4β,15-Diacetoxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-en-3α-ol (BioDeep_00000404715)
Main id: BioDeep_00000002620
natural product PANOMIX_OTCML-2023 Toxin
代谢物信息卡片
(3alpha,4beta,8alpha,12R)-4,15-Diacetoxy-3-hydroxy-12,13-epoxytrichothec-9-en-8-yl 3-methylbutanoate
化学式: C24H34O9 (466.2203)
中文名称: T2毒素
谱图信息:
最多检出来源 () 0%
Reviewed
Last reviewed on 2024-09-06.
Cite this Page
4β,15-Diacetoxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-en-3α-ol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/4β,15-diacetoxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-en-3α-ol (retrieved
2024-12-23) (BioDeep RN: BioDeep_00000404715). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CC(C)CC(=O)O[C@H]\1C[C@@]2(COC(C)=O)[C@H](O[C@@H]3[C@H](O)[C@@H](OC(C)=O)[C@@]2(C)[C@@]34CO4)\C=C1C
InChI: InChI=1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24+/m0/s1
描述信息
D009676 - Noxae > D011042 - Poisons > D014255 - Trichothecenes
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD50 values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BWa,respectively [1]. T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates[1]. T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides[1]. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues[2].
T 2 Toxin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=21259-20-1 (retrieved 2024-09-06) (CAS RN: 21259-20-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:181947
- KEGG: C09738
- PubChem: 442400
- MeSH: T-2 Toxin
- MoNA: CCMSLIB00000854457
- MoNA: CCMSLIB00000854456
- KNApSAcK: C00003192
- CAS: 21259-20-1
- 3DMET: B03237
- NIKKAJI: J3.789C
- medchemexpress: HY-N6792
- PubChem: 11926
- KNApSAcK: 181947
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marta Modrzewska, Dominik Popowski, Lidia Błaszczyk, Łukasz Stępień, Monika Urbaniak, Marcin Bryła, Benedikt Cramer, Hans-Ulrich Humpf, Magdalena Twarużek. Antagonistic properties against Fusarium sporotrichioides and glycosylation of HT-2 and T-2 toxins by selected Trichoderma strains.
Scientific reports.
2024 03; 14(1):5865. doi:
10.1038/s41598-024-55920-x. [PMID: 38467671] - Can Ning, Wenguang Xiao, Zengenni Liang, You Wu, Hui Fan, Siqi Wang, Xiangyi Kong, Yongkang Wang, Aoao Wu, Yuanyuan Li, Zhihang Yuan, Jing Wu, Chenglin Yang. Melatonin alleviates T-2 toxin-induced oxidative damage, inflammatory response, and apoptosis in piglet spleen and thymus.
International immunopharmacology.
2024 Mar; 129(?):111653. doi:
10.1016/j.intimp.2024.111653. [PMID: 38354511] - Octavian Augustin Mihalache, Raquel Torrijos, Chiara Dall'Asta. Occurrence of mycotoxins in meat alternatives: Dietary exposure, potential health risks, and burden of disease.
Environment international.
2024 Mar; 185(?):108537. doi:
10.1016/j.envint.2024.108537. [PMID: 38452463] - Shanshan Zhang, Wenxi Song, Zeao Hua, Juanjuan Du, Ricardo Barbosa Lucena, Xuebing Wang, Cong Zhang, Xu Yang. Overview of T-2 Toxin Enterotoxicity: From Toxic Mechanisms and Detoxification to Future Perspectives.
Journal of agricultural and food chemistry.
2024 Feb; 72(7):3314-3324. doi:
10.1021/acs.jafc.3c09416. [PMID: 38331717] - Thomas Svoboda, Roman Labuda, Michael Sulyok, Rudolf Krska, Markus Bacher, Franz Berthiller, Gerhard Adam. Fusarium sporotrichioides Produces Two HT-2-α-Glucosides on Rice.
Toxins.
2024 02; 16(2):. doi:
10.3390/toxins16020099. [PMID: 38393177] - Jun He, Hong Jin, Jiabin Guo, Kexin Li, Li Jia, Yujie Li, Li Zhang. T-2 toxin-induced testicular impairment by triggering oxidative stress and ferroptosis.
Ecotoxicology and environmental safety.
2024 Jan; 270(?):115844. doi:
10.1016/j.ecoenv.2023.115844. [PMID: 38134641] - Júlia Vörösházi, Máté Mackei, Csilla Sebők, Patrik Tráj, Rege Anna Márton, Dávid Géza Horváth, Korinna Huber, Zsuzsanna Neogrády, Gábor Mátis. Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures.
Scientific reports.
2024 01; 14(1):1195. doi:
10.1038/s41598-024-51689-1. [PMID: 38216675] - Tushuai Li, Wenxue Sun, Shenglong Zhu, Chengsheng He, Tong Chang, Jie Zhang, Yongquan Chen. T-2 Toxin-Mediated β-Arrestin-1 O-GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2023 Dec; ?(?):e2307648. doi:
10.1002/advs.202307648. [PMID: 38083975] - Ji Wang, Jianyu Qu, Sha Liu, Qiurong Xu, Xiaowen Li, Yuanyuan Zhu, Xiangyan Liu, Jine Yi, Zhihang Yuan, Peng Huang, Yulong Yin, Lixin Wen, Jing Wu. Tannic Acid Ameliorates Systemic Glucose and Lipid Metabolic Impairment Induced by Low-Dose T-2 Toxin Exposure.
Journal of agricultural and food chemistry.
2023 Aug; ?(?):. doi:
10.1021/acs.jafc.3c02934. [PMID: 37525894] - Amal Kahla, Carol Verheecke-Vaessen, Mariluz Delpino-Deelias, Maria Gutierrez-Pozo, Angel Medina, Naresh Magan, Fiona Doohan. Acclimatisation of Fusarium langsethiae, F. poae and F. sporotrichioides to elevated CO2: Impact on fungal growth and mycotoxin production on oat-based media.
International journal of food microbiology.
2023 Jun; 394(?):110176. doi:
10.1016/j.ijfoodmicro.2023.110176. [PMID: 36989929] - P Rachitha, K Krupashree, G V Jayashree, Vinay B Raghavendra, Ajay Pal, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Rajasree Shanmuganathan, Indira Karuppusamy, Kathirvel Brindhadevi. T-2 toxin induces dermal inflammation and toxicity in mice: The healing potential of menthol.
Environmental research.
2023 Apr; ?(?):115838. doi:
10.1016/j.envres.2023.115838. [PMID: 37024032] - Z A Chalyy, M G Kiseleva, I B Sedova, V A Tutelyan. [Mycotoxins in spices consumed in Russia].
Voprosy pitaniia.
2023; 92(2):26-34. doi:
10.33029/0042-8833-2023-92-2-26-34. [PMID: 37346017] - Xiawei Yu, Caiyan Zhang, Keke Chen, Yuan Liu, Ying Deng, Wenbin Liu, Dingdong Zhang, Guangzhen Jiang, Xiangfei Li, Sib Sankar Giri, Se Chang Park, Cheng Chi. Dietary T-2 toxin induces transcriptomic changes in hepatopancreas of Chinese mitten crab (Eriocheir sinensis) via nutrition metabolism and apoptosis-related pathways.
Ecotoxicology and environmental safety.
2023 Jan; 249(?):114397. doi:
10.1016/j.ecoenv.2022.114397. [PMID: 36527851] - Mei Qiu, Yijia Deng, Qi Deng, Lijun Sun, Zhijia Fang, Yaling Wang, Xiaoyue Huang, Jian Zhao. Cysteine Inhibits the Growth of Fusarium oxysporum and Promotes T-2 Toxin Synthesis through the Gtr/Tap42 Pathway.
Microbiology spectrum.
2022 12; 10(6):e0368222. doi:
10.1128/spectrum.03682-22. [PMID: 36314982] - Shao-Ji Li, Guangzhi Zhang, Bin Xue, Qiaoling Ding, Lu Han, Jian-Chu Huang, Fuhai Wu, Chonggao Li, Chunmin Yang. Toxicity and detoxification of T-2 toxin in poultry.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Nov; 169(?):113392. doi:
10.1016/j.fct.2022.113392. [PMID: 36044934] - Christina Rehagel, Ronald Maul, Kim Lara Gützkow, Ömer Akineden. Enzyme immunoassays for the detection of mycotoxins in plant-based milk alternatives: pitfalls and limitations.
Mycotoxin research.
2022 Nov; 38(4):265-274. doi:
10.1007/s12550-022-00467-x. [PMID: 36053453] - Gabriela Pilarska, Magdalena Twarużek, Iwona Ałtyn. The Presence of Molds and Their Secondary Metabolites in Purple Coneflower-Based Dietary Supplements (Echinacea purpurea (L.) Moench).
Toxins.
2022 09; 14(9):. doi:
10.3390/toxins14090607. [PMID: 36136545] - Xiaoyue Huang, Zhanrui Huang, Lijun Sun, Mei Qiu, Qi Deng, Zhijia Fang, Yaling Wang. Protective mechanisms of three antioxidants against T-2 toxin-induced muscle protein deterioration in shrimp.
Journal of the science of food and agriculture.
2022 Aug; 102(11):4883-4891. doi:
10.1002/jsfa.11851. [PMID: 35244220] - You Huang, Zihan Zhu, Chenxi Luo, Chaoyang Ma, Lijuan Zhu, Li Kong, Rongfang Li, Jing Wu, Zhihang Yuan, Jine Yi. Betulinic acid attenuates cognitive dysfunction, oxidative stress, and inflammation in a model of T-2 toxin-induced brain damage.
Environmental science and pollution research international.
2022 Jul; 29(34):52098-52110. doi:
10.1007/s11356-022-19498-z. [PMID: 35254615] - Jie Zhang, Tushuai Li, Qinghua Wu, Zihui Qin, Ben Wei, Ran Wu, Xinyi Guo, Huiping Xiao, Wenda Wu. Emetic Response to T-2 Toxin Correspond to Secretion of Glucagon-like Peptide-17-36 Amide and Glucose-Dependent Insulinotropic Polypeptide.
Toxins.
2022 06; 14(6):. doi:
10.3390/toxins14060389. [PMID: 35737050] - Jens C Meyer, Tim Birr, Inga Hennies, Detlev Wessels, Karin Schwarz. Reduction of deoxynivalenol, T-2 and HT-2 toxins and associated Fusarium species during commercial and laboratory de-hulling of milling oats.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2022 Jun; 39(6):1163-1183. doi:
10.1080/19440049.2022.2059576. [PMID: 35385360] - Xuliang Zhang, Jiayu Du, Bo Li, Siming Huo, Jian Zhang, Yilong Cui, Miao Song, Bing Shao, Yanfei Li. PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Jun; 164(?):113078. doi:
10.1016/j.fct.2022.113078. [PMID: 35489469] - Ingerd Skow Hofgaard, Guro Brodal, Marit Almvik, Morten Lillemo, Aina Lundon Russenes, Simon Graham Edwards, Heidi Udnes Aamot. Different Resistance to DON versus HT2 + T2 Producers in Nordic Oat Varieties.
Toxins.
2022 04; 14(5):. doi:
10.3390/toxins14050313. [PMID: 35622560] - Rastislav Boško, Marek Pernica, Sylvie Běláková, Marie Bjelková, Helena Pluháčková. Determination of T-2 and HT-2 Toxins in Seed of Milk Thistle [Silybum marianum (L.) Gaertn.] Using Immunoaffinity Column by UPLC-MS/MS.
Toxins.
2022 04; 14(4):. doi:
10.3390/toxins14040258. [PMID: 35448867] - Kuankuan Xiong, Lei Tan, Siliang Yi, Yingxin Wu, Yi Hu, Aibing Wang, Lingchen Yang. Low-Concentration T-2 Toxin Attenuates Pseudorabies Virus Replication in Porcine Kidney 15 Cells.
Toxins.
2022 02; 14(2):. doi:
10.3390/toxins14020121. [PMID: 35202147] - Guoyan Wang, Senlin Qin, Yining Zheng, Chao Xia, Pei Zhang, Linxuan Zhang, Junhu Yao, Yanglei Yi, Lu Deng. T-2 Toxin Induces Ferroptosis by Increasing Lipid Reactive Oxygen Species (ROS) and Downregulating Solute Carrier Family 7 Member 11 (SLC7A11).
Journal of agricultural and food chemistry.
2021 Dec; 69(51):15716-15727. doi:
10.1021/acs.jafc.1c05393. [PMID: 34918923] - Alfonso Narváez, Luana Izzo, Noelia Pallarés, Luigi Castaldo, Yelko Rodríguez-Carrasco, Alberto Ritieni. Human Biomonitoring of T-2 Toxin, T-2 Toxin-3-Glucoside and Their Metabolites in Urine through High-Resolution Mass Spectrometry.
Toxins.
2021 12; 13(12):. doi:
10.3390/toxins13120869. [PMID: 34941707] - Huan Deng, Mumba Mulutula Chilufya, Jiaxin Liu, Lichun Qiao, Xiang Xiao, Yan Zhao, Ziwei Guo, Yizhen Lv, Wenyue Wang, Jiaheng Zhang, Jing Han. Effect of Low Nutrition and T-2 Toxin on C28/I2 Chondrocytes Cell Line and Chondroitin Sulfate-Modifying Sulfotransferases.
Cartilage.
2021 12; 13(2_suppl):818S-825S. doi:
10.1177/19476035211023555. [PMID: 34151604] - Tongkun Shi, Xiaoyan Fu, Fenghua Wang, Xin Zhang, Yun Cai, Xianhao Wu, Liyan Sun. The WNT/β-catenin signalling pathway induces chondrocyte apoptosis in the cartilage injury caused by T-2 toxin in rats.
Toxicon : official journal of the International Society on Toxinology.
2021 Dec; 204(?):14-20. doi:
10.1016/j.toxicon.2021.11.003. [PMID: 34742779] - Xiangyan Liu, Ze Wang, Xianglin Wang, Xiaona Yan, Qing He, Sha Liu, Mengke Ye, Xiaowen Li, Zhihang Yuan, Jing Wu, Jine Yi, Lixin Wen, Rongfang Li. Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells.
Toxicology and applied pharmacology.
2021 12; 432(?):115753. doi:
10.1016/j.taap.2021.115753. [PMID: 34637808] - Lin Huang, Lijuan Zhu, Zhaoping Ou, Chaoyang Ma, Li Kong, You Huang, Yazhi Chen, Haoqiang Zhao, Lixin Wen, Jing Wu, Zhihang Yuan, Jine Yi. Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice.
International immunopharmacology.
2021 Dec; 101(Pt B):108210. doi:
10.1016/j.intimp.2021.108210. [PMID: 34628148] - Xiaowen Li, Xianglin Wang, Sha Liu, Ji Wang, XiangYan Liu, Yuanyuan Zhu, Linyu Zhang, Rongfang Li. Betulinic acid attenuates T-2 toxin-induced cytotoxicity in porcine kidney cells by blocking oxidative stress and endoplasmic reticulum stress.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Nov; 249(?):109124. doi:
10.1016/j.cbpc.2021.109124. [PMID: 34224893] - Yumei Liu, Ruiqi Dong, Yuxiang Yang, Hui Xie, Yufeng Huang, Xiaoguang Chen, Dongmei Wang, Ziqiang Zhang. Protective Effect of Organic Selenium on Oxidative Damage and Inflammatory Reaction of Rabbit Kidney Induced by T-2 Toxin.
Biological trace element research.
2021 May; 199(5):1833-1842. doi:
10.1007/s12011-020-02279-5. [PMID: 32656676] - Liwen Zhang, Qingyu Lv, Yuling Zheng, Xuan Chen, Decong Kong, Wenhua Huang, Peng Liu, Hua Jiang, Yongqiang Jiang. A rapid and accurate method for screening T-2 toxin in food and feed using competitive AlphaLISA.
FEMS microbiology letters.
2021 04; 368(6):. doi:
10.1093/femsle/fnab029. [PMID: 33755724] - Juliana Rubira Gerez, Thaynara Camacho, Victor Hugo Brunaldi Marutani, Ricardo Luís Nascimento de Matos, Miriam Sayuri Hohmann, Waldiceu Aparecido Verri Júnior, Ana Paula F R L Bracarense. Ovarian toxicity by fusariotoxins in pigs: Does it imply in oxidative stress?.
Theriogenology.
2021 Apr; 165(?):84-91. doi:
10.1016/j.theriogenology.2021.02.003. [PMID: 33640590] - Paweł Wojtacha, Wojciech Trybowski, Piotr Podlasz, Magdalena Żmigrodzka, Józef Tyburski, Magdalena Polak-Śliwińska, Ewa Jakimiuk, Tadeusz Bakuła, Mirosław Baranowski, Krystyna Żuk-Gołaszewska, Łukasz Zielonka, Kazimierz Obremski. Effects of a Low Dose of T-2 Toxin on the Percentage of T and B Lymphocytes and Cytokine Secretion in the Porcine Ileal Wall.
Toxins.
2021 04; 13(4):. doi:
10.3390/toxins13040277. [PMID: 33924586] - Basheer M Iqdiam, Ehsan Feizollahi, Muhammad Faisal Arif, Brasathe Jeganathan, Thava Vasanthan, Malinda S Thilakarathna, M S Roopesh. Reduction of T-2 and HT-2 mycotoxins by atmospheric cold plasma and its impact on quality changes and germination of wheat grains.
Journal of food science.
2021 Apr; 86(4):1354-1371. doi:
10.1111/1750-3841.15658. [PMID: 33682128] - Xuliang Zhang, Yucong Wang, Xu Yang, Menglin Liu, Wanyue Huang, Jian Zhang, Miao Song, Bing Shao, Yanfei Li. The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Mar; 149(?):112027. doi:
10.1016/j.fct.2021.112027. [PMID: 33508416] - Lirui Hou, Shuo Liu, Chong Zhao, Lihong Fan, Hongbo Hu, Shutao Yin. The combination of T-2 toxin and acrylamide synergistically induces hepatotoxicity and nephrotoxicity via the activation of oxidative stress and the mitochondrial pathway.
Toxicon : official journal of the International Society on Toxinology.
2021 Jan; 189(?):65-72. doi:
10.1016/j.toxicon.2020.11.007. [PMID: 33227324] - Chenxi Luo, Chenglong Huang, Lijuan Zhu, Li Kong, Zhihang Yuan, Lixin Wen, Rongfang Li, Jing Wu, Jine Yi. Betulinic Acid Ameliorates the T-2 Toxin-Triggered Intestinal Impairment in Mice by Inhibiting Inflammation and Mucosal Barrier Dysfunction through the NF-κB Signaling Pathway.
Toxins.
2020 12; 12(12):. doi:
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Microbial pathogenesis.
2020 Dec; 149(?):104517. doi:
10.1016/j.micpath.2020.104517. [PMID: 33007430] - Jiajia Zhang, Li You, Wenda Wu, Xu Wang, Zofia Chrienova, Eugenie Nepovimova, Qinghua Wu, Kamil Kuca. The neurotoxicity of trichothecenes T-2 toxin and deoxynivalenol (DON): Current status and future perspectives.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Nov; 145(?):111676. doi:
10.1016/j.fct.2020.111676. [PMID: 32805342] - Yuan Dong, Guixian Meng, Jian Guo, Moli Yin, Huijing Xu, Yujie Li, Jie Zhu, Wenhe Zhu, Mingguang Li, Yan Li, Huiyan Wang. Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity.
Molecular medicine reports.
2020 Nov; 22(5):4423-4431. doi:
10.3892/mmr.2020.11531. [PMID: 33000242] - Qinghua Wu, Zihui Qin, Kamil Kuca, Li You, Yingying Zhao, Aimei Liu, Kamil Musilek, Zofia Chrienova, Eugenie Nepovimova, Patrik Oleksak, Wenda Wu, Xu Wang. An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment.
Archives of toxicology.
2020 11; 94(11):3645-3669. doi:
10.1007/s00204-020-02899-9. [PMID: 32910237] - Edyta Janik, Marcin Niemcewicz, Michal Ceremuga, Maksymilian Stela, Joanna Saluk-Bijak, Adrian Siadkowski, Michal Bijak. Molecular Aspects of Mycotoxins-A Serious Problem for Human Health.
International journal of molecular sciences.
2020 Oct; 21(21):. doi:
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International journal of molecular sciences.
2020 Oct; 21(19):. doi:
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Mikrochimica acta.
2020 08; 187(9):514. doi:
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Toxins.
2020 08; 12(9):. doi:
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International journal of food sciences and nutrition.
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Mycotoxin research.
2020 Aug; 36(3):319-326. doi:
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Food chemistry.
2020 Jul; 317(?):126416. doi:
10.1016/j.foodchem.2020.126416. [PMID: 32087519] - Mercedes Taroncher, Maria-Chiari Pigni, Maria-Natalia Diana, Ana Juan-García, Maria-Jose Ruiz. Does low concentration mycotoxin exposure induce toxicity in HepG2 cells through oxidative stress?.
Toxicology mechanisms and methods.
2020 Jul; 30(6):417-426. doi:
10.1080/15376516.2020.1757000. [PMID: 32306886] - Maja Kiš, Slobodan Milošević, Ana Vulić, Zoran Herceg, Tomislava Vukušić, Jelka Pleadin. Efficacy of low pressure DBD plasma in the reduction of T-2 and HT-2 toxin in oat flour.
Food chemistry.
2020 Jun; 316(?):126372. doi:
10.1016/j.foodchem.2020.126372. [PMID: 32062580] - Ruifen Kang, Aneela Perveen, Chunmei Li. Effects of maternal T-2 toxin exposure on the hepatic glycolipid metabolism in young mice.
Ecotoxicology and environmental safety.
2020 Jun; 196(?):110530. doi:
10.1016/j.ecoenv.2020.110530. [PMID: 32229328] - Zelma Faisal, Virág Vörös, Eszter Fliszár-Nyúl, Beáta Lemli, Sándor Kunsági-Máté, Rita Csepregi, Tamás Kőszegi, Ferenc Zsila, Miklós Poór. Probing the Interactions of Ochratoxin B, Ochratoxin C, Patulin, Deoxynivalenol, and T-2 Toxin with Human Serum Albumin.
Toxins.
2020 06; 12(6):. doi:
10.3390/toxins12060392. [PMID: 32545742] - Depeng Dai, Yuanhu Pan, CuiPing Zeng, Shenghui Liu, Yi Yan, Xiaoxiong Wu, Zaiyan Xu, Lisheng Zhang. Activated FXR promotes xenobiotic metabolism of T-2 toxin and attenuates oxidative stress in broiler chicken liver.
Chemico-biological interactions.
2020 Jan; 316(?):108912. doi:
10.1016/j.cbi.2019.108912. [PMID: 31830458] - Silvia W Gratz, Valerie Currie, Gary Duncan, Diane Jackson. Multimycotoxin Exposure Assessment in UK Children Using Urinary Biomarkers-A Pilot Survey.
Journal of agricultural and food chemistry.
2020 Jan; 68(1):351-357. doi:
10.1021/acs.jafc.9b03964. [PMID: 31826612] - Shivasharanappa Nayakwadi, Ramith Ramu, Anil Kumar Sharma, Vivek Kumar Gupta, K Rajukumar, Vijay Kumar, Prithvi S Shirahatti, Rashmi L, Kanthesh M Basalingappa. Toxicopathological studies on the effects of T-2 mycotoxin and their interaction in juvenile goats.
PloS one.
2020; 15(3):e0229463. doi:
10.1371/journal.pone.0229463. [PMID: 32214355] - Xu Yang, Xuliang Zhang, Qiucheng Yao, Miao Song, Yanfei Han, Bing Shao, Yanfei Li. T-2 toxin impairs male fertility by disrupting hypothalamic-pituitary-testis axis and declining testicular function in mice.
Chemosphere.
2019 Nov; 234(?):909-916. doi:
10.1016/j.chemosphere.2019.06.145. [PMID: 31519099] - Bunmi K Olopade, Solomon U Oranusi, Obinna C Nwinyi, Isiaka A Lawal, Sefater Gbashi, Patrick B Njobeh. Decontamination of T-2 Toxin in Maize by Modified Montmorillonite Clay.
Toxins.
2019 10; 11(11):. doi:
10.3390/toxins11110616. [PMID: 31653066] - Wenchu Ye, Ruqin Lin, Xiaoxuan Chen, Jiongjie Chen, Ruohong Chen, Xuan Xie, Yiqun Deng, Jikai Wen. T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction.
Toxicology letters.
2019 Oct; 315(?):77-86. doi:
10.1016/j.toxlet.2019.08.021. [PMID: 31470059] - Laura Righetti, Tania Körber, Enrico Rolli, Gianni Galaverna, Michele Suman, Renato Bruni, Chiara Dall'Asta. Plant biotransformation of T2 and HT2 toxin in cultured organs of Triticum durum Desf.
Scientific reports.
2019 10; 9(1):14320. doi:
10.1038/s41598-019-50786-w. [PMID: 31586121] - Nikhil Maroli, Achuth Jayakrishnan, Renuka Ramalingam Manoharan, Ponmalai Kolandaivel, Kadirvelu Krishna. Combined Inhibitory Effects of Citrinin, Ochratoxin-A, and T-2 Toxin on Aquaporin-2.
The journal of physical chemistry. B.
2019 07; 123(27):5755-5768. doi:
10.1021/acs.jpcb.9b03829. [PMID: 31204482] - Jin-Tao Wei, Kun-Tan Wu, Hua Sun, Mahmoud Mohamed Khalil, Jie-Fan Dai, Ying Liu, Qiang Liu, Ni-Ya Zhang, De-Sheng Qi, Lv-Hui Sun. A Novel Modified Hydrated Sodium Calcium Aluminosilicate (HSCAS) Adsorbent Can Effectively Reduce T-2 Toxin-Induced Toxicity in Growth Performance, Nutrient Digestibility, Serum Biochemistry, and Small Intestinal Morphology in Chicks.
Toxins.
2019 04; 11(4):. doi:
10.3390/toxins11040199. [PMID: 30987049] - Edyta Janik, Michal Ceremuga, Joanna Saluk-Bijak, Michal Bijak. Biological Toxins as the Potential Tools for Bioterrorism.
International journal of molecular sciences.
2019 Mar; 20(5):. doi:
10.3390/ijms20051181. [PMID: 30857127] - Yong Fa Zhang, Jian Ying Yang, Xiang Ping Meng, Xiao Lan Qiao. l-arginine protects against T-2 toxin-induced male reproductive impairments in mice.
Theriogenology.
2019 Mar; 126(?):249-253. doi:
10.1016/j.theriogenology.2018.12.024. [PMID: 30590246] - Kun Sheng, Xi Lu, Jianming Yue, Wei Gu, Chao Gu, Haibin Zhang, Wenda Wu. Role of neurotransmitters 5-hydroxytryptamine and substance P in anorexia induction following oral exposure to the trichothecene T-2 toxin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Jan; 123(?):1-8. doi:
10.1016/j.fct.2018.10.041. [PMID: 30336258] - Yanxin Wang, Liyun Zhang, Dapeng Peng, Shuyu Xie, Dongmei Chen, Yuanhu Pan, Yanfei Tao, Zonghui Yuan. Construction of Electrochemical Immunosensor Based on Gold-Nanoparticles/Carbon Nanotubes/Chitosan for Sensitive Determination of T-2 Toxin in Feed and Swine Meat.
International journal of molecular sciences.
2018 Dec; 19(12):. doi:
10.3390/ijms19123895. [PMID: 30563124] - Csilla Pelyhe, Benjámin Kövesi, Erika Zándoki, Balázs Kovács, Márta Erdélyi, Szabina Kulcsár, Miklós Mézes, Krisztián Balogh. Multi-trichothecene mycotoxin exposure activates glutathione-redox system in broiler chicken.
Toxicon : official journal of the International Society on Toxinology.
2018 Oct; 153(?):53-57. doi:
10.1016/j.toxicon.2018.08.010. [PMID: 30170167] - Jie Zhang, Kun Sheng, Wenda Wu, Haibin Zhang. Anorectic responses to T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol correspond to plasma elevations of neurotransmitters 5-hydroxytryptamine and substance P.
Ecotoxicology and environmental safety.
2018 10; 161(?):451-458. doi:
10.1016/j.ecoenv.2018.06.005. [PMID: 29909314] - Shupeng Yang, Huiyan Zhang, Marthe De Boevre, Jinzhen Zhang, Yanshen Li, Suxia Zhang, Sarah De Saeger, Jinhui Zhou, Yi Li, Feifei Sun. Toxicokinetics of HT-2 Toxin in Rats and Its Metabolic Profile in Livestock and Human Liver Microsomes.
Journal of agricultural and food chemistry.
2018 Aug; 66(30):8160-8168. doi:
10.1021/acs.jafc.8b02893. [PMID: 29996643] - Henning Sören Schmidt, Mareike Schulz, Christine Focke, Stefanie Becker, Benedikt Cramer, Hans-Ulrich Humpf. Glucosylation of T-2 and HT-2 toxins using biotransformation and chemical synthesis: Preparation, stereochemistry, and stability.
Mycotoxin research.
2018 Aug; 34(3):159-172. doi:
10.1007/s12550-018-0310-9. [PMID: 29511991] - Kun Sheng, Hua Zhang, Jianming Yue, Wei Gu, Chao Gu, Haibin Zhang, Wenda Wu. Anorectic response to the trichothecene T-2 toxin correspond to plasma elevations of the satiety hormone glucose-dependent insulinotropic polypeptide and peptide YY3-36.
Toxicology.
2018 06; 402-403(?):28-36. doi:
10.1016/j.tox.2018.04.007. [PMID: 29689362] - Wenda Wu, Kun Sheng, Xinglian Xu, Haibin Zhang, Guanghong Zhou. Potential roles for glucagon-like peptide-17-36 amide and cholecystokinin in anorectic response to the trichothecene mycotoxin T-2 toxin.
Ecotoxicology and environmental safety.
2018 May; 153(?):181-187. doi:
10.1016/j.ecoenv.2018.02.003. [PMID: 29433086] - Minely Cerón-Bustamante, Todd J Ward, Amy Kelly, Martha M Vaughan, Susan P McCormick, Christina Cowger, Santos G Leyva-Mir, Héctor E Villaseñor-Mir, Victoria Ayala-Escobar, Cristian Nava-Díaz. Regional differences in the composition of Fusarium Head Blight pathogens and mycotoxins associated with wheat in Mexico.
International journal of food microbiology.
2018 May; 273(?):11-19. doi:
10.1016/j.ijfoodmicro.2018.03.003. [PMID: 29554557] - Zainab Fatima, Pu Guo, Deyu Huang, Qirong Lu, Qinghua Wu, Menghong Dai, Guyue Cheng, Dapeng Peng, Yanfei Tao, Muhammad Ayub, Muhammad Tahir Ul Qamar, Muhammad Waqar Ali, Xu Wang, Zonghui Yuan. The critical role of p16/Rb pathway in the inhibition of GH3 cell cycle induced by T-2 toxin.
Toxicology.
2018 05; 400-401(?):28-39. doi:
10.1016/j.tox.2018.03.006. [PMID: 29567467] - Kentaro Kamata, Hiroki Sato, Kazuyuki Maeda, Kazuo Furihata, Shunichi Aikawa, Kentaro Adachi, Akira Tanaka, Takeshi Tokai, Yuichi Nakajima, Yasuhiko Yoshida, Shohei Sakuda, Makoto Kimura, Naoko Takahashi-Ando. Exploring an Artificial Metabolic Route in Fusarium sporotrichioides: Production and Characterization of 7-Hydroxy T-2 Toxin.
Journal of natural products.
2018 04; 81(4):1041-1044. doi:
10.1021/acs.jnatprod.7b00398. [PMID: 29578706] - Md Zakir Hossain, Susan P McCormick, Chris M Maragos. An Imaging Surface Plasmon Resonance Biosensor Assay for the Detection of T-2 Toxin and Masked T-2 Toxin-3-Glucoside in Wheat.
Toxins.
2018 03; 10(3):. doi:
10.3390/toxins10030119. [PMID: 29534452] - Mangesh Nakade, Csilla Pelyhe, Benjámin Kövesi, Krisztián Balogh, Balázs Kovács, Judit Szabó-Fodor, Erika Zándoki, Miklós Mézes, Márta Erdélyi. Short-term effects of T-2 toxin or deoxynivalenol on glutathione status and expression of its regulatory genes in chicken.
Acta veterinaria Hungarica.
2018 03; 66(1):28-39. doi:
10.1556/004.2018.004. [PMID: 29580086] - Petra Varró, Melinda Béldi, Melinda Kovács, Ildikó Világi. T-2 mycotoxin treatment of newborn rat pups does not significantly affect nervous system functions in adulthood.
Acta biologica Hungarica.
2018 Mar; 69(1):29-41. doi:
10.1556/018.68.2018.1.3. [PMID: 29575911] - Lei Zhu, Zhi Jun Zhao, Xiao Bin Ren, Qiang Li, Hua Ding, Zhou Sun, Qing Jun Kao, Li Hua Wang. Serum Metabonomics of Articular Cartilage Destruction Induced by T-2 Toxin in Wistar Rats.
Biomedical and environmental sciences : BES.
2018 Jan; 31(1):76-80. doi:
10.3967/bes2018.009. [PMID: 29409588] - Jie Zhang, Shengli Liu, Hua Zhang, Yuanyuan Li, Wenda Wu, Haibin Zhang. Gut satiety hormones cholecystokinin and glucagon-like Peptide-17-36 amide mediate anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol.
Toxicology and applied pharmacology.
2017 11; 335(?):49-55. doi:
10.1016/j.taap.2017.09.020. [PMID: 28964791] - Jie Zhang, Hui Jia, Qingqing Wang, Yajie Zhang, Wenda Wu, Haibin Zhang. Role of Peptide YY3-36 and Glucose-Dependent Insulinotropic Polypeptide in Anorexia Induction by Trichothecences T-2 Toxin, HT-2 Toxin, Diacetoxyscirpenol, and Neosolaniol.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 09; 159(1):203-210. doi:
10.1093/toxsci/kfx128. [PMID: 28666375] - Nathan Broekaert, Mathias Devreese, Marthe De Boevre, Sarah De Saeger, Siska Croubels. T-2 Toxin-3α-glucoside in Broiler Chickens: Toxicokinetics, Absolute Oral Bioavailability, and in Vivo Hydrolysis.
Journal of agricultural and food chemistry.
2017 Jun; 65(23):4797-4803. doi:
10.1021/acs.jafc.7b00698. [PMID: 28520442] - Yang Lei, Zhao Guanghui, Wang Xi, Wang Yingting, Lin Xialu, Yu Fangfang, Mary B Goldring, Guo Xiong, Mikko J Lammi. Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes.
Scientific reports.
2017 05; 7(1):2231. doi:
10.1038/s41598-017-02568-5. [PMID: 28533525] - Manish Adhikari, Bhawana Negi, Neha Kaushik, Anupriya Adhikari, Abdulaziz A Al-Khedhairy, Nagendra Kumar Kaushik, Eun Ha Choi. T-2 mycotoxin: toxicological effects and decontamination strategies.
Oncotarget.
2017 May; 8(20):33933-33952. doi:
10.18632/oncotarget.15422. [PMID: 28430618] - Silvia W Gratz, Reshma Dinesh, Tomoya Yoshinari, Grietje Holtrop, Anthony J Richardson, Gary Duncan, Susan MacDonald, Antony Lloyd, Jonathan Tarbin. Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro.
Molecular nutrition & food research.
2017 04; 61(4):. doi:
10.1002/mnfr.201600680. [PMID: 27921366] - Giovanni Beccari, Antonio Prodi, Francesco Tini, Umberto Bonciarelli, Andrea Onofri, Souheib Oueslati, Marwa Limayma, Lorenzo Covarelli. Changes in the Fusarium Head Blight Complex of Malting Barley in a Three-Year Field Experiment in Italy.
Toxins.
2017 03; 9(4):. doi:
10.3390/toxins9040120. [PMID: 28353653] - Keqiu Jiang, Peng Huang, Lianjun Luan, Kai Fan, Wenbo Guo, Zhihui Zhao, Yongjiang Wu, Zheng Han. Iron (II, III) oxide/multi-walled carbon nanotube composite as solid-phase extraction sorbent followed by ultra-high performance liquid chromatography tandem mass spectrometry for simultaneous determination of zearalenone and type A trichothecenes in Salviae miltiorrhizae Radix et Rhizoma (Danshen).
Journal of chromatography. A.
2017 Jan; 1482(?):1-10. doi:
10.1016/j.chroma.2016.12.058. [PMID: 28017565] - Veronica M T Lattanzio, Michelangelo Pascale. Determination of T-2 and HT-2 Toxins in Oats and Oat-Based Breakfast Cereals by Liquid-Chromatography Tandem Mass Spectrometry.
Methods in molecular biology (Clifton, N.J.).
2017; 1536(?):127-136. doi:
10.1007/978-1-4939-6682-0_9. [PMID: 28132147] - Iveta Matejova, Martin Faldyna, Helena Modra, Jana Blahova, Miroslava Palikova, Zdenka Markova, Ales Franc, Monika Vicenova, Libor Vojtek, Jana Bartonkova, Pavla Sehonova, Martin Hostovsky, Zdenka Svobodova. Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.).
Fish & shellfish immunology.
2017 Jan; 60(?):458-465. doi:
10.1016/j.fsi.2016.11.032. [PMID: 27840172] - Jacqueline Meng-Reiterer, Christoph Bueschl, Justyna Rechthaler, Franz Berthiller, Marc Lemmens, Rainer Schuhmacher. Metabolism of HT-2 Toxin and T-2 Toxin in Oats.
Toxins.
2016 12; 8(12):. doi:
10.3390/toxins8120364. [PMID: 27929394] - R Yang, Y-M Wang, L Zhang, Z-M Zhao, J Zhao, S-Q Peng. Prepubertal exposure to T-2 toxin advances pubertal onset and development in female rats via promoting the onset of hypothalamic-pituitary-gonadal axis function.
Human & experimental toxicology.
2016 Dec; 35(12):1276-1285. doi:
10.1177/0960327116629529. [PMID: 26847343] - Csilla Pelyhe, Benjámin Kövesi, Erika Zándoki, Balázs Kovács, Judit Szabó-Fodor, Miklós Mézes, Krisztián Balogh. Short-term effects of T-2 toxin or deoxynivalenol on lipid peroxidation and the glutathione system in common carp.
Acta veterinaria Hungarica.
2016 12; 64(4):449-466. doi:
10.1556/004.2016.042. [PMID: 27993104] - A Szabó, J Szabó-Fodor, H Fébel, M Mézes, G Bajzik, M Kovács. Oral administration of fumonisin B1 and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits.
Physiology international.
2016 Sep; 103(3):321-333. doi:
10.1556/2060.103.2016.3.5. [PMID: 28229635] - A Bócsai, Cs Pelyhe, E Zándoki, Zs Ancsin, J Szabó-Fodor, M Erdélyi, M Mézes, K Balogh. Short-term effects of T-2 toxin exposure on some lipid peroxide and glutathione redox parameters of broiler chickens.
Journal of animal physiology and animal nutrition.
2016 Jun; 100(3):520-5. doi:
10.1111/jpn.12399. [PMID: 26412027] - Seon Hwa Kim, Vladimir Vujanovic. Relationship between mycoparasites lifestyles and biocontrol behaviors against Fusarium spp. and mycotoxins production.
Applied microbiology and biotechnology.
2016 Jun; 100(12):5257-72. doi:
10.1007/s00253-016-7539-z. [PMID: 27121573] - Csilla Pelyhe, Benjámin Kövesi, Erika Zándoki, Balázs Kovács, Judit Szabó-Fodor, Miklós Mézes, Krisztián Balogh. Effect of 4-week feeding of deoxynivalenol- or T-2-toxin-contaminated diet on lipid peroxidation and glutathione redox system in the hepatopancreas of common carp (Cyprinus carpio L.).
Mycotoxin research.
2016 May; 32(2):77-83. doi:
10.1007/s12550-016-0242-1. [PMID: 26920403] - Ronghui Lei, Ning Jiang, Qiang Zhang, Senke Hu, Bannel Sando Dennis, Shanshan He, Xiong Guo. Prevalence of Selenium, T-2 Toxin, and Deoxynivalenol in Kashin-Beck Disease Areas in Qinghai Province, Northwest China.
Biological trace element research.
2016 May; 171(1):34-40. doi:
10.1007/s12011-015-0495-0. [PMID: 26349761]
