Asymmetric dimethylarginine (BioDeep_00000002992)

 

Secondary id: BioDeep_00000178363, BioDeep_00000403116, BioDeep_00000405912

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin natural product


代谢物信息卡片


(2S)-2-amino-5-[(E)-[amino(dimethylamino)methylidene]amino]pentanoic acid

化学式: C8H18N4O2 (202.143)
中文名称: (2S)-2-氨基-5-[(氨基-二甲基氨基甲基亚基)氨基]戊酸, N5 - [(二甲基氨基)亚氨基甲基] -L-鸟氨酸, 二甲基精氨酸, 不对称二甲基精氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 18.93%

Reviewed

Last reviewed on 2024-08-26.

Cite this Page

Asymmetric dimethylarginine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/asymmetric_dimethylarginine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000002992). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN(C)C(=N)NCCCC(N)C(=O)O
InChI: InChI=1S/C8H18N4O2/c1-12(2)8(10)11-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14)

描述信息

Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and thence into blood plasma. Asymmetric dimethylarginine is measured using high performance liquid chromatography. ADMA has been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821).
Isolated from broad bean seeds (Vicia faba). NG,NG-Dimethyl-L-arginine is found in many foods, some of which are yellow wax bean, spinach, green zucchini, and white cabbage.
D004791 - Enzyme Inhibitors
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.

同义名列表

23 个代谢物同义名

(2S)-2-amino-5-[(E)-[amino(dimethylamino)methylidene]amino]pentanoic acid; (2S)-2-amino-5-[[amino(dimethylamino)methylidene]amino]pentanoic acid; 2-Amino-5-(amino-dimethylamino-methylidene)amino-pentanoic acid; 2-Amino-5-(amino-dimethylamino-methylidene)amino-pentanoate; N(5)-((Dimethylamino)iminomethyl)-L-ornithine; N5-[(dimethylamino)iminomethyl]-L-ornithine; N(Omega),N(omega)-dimethyl-L-arginine; Nomega,nomega-dimethyl-L-arginine; L-Arg(Me, Me)-OH (asymmetrical); Guanidino-N,N-dimethylarginine; N(g1),N(g1)-Dimethylarginine; Asymmetric dimethylarginine; N(g),N(g)-Dimethylarginine; NG,NG-Dimethyl-L-arginine; NG,NG-Dimethylarginine; N(g)-Dimethylarginine; N,N-Dimethylarginine; NG-Dimethylarginine; Dimethyl-L-arginine; ADMA; Asymmetric dimethylarginine; NG,NG-Dimethyl-L-arginine; NG,NG-Dimethyl-L-arginine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, AKT1, ALB, HIF1A, IL18, PRMT1, VEGFA
Endoplasmic reticulum membrane 1 PON1
Nucleus 6 AKT1, ALB, HIF1A, KDR, PRMT1, VEGFA
cytosol 6 AKT1, ALB, HIF1A, IL18, LEP, PRMT1
nuclear body 1 HIF1A
centrosome 1 ALB
nucleoplasm 3 AKT1, HIF1A, PRMT1
RNA polymerase II transcription regulator complex 1 HIF1A
Cell membrane 7 ACE, AGTR1, AKT1, KDR, SELE, SELP, SLC7A1
lamellipodium 1 AKT1
Multi-pass membrane protein 2 AGTR1, SLC7A1
cell cortex 1 AKT1
cell junction 1 KDR
cell surface 1 VEGFA
glutamatergic synapse 1 AKT1
Golgi apparatus 3 ALB, KDR, VEGFA
lysosomal membrane 1 PRMT1
postsynapse 1 AKT1
Cytoplasm, cytosol 2 IL18, PRMT1
Lysosome 1 ACE
endosome 2 ACE, KDR
plasma membrane 7 ACE, AGTR1, AKT1, KDR, SELE, SELP, SLC7A1
Membrane 5 ACE, AGTR1, AKT1, SLC7A1, VEGFA
apical plasma membrane 1 SLC7A1
basolateral plasma membrane 1 SLC7A1
caveola 1 SELE
extracellular exosome 6 ACE, ALB, PON1, RETN, SELP, VWF
Lysosome membrane 1 PRMT1
endoplasmic reticulum 4 ALB, KDR, VEGFA, VWF
extracellular space 13 ACE, ALB, CCL2, IL18, IL6, LEP, LPA, PON1, RETN, SELE, SELP, VEGFA, VWF
perinuclear region of cytoplasm 1 SELE
adherens junction 1 VEGFA
mitochondrion 1 AGXT2
protein-containing complex 4 AKT1, ALB, HIF1A, SLC7A1
Single-pass type I membrane protein 3 ACE, SELE, SELP
Secreted 10 ACE, ALB, CCL2, IL18, IL6, LEP, RETN, SELP, VEGFA, VWF
extracellular region 13 ACE, ALB, CCL2, IL18, IL6, KDR, LEP, LPA, PON1, RETN, SELP, VEGFA, VWF
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 AGXT2
anchoring junction 2 ALB, KDR
motile cilium 1 HIF1A
external side of plasma membrane 4 ACE, KDR, SELE, SELP
Secreted, extracellular space, extracellular matrix 2 VEGFA, VWF
high-density lipoprotein particle 1 PON1
microtubule cytoskeleton 1 AKT1
axon cytoplasm 1 HIF1A
Early endosome 1 KDR
cell-cell junction 1 AKT1
clathrin-coated pit 1 SELE
vesicle 1 AKT1
Membrane raft 2 KDR, SELE
spindle 1 AKT1
extracellular matrix 2 VEGFA, VWF
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 VWF
secretory granule 1 VEGFA
nuclear speck 1 HIF1A
receptor complex 1 KDR
ciliary basal body 2 AKT1, ALB
chromatin 1 HIF1A
centriole 1 ALB
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 2 ALB, PON1
sperm midpiece 1 ACE
sorting endosome 1 KDR
Nucleus, nucleoplasm 1 PRMT1
Nucleus speckle 1 HIF1A
euchromatin 1 HIF1A
basal plasma membrane 2 ACE, SLC7A1
platelet alpha granule 1 VWF
platelet dense granule membrane 1 SELP
endoplasmic reticulum lumen 2 ALB, IL6
platelet alpha granule lumen 3 ALB, VEGFA, VWF
specific granule lumen 1 RETN
azurophil granule lumen 1 RETN
methylosome 1 PRMT1
platelet alpha granule membrane 1 SELP
spherical high-density lipoprotein particle 1 PON1
cortical cytoskeleton 1 SELE
platelet dense granule lumen 1 SELP
Weibel-Palade body 1 VWF
interleukin-6 receptor complex 1 IL6
plasma lipoprotein particle 1 LPA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
ciliary transition fiber 1 ALB


文献列表

  • Shao-Sung Huang, Wei-Chieh Huang, Chuan-Tsai Tsai, Ying-Ying Chen, Sheng-Hua Lee, Tse-Min Lu. Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease. Scientific reports. 2023 May; 13(1):7541. doi: 10.1038/s41598-023-32728-9. [PMID: 37160906]
  • Laura Dowsett, Lucie Duluc, Erin Higgins, Fatmah Alghamdi, Walter Fast, Ian P Salt, James Leiper. Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular signalling. 2023 Apr; ?(?):110676. doi: 10.1016/j.cellsig.2023.110676. [PMID: 37028778]
  • Asmaa A Mahmoud, Hesham M Aboelghar, Sabry Moawad Abdelmageed, Heba M Abdallah, Mohamed I Garib, Nahla M S Abd El Hady. Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs. Pediatric research. 2022 12; 92(6):1606-1612. doi: 10.1038/s41390-022-02132-6. [PMID: 35688962]
  • Behnaz Pourrajab, Nasim Naderi, Leila Janani, Marjan Hajahmadi, Vahid Mofid, Afsaneh Dehnad, Mohammad Hassan Sohouli, Sharieh Hosseini, Farzad Shidfar. The impact of probiotic yogurt versus ordinary yogurt on serum sTWEAK, sCD163, ADMA, LCAT and BUN in patients with chronic heart failure: a randomized, triple-blind, controlled trial. Journal of the science of food and agriculture. 2022 Oct; 102(13):6024-6035. doi: 10.1002/jsfa.11955. [PMID: 35460085]
  • Roman N Rodionov, Natalia Jarzebska, Dmitrii Burdin, Vladimir Todorov, Jens Martens-Lobenhoffer, Anja Hofmann, Anne Kolouschek, Nada Cordasic, Johannes Jacobi, Elena Rubets, Henning Morawietz, John F O'Sullivan, Alexander G Markov, Stefan R Bornstein, Karl Hilgers, Renke Maas, Christian Pfluecke, YingJie Chen, Stefanie M Bode-Böger, Christian P M Hugo, Bernd Hohenstein, Norbert Weiss. Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. Scientific reports. 2022 06; 12(1):9381. doi: 10.1038/s41598-022-13169-2. [PMID: 35672381]
  • Zeynep Cetin, Arzu Kosem, Merve Catak, Bulent Can, Ozden Baser, Serdar Guler. The Relationship of Thyroid Functions with ADMA, IMA, and Metabolic Laboratory Parameters in Euthyroid Adults with and without Autoimmune Thyroiditis. Laboratory medicine. 2022 May; 53(3):290-295. doi: 10.1093/labmed/lmab098. [PMID: 34792122]
  • Kensuke Ikenaka, Yasuhiro Maeda, Yuji Hotta, Seiichi Nagano, Shinichiro Yamada, Daisuke Ito, Ryota Torii, Keita Kakuda, Harutsugu Tatebe, Naoki Atsuta, Cesar Aguirre, Yasuyoshi Kimura, Kousuke Baba, Takahiko Tokuda, Masahisa Katsuno, Kazunori Kimura, Gen Sobue, Hideki Mochizuki. Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis. European journal of neurology. 2022 05; 29(5):1410-1416. doi: 10.1111/ene.15254. [PMID: 35128793]
  • Angelo Zinellu, Arduino A Mangoni. An updated systematic review and meta-analysis of the effect of statins on asymmetric dimethylarginine. Nitric oxide : biology and chemistry. 2022 03; 120(?):26-37. doi: 10.1016/j.niox.2022.01.001. [PMID: 35032642]
  • Beatrice Hanusch, Kathrin Sinningen, Folke Brinkmann, Stefanie Dillenhöfer, Mirjam Frank, Karl-Heinz Jöckel, Cordula Koerner-Rettberg, Martin Holtmann, Tanja Legenbauer, Christian Langrock, Thomas Reinehr, Patricia Maasjosthusmann, Bibiana Beckmann, Eckard Hamelmann, Dimitrios Tsikas, Thomas Lücke. Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042136. [PMID: 35216250]
  • Suellen Rodrigues Martins, Sílvia Letícia de Oliveira Toledo, Aislander Junio da Silva, Fernanda Santos Mendes, Marina Mendes de Oliveira, Leticia Gonçalves Resende Ferreira, Luci Maria Sant'Ana Dusse, Maria das Graças Carvalho, Danyelle Romana Alves Rios, Patrícia Nessralla Alpoim, Melina de Barros Pinheiro. Endothelial dysfunction biomarkers in sickle cell disease: is there a role for ADMA and PAI-1?. Annals of hematology. 2022 Feb; 101(2):273-280. doi: 10.1007/s00277-021-04695-6. [PMID: 34665295]
  • Guo-Hua Ni, Jin-Fang Cheng, Yuan-Jian Li, Qi-Ying Xie, Tian-Lun Yang, Mei-Fang Chen. Effect of profilin-1 on the asymmetric dimethylarginine-induced vascular lesion-associated hypertension. The Kaohsiung journal of medical sciences. 2022 Feb; 38(2):149-156. doi: 10.1002/kjm2.12468. [PMID: 34741409]
  • Wen-Ting Zhang, Qin Lu, Jie-Jun Ding, Meng Gu. Association of asymmetric dimethylarginine with the pathological process of persistent pulmonary hypertension of the newborn. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2022 Jan; 24(1):54-59. doi: 10.7499/j.issn.1008-8830.2108145. [PMID: 35177176]
  • Ziang Xie, Lei Hou, Shuying Shen, Yizheng Wu, Jian Wang, Zhiwei Jie, Xiangde Zhao, Xiang Li, Xuyang Zhang, Junxin Chen, Wenbin Xu, Lei Ning, Qingliang Ma, Shiyu Wang, Haoming Wang, Putao Yuan, Xiangqian Fang, An Qin, Shunwu Fan. Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation. Nature communications. 2022 01; 13(1):50. doi: 10.1038/s41467-021-27629-2. [PMID: 35013196]
  • Arne Gessner, Anna Gemeinhardt, Agnes Bosch, Dennis Kannenkeril, Christian Staerk, Andreas Mayr, Martin F Fromm, Roland E Schmieder, Renke Maas. Effects of treatment with SGLT-2 inhibitors on arginine-related cardiovascular and renal biomarkers. Cardiovascular diabetology. 2022 01; 21(1):4. doi: 10.1186/s12933-021-01436-x. [PMID: 34991562]
  • Ayça Türer Cabbar, M Muzaffer Değertekin, Mustafa A Şimşek, Olcay Özveren, Seda Güleç, Mehmed Yanartaş, Serpil Gezer Taş, Şehnaz Olgun Yıldızeli, Bülent Mutlu, Turgay İşbir, Bedrettin Yıldızeli. Evaluation of Asymmetric Dimethylarginine Levels in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Pulmonary Endarterectomy. Heart, lung & circulation. 2022 Jan; 31(1):110-118. doi: 10.1016/j.hlc.2021.05.090. [PMID: 34130918]
  • Yichen Zhao, Minjie Zhang, Yunxiao Dou, Kangshuai Du, Xueyuan Liu, Yanxin Zhao. DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway. Oxidative medicine and cellular longevity. 2022; 2022(?):2350857. doi: 10.1155/2022/2350857. [PMID: 35509834]
  • Huseyin Samet Ozcelik, Derya Arslan, Cigdem Damla Deniz, Oguzhan Gunenc, Husamettin Vatansev, Celil Uysal. Evaluation of Plasma Asymmetric Dimethylarginine Levels and Abdominal Aortic Intima-Media Thickness in Infants of Smoker Mothers. American journal of perinatology. 2021 12; 38(14):1494-1499. doi: 10.1055/s-0040-1713816. [PMID: 32683669]
  • Bo Zhou, Gulinigaer Tuerhong Jiang, Hui Liu, Manyun Guo, Junhui Liu, Jianqing She. Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells. Nutrients. 2021 Nov; 13(11):. doi: 10.3390/nu13114116. [PMID: 34836371]
  • Heng Zhang, Shouyan Xiang, Zhe Dai, Yu Fan. Asymmetric dimethylarginine level as biomarkers of cardiovascular or all-cause mortality in patients with chronic kidney disease: a meta-analysis. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2021 Nov; 26(7):579-585. doi: 10.1080/1354750x.2021.1954694. [PMID: 34253095]
  • Hüseyin Korkmaz, Mehmet Asıl, Tuncer Temel, Bahadır Öztürk, Levent Kebapçılar. Evaluation of serum neutrophil gelatinase-associated lipocalin (NGAL), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels, and their relations with disease type and activity in inflammatory bowel diseases. Turkish journal of medical sciences. 2021 10; 51(5):2403-2412. doi: 10.3906/sag-2103-220. [PMID: 33984894]
  • Boris K Kurbatov, Ekaterina S Prokudina, Leonid N Maslov, Natalia V Naryzhnaya, Sergey V Logvinov, Alexander S Gorbunov, Alexandr V Mukhomedzyanov, Andrey V Krylatov, Nikita S Voronkov, Andrey S Sementsov, Konstantin V Zavadovsky, Viktor V Saushkin, Rajendra P Nagarajan, Peter R Oeltgen. The role of adrenergic and muscarinic receptors in stress-induced cardiac injury. Pflugers Archiv : European journal of physiology. 2021 10; 473(10):1641-1655. doi: 10.1007/s00424-021-02602-6. [PMID: 34245378]
  • Tzong-Shyuan Lee, Tse-Min Lu, Chia-Hui Chen, Bei-Chia Guo, Chiao-Po Hsu. Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway. Redox biology. 2021 10; 46(?):102108. doi: 10.1016/j.redox.2021.102108. [PMID: 34438260]
  • Mei-Hsin Hsu, Kow-Aung Chang, Yu-Chieh Chen, I-Chun Lin, Jiunn-Ming Sheen, Li-Tung Huang. Resveratrol prevented spatial deficits and rescued disarrayed hippocampus asymmetric dimethylarginine and brain-derived neurotrophic factor levels in young rats with increased circulating asymmetric dimethylarginine. Neuroreport. 2021 09; 32(13):1091-1099. doi: 10.1097/wnr.0000000000001698. [PMID: 34284453]
  • Mark A McEvoy, John R Attia, Christopher Oldmeadow, Elizabeth Holliday, Wayne T Smith, Arduino A Mangoni, Roseanne Peel, Stephen J Hancock, Marjorie M Walker, Nicholas J Talley. Serum L-arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case-control study. United European gastroenterology journal. 2021 09; 9(7):809-818. doi: 10.1002/ueg2.12137. [PMID: 34431615]
  • Duygu Eryavuz Onmaz, Kevser Isik, Abdullah Sivrikaya, Sedat Abusoglu, İlknur Albayrak Gezer, Gulsum Abusoglu, Fatma Humeyra Yerlikaya, Ali Unlu. Determination of serum methylarginine levels by tandem mass spectrometric method in patients with ankylosing spondylitis. Amino acids. 2021 Sep; 53(9):1329-1338. doi: 10.1007/s00726-021-03046-z. [PMID: 34273021]
  • Kenta Toyomasu, Hisashi Adachi, Mika Enomoto, Ako Fukami, Sachiko Nakamura, Yume Nohara, Nagisa Morikawa, Akiko Sakaue, Hitoshi Hamamura, Maki Yamamoto, Yoshihiro Fukumoto. Impact of combined elevations of homocysteine and asymmetric dimethylarginine on all-cause death - The Tanushimaru Study. Journal of cardiology. 2021 08; 78(2):129-135. doi: 10.1016/j.jjcc.2021.01.011. [PMID: 33551145]
  • Marius M Mader, Rainer Böger, Daniel Appel, Edzard Schwedhelm, Munif Haddad, Malte Mohme, Katrin Lamszus, Manfred Westphal, Patrick Czorlich, Juliane Hannemann. Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 08; 41(8):1964-1977. doi: 10.1177/0271678x20983216. [PMID: 33461409]
  • Zhen Qin, Lisha Tang, Qianyi Huang, Yan Chen, Wei Zhong, Xiangqi Tang. A systematic review of the correlation between serum asymmetric dimethylarginine, carotid atherosclerosis and ischaemic stroke. European journal of clinical investigation. 2021 Aug; 51(8):e13558. doi: 10.1111/eci.13558. [PMID: 33756002]
  • Tolga Baş, Murat Koç, Onur Işık, Hakan Hançer, Ali Kutsal. Asymmetric dimethylarginine: Is it a risk facgtor in the repair of aortic coarctation?. Journal of cardiac surgery. 2021 Aug; 36(8):2735-2740. doi: 10.1111/jocs.15601. [PMID: 33993556]
  • Damian Gajecki, Jakub Gawryś, Jerzy Wiśniewski, Paulina Fortuna, Ewa Szahidewicz-Krupska, Adrian Doroszko. A Cross-Talk between the Erythrocyte L-Arginine/ADMA/Nitric Oxide Metabolic Pathway and the Endothelial Function in Subjects with Type 2 Diabetes Mellitus. Nutrients. 2021 Jul; 13(7):. doi: 10.3390/nu13072306. [PMID: 34371816]
  • Yichen Zhao, Xiaoye Ma, Yuchen Zhou, Junchao Xie, Xueyuan Liu, Yanxin Zhao. DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage. Laboratory investigation; a journal of technical methods and pathology. 2021 07; 101(7):808-823. doi: 10.1038/s41374-021-00541-5. [PMID: 33574439]
  • Daniel Braun, Jens Schlossmann, Ekkehard Haen. Asymmetric dimethylarginine in psychiatric disorders. Psychiatry research. 2021 06; 300(?):113901. doi: 10.1016/j.psychres.2021.113901. [PMID: 33819866]
  • Juliane Hannemann, Paul Balfanz, Edzard Schwedhelm, Bojan Hartmann, Johanna Ule, Dirk Müller-Wieland, Edgar Dahl, Michael Dreher, Nikolaus Marx, Rainer Böger. Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients. Scientific reports. 2021 05; 11(1):9895. doi: 10.1038/s41598-021-89180-w. [PMID: 33972591]
  • Duygu Eryavuz Onmaz, Saziye Melike Turan Isık, Sedat Abusoglu, Ahmet Hakan Ekmekci, Abdullah Sivrikaya, Gulsum Abusoglu, Serefnur Ozturk, Humeyra Yerlikaya Aydemir, Ali Unlu. Serum ADMA levels were positively correlated with EDSS scores in patients with multiple sclerosis. Journal of neuroimmunology. 2021 04; 353(?):577497. doi: 10.1016/j.jneuroim.2021.577497. [PMID: 33549941]
  • Adrian Post, Alexander Bollenbach, Stephan J L Bakker, Dimitrios Tsikas. Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients. Amino acids. 2021 Apr; 53(4):541-554. doi: 10.1007/s00726-021-02965-1. [PMID: 33651245]
  • Ozge Tugce Pasaoglu, Filiz Sezen Bircan, Turgut Topal, Nurten Turkozkan. Positive Effects of Melatonin on Renal Nitric Oxide-Asymmetric Dimethylarginine Metabolism in Fructose-Fed Rats. Metabolic syndrome and related disorders. 2021 04; 19(3):120-126. doi: 10.1089/met.2020.0084. [PMID: 33090894]
  • Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata. Association Between the Asymmetric Dimethylarginine Levels and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study. Investigative ophthalmology & visual science. 2021 04; 62(4):7. doi: 10.1167/iovs.62.4.7. [PMID: 33821880]
  • Petr Tůma, Blanka Sommerová, Dušan Koval, François Couderc. Electrophoretic Determination of Symmetric and Asymmetric Dimethylarginine in Human Blood Plasma with Whole Capillary Sample Injection. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22062970. [PMID: 33804011]
  • Parinaz Nikooei, Mohammad J Hosseinzadeh-Attar, Somayyeh Asghari, Abdolreza Norouzy, Mehdi Yaseri, Ali Vasheghani-Farahani. Effects of virgin coconut oil consumption on metabolic syndrome components and asymmetric dimethylarginine: A randomized controlled clinical trial. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2021 03; 31(3):939-949. doi: 10.1016/j.numecd.2020.11.020. [PMID: 33549429]
  • C Bening, V L Sales, K Alhussini, D Radakovic, R Cris Benitez, N Madrahimov, D Keller, R Leyh. Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease. BMC cardiovascular disorders. 2021 03; 21(1):125. doi: 10.1186/s12872-021-01926-6. [PMID: 33663396]
  • Zanna Fiodorenko-Dumas, Ilias Dumas, Maciej Rabczynski, Rafał Małecki, Rajmund Adamiec, Małgorzata Paprocka-Borowicz. Lack of evidence of the correlation between plasma Asymmetrical Dimethylarginine correlation and IMT in type 2 diabetic patients with chronic vascular complication. Acta biochimica Polonica. 2021 Feb; 68(1):143-149. doi: 10.18388/abp.2020_5424. [PMID: 33543609]
  • Young Lee, Purvi Mehrotra, David Basile, Mahbub Ullah, Arshnoor Singh, Nicholas Skill, Subhi Talal Younes, Jennifer Sasser, Anantha Shekhar, Jaipal Singh. Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury. The Journal of pharmacology and experimental therapeutics. 2021 02; 376(2):181-189. doi: 10.1124/jpet.120.000212. [PMID: 33214214]
  • A Ertelt, F Stumpff, R Merle, S Kuban, L Bollinger, S Liertz, H Gehlen. Asymmetric dimethylarginine-A potential cardiac biomarker in horses. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 2021 Feb; 33(?):43-51. doi: 10.1016/j.jvc.2020.11.002. [PMID: 33360109]
  • Yasin Saygın, Abdullah Sivrikaya, Turan Akdağ, Duygu Dursunoğlu, Mehmet Kaynar, Gülsüm Abuşoğlu, Ali Ünlü. Is there a relation between serum methylarginine levels and infertility?. Hormone molecular biology and clinical investigation. 2021 Jan; 42(3):273-278. doi: 10.1515/hmbci-2020-0083. [PMID: 33544480]
  • Patrycja Molek, Pawel Zmudzki, Aleksandra Wlodarczyk, Jadwiga Nessler, Jaroslaw Zalewski. The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance. Scientific reports. 2021 01; 11(1):83. doi: 10.1038/s41598-020-80230-3. [PMID: 33420142]
  • Neveen Tawfik Abed, Omima Mohamed Abdel Haie, Amira Ibrahim Mansour, Eman Rateb Abd Almonaem. Relation of asymmetric dimethylarginine with pulmonary morbidities in neonatal respiratory distress syndrome. Journal of neonatal-perinatal medicine. 2021; 14(4):511-517. doi: 10.3233/npm-200604. [PMID: 33646184]
  • Ayako Okada, Takatoshi Murata, Khairul Matin, Meu Ariyoshi, Ryoko Otsuka, Mamiko Yamashita, Masayuki Suzuki, Rumi Wakiyama, Ken Tateno, Megumi Suzuki, Hitomi Aoyagi, Hiromi Uematsu, Akiko Imamura, Miki Kosaka, Tomoko Mizukaki, Tsutomu Sato, Hiroshi Kawahara, Nobuhiro Hanada. Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial. PloS one. 2021; 16(9):e0257247. doi: 10.1371/journal.pone.0257247. [PMID: 34555048]
  • Hawley E Kunz, Jessica M Dorschner, Taylor E Berent, Thomas Meyer, Xuewei Wang, Aminah Jatoi, Rajiv Kumar, Ian R Lanza. Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. The Journal of biological chemistry. 2020 12; 295(51):17441-17459. doi: 10.1074/jbc.ra120.014884. [PMID: 33453990]
  • Fatma Tunçez Akyürek, Gulcan Saylam Kurtipek, Huseyin Kurku, Fikret Akyurek, Ali Unlu, Sedat Abusoglu, Arzu Ataseven. Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris. Journal of cosmetic dermatology. 2020 Dec; 19(12):3408-3413. doi: 10.1111/jocd.13590. [PMID: 32623816]
  • Jing Chen, L Lee Hamm, Joshua D Bundy, Damodar R Kumbala, Shirisha Bodana, Sehgal Chandra, Chung-Shiuan Chen, Charlton C Starcke, Yajun Guo, Caroline M Schaefer, Eva Lustigova, Erin Mahone, Aarti M Vadalia, Terra Livingston, Katherine Obst, Jesus Hernandez, Syed Rizwan Bokhari, Myra Kleinpeter, Arnold B Alper, Ivo Lukitsch, Hua He, David C Nieman, Jiang He. Combination Treatment with Sodium Nitrite and Isoquercetin on Endothelial Dysfunction among Patients with CKD: A Randomized Phase 2 Pilot Trial. Clinical journal of the American Society of Nephrology : CJASN. 2020 11; 15(11):1566-1575. doi: 10.2215/cjn.02020220. [PMID: 33023894]
  • R Bentli, H Taskapan, M C Taskapan, A Dogan. Serum asymmetric-dimethylarginine, apelin and NT-pro BNP levels in dialysis patients. Nigerian journal of clinical practice. 2020 Nov; 23(11):1542-1547. doi: 10.4103/njcp.njcp_171_19. [PMID: 33221779]
  • Qiuna Du, Jiayuan Gao, Renhua Lu, Yun Jin, Yanfang Zou, Chen Yu, Yucheng Yan. Asymmetric dimethylarginine compartmental behavior during high-flux hemodialysis. Renal failure. 2020 Nov; 42(1):760-766. doi: 10.1080/0886022x.2020.1797790. [PMID: 32727241]
  • Daniel de Oliveira Beraldo, Cássio J Rodrigues, Beata M R Quinto, Marcelo C Batista. Role of endothelial function determined by asymmetric dimethylarginine in the prediction of resistant hypertension: A subanalysis of ReHOT trial. Journal of clinical hypertension (Greenwich, Conn.). 2020 11; 22(11):2059-2068. doi: 10.1111/jch.13936. [PMID: 33164259]
  • Ming Wu, Meijie Yuan, Yanzhe Wang, Bo Tan, Di Huang, Chen Wang, Yun Zou, Chaoyang Ye. Renal asymmetric dimethylarginine inhibits fibrosis. FEBS open bio. 2020 10; 10(10):2003-2009. doi: 10.1002/2211-5463.12949. [PMID: 32794631]
  • Ángeles C Ochoa-Martínez, Sandra T Orta-García, José A Varela-Silva, Iván N Pérez-Maldonado. Influence of Human Paraoxonase-1 Polymorphism (Q192R) on Serum Levels of Clinical Biomarkers Indicatives of Cardiovascular Diseases Risk in Mexican Women. Biochemical genetics. 2020 Oct; 58(5):801-820. doi: 10.1007/s10528-020-09975-w. [PMID: 32519276]
  • Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi, Matthew L Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C Zeldin, Rolf Nüsing, Yingbi Zhou, Per-Johan Jakobsson, Jane A Mitchell. Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis. Cardiovascular research. 2020 10; 116(12):1972-1980. doi: 10.1093/cvr/cvz290. [PMID: 31688905]
  • Deborah E Malden, Arduino A Mangoni, Richard J Woodman, Frank Thies, Chris McNeil, Alison D Murray, Roy L Soiza. Circulating asymmetric dimethylarginine and cognitive decline: A 4-year follow-up study of the 1936 Aberdeen Birth Cohort. International journal of geriatric psychiatry. 2020 10; 35(10):1181-1188. doi: 10.1002/gps.5355. [PMID: 32452069]
  • Isaivani Jayachandran, Saravanakumar Sundararajan, Saravanakumar Venkatesan, Sairaj Paadukaana, Muthuswamy Balasubramanyam, Viswanathan Mohan, Nagaraj Manickam. Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway. Scientific reports. 2020 09; 10(1):16005. doi: 10.1038/s41598-020-72943-2. [PMID: 32994511]
  • Gian Luca Erre, Arduino Aleksander Mangoni, Giuseppe Passiu, Stefania Bassu, Floriana Castagna, Ciriaco Carru, Matteo Piga, Angelo Zinellu, Salvatore Sotgia. Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study. Microvascular research. 2020 09; 131(?):104038. doi: 10.1016/j.mvr.2020.104038. [PMID: 32622695]
  • Robert E Bergia, Wayne W Campbell, Bruno T Roseguini, Jung Eun Kim. A high-protein meal does not improve blood pressure or vasoactive biomarker responses to acute exercise in humans. Nutrition research (New York, N.Y.). 2020 09; 81(?):97-107. doi: 10.1016/j.nutres.2020.08.001. [PMID: 32949918]
  • Achim Leo Burger, Stefan Stojkovic, André Diedrich, Svitlana Demyanets, Johann Wojta, Thomas Pezawas. Elevated plasma levels of asymmetric dimethylarginine and the risk for arrhythmic death in ischemic and non-ischemic, dilated cardiomyopathy - A prospective, controlled long-term study. Clinical biochemistry. 2020 Sep; 83(?):37-42. doi: 10.1016/j.clinbiochem.2020.05.016. [PMID: 32504703]
  • Daniel Appel, Rainer Böger, Julia Windolph, Gina Heinze, Alwin E Goetz, Juliane Hannemann. Asymmetric dimethylarginine predicts perioperative cardiovascular complications in patients undergoing medium-to-high risk non-cardiac surgery. The Journal of international medical research. 2020 Aug; 48(8):300060520940450. doi: 10.1177/0300060520940450. [PMID: 32842812]
  • Batool Hossein Rashidi, Fatemeh Mohammad Hosseinzadeh, Elham Alipoor, Somayyeh Asghari, Mir Saeed Yekaninejad, Mohammad Javad Hosseinzadeh-Attar. Effects of Selenium Supplementation on Asymmetric Dimethylarginine and Cardiometabolic Risk Factors in Patients with Polycystic Ovary Syndrome. Biological trace element research. 2020 Aug; 196(2):430-437. doi: 10.1007/s12011-019-01954-6. [PMID: 31667685]
  • Johan Frangky Selanno, Deviana Soraya Riu, Telly Tessy, Maisuri Tajuddin Chalid, Nugraha Utama Pelupessy, Eddy Hartono. Maternal serum levels of asymmetric dimethylarginine in normal and preeclamptic pregnancies. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2020 Aug; 36(8):702-704. doi: 10.1080/09513590.2019.1707793. [PMID: 32129698]
  • Emir Taghikhani, Renke Maas, R Verena Taudte, Arne Gessner, Martin F Fromm, Jörg König. Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells. Amino acids. 2020 Jul; 52(6-7):975-985. doi: 10.1007/s00726-020-02867-8. [PMID: 32642843]
  • Figen Bezci Aygun, Sibel Kocabeyoglu, Murat Irkec, Zeliha Gunnur Dikmen, M Mutlu Umaroglu, Anastasios G P Konstas. Serum Apelin and Asymmetric Dimethylarginine Levels in Patients With Exfoliation Syndrome or Exfoliative Glaucoma. Journal of glaucoma. 2020 07; 29(7):593-597. doi: 10.1097/ijg.0000000000001513. [PMID: 32287143]
  • K Ashokachakkaravarthy, Medha Rajappa, Sreejith Parameswaran, Santhosh Satheesh, G Priyadarshini, P S Mohan Raj, G Revathy, M Priyadarssini. Asymmetric dimethylarginine and angiopoietin-like protein-2 are independent predictors of cardiovascular risk in pre-dialysis non-diabetic chronic kidney disease patients. International urology and nephrology. 2020 Jul; 52(7):1321-1328. doi: 10.1007/s11255-020-02484-0. [PMID: 32409974]
  • Maserame C Mokhaneli, Carla M T Fourie, Shani Botha-Le Roux, Rainer H Böger, Edzard Schwedhelm, Catharina M C Mels. Asymmetric dimethylarginine and L-homoarginine prospectively relate to carotid wall thickness in a South African cohort. Amino acids. 2020 Jul; 52(6-7):965-973. doi: 10.1007/s00726-020-02866-9. [PMID: 32613307]
  • Mahmut Ilker Yilmaz, Micol Romano, Mustafa Kemal Basarali, Abdelbaset Elzagallaai, Murat Karaman, Zeynep Demir, Muhammet Fatih Demir, Fatih Akcay, Melik Seyrek, Nuri Haksever, David Piskin, Rolando Cimaz, Michael J Rieder, Erkan Demirkaya. The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study. Scientific reports. 2020 06; 10(1):9018. doi: 10.1038/s41598-020-65528-6. [PMID: 32488098]
  • Anastasios Vamvakis, Eugenia Gkaliagkousi, Antonios Lazaridis, Maria G Grammatikopoulou, Areti Triantafyllou, Barbara Nikolaidou, Nikolaos Koletsos, Panagiota Anyfanti, Christos Tzimos, Pantelis Zebekakis, Stella Douma. Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial. Nutrients. 2020 05; 12(5):. doi: 10.3390/nu12051326. [PMID: 32392715]
  • Dafeng Yang, Zhousheng Yang, Lei Chen, Dabin Kuang, Yang Zou, Jie Li, Xu Deng, Songyuan Luo, Jianfang Luo, Jun He, Miao Yan, Guixia He, Yang Deng, Rong Li, Qiong Yuan, Yangzhao Zhou, Pei Jiang, Shenglan Tan. Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice. Journal of cellular and molecular medicine. 2020 05; 24(10):5911-5925. doi: 10.1111/jcmm.15278. [PMID: 32301289]
  • Eleonora Gori, Alessio Pierini, Ilaria Lippi, Valentina Meucci, Francesca Perondi, Veronica Marchetti. Evaluation of asymmetric dimethylarginine as an inflammatory and prognostic marker in dogs with acute pancreatitis. Journal of veterinary internal medicine. 2020 May; 34(3):1144-1149. doi: 10.1111/jvim.15785. [PMID: 32378771]
  • Yu-Chieh Chen, Jiunn-Ming Sheen, Mei-Hsin Hsu, Chih-Cheng Hsiao, Su-Chen Wang, Li-Tung Huang. Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats. Life sciences. 2020 Feb; 242(?):116931. doi: 10.1016/j.lfs.2019.116931. [PMID: 31618610]
  • Michael D Wetzel, Ting Gao, Kristen Stanley, Timothy K Cooper, Sidney M Morris, Alaa S Awad. Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy. American journal of physiology. Renal physiology. 2020 02; 318(2):F509-F517. doi: 10.1152/ajprenal.00518.2019. [PMID: 31904280]
  • Rushi V Parikh, Vedant Pargaonkar, Robyn L Ball, Yuhei Kobayashi, Takumi Kimura, Alan C Yeung, John P Cooke, Jennifer A Tremmel. Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease. International journal of cardiology. 2020 01; 299(?):7-11. doi: 10.1016/j.ijcard.2019.07.062. [PMID: 31416658]
  • Paweł Gać, Małgorzata Poręba, Marta Jurdziak, Ewa Trzmielewska, Katarzyna Gocławska, Arkadiusz Derkacz, Grzegorz Mazur, Andrzej Szuba, Rafał Poręba. Cardiovascular risk factors and the concentration of asymmetric dimethylarginine. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2020 Jan; 29(1):63-70. doi: 10.17219/acem/111808. [PMID: 31967743]
  • Hugh W F Kingston, Aniruddha Ghose, Voravut Rungpradubvong, Sudarat Satitthummanid, M Trent Herdman, Katherine Plewes, Haruhiko Ishioka, Stije J Leopold, Ipsita Sinha, Benjamas Intharabut, Kim Piera, Yvette McNeil, Sanjib Mohanty, Richard J Maude, Nicholas J White, Nicholas P J Day, Tsin W Yeo, Md Amir Hossain, Nicholas M Anstey, Arjen M Dondorp. Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria. The Journal of infectious diseases. 2020 01; 221(1):127-137. doi: 10.1093/infdis/jiz359. [PMID: 31693729]
  • Mohammad Javad Hosseinzadeh-Attar, Amrollah Sharifi, Saharnaz Nedjat, Ashraf Mohamadkhani, Homayoon Vahedi. The Effect of Vitamin D on Serum Asymmetric Dimethylarginine in Patients with Mild to Moderate Ulcerative Colitis. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 2020 Jan; 90(1-2):17-22. doi: 10.1024/0300-9831/a000303. [PMID: 30982443]
  • Jakub Gawryś, Jerzy Wiśniewski, Ewa Szahidewicz-Krupska, Damian Gajecki, Julia Leśniewska, Filip Majda, Karolina Gawryś, Paulina Fortuna, Piotr Mlynarz, Adrian Doroszko. Increased Intraplatelet ADMA Level May Promote Platelet Activation in Diabetes Mellitus. Oxidative medicine and cellular longevity. 2020; 2020(?):6938629. doi: 10.1155/2020/6938629. [PMID: 33062144]
  • Weiqing Hu, Wenyue Wang, Qing Ma, Tao Liu, Jiefeng Zhang, Jicun Zhang. Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice. Molecular medicine reports. 2020 01; 21(1):454-462. doi: 10.3892/mmr.2019.10800. [PMID: 31746378]
  • Muserref Hosaf, Sedat Abusoglu, Ahmet Avci, Kenan Demir, Ali Unlu, Duygu Eryavuz, Gulsum Abusoglu. Total methylated arginine load as a risk parameter in subjects with masked hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993). 2020; 42(2):126-130. doi: 10.1080/10641963.2019.1583246. [PMID: 30795691]
  • Kensei Taguchi, Bertha C Elias, Craig R Brooks, Seiji Ueda, Kei Fukami. Uremic Toxin-Targeting as a Therapeutic Strategy for Preventing Cardiorenal Syndrome. Circulation journal : official journal of the Japanese Circulation Society. 2019 12; 84(1):2-8. doi: 10.1253/circj.cj-19-0872. [PMID: 31827008]
  • Hye Rin Choi, Seung Won Lee, Da-Hye Jeon, Nam Wook Hur, Yoosik Youm, Hyeon Chang Kim. Association between estimated glomerular filtration rate (eGFR) and asymmetric dimethylarginine (ADMA) concentrations among the elderly in a rural community: a cross-sectional study. BMC geriatrics. 2019 12; 19(1):370. doi: 10.1186/s12877-019-1388-4. [PMID: 31870320]
  • Fernando Holguin, Hartmut Grasemann, Sunita Sharma, Daniel Winnica, Karen Wasil, Vong Smith, Margaret H Cruse, Nancy Perez, Erika Coleman, Timothy J Scialla, Loretta G Que. L-Citrulline increases nitric oxide and improves control in obese asthmatics. JCI insight. 2019 12; 4(24):. doi: 10.1172/jci.insight.131733. [PMID: 31714895]
  • Heng-Huei Lin, Tzong-Shyuan Lee, Shing-Jong Lin, Yi-Chen Yeh, Tse-Min Lu, Chiao-Po Hsu. DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase. Clinical science (London, England : 1979). 2019 12; 133(23):2361-2378. doi: 10.1042/cs20190455. [PMID: 31763675]
  • Roman N Rodionov, Natalia Jarzebska, Alfred Schneider, Annett Rexin, Jan Sradnick, Silke Brilloff, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Vladimir Todorov, Christian Hugo, Norbert Weiss, Bernd Hohenstein. ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus. Atherosclerosis. Supplements. 2019 Dec; 40(?):100-105. doi: 10.1016/j.atherosclerosissup.2019.08.040. [PMID: 31818438]
  • Saddaf Ayub, Amena Rahim, Muhammad Afzal, Saira Jahan, Aisha Hasan, Abeerah Zainub. Comparison of asymmetric dimethylarginine levels between pre- and post-menopausal women - a cross-sectional study from Rawalpindi. JPMA. The Journal of the Pakistan Medical Association. 2019 Dec; 69(12):1808-1811. doi: 10.5455/jpma.296507. [PMID: 31853108]
  • Jiunn-Ming Sheen, Hong-Ren Yu, You-Lin Tain, Yu-Chieh Chen, Mei-Hsin Hsu, Li-Tung Huang. Young rats with increased circulatory asymmetric dimethylarginine exhibited spatial deficit and alterations in dorsal hippocampus brain-derived neurotrophic factor and asymmetric dimethylarginine: Effects of melatonin. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2019 Nov; 78(?):83-89. doi: 10.1016/j.ijdevneu.2019.09.003. [PMID: 31550497]
  • Chia-Hui Chen, Jin-Feng Zhao, Chiao-Po Hsu, Yu Ru Kou, Tse-Min Lu, Tzong-Shyuan Lee. The detrimental effect of asymmetric dimethylarginine on cholesterol efflux of macrophage foam cells: Role of the NOX/ROS signaling. Free radical biology & medicine. 2019 11; 143(?):354-365. doi: 10.1016/j.freeradbiomed.2019.08.016. [PMID: 31437479]
  • Wojciech Wołyniec, Katarzyna Kasprowicz, Joanna Giebułtowicz, Natalia Korytowska, Katarzyna Zorena, Maria Bartoszewicz, Patrycja Rita-Tkachenko, Marcin Renke, Wojciech Ratkowski. Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs. International journal of environmental research and public health. 2019 10; 16(21):. doi: 10.3390/ijerph16214153. [PMID: 31661892]
  • J Hajal, N Joubran, G Sleilaty, D Chacra, Y Saliba, S Assaad, D Chelala, N Fares. Intradialytic hypotension: beyond hemodynamics. Physiological research. 2019 10; 68(5):793-805. doi: 10.33549/physiolres.934080. [PMID: 31424249]
  • Begoña Quintana-Villamandos, Laia Pazó-Sayós, Silvia Magdalena Arribas, Pilar Rodríguez-Rodríguez, Rainer H Böger, Nicole Lüneburg, Emilio Delgado-Baeza, Maria Carmen González. Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status. Hypertension research : official journal of the Japanese Society of Hypertension. 2019 10; 42(10):1485-1494. doi: 10.1038/s41440-019-0257-z. [PMID: 30992541]
  • Akihiro Nakamura, Shoko Kajitani, Kenjiro Sato, Masanori Kanazawa, Masateru Kondo, Hideaki Endo, Eiji Nozaki. Decline of popliteal artery flow-mediated dilation with aging and possible involvement of asymmetric dimethylarginine in healthy men. Journal of medical ultrasonics (2001). 2019 Oct; 46(4):503-511. doi: 10.1007/s10396-019-00946-2. [PMID: 31011935]
  • Nobuhiro Tahara, Ruchia Kojima, Risa Yoshida, Munehisa Bekki, Yoichi Sugiyama, Atsuko Tahara, Shoko Maeda, Akihiro Honda, Sachiyo Igata, Tomohisa Nakamura, Jiahui Sun, Takanori Matsui, Yoshihiro Fukumoto, Toshiro Matsui, Sho-Ichi Yamagishi. Serum Levels of Protein-Bound Methylglyoxal-Derived Hydroimidazolone-1 are Independently Correlated with Asymmetric Dimethylarginine. Rejuvenation research. 2019 Oct; 22(5):431-438. doi: 10.1089/rej.2018.2152. [PMID: 30661488]
  • Lutfiye Tutkun, Meside Gunduzoz, Vugar A Turksoy, Serdar Deniz, Ozgur Oztan, Sultan P Cetintepe, Servet B Iritas, Gulsum Tekin, Ali Unlu. Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study. Clinical laboratory. 2019 Oct; 65(10):. doi: 10.7754/clin.lab.2019.181249. [PMID: 31625365]
  • Arne Gessner, Maren Mieth, Daniel Auge, Anja Chafai, Fabian Müller, Martin F Fromm, Renke Maas. Establishment of reference values for the lysine acetylation marker Nɛ-acetyllysine in small volume human plasma samples by a multi-target LC-MS/MS method. Amino acids. 2019 Sep; 51(9):1259-1271. doi: 10.1007/s00726-019-02765-8. [PMID: 31388851]
  • Wei-Chieh Huang, Hsin-I Teng, Hsiang-Yao Chen, Ching-Ju Wu, Chuan-Tsai Tsai, Chien-Hung Hsueh, Ying-Ying Chen, William K Hau, Tse-Min Lu. Association between asymmetric dimethylarginine and in-stent restenosis tissue characteristics assessed by optical coherence tomography. International journal of cardiology. 2019 08; 289(?):131-137. doi: 10.1016/j.ijcard.2019.05.003. [PMID: 31079970]
  • Mervat H El-Saka, Nermin M Madi, Rowida Raafat Ibrahim, Ghada Mahmoud Alghazaly, Shereef Elshwaikh, Manal El-Bermawy. The ameliorative effect of angiotensin 1-7 on experimentally induced-preeclampsia in rats: Targeting the role of peroxisome proliferator-activated receptors gamma expression & asymmetric dimethylarginine. Archives of biochemistry and biophysics. 2019 08; 671(?):123-129. doi: 10.1016/j.abb.2019.07.006. [PMID: 31295432]
  • Elena Oliva-Damaso, Nestor Oliva-Damaso, Francisco Rodriguez-Esparragon, Juan Payan, Eduardo Baamonde-Laborda, Fayna Gonzalez-Cabrera, Raquel Santana-Estupiñan, Jose Carlos Rodriguez-Perez. Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach. International journal of molecular sciences. 2019 Jul; 20(15):. doi: 10.3390/ijms20153668. [PMID: 31357472]