3-Hydroxyisobutyric acid (BioDeep_00000004608)

 

Secondary id: BioDeep_00000014319

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-Hydroxyisobutyric acid

化学式: C4H8O3 (104.0473)
中文名称: 3-羟基异丁酸
谱图信息: 最多检出来源 Homo sapiens(plant) 19.7%

Reviewed

Last reviewed on 2024-07-19.

Cite this Page

3-Hydroxyisobutyric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/3-hydroxyisobutyric_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000004608). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(CO)C(=O)O
InChI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)

描述信息

A 4-carbon, branched hydroxy fatty acid and intermediate in the metabolism of valine.
3-Hydroxyisobutyric acid is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.

同义名列表

2 个代谢物同义名

3-Hydroxyisobutyric acid; 3-Hydroxy-2-methylpropanoate



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

284 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(284)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, CAT, CD36, COASY, EGFR, ENO2, FGF21, MTOR
Peripheral membrane protein 2 MTOR, SDHB
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 DGAT1, EGFR, MTOR
Nucleus 4 ALB, EGFR, FABP3, MTOR
cytosol 5 ALB, CAT, ENO2, FABP3, MTOR
dendrite 1 MTOR
mitochondrial membrane 1 SDHB
phagocytic vesicle 2 CD36, MTOR
centrosome 1 ALB
nucleoplasm 4 ALDH6A1, ATP2B1, MTOR, SDHB
Cell membrane 4 ATP2B1, CD36, EGFR, ENO2
Cytoplasmic side 1 MTOR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 ATP2B1, CD36, DGAT1
Golgi apparatus membrane 1 MTOR
Synapse 1 ATP2B1
cell junction 1 EGFR
cell surface 3 ADIPOQ, CD36, EGFR
glutamatergic synapse 2 ATP2B1, EGFR
Golgi apparatus 2 ALB, CD36
Golgi membrane 3 EGFR, INS, MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 SDHB
presynaptic membrane 1 ATP2B1
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 7 ATP2B1, CD36, DGAT1, EGFR, ENO2, SDHB, SUCLG2
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ATP2B1, CAT, CD36, DGAT1, EGFR, ENO2, MTOR
apical plasma membrane 2 CD36, EGFR
basolateral plasma membrane 2 ATP2B1, EGFR
caveola 1 CD36
extracellular exosome 6 ALB, ATP2B1, CAT, COASY, ENO2, FABP3
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ADIPOQ, ALB
extracellular space 8 ADIPOQ, ALB, CD36, EGFR, ENO2, FABP3, FGF21, INS
perinuclear region of cytoplasm 1 EGFR
mitochondrion 8 ALDH6A1, CAT, COASY, HIBADH, HIBCH, PDK4, SDHB, SUCLG2
protein-containing complex 3 ALB, CAT, EGFR
intracellular membrane-bounded organelle 2 ATP2B1, CAT
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 EGFR
Secreted 4 ADIPOQ, ALB, FGF21, INS
extracellular region 5 ADIPOQ, ALB, CAT, FGF21, INS
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 2 COASY, MTOR
Mitochondrion matrix 2 COASY, PDK4
mitochondrial matrix 8 ALDH6A1, CAT, COASY, HIBADH, HIBCH, PDK4, SDHB, SUCLG2
anchoring junction 1 ALB
photoreceptor inner segment 1 ENO2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 EGFR
external side of plasma membrane 1 CD36
perikaryon 1 ENO2
Apical cell membrane 1 CD36
Mitochondrion inner membrane 1 SDHB
Matrix side 1 SDHB
Membrane raft 2 CD36, EGFR
focal adhesion 2 CAT, EGFR
Peroxisome 1 CAT
collagen trimer 2 ADIPOQ, CD36
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ADIPOQ
lateral plasma membrane 1 ATP2B1
receptor complex 2 CD36, EGFR
ciliary basal body 1 ALB
cell projection 1 ATP2B1
cell periphery 1 CD36
centriole 1 ALB
brush border membrane 1 CD36
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
specific granule membrane 2 CD36, DGAT1
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 CD36
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
respiratory chain complex II (succinate dehydrogenase) 1 SDHB
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 EGFR
Cytoplasmic vesicle, phagosome 1 MTOR
platelet alpha granule membrane 1 CD36
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
catalase complex 1 CAT
phosphopyruvate hydratase complex 1 ENO2
photoreceptor ribbon synapse 1 ATP2B1
ciliary transition fiber 1 ALB
succinate-CoA ligase complex (GDP-forming) 1 SUCLG2
succinate-CoA ligase complex 1 SUCLG2


文献列表

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  • Elisa Biliotti, Ottavia Giampaoli, Fabio Sciubba, Federico Marini, Alberta Tomassini, Donatella Palazzo, Giorgio Capuani, Rozenn Esvan, Martina Spaziante, Gloria Taliani, Alfredo Miccheli. Urinary metabolomics of HCV patients with severe liver fibrosis before and during the sustained virologic response achieved by direct acting antiviral treatment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Nov; 143(?):112217. doi: 10.1016/j.biopha.2021.112217. [PMID: 34560544]
  • Melanie Meyer, Jana C Hollenbeck, Janine Reunert, Anja Seelhöfer, Stephan Rust, Manfred Fobker, Saskia Biskup, Ulrike Och, Mechthild Linden, Jörn Oliver Sass, Thorsten Marquardt. 3-Hydroxyisobutyrate dehydrogenase (HIBADH) deficiency-A novel disorder of valine metabolism. Journal of inherited metabolic disease. 2021 11; 44(6):1323-1329. doi: 10.1002/jimd.12410. [PMID: 34176136]
  • Mona Synnøve Bjune, Carine Lindquist, Marit Hallvardsdotter Stafsnes, Bodil Bjørndal, Per Bruheim, Thomas A Aloysius, Ottar Nygård, Jon Skorve, Lise Madsen, Simon N Dankel, Rolf Kristian Berge. Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2021 04; 1866(4):158887. doi: 10.1016/j.bbalip.2021.158887. [PMID: 33454435]
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  • Ulrika Andersson-Hall, Carolina Gustavsson, Anders Pedersen, Daniel Malmodin, Louise Joelsson, Agneta Holmäng. Higher Concentrations of BCAAs and 3-HIB Are Associated with Insulin Resistance in the Transition from Gestational Diabetes to Type 2 Diabetes. Journal of diabetes research. 2018; 2018(?):4207067. doi: 10.1155/2018/4207067. [PMID: 29967793]
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