Dimethylarginine (BioDeep_00000178363)
Main id: BioDeep_00000002992
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
5-[(diaminomethylidene)amino]-2-(dimethylamino)pentanoic acid
化学式: C8H18N4O2 (202.143)
中文名称: (2S)-2-氨基-5-[(氨基-二甲基氨基甲基亚基)氨基]戊酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C(=N)NCCC[C@@H](C(=O)O)N
InChI: InChI=1S/C8H18N4O2/c1-12(2)6(7(13)14)4-3-5-11-8(9)10/h6H,3-5H2,1-2H3,(H,13,14)(H4,9,10,11)
描述信息
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- PubChem: 17801140
- HMDB: HMDB0251395
- KNApSAcK: C00052203
- chemspider: 10752051
- CAS: 30315-93-6
- RefMet: Dimethylarginine
- medchemexpress: HY-113216
- KEGG: C03626
- PubChem: 6410
- KNApSAcK: 17929
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Helen Michael, Donald Szlosek, Celeste Clements, Rebekah Mack. Symmetrical Dimethylarginine: Evaluating Chronic Kidney Disease in the Era of Multiple Kidney Biomarkers.
The Veterinary clinics of North America. Small animal practice.
2022 May; 52(3):609-629. doi:
10.1016/j.cvsm.2022.01.003. [PMID: 35379500] - Michalina Jezierska, Anna Owczarzak, Joanna Stefanowicz. Dimethylarginines in Children after Anti-Neoplastic Treatment.
Medicina (Kaunas, Lithuania).
2022 Jan; 58(1):. doi:
10.3390/medicina58010108. [PMID: 35056416] - Madalina Irina Mitran, Mircea Tampa, Ilinca Nicolae, Cristina Iulia Mitran, Clara Matei, Simona Roxana Georgescu, Mircea Ioan Popa. New markers of oxidative stress in lichen planus and the influence of hepatitis C virus infection - a pilot study.
Romanian journal of internal medicine = Revue roumaine de medecine interne.
2021 Dec; 59(4):359-368. doi:
10.2478/rjim-2021-0017. [PMID: 33951354] - Tzong-Shyuan Lee, Tse-Min Lu, Chia-Hui Chen, Bei-Chia Guo, Chiao-Po Hsu. Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway.
Redox biology.
2021 10; 46(?):102108. doi:
10.1016/j.redox.2021.102108. [PMID: 34438260] - Sujith Kumar Pulukool, Sai Krishna Srimadh Bhagavatham, Vishnu Kannan, Piruthivi Sukumar, Rajesh Babu Dandamudi, Shamika Ghaisas, Haripriya Kunchala, Darshan Saieesh, Ashwin Ashok Naik, Ashish Pargaonkar, Anuj Sharma, Venketesh Sivaramakrishnan. Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma.
Scientific reports.
2021 05; 11(1):9766. doi:
10.1038/s41598-021-89137-z. [PMID: 33963197] - Adrian Post, Alexander Bollenbach, Stephan J L Bakker, Dimitrios Tsikas. Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients.
Amino acids.
2021 Apr; 53(4):541-554. doi:
10.1007/s00726-021-02965-1. [PMID: 33651245] - Xi Mei, Jun Zeng, Dong-Fang Liu, Ye Zhao, Hui-Lan Yang, Yao Li, Ping Qiu, Ming-Wei Tang. Abnormalities of the PRMT1-ADMA-DDAH1 metabolism axis and probucol treatment in diabetic patients and diabetic rats.
Annals of palliative medicine.
2021 Mar; 10(3):3343-3353. doi:
10.21037/apm-21-417. [PMID: 33849119] - Tansim Akhter, Gerhard Wikström, Marita Larsson, Ulf Bondesson, Mikael Hedeland, Tord Naessen. Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study.
European journal of obstetrics, gynecology, and reproductive biology.
2021 Mar; 258(?):288-293. doi:
10.1016/j.ejogrb.2021.01.016. [PMID: 33498001] - Cecilia Castro-Diehl, Rachel Ehrbar, Vanesa Obas, Albin Oh, Ramachandran S Vasan, Vanessa Xanthakis. Biomarkers representing key aging-related biological pathways are associated with subclinical atherosclerosis and all-cause mortality: The Framingham Study.
PloS one.
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2020 08; 10(1):14036. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Mar; 1141(?):122024. doi:
10.1016/j.jchromb.2020.122024. [PMID: 32062367] - Ibrahim Kocayigit, Mehmet Akif Cakar, Behlül Kahyaoğlu, Muhammed Necati Murat Aksoy, Ersan Tatli, Ramazan Akdemir. The relationship between serum asymmetric dimethylarginine levels and radial artery spasm.
Anatolian journal of cardiology.
2020 Mar; 23(4):228-232. doi:
10.14744/anatoljcardiol.2020.93213. [PMID: 32235140] - Dharmeshkumar Parmar, Nivedita Bhattacharya, Shanthini Kannan, Sangeetha Vadivel, Gautam Kumar Pandey, Avinash Ghanate, Nagarjuna Chary Ragi, Paramasivam Prabu, Thyparambil Aravindakshan Pramodkumar, Nagaraj Manickam, Viswanathan Mohan, Prabhakar Sripadi, Gokulakrishnan Kuppan, Venkateswarlu Panchagnula. Plausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy.
Scientific reports.
2020 02; 10(1):2970. doi:
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Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
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NULL. [PMID: 32068357] - Arisoy Ozden, Halaris Angelos, Aricioglu Feyza, Wild Elizabeth, Piletz John. Altered plasma levels of arginine metabolites in depression.
Journal of psychiatric research.
2020 01; 120(?):21-28. doi:
10.1016/j.jpsychires.2019.10.004. [PMID: 31629205] - Guilhermo Brites-Anselmi, Ana Maria Milanez Azevedo, Anderson Heiji Lima Miyazaki, Lucas Cezar Pinheiro, Fernanda Borchers Coeli-Lacchini, Murilo Ferreira de Andrade, Carlos Augusto Fernandes Molina, Silvio Tucci, Emilio Hirsch, Jose Eduardo Tanus-Santos, Riccardo Lacchini. DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls.
Nitric oxide : biology and chemistry.
2019 11; 92(?):11-17. doi:
10.1016/j.niox.2019.08.001. [PMID: 31394201] - Adem Atıcı, Gonul Aciksari, Omer Faruk Baycan, Hasan Ali Barman, Mehmet Rasih Sonsöz, Mustafa Sahin, Ramazan Asoglu, Ahmet Demirkıran, Şeref Kul, Baris Gungor, Eser Durmaz, Ahmet Kaya Bilge, Irfan Sahin. Serum Asymmetric Dimethylarginine Levels in Patients with Vasovagal Syncope.
Medicina (Kaunas, Lithuania).
2019 Oct; 55(11):. doi:
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Amino acids.
2019 Sep; 51(9):1259-1271. doi:
10.1007/s00726-019-02765-8. [PMID: 31388851] - Liv Nesse Hande, Hilde Thunhaug, Terje Enebakk, Judith Ludviksen, Kristin Pettersen, Anders Hovland, Knut Tore Lappegård. Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function.
Journal of clinical lipidology.
2019 Sep; 13(5):762-770. doi:
10.1016/j.jacl.2019.08.004. [PMID: 31543373] - Shan Huang, Yong Xu, Wen-Fang Peng, Jie Cheng, Hui-Hua Li, Li-Sha Shen, Li-Li Xia. A correlational study between serum asymmetric dimethylarginine level and impaired glucose tolerance patients associated with obesity.
Journal of cellular physiology.
2019 07; 234(7):10640-10645. doi:
10.1002/jcp.27743. [PMID: 30536533] - Aleksandra Czumaj, Marta Śledzińska, Michał Brzeziński, Agnieszka Szlagatys-Sidorkiewicz, Ewa Słomińska, Tomasz Śledziński. Decreased serum level of nitric oxide in children with excessive body weight.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2019 Apr; 28(4):439-446. doi:
10.17219/acem/77982. [PMID: 30129293] - Gerrit M Grosse, Saskia Biber, Jan-Thorben Sieweke, Jens Martens-Lobenhoffer, Maria M Gabriel, Anne-Sophie Putzer, Isabel Hasse, Till van Gemmeren, Ramona Schuppner, Hans Worthmann, Ralf Lichtinghagen, Stefanie M Bode-Böger, Udo Bavendiek, Karin Weissenborn. Plasma Dimethylarginine Levels and Carotid Intima-Media Thickness are related to Atrial Fibrillation in Patients with Embolic Stroke.
International journal of molecular sciences.
2019 02; 20(3):. doi:
10.3390/ijms20030730. [PMID: 30744089] - Theodore W Kurtz, Stephen E DiCarlo, Michal Pravenec, R Curtis Morris. Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 01; 42(1):6-18. doi:
10.1038/s41440-018-0122-5. [PMID: 30390036] - Mohammad Badran, Bisher Abuyassin, Saeid Golbidi, Najib Ayas, Ismail Laher. Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia.
Oxidative medicine and cellular longevity.
2019; 2019(?):4093018. doi:
10.1155/2019/4093018. [PMID: 31093313] - Martin Sebastian Winkler, Axel Nierhaus, Gilbert Rösler, Susanne Lezius, Olaf Harlandt, Edzard Schwedhelm, Rainer H Böger, Stefan Kluge. Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival.
Critical care (London, England).
2018 09; 22(1):216. doi:
10.1186/s13054-018-2090-1. [PMID: 30231905] - Florian Kronenberg. HDL in CKD-The Devil Is in the Detail.
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2018 05; 29(5):1356-1371. doi:
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Pediatric nephrology (Berlin, Germany).
2018 02; 33(2):315-323. doi:
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European journal of applied physiology.
2017 Dec; 117(12):2509-2518. doi:
10.1007/s00421-017-3738-2. [PMID: 29018989] - Esra Aycan-Ustyol, Merve Kabasakal, Seldag Bekpinar, F Ilkay Alp-Yıldırım, Ozge Tepe, Murat Giris, Yasemin Ozluk, Yesim Unlucerci, B Sonmez Uydes-Dogan, Mujdat Uysal. Vascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin.
Canadian journal of physiology and pharmacology.
2017 Dec; 95(12):1406-1413. doi:
10.1139/cjpp-2016-0578. [PMID: 28489953] - Ángeles C Ochoa-Martínez, Tania Ruíz-Vera, Claudia I Almendarez-Reyna, Sandra T Orta-García, Iván N Pérez-Maldonado. Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction.
Chemosphere.
2017 Nov; 186(?):770-779. doi:
10.1016/j.chemosphere.2017.08.055. [PMID: 28821001] - Nicole Lüneburg, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, Rainer H Böger. Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults.
High altitude medicine & biology.
2017 Sep; 18(3):226-233. doi:
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Critical care (London, England).
2017 Jul; 21(1):189. doi:
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Cardiovascular diabetology.
2017 07; 16(1):88. doi:
10.1186/s12933-017-0569-8. [PMID: 28697799] - Theodoros Dimitroulas, James Hodson, Vasileios F Panoulas, Aamer Sandoo, Jacqueline Smith, George Kitas. Genetic variations in the alanine-glyoxylate aminotransferase 2 (AGXT2) gene and dimethylarginines levels in rheumatoid arthritis.
Amino acids.
2017 06; 49(6):1133-1141. doi:
10.1007/s00726-017-2413-6. [PMID: 28357606] - Murat Aydin, Nejat Altintas, Levent Cem Mutlu, Bulent Bilir, Mustafa Oran, Feti Tülübaş, Birol Topçu, İsmail Tayfur, Volkan Küçükyalçin, Gizem Kaplan, Ahmet Gürel. Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD.
The clinical respiratory journal.
2017 May; 11(3):318-327. doi:
10.1111/crj.12337. [PMID: 26076870] - Szilvia Erdélyi-Bótor, Hedvig Komáromy, David Olayinka Kamson, Norbert Kovács, Gábor Perlaki, Gergely Orsi, Tihamér Molnár, Zsolt Illes, Lajos Nagy, Sándor Kéki, Gabriella Deli, Edit Bosnyák, Anita Trauninger, Zoltán Pfund. Serum L-arginine and dimethylarginine levels in migraine patients with brain white matter lesions.
Cephalalgia : an international journal of headache.
2017 May; 37(6):571-580. doi:
10.1177/0333102416651454. [PMID: 27206959] - Junji Takaya, Yuko Tanabe, Yuichi Kuroyanagi, Kazunari Kaneko. Relationship between asymmetric dimethylarginine in umbilical cord plasma and birth weight follows a U-shaped curve.
Endocrine journal.
2017 Apr; 64(4):431-436. doi:
10.1507/endocrj.ej16-0378. [PMID: 28302957] - Anna Buck, Arslan Arinc Kayacelebi, Kristine Chobanyan-Jürgens, Sabine Illsinger, Bettina Bohnhorst, Bibiana Beckmann, Erik Hanff, Anibh M Das, Dimitrios Tsikas, Thomas Lücke. Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in foetal growth.
Amino acids.
2017 04; 49(4):783-794. doi:
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European journal of nutrition.
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European journal of clinical investigation.
2017 Apr; 47(4):279-288. doi:
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The Journal of asthma : official journal of the Association for the Care of Asthma.
2017 03; 54(2):153-161. doi:
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The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
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PloS one.
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Acta biochimica Polonica.
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Neurotoxicity research.
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Psychiatry research.
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The Science of the total environment.
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The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
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Scientific reports.
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Neuroreport.
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Zhonghua yi xue za zhi.
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Diabetes & metabolic syndrome.
2016 Apr; 10(2 Suppl 1):S106-9. doi:
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Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
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Biomeditsinskaia khimiia.
2016 Mar; 62(2):198-205. doi:
10.18097/pbmc20166202198. [PMID: 27143380] - Eiko Sunami, Koichi Nomura, Yutaka Nishiyama, Yasuo Katayama. Effects of Candesartan Cilexetil Compared with Amlodipine on Serum Asymmetric Dimethylarginine Levels in the Chronic Stage of Cerebral Infarction: A Preliminary Study.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.
2016; 83(6):272-276. doi:
10.1272/jnms.83.272. [PMID: 28133009] - Christopher R Martens, Danielle L Kirkman, David G Edwards. The Vascular Endothelium in Chronic Kidney Disease: A Novel Target for Aerobic Exercise.
Exercise and sport sciences reviews.
2016 Jan; 44(1):12-9. doi:
10.1249/jes.0000000000000065. [PMID: 26509484] - Faye B Vicente, Gina Vespa, Alan Miller, Shannon Haymond. Quantification of Arginine and Its Methylated Derivatives in Plasma by High-Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS).
Methods in molecular biology (Clifton, N.J.).
2016; 1378(?):21-30. doi:
10.1007/978-1-4939-3182-8_3. [PMID: 26602113] - Jiwei Ma, Shupeng Zhao, Guojun Gao, Haigang Chang, Pengju Ma, Baozhe Jin. Probucol Protects Against Asymmetric Dimethylarginine-Induced Apoptosis in the Cultured Human Brain Microvascular Endothelial Cells.
Journal of molecular neuroscience : MN.
2015 Dec; 57(4):546-53. doi:
10.1007/s12031-015-0635-1. [PMID: 26254912] - Jose Lara, Ikponmwonsa Ogbonmwan, Clio Oggioni, Dingchang Zheng, Othman Qadir, Ammar Ashor, Kirsten Brandt, John C Mathers, Mario Siervo. Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT.
Maturitas.
2015 Oct; 82(2):228-35. doi:
10.1016/j.maturitas.2015.07.028. [PMID: 26316026] - Krzysztof Milewski, Wojciech Hilgier, Jan Albrecht, Magdalena Zielińska. The dimethylarginine (ADMA)/nitric oxide pathway in the brain and periphery of rats with thioacetamide-induced acute liver failure: Modulation by histidine.
Neurochemistry international.
2015 Sep; 88(?):26-31. doi:
10.1016/j.neuint.2014.12.004. [PMID: 25523831] - Aiden Haghikia, Arslan Arinc Kayacelebi, Bibiana Beckmann, Erik Hanff, Ralf Gold, Arash Haghikia, Dimitrios Tsikas. Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica.
Amino acids.
2015 Sep; 47(9):1837-45. doi:
10.1007/s00726-015-2015-0. [PMID: 26055922] - Stefan Pilz, Csilla Putz-Bankuti, Andreas Meinitzer, Winfried März, Katharina Kienreich, Tatjana Stojakovic, Thomas R Pieber, Rudolf E Stauber. Association of homoarginine and methylarginines with liver dysfunction and mortality in chronic liver disease.
Amino acids.
2015 Sep; 47(9):1817-26. doi:
10.1007/s00726-015-2000-7. [PMID: 25952253] - Gunhild Garmo Hov, Knut Ivar Aasarød, Erling Sagen, Arne Åsberg. Arginine, dimethylated arginine and homoarginine in relation to cardiovascular risk in patients with moderate chronic kidney disease.
Clinical biochemistry.
2015 Jul; 48(10-11):646-51. doi:
10.1016/j.clinbiochem.2015.03.012. [PMID: 25828044] - Sevda Tanrikulu-Küçük, Hikmet Koçak, Yildiz Öner-İyidoğan, Muhammed Seyithanoğlu, Erdal Topparmak, Tuba Kayan-Tapan. Serum fetuin-A and arginase-1 in human obesity model: Is there any interaction between inflammatory status and arginine metabolism?.
Scandinavian journal of clinical and laboratory investigation.
2015 Jul; 75(4):301-7. doi:
10.3109/00365513.2015.1010177. [PMID: 25723054] - Şerife Kantar, Nurten Türközkan, Filiz Sezen Bircan, Özge Tuğçe Paşaoğlu. Beneficial effects of melatonin on serum nitric oxide, homocysteine, and ADMA levels in fructose-fed rats.
Pharmaceutical biology.
2015 Jul; 53(7):1035-41. doi:
10.3109/13880209.2014.957782. [PMID: 25609150] - Jeremy A Scott, Michelle L North, Mahrouk Rafii, Hailu Huang, Paul Pencharz, Hartmut Grasemann. Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
Journal of applied physiology (Bethesda, Md. : 1985).
2015 May; 118(10):1229-33. doi:
10.1152/japplphysiol.00865.2014. [PMID: 25979935] - Kozi Hosoya, Hitoshi Minakuchi, Shu Wakino, Keiko Fujimura, Kazuhiro Hasegawa, Motoaki Komatsu, Ayumi Yoshifuji, Koji Futatsugi, Keisuke Shinozuka, Naoki Washida, Takeshi Kanda, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Itoh. Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans.
Kidney international.
2015 Apr; 87(4):749-60. doi:
10.1038/ki.2014.348. [PMID: 25337775] - Vladimír Teplan, Andrea Mahrová, Ivana Králová-Lesná, Jaroslav Racek, Ivo Valkovský, Milena Štollová. Endothelial progenitor cells and asymmetric dimethylarginine after renal transplantation.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2015 Mar; 25(2):247-9. doi:
10.1053/j.jrn.2014.10.021. [PMID: 25576240] - Toralf Melsom, Ole Martin Fuskevåg, Ulla Dorte Mathisen, Harald Strand, Jørgen Schei, Trond Jenssen, Marit Solbu, Bjørn Odvar Eriksen. Estimated GFR is biased by non-traditional cardiovascular risk factors.
American journal of nephrology.
2015; 41(1):7-15. doi:
10.1159/000371557. [PMID: 25612475] - Claudia Di Giacomo, Rosa Santangelo, Valeria Sorrenti, Giovanni L Volti, Rosaria Acquaviva. Neuroprotective effects of a glutathione depletor in rat post-ischemic reperfusion brain damage.
CNS & neurological disorders drug targets.
2015; 14(1):41-8. doi:
10.2174/1871527314666150116113647. [PMID: 25613502] - J Piťha, I Králová Lesná, P Stávek, A Mahrová, J Racek, A Sekerková, V Teplan, M Štollová. Effect of exercise on markers of vascular health in renal transplant recipients.
Physiological research.
2015; 64(6):945-9. doi:
10.33549/physiolres.933123. [PMID: 26447524] - Chiao-Po Hsu, Pai-Feng Hsu, Ming-Yi Chung, Shing-Jong Lin, Tse-Min Lu. Asymmetric dimethylarginine and long-term adverse cardiovascular events in patients with type 2 diabetes: relation with the glycemic control.
Cardiovascular diabetology.
2014 Dec; 13(?):156. doi:
10.1186/s12933-014-0156-1. [PMID: 25467091] - Seval Develi-Is, Gulsev Ozen, Seldag Bekpinar, Gokce Topal, Yesim Unlucerci, B Sonmez Uydes Dogan, Mujdat Uysal. Resveratrol improves high-fructose-induced vascular dysfunction in rats.
Canadian journal of physiology and pharmacology.
2014 Dec; 92(12):1021-7. doi:
10.1139/cjpp-2014-0245. [PMID: 25392295] - C Coskun, B Avci, M Yalcin, A Yermezler, M S Yilmaz, V Savci. Protective effect of CDP-choline on ischemia-reperfusion-induced myocardial tissue injury in rats.
Irish journal of medical science.
2014 Dec; 183(4):539-48. doi:
10.1007/s11845-013-1046-3. [PMID: 24293295] - Jasmohan S Bajaj, I Jane Cox, Naga S Betrapally, Douglas M Heuman, Mitchell L Schubert, Maiyuran Ratneswaran, Phillip B Hylemon, Melanie B White, Kalyani Daita, Nicole A Noble, Masoumeh Sikaroodi, Roger Williams, Mary M E Crossey, Simon D Taylor-Robinson, Patrick M Gillevet. Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function.
American journal of physiology. Gastrointestinal and liver physiology.
2014 Nov; 307(10):G951-7. doi:
10.1152/ajpgi.00268.2014. [PMID: 25258407] - Emel Kiyak Caglayan, Kasim Caglayan, Ayse Yesim Göcmen, Hamza Cinar, Levent Seckin, Selda Seckin, Bülent Güngör, Muhammet Fevzi Polat. Protective effect of ethyl pyruvate on ischemia-reperfusion injury in rat ovary: biochemical and histopathological evaluation.
European journal of obstetrics, gynecology, and reproductive biology.
2014 Nov; 182(?):154-9. doi:
10.1016/j.ejogrb.2014.09.023. [PMID: 25291349] - Joe Brice Weinberg, Tsin W Yeo, Jackson P Mukemba, Salvatore M Florence, Alicia D Volkheimer, Hao Wang, Youwei Chen, Matthew Rubach, Donald L Granger, Esther D Mwaikambo, Nicholas M Anstey. Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria.
The Journal of infectious diseases.
2014 Sep; 210(6):913-22. doi:
10.1093/infdis/jiu156. [PMID: 24620026] - Piotr Tomasz Protas, Edyta Tenderenda-Banasiuk, Katarzyna Taranta-Janusz, Renata Fiłonowicz, Magdalena Zając, Anna Wasilewska. Is symmetric dimethylarginine a sensitive biomarker of subclinical kidney injury in children born with low birth weight?.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2014 May; 19(3):231-5. doi:
10.3109/1354750x.2014.899393. [PMID: 24678914] - Rainer H Böger. The pharmacodynamics of L-arginine.
Alternative therapies in health and medicine.
2014 May; 20(3):48-54. doi:
NULL. [PMID: 24755570] - Mochammad Thaha, Wenny P Nilamsari, Mochammad Yusuf, M Amin. Profile of PRMT-1 gene polymorphism in hemodialysis patients with increased ADMA levels.
Acta medica Indonesiana.
2014 Apr; 46(2):97-103. doi:
NULL. [PMID: 25053681] - Augustine Purnomowati, Sri Hartini K S Kariadi, Tri H Achmad, Johanes C Mose, Budhi Setianto. Endothelial dysfunction in the young adult: a retrospective cohort study on the effect of low birth weight.
Acta medica Indonesiana.
2014 Apr; 46(2):111-6. doi:
NULL. [PMID: 25053683] - Cassandra Richardson, Ramin Nilforooshan, Paul R Gard, Gary Weaving, Naji Tabet. Impaired renal function and biomarkers of vascular disease in Alzheimer's disease.
Current Alzheimer research.
2014 Mar; 11(3):253-8. doi:
10.2174/1567205011666140131121739. [PMID: 24484276] - Altan Onat, Bayram Köroğlu, Günay Can, Ahmet Karagöz, Murat Yüksel, Mesut Aydın. Apparently "low" serum asymmetric dimethylarginine is associated with fasting glucose and tends toward association with type-2 diabetes.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.
2014 Feb; 14(1):26-33. doi:
10.5152/akd.2013.5009. [PMID: 24342929] - Yang Wang, Ye-Hua Xu, Ai-Qin Xiong, Ya-Ni Yuan, Ping Zheng, Ping Ma, Gui-Dong Dai, Qing-Bin Xu. [Protective effect of oxymatrine on chronic heart failure and ADMA metabolism pathway in isoproterenol-induced chronic heart failure in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 Feb; 39(3):471-7. doi:
. [PMID: 24946550] - Andrea Ferrigno, Giuseppina Palladini, Alberto Bianchi, Vittoria Rizzo, Laura G Di Pasqua, Stefano Perlini, Plinio Richelmi, Mariapia Vairetti. Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
BioMed research international.
2014; 2014(?):327537. doi:
10.1155/2014/327537. [PMID: 25013773] - Maike Anderssohn, Stela McLachlan, Nicole Lüneburg, Christine Robertson, Edzard Schwedhelm, Rachel M Williamson, Mark W J Strachan, Ramzi Ajjan, Peter J Grant, Rainer H Böger, Jackie F Price. Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes.
Diabetes care.
2014; 37(3):846-54. doi:
10.2337/dc13-0546. [PMID: 24186881] - Alexander Lukasz, Bodo Hoffmeister, Barbara Graf, Benno Wölk, Karsten Noeckler, Stefanie M Bode-Böger, Johannes Hadem, Sven Pischke, Jan T Kielstein. Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis.
PloS one.
2014; 9(1):e87490. doi:
10.1371/journal.pone.0087490. [PMID: 24498116] - Anja Kittel, Fabian Müller, Jörg König, Maren Mieth, Heinrich Sticht, Oliver Zolk, Ana Kralj, Markus R Heinrich, Martin F Fromm, Renke Maas. Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers.
PloS one.
2014; 9(2):e88544. doi:
10.1371/journal.pone.0088544. [PMID: 24586340] - Rika Watarai, Koji Suzuki, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroya Yamada, Takeshi Hamajima, Nobuyuki Hamajima, Takashi Inoue. Association between serum levels of carotenoids and serum asymmetric dimethylarginine levels in Japanese subjects.
Journal of epidemiology.
2014; 24(3):250-7. doi:
10.2188/jea.je20130137. [PMID: 24727752] - Serpil Canpolat, Ismet Kırpınar, Erdem Deveci, Hülya Aksoy, Zafer Bayraktutan, Ibrahim Eren, Recep Demir, Salih Selek, Nazan Aydın. Relationship of asymmetrical dimethylarginine, nitric oxide, and sustained attention during attack in patients with major depressive disorder.
TheScientificWorldJournal.
2014; 2014(?):624395. doi:
10.1155/2014/624395. [PMID: 24558318] - Sara Franceschelli, Alessio Ferrone, Mirko Pesce, Graziano Riccioni, Lorenza Speranza. Biological functional relevance of asymmetric dimethylarginine (ADMA) in cardiovascular disease.
International journal of molecular sciences.
2013 Dec; 14(12):24412-21. doi:
10.3390/ijms141224412. [PMID: 24351825] - Martin Kleparnik, Marie Tomandlova, Zdenek Glatz, Josef Tomandl. Determination of asymmetric and symmetric dimethylarginines in human plasma by HPLC with electrochemical detection.
Journal of separation science.
2013 Dec; 36(23):3696-701. doi:
10.1002/jssc.201300813. [PMID: 24115463] - Aleksandra Jaźwińska-Kozuba, Jens Martens-Lobenhoffer, Olga Kruszelnicka, Jarosław Rycaj, Bernadeta Chyrchel, Andrzej Surdacki, Stefanie M Bode-Böger. Opposite associations of plasma homoarginine and ornithine with arginine in healthy children and adolescents.
International journal of molecular sciences.
2013 Nov; 14(11):21819-32. doi:
10.3390/ijms141121819. [PMID: 24192823] - Hye Young Kim, Jung Hae Kim, Hee Sun Kim. Effect of CCL5 on dimethylarginine dimethylaminohydrolase-1 production in vascular smooth muscle cells from spontaneously hypertensive rats.
Cytokine.
2013 Oct; 64(1):227-33. doi:
10.1016/j.cyto.2013.06.316. [PMID: 23834755] - Joachim Strobel, Fabian Müller, Oliver Zolk, Beate Endreß, Jörg König, Martin F Fromm, Renke Maas. Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).
Amino acids.
2013 Oct; 45(4):989-1002. doi:
10.1007/s00726-013-1556-3. [PMID: 23864433] - Gordana Zunić, Aleksandar Tomić, Slavica Spasić. Unilateral nephrectomy causes an early abrupt decrease in plasma arginine and simultaneous reduction in glomerular filtration rate in living kidney donors.
Clinical biochemistry.
2013 Oct; 46(15):1394-8. doi:
10.1016/j.clinbiochem.2013.04.031. [PMID: 23669210] - Aysegul Kudu Cobanoglu, Ozkan Gungor, Fatih Kircelli, Ekrem Altunel, Gulay Asci, Sureyya Suha Ozbek, Huseyin Toz, Ercan Ok. Role of asymmetric dimethylarginine in the progression of carotid atherosclerosis in renal transplant patients.
International urology and nephrology.
2013 Oct; 45(5):1463-9. doi:
10.1007/s11255-012-0345-3. [PMID: 23212148] - Hendrik Veldink, Robert Faulhaber-Walter, Joon-Keun Park, Jens Martens-Lobenhoffer, Stefanie Bode-Böger, Harald Schuett, Arash Haghikia, Denise Hilfiker-Kleiner, Jan T Kielstein. Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2013 Jun; 28(6):1434-9. doi:
10.1093/ndt/gfs554. [PMID: 23291365] - P A Wick, A Mombelli, S Pagano, X Moren, C Giannopoulou, F Mach, P Roux-Lombard, N Vuilleumier. Anti-apolipoprotein A-1 autoantibodies as biomarker for atherosclerosis burden in patients with periodontitis.
Journal of periodontal research.
2013 Jun; 48(3):350-6. doi:
10.1111/jre.12014. [PMID: 23050768]
