640. [PMID: 32488885]
  • Sung Il Bae, Ju-Tae Sohn. Lipid Emulsion Treatment for Trazodone Toxicity-Induced Coma. Clinical neuropharmacology. 2020 Nov; 43(6):201. doi: 10.1097/wnf.0000000000000413. [PMID: 32925182]
  • Mark Unruh, Daniel Cukor, Tessa Rue, Kashif Abad, Maria-Eleni Roumelioti, Susan M McCurry, Patrick Heagerty, Rajnish Mehrotra. Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis. BMC nephrology. 2020 10; 21(1):443. doi: 10.1186/s12882-020-02107-x. [PMID: 33081705]
  • Erica M O'Donnell, Saya A Press, Margo J Karriker, Stephanie A Istvan. Pharmacokinetics and efficacy of trazodone following rectal administration of a single dose to healthy dogs. American journal of veterinary research. 2020 Sep; 81(9):739-746. doi: 10.2460/ajvr.81.9.739. [PMID: 33112166]
  • Nahla Elhesaisy, Shady Swidan. Trazodone Loaded Lipid Core Poly (ε-caprolactone) Nanocapsules: Development, Characterization and in Vivo Antidepressant Effect Evaluation. Scientific reports. 2020 02; 10(1):1964. doi: 10.1038/s41598-020-58803-z. [PMID: 32029776]
  • Alexandra Warnant, Ludovic Gerard, Vincent Haufroid, Philippe Hantson. Coma Reversal After Intravenous Lipid Emulsion Therapy in a Trazodone-Poisoned Patient. Clinical neuropharmacology. 2020 Jan; 43(1):31-33. doi: 10.1097/wnf.0000000000000376. [PMID: 31934922]
  • Kalpana P Padala, Christopher M Parkes, Prasad R Padala. Neuropsychological and Functional Impact of COVID-19 on Mild Cognitive Impairment. American journal of Alzheimer's disease and other dementias. 2020 Jan; 35(?):1533317520960875. doi: 10.1177/1533317520960875. [PMID: 32969235]
  • Lakshmi P Digala, Scott Lucchese. IV Lidocaine Infusion Leading to the Toxic Levels in Serum Causing Asystole - A Case Report. Headache. 2020 01; 60(1):269-270. doi: 10.1111/head.13699. [PMID: 31743428]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Hong-Ming Chen, Yao-Hsu Yang, Ko-Jung Chen, Yena Lee, Roger S McIntyre, Mong-Liang Lu, Yi-Chen Lee, Ming-Chia Hsieh, Vincent Chin-Hung Chen. Antidepressants Reduced Risk of Mortality in Patients With Diabetes Mellitus: A Population-Based Cohort Study in Taiwan. The Journal of clinical endocrinology and metabolism. 2019 10; 104(10):4619-4625. doi: 10.1210/jc.2018-02362. [PMID: 31265070]
  • Jia-Lian Zhu, Yi Gong, Wen-Wen Luo, Qi-Zhi Zhang, Rong-Hua Zhu, Wen-Xing Peng. Pharmacokinetics of trazodone sustained-release tablets in healthy subjects: Three open-label, randomized crossover studies
. International journal of clinical pharmacology and therapeutics. 2019 Oct; 57(10):520-530. doi: 10.5414/cp203482. [PMID: 31262398]
  • G H Ragab, E A Bahgat. Development of HPLC method coupled with fluorescence detection for simultaneous determination of donepezil HCl and trazodone HCl in spiked human plasma and tablets dosage forms. Annales pharmaceutiques francaises. 2019 Jul; 77(4):286-294. doi: 10.1016/j.pharma.2019.02.003. [PMID: 31027753]
  • Silvana Olivieri, Graziella Bovi, Vanessa Petrucci, Anna Alfieri, Laura Oggianu, Rossella Picollo, Carolina Devastato, Patrizia Dragone, Fabio Garofolo, Serena Tongiani. Juvenile rat and pediatric trazodone studies: how to gain extra sensitivity to overcome bioanalytical challenges. Bioanalysis. 2019 Jan; 11(1):21-32. doi: 10.4155/bio-2018-0236. [PMID: 30525928]
  • Marion R Desmarchelier, Francis Beaudry, Shannon T Ferrell, Diane Frank. Determination of the pharmacokinetics of a single oral dose of trazodone and its effect on the activity level of domestic pigeons (Columba livia). American journal of veterinary research. 2019 Jan; 80(1):102-109. doi: 10.2460/ajvr.80.1.102. [PMID: 30605036]
  • O Atli, V Kilic, M Baysal, G Kilic, G Gormus, S Ucarcan, B Korkut, S Ilgin. Assessment of trazodone-induced cardiotoxicity after repeated doses in rats. Human & experimental toxicology. 2019 Jan; 38(1):45-55. doi: 10.1177/0960327118769717. [PMID: 29774748]
  • J L Davis, J Schirmer, E Medlin. Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse. Journal of veterinary pharmacology and therapeutics. 2018 Jun; 41(3):393-401. doi: 10.1111/jvp.12477. [PMID: 29333613]
  • Bernd Reichl, Markus Himmelsbach, Lisa Emhofer, Christian W Klampfl, Wolfgang Buchberger. Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model. Electrophoresis. 2018 05; 39(9-10):1301-1308. doi: 10.1002/elps.201700482. [PMID: 29427324]
  • Sinem Ilgın, Gözde Aydoğan-Kılıç, Merve Baysal, Volkan Kılıç, Mina Ardıç, Şeyda Uçarcan, Özlem Atlı. Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress. Oxidative medicine and cellular longevity. 2018; 2018(?):7196142. doi: 10.1155/2018/7196142. [PMID: 30151072]
  • Zeljka Korade, Thiago C Genaro-Mattos, Keri A Tallman, Wei Liu, Krassimira A Garbett, Katalin Koczok, Istvan Balogh, Karoly Mirnics, Ned A Porter. Vulnerability of DHCR7+/- mutation carriers to aripiprazole and trazodone exposure. Journal of lipid research. 2017 11; 58(11):2139-2146. doi: 10.1194/jlr.m079475. [PMID: 28972118]
  • Miriam Saiz-Rodríguez, Carmen Belmonte, Nieves Derqui-Fernández, Teresa Cabaleiro, Manuel Román, Dolores Ochoa, María Talegón, María C Ovejero-Benito, Francisco Abad-Santos. Pharmacogenetics of trazodone in healthy volunteers: association with pharmacokinetics, pharmacodynamics and safety. Pharmacogenomics. 2017 Nov; 18(16):1491-1502. doi: 10.2217/pgs-2017-0116. [PMID: 29061081]
  • Heather K Knych, Khursheed R Mama, Eugene P Steffey, Scott D Stanley, Philip H Kass. Pharmacokinetics and selected pharmacodynamics of trazodone following intravenous and oral administration to horses undergoing fitness training. American journal of veterinary research. 2017 Oct; 78(10):1182-1192. doi: 10.2460/ajvr.78.10.1182. [PMID: 28945130]
  • Andrea Looney, Joseph Wakshlag. Dietary Management of Hyperthyroidism in a Dog. Journal of the American Animal Hospital Association. 2017 Mar; 53(2):111-118. doi: 10.5326/jaaha-ms-6385. [PMID: 28282233]
  • A Najibi, R Heidari, J Zarifi, A Jamshidzadeh, N Firoozabadi, H Niknahad. Evaluating the Role of Drug Metabolism and Reactive Intermediates in Trazodone-Induced Cytotoxicity toward Freshly-Isolated Rat Hepatocytes. Drug research. 2016 Nov; 66(11):592-596. doi: 10.1055/s-0042-109536. [PMID: 27643409]
  • S Lee, H-A Lee, S J Kim, K-S Kim. Cellular mechanisms for trazodone-induced cardiotoxicity. Human & experimental toxicology. 2016 May; 35(5):501-10. doi: 10.1177/0960327115595683. [PMID: 26187900]
  • Cynthia M Cooper, Jason M Baron. Case records of the Massachusetts General Hospital. Case 4-2015. A 49-year-old man with obtundation followed by agitation and acidosis. The New England journal of medicine. 2015 Jan; 372(5):465-73. doi: 10.1056/nejmcpc1410940. [PMID: 25629745]
  • Prashant Kale, Yadvendra K Agrawal. Pharmacokinetics of single oral dose trazodone: a randomized, two-period, cross-over trial in healthy, adult, human volunteers under fed condition. Frontiers in pharmacology. 2015; 6(?):224. doi: 10.3389/fphar.2015.00224. [PMID: 26483693]
  • Helen E Ritchie, Cecilie Haaland Svensson, Mats F Nilsson, William S Webster. A comparison of drug-induced cardiotoxicity in rat embryos cultured in human serum or protein free media. Journal of pharmacological and toxicological methods. 2014 Nov; 70(3):276-82. doi: 10.1016/j.vascn.2014.07.008. [PMID: 25091319]
  • Dilek Yonar, M Maral Sünnetçioğlu. Spectroscopic and calorimetric studies on trazodone hydrochloride-phosphatidylcholine liposome interactions in the presence and absence of cholesterol. Biochimica et biophysica acta. 2014 Oct; 1838(10):2369-79. doi: 10.1016/j.bbamem.2014.06.009. [PMID: 24950245]
  • Dai Li-Bo, Zhu Rong-Hua, Li Huan-De, Wang Feng, Fang Ping-Fei, Lou Jiang. Quantitative analysis of trazodone in human plasma by using HPLC-fluorescence detector coupled with strong cation exchange chromatographic column: application to a pharmacokinetic study in Chinese healthy volunteers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jan; 944(?):43-8. doi: 10.1016/j.jchromb.2013.11.013. [PMID: 24291719]
  • Ariane R Jay, Ursula Krotscheck, Elizabeth Parsley, Lisa Benson, Ariel Kravitz, Abby Mulligan, Jharon Silva, Hussni Mohammed, Wayne S Schwark. Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs. American journal of veterinary research. 2013 Nov; 74(11):1450-6. doi: 10.2460/ajvr.74.11.1450. [PMID: 24168312]
  • Shohreh Taziki, Mohammad Reza Sattari, Mohammad Ali Eghbal. Mechanisms of trazodone-induced cytotoxicity and the protective effects of melatonin and/or taurine toward freshly isolated rat hepatocytes. Journal of biochemical and molecular toxicology. 2013 Oct; 27(10):457-62. doi: 10.1002/jbt.21509. [PMID: 24023050]
  • Michael C Milone. Commentary. Clinical chemistry. 2012 Dec; 58(12):1635. doi: 10.1373/clinchem.2012.184127. [PMID: 23193150]
  • Michael Ganetsky. Commentary. Clinical chemistry. 2012 Dec; 58(12):1634-5. doi: 10.1373/clinchem.2012.182261. [PMID: 23193149]
  • Matthew S Petrie, Kara L Lynch, Alan H B Wu, Angela A Steinhardt, Gary L Horowitz. Prescription compliance or illicit designer drug abuse?. Clinical chemistry. 2012 Dec; 58(12):1631-4. doi: 10.1373/clinchem.2011.174649. [PMID: 23193148]
  • Yusuf Cem Kaplan, Almla Erol, Barş Karadaş. False-positive amphetamine/ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (CEDIA) and ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (DRI) test results with fenofibrate. Therapeutic drug monitoring. 2012 Oct; 34(5):493-5. doi: 10.1097/ftd.0b013e3182690127.. [PMID: 22972534]
  • Justin L Poklis, Carl E Wolf, Ashley Goldstein, M Lauren Wolfe, Alphonse Poklis. Detection and quantification of tricyclic antidepressants and other psychoactive drugs in urine by HPLC/MS/MS for pain management compliance testing. Journal of clinical laboratory analysis. 2012 Jul; 26(4):286-94. doi: 10.1002/jcla.21519. [PMID: 22811363]
  • Kristina Yasmin Rust, Markus R Baumgartner, Annika M Dally, Thomas Kraemer. Prevalence of new psychoactive substances: A retrospective study in hair. Drug testing and analysis. 2012 Jun; 4(6):402-8. doi: 10.1002/dta.1338. [PMID: 22522922]
  • Gabriella Inczedy-Farkas, Viktoria Remenyi, Aniko Gal, Zsofia Varga, Petra Balla, Agnes Udvardy-Meszaros, Benjamin Bereznai, Maria Judit Molnar. Psychiatric symptoms of patients with primary mitochondrial DNA disorders. Behavioral and brain functions : BBF. 2012 Feb; 8(?):9. doi: 10.1186/1744-9081-8-9. [PMID: 22329956]
  • María del Mar Ramírez Fernández, Sarah M R Wille, Nele Samyn. Quantitative method validation for the analysis of 27 antidepressants and metabolites in plasma with ultraperformance liquid chromatography-tandem mass spectrometry. Therapeutic drug monitoring. 2012 Feb; 34(1):11-24. doi: 10.1097/ftd.0b013e31823bf0fd. [PMID: 22210095]
  • Emanuel Calenoff. Interplaying factors that effect multiple sclerosis causation and sustenance. ISRN neurology. 2012; 2012(?):851541. doi: 10.5402/2012/851541. [PMID: 22462023]
  • Michael D Stein, Megan E Kurth, Katherine M Sharkey, Bradley J Anderson, Richard P Corso, Richard P Millman. Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial. Drug and alcohol dependence. 2012 Jan; 120(1-3):65-73. doi: 10.1016/j.drugalcdep.2011.06.026. [PMID: 21798674]
  • Tarun Dua, Corrado Barbui, Nicolas Clark, Alexandra Fleischmann, Vladimir Poznyak, Mark van Ommeren, M Taghi Yasamy, Jose Luis Ayuso-Mateos, Gretchen L Birbeck, Colin Drummond, Melvyn Freeman, Panteleimon Giannakopoulos, Itzhak Levav, Isidore S Obot, Olayinka Omigbodun, Vikram Patel, Michael Phillips, Martin Prince, Afarin Rahimi-Movaghar, Atif Rahman, Josemir W Sander, John B Saunders, Chiara Servili, Thara Rangaswamy, Jürgen Unützer, Peter Ventevogel, Lakshmi Vijayakumar, Graham Thornicroft, Shekhar Saxena. Evidence-based guidelines for mental, neurological, and substance use disorders in low- and middle-income countries: summary of WHO recommendations. PLoS medicine. 2011 Nov; 8(11):e1001122. doi: 10.1371/journal.pmed.1001122. [PMID: 22110406]
  • Stephen W Waldo, Kathryn Treit, Nora Goldschlager. Possible acute myocardial infarction in a hypothermic patient. Archives of internal medicine. 2011 Sep; 171(16):1430; discussion 1431-2. doi: 10.1001/archinternmed.2011.404. [PMID: 21911626]
  • Abdulrazaq A H Sokoro, Joel Zivot, Robert E Ariano. Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. The Annals of pharmacotherapy. 2011 Sep; 45(9):e50. doi: 10.1345/aph.1p787. [PMID: 21878660]
  • Jason M Baron, David A Griggs, Andrea L Nixon, William H Long, James G Flood. The trazodone metabolite meta-chlorophenylpiperazine can cause false-positive urine amphetamine immunoassay results. Journal of analytical toxicology. 2011 Jul; 35(6):364-8. doi: 10.1093/anatox/35.6.364. [PMID: 21740694]
  • Eva Choong, Serge Rudaz, Astrid Kottelat, Sophie Haldemann, Davy Guillarme, Jean-Luc Veuthey, Chin B Eap. Quantification of 4 antidepressants and a metabolite by LC-MS for therapeutic drug monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jun; 879(19):1544-50. doi: 10.1016/j.jchromb.2011.03.049. [PMID: 21524943]
  • Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller, Hinnerk Boriss. Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals. 2011 Feb; 39(2):312-21. doi: 10.1124/dmd.110.036095. [PMID: 21071520]
  • X-W Chen, E S Serag, K B Sneed, J Liang, H Chew, S-Y Pan, S-F Zhou. Clinical herbal interactions with conventional drugs: from molecules to maladies. Current medicinal chemistry. 2011; 18(31):4836-50. doi: 10.2174/092986711797535317. [PMID: 21919844]
  • Gbolagade Sunmaila Akintomide, Hugh Rickards. Narcolepsy: a review. Neuropsychiatric disease and treatment. 2011; 7(?):507-18. doi: 10.2147/ndt.s23624. [PMID: 21931493]
  • David Karhu, Gerhard Groenewoud, Maria A Potgieter, Diane R Mould. Dose proportionality of once-daily trazodone extended-release caplets under fasting conditions. Journal of clinical pharmacology. 2010 Dec; 50(12):1438-49. doi: 10.1177/0091270009360979. [PMID: 20173086]
  • Seong Taeck Kim, Jae Woong Koh, Joon Mo Kim, Won Young Kim, Gwang Ju Choi. Methotrimeprazine-induced corneal deposits and cataract revealed by urine drug profiling test. Journal of Korean medical science. 2010 Nov; 25(11):1688-91. doi: 10.3346/jkms.2010.25.11.1688. [PMID: 21060765]
  • Marilyne Labasque, Julie Meffre, Gaelle Carrat, Carine Becamel, Joël Bockaert, Philippe Marin. Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants. Molecular pharmacology. 2010 Nov; 78(5):818-26. doi: 10.1124/mol.110.066035. [PMID: 20699324]
  • Anil Kumar, Ruchika Garg, Vaibhav Gaur, Puneet Kumar. Possible role of NO modulators in protective effect of trazodone and citalopram (antidepressants) in acute immobilization stress in mice. Indian journal of experimental biology. 2010 Nov; 48(11):1131-5. doi: . [PMID: 21117454]
  • Barry K Logan, Anthony G Costantino, Eric F Rieders, David Sanders. Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react with the EMIT®II ecstasy immunoassay in urine. Journal of analytical toxicology. 2010 Nov; 34(9):587-9. doi: 10.1093/jat/34.9.587. [PMID: 21073812]
  • Sean Hyun Rhyee, Ernest Vijay Pedapati, Jennifer Thompson. Prolonged delirium after quetiapine overdose. Pediatric emergency care. 2010 Oct; 26(10):754-6. doi: 10.1097/pec.0b013e3181f39d5b. [PMID: 20930599]
  • Vaibhav Gaur, Anil Kumar. Protective effect of desipramine, venlafaxine and trazodone against experimental animal model of transient global ischemia: possible involvement of NO-cGMP pathway. Brain research. 2010 Sep; 1353(?):204-12. doi: 10.1016/j.brainres.2010.07.004. [PMID: 20624374]
  • Gislaine Z Réus, Roberto B Stringari, Bruna de Souza, Fabrícia Petronilho, Felipe Dal-Pizzol, Jaime E Hallak, Antônio W Zuardi, José A Crippa, João Quevedo. Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus. Oxidative medicine and cellular longevity. 2010 Sep; 3(5):325-31. doi: 10.4161/oxim.3.5.13109. [PMID: 21150338]
  • Nancy C Brahm, Lynn L Yeager, Mark D Fox, Kevin C Farmer, Tony A Palmer. Commonly prescribed medications and potential false-positive urine drug screens. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2010 Aug; 67(16):1344-50. doi: 10.2146/ajhp090477. [PMID: 20689123]
  • O Me Abdel Salam, A A Sleem, N Shafee. Effect of trazodone and nefazodone on hepatic injury induced by carbon tetrachloride. Drug discoveries & therapeutics. 2010 Aug; 4(4):285-97. doi: . [PMID: 22491211]
  • Kyung Hee Choi, Ah Jeong Kim, In Ja Son, Kyung-Hwan Kim, Ki-Bong Kim, Hyuk Ahn, Eun Bong Lee. Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting. Journal of Korean medical science. 2010 Mar; 25(3):337-41. doi: 10.3346/jkms.2010.25.3.337. [PMID: 20191029]
  • F Giuliano, G Jackson, F Montorsi, A Martin-Morales, P Raillard. Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database. International journal of clinical practice. 2010 Jan; 64(2):240-55. doi: 10.1111/j.1742-1241.2009.02254.x. [PMID: 19900167]
  • David A Mrazek. Psychiatric pharmacogenomic testing in clinical practice. Dialogues in clinical neuroscience. 2010; 12(1):69-76. doi: NULL. [PMID: 20373668]
  • Eric B Larson, Felise S Zollman. The effect of sleep medications on cognitive recovery from traumatic brain injury. The Journal of head trauma rehabilitation. 2010 Jan; 25(1):61-7. doi: 10.1097/htr.0b013e3181c1d1e1. [PMID: 20051895]
  • Miguel Ángel Artacho, Pablo Barreiro, José Vicente Fernández-Montero. Long-term treatment of patients with HIV-1: the role of atazanavir. HIV/AIDS (Auckland, N.Z.). 2010; 2(?):157-66. doi: 10.2147/hiv.s5069. [PMID: 22096394]
  • Xiuyao Zhang, Xinxin Cai, Xiaoyi Zhang. [Rapid simultaneous determination of 42 psychoactive drugs and their metabolites in human plasma and urine by ultra performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2010 Jan; 28(1):23-33. doi: 10.3724/sp.j.1123.2010.00023. [PMID: 20458916]
  • Sarah M R Wille, Els A De Letter, Michel H A Piette, Lien K Van Overschelde, Carlos H Van Peteghem, Willy E Lambert. Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry. International journal of legal medicine. 2009 Nov; 123(6):451-8. doi: 10.1007/s00414-008-0287-6. [PMID: 18839201]
  • Yukitaka Yoshikawa, Hiroko Hosomi, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity. Toxicology in vitro : an international journal published in association with BIBRA. 2009 Sep; 23(6):1179-87. doi: 10.1016/j.tiv.2009.05.024. [PMID: 19501153]
  • François-Ludovic Sauvage, Nicolas Picard, Franck Saint-Marcoux, Jean-Michel Gaulier, Gérard Lachâtre, Pierre Marquet. General unknown screening procedure for the characterization of human drug metabolites in forensic toxicology: applications and constraints. Journal of separation science. 2009 Sep; 32(18):3074-83. doi: 10.1002/jssc.200900092. [PMID: 19697309]
  • Erin N Adams, Alla Marks, Mitsi H Lizer. Carbamazepine-induced hyperammonemia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2009 Aug; 66(16):1468-70. doi: 10.2146/ajhp080454. [PMID: 19667003]
  • Rajesh N Hegde, Nagaraj P Shetti, Sharanappa T Nandibewoor. Electro-oxidation and determination of trazodone at multi-walled carbon nanotube-modified glassy carbon electrode. Talanta. 2009 Jul; 79(2):361-8. doi: 10.1016/j.talanta.2009.03.064. [PMID: 19559891]
  • A Kumar, R Garg. Possible role of trazodone and imipramine in sleep deprivation-induced anxiety-like behavior and oxidative damage in mice. Methods and findings in experimental and clinical pharmacology. 2009 Jul; 31(6):383-7. doi: 10.1358/mf.2009.31.6.1386992. [PMID: 19798453]
  • M Soledad García, Joaquín Ortuño, M Isabel Albero, María Cuartero. Application of a trazodone-selective electrode to pharmaceutical quality control and urine analyses. Analytical and bioanalytical chemistry. 2009 Jul; 394(6):1563-7. doi: 10.1007/s00216-009-2699-7. [PMID: 19238364]
  • D Farkas, L P Volak, J S Harmatz, L L von Moltke, M H Court, D J Greenblatt. Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem. Clinical pharmacology and therapeutics. 2009 Jun; 85(6):644-50. doi: 10.1038/clpt.2008.293. [PMID: 19242403]
  • Guillaume Hoizey, Denis Lamiable, Claire Gozalo, Thomas Miric, Aurélie Thomas, Laurent Binet, Olivier Oget, Hervé Millart, Cédric Mauprivez. Determination of articaine in human plasma by liquid chromatography-mass spectrometry and its application in a preliminary pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2009 May; 49(4):1082-7. doi: 10.1016/j.jpba.2009.01.028. [PMID: 19237257]
  • Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry. 2009 Mar; 52(6):1693-700. doi: 10.1021/jm801441s. [PMID: 19256501]
  • Angelo A Izzo, Edzard Ernst. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs. 2009; 69(13):1777-98. doi: 10.2165/11317010-000000000-00000. [PMID: 19719333]
  • Marco Menchetti, Beatrice Ferrari Gozzi, Maria Addolorata Saracino, Laura Mercolini, Carmine Petio, Maria Augusta Raggi. Non-fatal overdose of duloxetine in combination with other antidepressants and benzodiazepines. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2009; 10(4 Pt 2):385-9. doi: 10.1080/15622970701586331. [PMID: 18609436]
  • Michael Kaye. Nocturia: a blinded, randomized, parallel placebo-controlled self-study of the effect of 5 different sedatives and analgesics. Canadian Urological Association journal = Journal de l'Association des urologues du Canada. 2008 Dec; 2(6):604-8. doi: . [PMID: 19066678]
  • E J Cobos, J M Entrena, F R Nieto, C M Cendán, E Del Pozo. Pharmacology and therapeutic potential of sigma(1) receptor ligands. Current neuropharmacology. 2008 Dec; 6(4):344-66. doi: 10.2174/157015908787386113. [PMID: 19587856]
  • Gert Laekeman, Lieven Zwaenepoel, Johan Reyntens, Marc de Vos, Minne Casteels. Osteoporosis after combined use of a neuroleptic and antidepressants. Pharmacy world & science : PWS. 2008 Oct; 30(5):613-6. doi: 10.1007/s11096-008-9231-6. [PMID: 18574709]
  • Anil Kumar, Ruchika Garg, Puneet Kumar. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Pharmacological reports : PR. 2008 Sep; 60(5):664-72. doi: . [PMID: 19066412]