Eicosapentaenoic acid (BioDeep_00000001307)

 

Secondary id: BioDeep_00000404901, BioDeep_00000868528, BioDeep_00001891867

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


cis, cis, cis, cis, cis-Eicosa-5,8,11,14,17-pentaenoic acid

化学式: C20H30O2 (302.2246)
中文名称: 顺式-5,8,11,14,17-二十碳五烯酸(EPA), 5Z,8Z,11Z,14Z,17Z-二十碳五烯酸, 花生五烯酸, 顺式-5,8,11,14,17-二十碳五烯酸, 二十碳五烯酸
谱图信息: 最多检出来源 Homo sapiens(blood) 16.66%

Reviewed

Last reviewed on 2024-07-02.

Cite this Page

Eicosapentaenoic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/eicosapentaenoic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001307). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(=O)(O)CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC
InChI: InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-

描述信息

Icosapent, also known as icosapentaenoate or (5z,8z,11z,14z,17z)-eicosapentaenoic acid, is a member of the class of compounds known as long-chain fatty acids. Long-chain fatty acids are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms. Thus, icosapent is considered to be a fatty acid lipid molecule. Icosapent is practically insoluble (in water) and a weakly acidic compound (based on its pKa). Icosapent can be found in a number of food items such as barley, sacred lotus, white lupine, and rape, which makes icosapent a potential biomarker for the consumption of these food products. Icosapent can be found primarily in blood, feces, sweat, and urine, as well as throughout most human tissues. In humans, icosapent is involved in the alpha linolenic acid and linoleic acid metabolism. Moreover, icosapent is found to be associated with essential hypertension and hypertension. Ethyl eicosapentaenoic acid (E-EPA, icosapent ethyl) is a derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA) that is used in combination with changes in diet to lower triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia. This was the second class of fish oil-based drug to be approved for use as a drug and was approved by the FDA in 2012. These fish oil drugs are similar to fish oil dietary supplements but the ingredients are better controlled and have been tested in clinical trials . The anti-inflammatory, antithrombotic and immunomodulatory actions of EPA is probably due to its role in eicosanoid physiology and biochemistry. Most eicosanoids are produced by the metabolism of omega-3 fatty acids, specifically, arachidonic acid. These eicosanoids, leukotriene B4 (LTB4) and thromboxane A2 (TXA2) stimulate leukocyte chemotaxis, platelet aggregation and vasoconstriction. They are thrombogenic and artherogenic. On the other hand, EPA is metabolized to leukotriene B5 (LTB5) and thromboxane A3 (TXA3), which are eicosanoids that promote vasodilation, inhibit platelet aggregation and leukocyte chemotaxis and are anti-artherogenic and anti-thrombotic. The triglyceride-lowering effect of EPA results from inhibition of lipogenesis and stimulation of fatty acid oxidation. Fatty acid oxidation of EPA occurs mainly in the mitochondria. EPA is a substrate for Prostaglandin-endoperoxide synthase 1 and 2. It also appears to affect the function and bind to the Carbohydrate responsive element binding protein (ChREBP) and to a fatty acid receptor (G-coupled receptor) known as GP40 (DrugBank).
Eicosapentaenoic acid (EPA or also icosapentaenoic acid) is an important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. Eicosapentaenoic acid is an omega-3 fatty acid. In physiological literature, it is given the name 20:5(n-3). Its systematic chemical name is all-cis-5,8,11,14,17-icosapentaenoic acid. It also has the trivial name timnodonic acid. Chemically, EPA is a carboxylic acid with a 20-carbon chain and five cis double bonds; the first double bond is located at the third carbon from the omega end. Because of the presence of double bonds, EPS is a polyunsaturated fatty acid. Metabolically it acts as a precursor for prostaglandin-3 (which inhibits platelet aggregation), thromboxane-3, and leukotriene-5 groups. It is found in fish oils of cod liver, herring, mackerel, salmon, menhaden, and sardine. It is also found in human breast milk (Wikipedia).
Chemical was purchased from CAY 90110 (Lot. 0443819-6); Diagnostic ions: 301.2, 257.1, 202.9
CONFIDENCE standard compound; INTERNAL_ID 305
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

同义名列表

59 个代谢物同义名

cis, cis, cis, cis, cis-Eicosa-5,8,11,14,17-pentaenoic acid; (5Z,8Z,11Z,14Z,17Z)-Eicosa-5,8,11,14,17-pentaenoic acid; cis, cis, cis, cis, cis-Eicosa-5,8,11,14,17-pentaenoate; (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic acid; (5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaenoic acid; (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoate; (5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaenoate; (all-Z)-delta5,8,11,14,17-Eicosapentaenoic acid; cis-Delta(5,8,11,14,17)-Eicosapentaenoic acid; 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid (d5); (all-cis)-5,8,11,14,17-Eicosapentaenoic acid; (all-Z)-Δ5,8,11,14,17-eicosapentaenoic acid; all-cis-5,8,11,14,17-Eicosapentaenoic acid; all-cis-Icosa-5,8,11,14,17-pentaenoic acid; (all-Z)-5,8,11,14,17-Eicosapentaenoic acid; cis-delta(5,8,11,14,17)-Eicosapentaenoate; (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid; cis-Δ(5,8,11,14,17)-eicosapentaenoic acid; (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid; 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid; (all-Z)-5,8,11,14,17-Eicosapentaenoate; all-cis-Icosa-5,8,11,14,17-pentaenoate; all-cis-5,8,11,14,17-Eicosapentaenoate; cis-5,8,11,14,17-Eicosapentaenoic acid; (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate; cis-Δ(5,8,11,14,17)-eicosapentaenoate; (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoate; 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoate; 5,8,11,14,17-Eicosapentaenoic Acid; cis-5,8,11,14,17-Eicosapentaenoate; 5,8,11,14,17-Icosapentaenoic acid; 5,8,11,14,17-EICOSAPENTAENOate; 5,8,11,14,17-Icosapentaenoate; Omega-3-eicosapentaenoic acid; Omega 3 eicosapentaenoic acid; all-cis-Icosapentaenoic acid; FA(20:5(5Z,8Z,11Z,14Z,17Z)); all-cis-Icosapentaenoate; Eicosapentaenoic acid; Acid, eicosapentanoic; cis-5,8,11,14,17-EPA; Icosapentaenoic acid; Eicosapentanoic acid; EPA;Timnodonic acid; C20:5n-3,6,9,12,15; Eicosapentaenoate; Icosapentaenoate; Timnodonic acid; Timnodonate; Icosapentum; FA(20:5n3); Icosapento; Icosapent; EPA (d5); FA 20:5; EPA; 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoic Acid; (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid; cis-5,8,11,14,17-Eicosapentaenoic acid



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

71 个相关的代谢反应过程信息。

Reactome(63)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(6)

PharmGKB(0)

212 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ALOX12, ALOX15B, ALOX5, ITPR3
Peripheral membrane protein 3 ALOX15, ALOX15B, ALOX5
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 2 ALOX15B, NAP1L2
cytosol 6 ALOX12, ALOX15, ALOX15B, ALOX5, LIPE, PRKCQ
nucleoplasm 2 ALOX5, ITPR3
Cell membrane 4 ALOX15, ALOX15B, CYSLTR2, LIPE
Multi-pass membrane protein 2 CYSLTR2, ITPR3
Golgi membrane 1 INS
neuronal cell body 1 ITPR3
sarcolemma 1 ALOX12
Cytoplasm, cytosol 4 ALOX15, ALOX15B, ALOX5, LIPE
plasma membrane 5 ALOX15, ALOX15B, CYSLTR2, ITPR3, PRKCQ
Membrane 5 ALOX12, ALOX15, ALOX15B, ITPR3, LIPE
brush border 1 ITPR3
caveola 1 LIPE
extracellular exosome 2 ALOX12, ALOX15B
endoplasmic reticulum 1 ITPR3
extracellular space 2 ALOX5, INS
perinuclear region of cytoplasm 1 ALOX5
adherens junction 1 ALOX15B
Secreted 1 INS
extracellular region 2 ALOX5, INS
cytoplasmic side of plasma membrane 1 ALOX15
centriolar satellite 1 PRKCQ
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
nucleolus 1 ITPR3
apical part of cell 1 ITPR3
Cytoplasm, perinuclear region 1 ALOX5
Cell junction, focal adhesion 1 ALOX15B
Cytoplasm, cytoskeleton 1 ALOX15B
focal adhesion 1 ALOX15B
Cell junction, adherens junction 1 ALOX15B
sarcoplasmic reticulum 1 ITPR3
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
chromatin 1 NAP1L2
cytoskeleton 1 ALOX15B
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
endosome lumen 1 INS
Lipid droplet 2 ALOX15, LIPE
Membrane, caveola 1 LIPE
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 2 ALOX5, INS
secretory granule membrane 1 ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 ALOX5
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
platelet dense tubular network membrane 1 ITPR3
[Isoform a]: Nucleus 1 ALOX15B
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
transport vesicle membrane 1 ITPR3
Nucleus intermembrane space 1 ALOX5
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3


文献列表

  • Karolina Beton-Mysur, Jakub Surmacki, Beata Brożek-Płuska. Raman-AFM-fluorescence-guided impact of linoleic and eicosapentaenoic acids on subcellular structure and chemical composition of normal and cancer human colon cells. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2024 Jul; 315(?):124242. doi: 10.1016/j.saa.2024.124242. [PMID: 38581725]
  • Emily G Oakes, Iliyan Vlasakov, Gregory Kotler, Vadim Bubes, Samia Mora, Raju Tatituri, Nancy R Cook, JoAnn E Manson, Karen H Costenbader. Joint effects of one year of marine omega-3 fatty acid supplementation and participant dietary fish intake upon circulating lipid mediators of inflammation resolution in a randomized controlled trial. Nutrition (Burbank, Los Angeles County, Calif.). 2024 Jul; 123(?):112413. doi: 10.1016/j.nut.2024.112413. [PMID: 38518540]
  • Hyun Gi Koh, Seungjib Jeon, Minsik Kim, Yong Keun Chang, Kyungmoon Park, See-Hyoung Park, Nam Kyu Kang. Optimization and mechanism analysis of photosynthetic EPA production in Nannochloropsis salina: Evaluating the effect of temperature and nitrogen concentrations. Plant physiology and biochemistry : PPB. 2024 Jun; 211(?):108729. doi: 10.1016/j.plaphy.2024.108729. [PMID: 38754177]
  • Ying Ou, Yu Qin, Shoushuai Feng, Hailin Yang. Dual stress factors adaptive evolution for high EPA production in Schizochytrium sp. and metabolomics mechanism analysis. Bioprocess and biosystems engineering. 2024 Jun; 47(6):863-875. doi: 10.1007/s00449-024-03013-4. [PMID: 38687387]
  • Rachel Grazda, Allison N Seyfried, Krishna Rao Maddipati, Gabrielle Fredman, Katherine C MacNamara. Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice. Cell death & disease. 2024 May; 15(5):324. doi: 10.1038/s41419-024-06705-7. [PMID: 38724533]
  • Bodo Speckmann, Tanja Wagner, Paul M Jordan, Oliver Werz, Manfred Wilhelm, Heike Tom Dieck, Christiane Schön. Synbiotic Bacillus megaterium DSM 32963 and n-3 PUFA Salt Composition Elevates Pro-Resolving Lipid Mediator Levels in Healthy Subjects: A Randomized Controlled Study. Nutrients. 2024 Apr; 16(9):. doi: 10.3390/nu16091354. [PMID: 38732601]
  • Lena Hong, Peter Zahradka, Carla G Taylor. Differential Modulation by Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) of Mesenteric Fat and Macrophages and T Cells in Adipose Tissue of Obese fa/fa Zucker Rats. Nutrients. 2024 Apr; 16(9):. doi: 10.3390/nu16091311. [PMID: 38732558]
  • Michael Szarek, Deepak L Bhatt, Michael Miller, Eliot A Brinton, Terry A Jacobson, Jean-Claude Tardif, Christie M Ballantyne, R Preston Mason, Steven B Ketchum, Armando Lira Pineda, Ralph T Doyle, Ph Gabriel Steg. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. Journal of the American College of Cardiology. 2024 Apr; 83(16):1529-1539. doi: 10.1016/j.jacc.2024.02.016. [PMID: 38530686]
  • Sylwia Klińska-Bąchor, Kamil Demski, Yangmin Gong, Antoni Banaś. Biochemical characterization of acyl-CoA:diacylglycerol acyltransferase2 from the diatom Phaeodactylum tricornutum and its potential effect on LC-PUFAs biosynthesis in planta. BMC plant biology. 2024 Apr; 24(1):309. doi: 10.1186/s12870-024-05014-7. [PMID: 38649801]
  • Wenting Wei, Siyan Yu, Huanting Zeng, Weifeng Tan, Manjiang Hu, Jie Huang, Xudong Li, Limei Mao. Docosahexaenoic and Eicosapentaenoic Acids Promote the Accumulation of Browning-Related Myokines via Calcium Signaling in Insulin-Resistant Mice. The Journal of nutrition. 2024 Apr; 154(4):1271-1281. doi: 10.1016/j.tjnut.2024.02.016. [PMID: 38367811]
  • Neila Sayah, Deepak L Bhatt, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Lixia Jiao, Armando Lira Pineda, Ralph T Doyle, Jean Claude Tardif, Christie M Ballantyne, Ph Gabriel Steg. Icosapent ethyl following acute coronary syndrome: the REDUCE-IT trial. European heart journal. 2024 Apr; 45(13):1173-1176. doi: 10.1093/eurheartj/ehad889. [PMID: 38252107]
  • Ivana Djuricic, Philip C Calder. Omega-3 (n-3) Fatty Acid-Statin Interaction: Evidence for a Novel Therapeutic Strategy for Atherosclerotic Cardiovascular Disease. Nutrients. 2024 Mar; 16(7):. doi: 10.3390/nu16070962. [PMID: 38612996]
  • Hsien-Yin Liao, Chia-Ming Yen, I-Han Hsiao, Hsin-Cheng Hsu, Yi-Wen Lin. Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model. International journal of molecular sciences. 2024 Mar; 25(5):. doi: 10.3390/ijms25052901. [PMID: 38474148]
  • Lin-Hui Yang, Meng-Zhen Liu, Zi-Lei Chen, Ling-Ling Tong, Dong-Sheng Guo. Lipidomic and transcriptomic analysis of the increase in eicosapentaenoic acid under cobalamin deficiency of Schizochytrium sp. Biotechnology journal. 2024 Mar; 19(3):e2300612. doi: 10.1002/biot.202300612. [PMID: 38472102]
  • Samuel C R Sherratt, R Preston Mason, Peter Libby, Ph Gabriel Steg, Deepak L Bhatt. Do patients benefit from omega-3 fatty acids?. Cardiovascular research. 2024 02; 119(18):2884-2901. doi: 10.1093/cvr/cvad188. [PMID: 38252923]
  • Ajeet Singh Chauhan, Anil Kumar Patel, Reeta Rani Singhania, Akash Pralhad Vadrale, Chiu-Wen Chen, Balendu Sheker Giri, Jo-Shu Chang, Cheng-Di Dong. Fine-tuning of key parameters to enhance biomass and nutritional polyunsaturated fatty acids production from Thraustochytrium sp. Bioresource technology. 2024 Feb; 394(?):130252. doi: 10.1016/j.biortech.2023.130252. [PMID: 38145766]
  • Irene Cetin, Susan E Carlson, Christy Burden, Eduardo B da Fonseca, Gian Carlo di Renzo, Adamos Hadjipanayis, William S Harris, Kishore R Kumar, Sjurdur Frodi Olsen, Silke Mader, Fionnuala M McAuliffe, Beverly Muhlhausler, Emily Oken, Liona C Poon, Lucilla Poston, Usha Ramakrishnan, Charles C Roehr, Charles Savona-Ventura, Cornelius M Smuts, Alexandros Sotiriadis, Kuan-Pin Su, Rachel M Tribe, Gretchen Vannice, Berthold Koletzko. Omega-3 fatty acid supply in pregnancy for risk reduction of preterm and early preterm birth. American journal of obstetrics & gynecology MFM. 2024 Feb; 6(2):101251. doi: 10.1016/j.ajogmf.2023.101251. [PMID: 38070679]
  • Zeyan Chen, Yonghui Kong, Zishu Huang, Xiaoyu Zheng, Zhihong Zheng, Defu Yao, Shen Yang, Yueling Zhang, Jude Juventus Aweya. Exogenous alpha-linolenic acid and Vibrio parahaemolyticus induce EPA and DHA levels mediated by delta-6 desaturase to enhance shrimp immunity. International journal of biological macromolecules. 2024 Feb; 257(Pt 2):128583. doi: 10.1016/j.ijbiomac.2023.128583. [PMID: 38056755]
  • Maëlle Briottet, Khadeeja Sy, Charlie London, Abdel Aissat, Mickael Shum, Virginie Escabasse, Bruno Louis, Valérie Urbach. Specialized proresolving mediator resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamics. Proceedings of the National Academy of Sciences of the United States of America. 2024 Jan; 121(5):e2313089121. doi: 10.1073/pnas.2313089121. [PMID: 38252817]
  • William S Weintraub, Deepak L Bhatt, Zugui Zhang, Sarahfaye Dolman, William E Boden, Adam P Bress, Brandon K Bellows, Catherine G Derington, Sephy Philip, Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Jean-Claude Tardif, Christie M Ballantyne, Paul Kolm. Cost-Effectiveness of Icosapent Ethyl in REDUCE-IT USA: Results From Patients Randomized in the United States. Journal of the American Heart Association. 2024 Jan; 13(1):e032413. doi: 10.1161/jaha.123.032413. [PMID: 38156550]
  • Gerard Marrugat, Ainara Cano, Javier Amézaga, Sara Arranz, Nieves Embade, Óscar Millet, Carla Ferreri, Itziar Tueros. Effect of age and dietary habits on Red Blood Cell membrane fatty acids in a Southern Europe population (Basque Country). Prostaglandins, leukotrienes, and essential fatty acids. 2024 Jan; 200(?):102602. doi: 10.1016/j.plefa.2023.102602. [PMID: 38147804]
  • Archana S Rao, Ajay Nair, K Nivetha, Bibi Ayesha, Kapadia Hardi, Vora Divya, S M Veena, K S Anantharaju, Sunil S More. Impacts of Omega-3 Fatty Acids, Natural Elixirs for Neuronal Health, on Brain Development and Functions. Methods in molecular biology (Clifton, N.J.). 2024; 2761(?):209-229. doi: 10.1007/978-1-0716-3662-6_15. [PMID: 38427239]
  • Chun-Xiao Yan, Ying Zhang, Wen-Qian Yang, Wang Ma, Xiao-Man Sun, He Huang. Universal and unique strategies for the production of polyunsaturated fatty acids in industrial oleaginous microorganisms. Biotechnology advances. 2024 Jan; 70(?):108298. doi: 10.1016/j.biotechadv.2023.108298. [PMID: 38048920]
  • Ateequr Rehman, Van Pham, Nicole Seifert, Nathalie Richard, Wilbert Sybesma, Robert E Steinert. The Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid, and Vitamin K1 Modulate the Gut Microbiome: A Study Using an In Vitro Shime Model. Journal of dietary supplements. 2024; 21(2):135-153. doi: 10.1080/19390211.2023.2198007. [PMID: 37078491]
  • Wen Liu, Min Zhu, Jingyi Liu, Shan Su, Xin Zeng, Fudong Fu, Yanrong Lu, Zhiyong Rao, Younan Chen. Comparison of the effects of monounsaturated fatty acids and polyunsaturated fatty acids on the lipotoxicity of islets. Frontiers in endocrinology. 2024; 15(?):1368853. doi: 10.3389/fendo.2024.1368853. [PMID: 38501107]
  • Yusuke Kobayashi, Tetsuya Fujikawa, Aiko Haruna, Rina Kawano, Moe Ozawa, Tatsuya Haze, Shiro Komiya, Shota Suzuki, Yuki Ohki, Akira Fujiwara, Sanae Saka, Nobuhito Hirawa, Yoshiyuki Toya, Kouichi Tamura. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. Medicina (Kaunas, Lithuania). 2023 Dec; 60(1):. doi: 10.3390/medicina60010075. [PMID: 38256336]
  • Ella J Baker. Alternative sources of bioactive omega-3 fatty acids: what are the options?. Current opinion in clinical nutrition and metabolic care. 2023 Dec; ?(?):. doi: 10.1097/mco.0000000000001006. [PMID: 38126230]
  • Tamil Selvi Sundaram, Maria Filippa Addis, Carlotta Giromini, Raffaella Rebucci, Salvatore Pisanu, Daniela Pagnozzi, Antonella Baldi. Comprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes. Scientific reports. 2023 12; 13(1):21595. doi: 10.1038/s41598-023-48018-3. [PMID: 38062040]
  • Siqing Mao, Ziling Liu, Yuan Tian, Dan Li, Xin Gao, Yanqiong Wen, Tao Peng, Weijun Shen, Dingfu Xiao, Fachun Wan, Lei Liu. Branched-Long-Chain Monomethyl Fatty Acids: Are They Hidden Gems?. Journal of agricultural and food chemistry. 2023 Dec; 71(48):18674-18684. doi: 10.1021/acs.jafc.3c06300. [PMID: 37982580]
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