(2R)-2-hydroxypentanedioic acid (BioDeep_00001868343)
Main id: BioDeep_00000002868
PANOMIX_OTCML-2023
代谢物信息卡片
(2R)-2-hydroxypentanedioic acid
化学式: C5H8O5 (148.0371718)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(=O)O)C(C(=O)O)O
InChI: InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m1/s1
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:32796
- KEGG: C01087
- PubChem: 439391
- ChEMBL: CHEMBL1614745
- CAS: 13095-47-1
- CAS: 636-67-9
- ChEBI: CHEBI:15801
- PubChem: 4322
- PDB-CCD: 2HG
- NIKKAJI: J1.280.876C
分类词条
相关代谢途径
Reactome(6)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3055 - Chlamydomonas reinhardtii: 10.1111/TPJ.12747
- 457265 - Euphorbia resinifera: 10.3891/ACTA.CHEM.SCAND.23-3609
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinting Zhu, Juan Hao, Hong Zhang, Mengyi Chi, Yaxian Wang, Jinlu Huang, Rong Xu, Zhao Xincai, Bo Xin, Xipeng Sun, Jianping Zhang, Shumin Zhou, Dongdong Cheng, Ting Yuan, Jun Ding, Shuier Zheng, Cheng Guo, Quanjun Yang. Oncometabolite D-2-hydroxyglutarate-dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia.
Communications biology.
2023 Sep; 6(1):977. doi:
10.1038/s42003-023-05366-0. [PMID: 37741882] - Daniel Thomas, Manhong Wu, Yusuke Nakauchi, Ming Zheng, Chloe A L Thompson-Peach, Kelly Lim, Niklas Landberg, Thomas Köhnke, Nirmal Robinson, Satinder Kaur, Monika Kutyna, Melissa Stafford, Devendra Hiwase, Andreas Reinisch, Gary Peltz, Ravindra Majeti. Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability.
Cancer discovery.
2023 Feb; 13(2):496-515. doi:
10.1158/2159-8290.cd-21-0218. [PMID: 36355448] - Qingwen Zhao. Mutant IDH1 attenuates hepatic lipogenesis through PTEN dependent pathway.
Biochemical and biophysical research communications.
2022 12; 637(?):254-258. doi:
10.1016/j.bbrc.2022.11.041. [PMID: 36410274] - Rafael Teixeira Ribeiro, Andrey Vinícios Soares Carvalho, Rafael Palavro, Luz Elena Durán-Carabali, Ângela Beatris Zemniaçak, Alexandre Umpierrez Amaral, Carlos Alexandre Netto, Moacir Wajner. L-2-Hydroxyglutaric Acid Administration to Neonatal Rats Elicits Marked Neurochemical Alterations and Long-Term Neurobehavioral Disabilities Mediated by Oxidative Stress.
Neurotoxicity research.
2022 Dec; ?(?):. doi:
10.1007/s12640-022-00625-0. [PMID: 36580261] - Gamze Tuna, Nazlı Ecem Dal-Bekar, Ali Akay, Mete Rükşen, Sertaç İşlekel, Gül Hüray İşlekel. Minimally Invasive Detection of IDH1 Mutation With Cell-Free Circulating Tumor DNA and D-2-Hydroxyglutarate, D/L-2-Hydroxyglutarate Ratio in Gliomas.
Journal of neuropathology and experimental neurology.
2022 Jun; 81(7):502-510. doi:
10.1093/jnen/nlac036. [PMID: 35582888] - Quanjun Yang, Juan Hao, Mengyi Chi, Yaxian Wang, Jie Li, Jinlu Huang, Jianping Zhang, Mengqi Zhang, Jin Lu, Shumin Zhou, Ting Yuan, Zan Shen, Shuier Zheng, Cheng Guo. D2HGDH-mediated D2HG catabolism enhances the anti-tumor activities of CAR-T cells in an immunosuppressive microenvironment.
Molecular therapy : the journal of the American Society of Gene Therapy.
2022 03; 30(3):1188-1200. doi:
10.1016/j.ymthe.2022.01.007. [PMID: 35007759] - Bo Wu, Zehua Li, Zepeng Kang, Chunling Ma, Haiyan Song, Fuping Lu, Zhiguang Zhu. An Enzymatic Biosensor for the Detection of D-2-Hydroxyglutaric Acid in Serum and Urine.
Biosensors.
2022 Jan; 12(2):. doi:
10.3390/bios12020066. [PMID: 35200327] - Bernhard Strasser, Nicolas S Arango, Jason P Stockmann, Borjan Gagoski, Bijaya Thapa, Xianqi Li, Wolfgang Bogner, Philipp Moser, Julia Small, Daniel P Cahill, Tracy T Batchelor, Jorg Dietrich, Andre van der Kouwe, Jacob White, Elfar Adalsteinsson, Ovidiu C Andronesi. Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B0 -shim array coils at 3 T.
NMR in biomedicine.
2022 01; 35(1):e4621. doi:
10.1002/nbm.4621. [PMID: 34609036] - Dan Xiao, Wen Zhang, Xiaoting Guo, Yidong Liu, Chunxia Hu, Shiting Guo, Zhaoqi Kang, Xianzhi Xu, Cuiqing Ma, Chao Gao, Ping Xu. A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR.
Nature communications.
2021 12; 12(1):7108. doi:
10.1038/s41467-021-27357-7. [PMID: 34876568] - Mònica Bulló, Christopher Papandreou, Jesus García-Gavilán, Miguel Ruiz-Canela, Jun Li, Marta Guasch-Ferré, Estefanía Toledo, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Chih-Hao Lee, Kerry Pierce, Cristina Razquin, Fernando Arós, Lluís Serra-Majem, Liming Liang, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure.
Metabolism: clinical and experimental.
2021 12; 125(?):154915. doi:
10.1016/j.metabol.2021.154915. [PMID: 34678258] - Yue Chen, Nelamangala V Nagaraja, Bin Fan, Luke Utley, Rene M Lemieux, Janeta Popovici-Muller, Lenny Dang, Hyeryun Kim, Liping Yan, Shin-San M Su, Scott A Biller, Hua Yang. Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies.
Drug metabolism and disposition: the biological fate of chemicals.
2021 10; 49(10):870-881. doi:
10.1124/dmd.120.000234. [PMID: 34321251] - Pegah Askari, Ivan E Dimitrov, Sandeep K Ganji, Vivek Tiwari, Michael Levy, Toral R Patel, Edward Pan, Bruce E Mickey, Craig R Malloy, Elizabeth A Maher, Changho Choi. Spectral fitting strategy to overcome the overlap between 2-hydroxyglutarate and lipid resonances at 2.25 ppm.
Magnetic resonance in medicine.
2021 10; 86(4):1818-1828. doi:
10.1002/mrm.28829. [PMID: 33977579] - Rafael Teixeira Ribeiro, Bianca Seminotti, Ângela Zanatta, Francine Hehn de Oliveira, Alexandre Umpierrez Amaral, Guilhian Leipnitz, Moacir Wajner. Neuronal Death, Glial Reactivity, Microglia Activation, Oxidative Stress and Bioenergetics Impairment Caused by Intracerebroventricular Administration of D-2-hydroxyglutaric Acid to Neonatal Rats.
Neuroscience.
2021 09; 471(?):115-132. doi:
10.1016/j.neuroscience.2021.07.024. [PMID: 34333063] - C J Pirola, M Garaycoechea, D Flichman, G O Castaño, S Sookoian. Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease.
Journal of internal medicine.
2021 01; 289(1):84-96. doi:
10.1111/joim.13147. [PMID: 32634278] - Garrett Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M Tennessen, Juan Liu, Jason W Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K Challa, Sunil Sudarshan. Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.
Disease models & mechanisms.
2020 11; 13(11):. doi:
10.1242/dmm.045898. [PMID: 32928875] - Martin Kery, Ioanna Papandreou. Emerging strategies to target cancer metabolism and improve radiation therapy outcomes.
The British journal of radiology.
2020 Nov; 93(1115):20200067. doi:
10.1259/bjr.20200067. [PMID: 32462882] - Feng Yin, Yonghua Ling, Jennifer Keller, Dennis Kraus, Rohini Narayanaswamy, Heidi Mangus, Fumin Li, Hua Yang, Guowen Liu. Quantitation of 2-hydroxyglutarate in human plasma via LC-MS/MS using a surrogate analyte approach.
Bioanalysis.
2020 Aug; 12(16):1149-1159. doi:
10.4155/bio-2020-0131. [PMID: 32757862] - Chong Hyun Suh, Ho Sung Kim, Ji Eun Park, Seung Chai Jung, Choong Gon Choi, Dong-Cheol Woo, Ho Beom Lee, Sang Joon Kim. Comparative Value of 2-Hydroxyglutarate-to-Lipid and Lactate Ratio versus 2-Hydroxyglutarate Concentration on MR Spectroscopic Images for Predicting Isocitrate Dehydrogenase Mutation Status in Gliomas.
Radiology. Imaging cancer.
2020 07; 2(4):e190083. doi:
10.1148/rycan.2020190083. [PMID: 33778723] - Nanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-Cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-Ping Ge. Using arterial-venous analysis to characterize cancer metabolic consumption in patients.
Nature communications.
2020 06; 11(1):3169. doi:
10.1038/s41467-020-16810-8. [PMID: 32576825] - Tong Liu, Xiang Gu, Li-Xiang Li, Ming Li, Bing Li, Xiao Cui, Xiu-Li Zuo. Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients.
BMC microbiology.
2020 06; 20(1):168. doi:
10.1186/s12866-020-01841-4. [PMID: 32552668] - Bin Fan, Ingo K Mellinghoff, Patrick Y Wen, Maeve A Lowery, Lipika Goyal, William D Tap, Shuchi S Pandya, Erika Manyak, Liewen Jiang, Guowen Liu, Tara Nimkar, Camelia Gliser, Molly Prahl Judge, Sam Agresta, Hua Yang, David Dai. Clinical pharmacokinetics and pharmacodynamics of ivosidenib, an oral, targeted inhibitor of mutant IDH1, in patients with advanced solid tumors.
Investigational new drugs.
2020 04; 38(2):433-444. doi:
10.1007/s10637-019-00771-x. [PMID: 31028664] - Valeria Cuccarini, Luigi Antelmi, Bianca Pollo, Rosina Paterra, Chiara Calatozzolo, Anna Nigri, Francesco DiMeco, Marica Eoli, Gaetano Finocchiaro, Greta Brenna, Irene Tramacere, Maria Grazia Bruzzone, Elena Anghileri. In vivo 2-hydroxyglutarate-proton magnetic resonance spectroscopy (3 T, PRESS technique) in treatment-naïve suspect lower-grade gliomas: feasibility and accuracy in a clinical setting.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2020 Feb; 41(2):347-355. doi:
10.1007/s10072-019-04087-9. [PMID: 31650436] - Tian-Xiang Wang, Jun-Yun Liang, Cheng Zhang, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis.
Cell death & disease.
2019 10; 10(10):755. doi:
10.1038/s41419-019-1984-4. [PMID: 31591388] - Shinji K Strain, Morris D Groves, Mark R Emmett. Differentiation of 2-hydroxyglutarate enantiomers and its lactones by gas chromatography/electron ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2019 Sep; 33(17):1401-1409. doi:
10.1002/rcm.8485. [PMID: 31148247] - Hao-Wen Sim, Romina Nejad, Wenjiang Zhang, Farshad Nassiri, Warren Mason, Kenneth D Aldape, Gelareh Zadeh, Eric X Chen. Tissue 2-Hydroxyglutarate as a Biomarker for Isocitrate Dehydrogenase Mutations in Gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019 06; 25(11):3366-3373. doi:
10.1158/1078-0432.ccr-18-3205. [PMID: 30777876] - Phuong-Nhi Bories, Samir Nakib, Luc Cynober, Anne-Sophie Alary, Marie-Magdelaine Coude, Florian Chevillon, Jérôme Tamburini, Rudy Birsen, Olivier Kosmider, Didier Bouscary. Establishing assay-specific 97.5th percentile upper reference limit for serum D-2-hydroxyglutarate for the management of patients with acute myeloid leukemia.
Clinical chemistry and laboratory medicine.
2019 03; 57(4):e57-e59. doi:
10.1515/cclm-2018-0427. [PMID: 30267623] - Andrew M Brunner, Donna S Neuberg, Seth A Wander, Hossein Sadrzadeh, Karen K Ballen, Philip C Amrein, Eyal Attar, Gabriela S Hobbs, Yi-Bin Chen, Ashley Perry, Christine Connolly, Christelle Joseph, Meghan Burke, Aura Ramos, Ilene Galinsky, Katharine Yen, Hua Yang, Kimberly Straley, Sam Agresta, Sophia Adamia, Darrell R Borger, Anthony Iafrate, Timothy A Graubert, Richard M Stone, Amir T Fathi. Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia.
Cancer.
2019 02; 125(4):541-549. doi:
10.1002/cncr.31729. [PMID: 30422308] - Sandeep Shelar, Eun-Hee Shim, Garrett J Brinkley, Anirban Kundu, Francesca Carobbio, Tyler Poston, Jubilee Tan, Vishwas Parekh, Daniel Benson, David K Crossman, Phillip J Buckhaults, Dinesh Rakheja, Richard Kirkman, Yusuke Sato, Seishi Ogawa, Shilpa Dutta, Sadanandan E Velu, Ethan Emberley, Alison Pan, Jason Chen, Tony Huang, Devin Absher, Anja Becker, Conrad Kunick, Sunil Sudarshan. Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2018 12; 24(24):6433-6446. doi:
10.1158/1078-0432.ccr-18-1727. [PMID: 30108105] - Conor A Bradley. Oncometabolite mechanism unravelled.
Nature reviews. Urology.
2018 11; 15(11):656-657. doi:
10.1038/s41585-018-0086-x. [PMID: 30185913] - Lucille Stuani, Fabien Riols, Pierre Millard, Marie Sabatier, Aurélie Batut, Estelle Saland, Fanny Viars, Laure Tonini, Sonia Zaghdoudi, Laetitia K Linares, Jean-Charles Portais, Jean-Emmanuel Sarry, Justine Bertrand-Michel. Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia.
International journal of molecular sciences.
2018 Oct; 19(11):. doi:
10.3390/ijms19113325. [PMID: 30366412] - Mehmet G Badur, Thangaselvam Muthusamy, Seth J Parker, Shenghong Ma, Samuel K McBrayer, Thekla Cordes, Jose H Magana, Kun-Liang Guan, Christian M Metallo. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.
Cell reports.
2018 10; 25(4):1018-1026.e4. doi:
10.1016/j.celrep.2018.09.074. [PMID: 30355481] - Garfield A Simon, Andrea Wierenga. Quantitation of plasma and urine 3-hydroxyglutaric acid, after separation from 2-hydroxyglutaric acid and other compounds of similar ion transition, by liquid chromatography-tandem mass spectrometry for the confirmation of glutaric aciduria type 1.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Oct; 1097-1098(?):101-110. doi:
10.1016/j.jchromb.2018.09.007. [PMID: 30218917] - Yuanfeng Zhang, Chunmei Wang, Kunfang Yang, Simei Wang, Guoli Tian, Yucai Chen. A novel compound heterozygous mutation of the L2HGDH gene in a Chinese boy with L-2-hydroxyglutaric aciduria: case report and literature review.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2018 Oct; 39(10):1697-1703. doi:
10.1007/s10072-018-3483-2. [PMID: 29980873] - Christophe Willekens, Aline Renneville, Sophie Broutin, Véronique Saada, Jean-Baptiste Micol, Julia Delahousse, Vianney Poinsignon, Claire Bories, Céline Berthon, Raphael Itzykson, Nicolas Boissel, Cyril Quivoron, Marie Terroir-Cassou-Mounat, Jacques Bosq, Claude Preudhomme, Angelo Paci, Virginie Penard-Lacronique, Stéphane De Botton. Mutational profiling of isolated myeloid sarcomas and utility of serum 2HG as biomarker of IDH1/2 mutations.
Leukemia.
2018 09; 32(9):2008-2081. doi:
10.1038/s41375-018-0056-6. [PMID: 29479068] - Peipei Lin, Yingwan Luo, Shuanghong Zhu, Dominic Maggio, Haiyang Yang, Chao Hu, Jinghan Wang, Hua Zhang, Yanling Ren, Xinping Zhou, Chen Mei, Liya Ma, Weilai Xu, Li Ye, Zhengping Zhuang, Jie Jin, Hongyan Tong. Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes.
Journal of cancer research and clinical oncology.
2018 Jun; 144(6):1037-1047. doi:
10.1007/s00432-018-2627-3. [PMID: 29549529] - Tie Li, Christopher D Cox, Byram H Ozer, Nhung T Nguyen, HuyTram N Nguyen, Thomas J Lai, Sichen Li, Fei Liu, Harley I Kornblum, Linda M Liau, Phioanh L Nghiemphu, Timothy F Cloughesy, Albert Lai. D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.
Molecular cancer research : MCR.
2018 06; 16(6):947-960. doi:
10.1158/1541-7786.mcr-17-0367. [PMID: 29545476] - Xuemei Ding, Shuhai Lin, Hongbo Weng, Jianying Liang. Separation and determination of the enantiomers of lactic acid and 2-hydroxyglutaric acid by chiral derivatization combined with gas chromatography and mass spectrometry.
Journal of separation science.
2018 Jun; 41(12):2576-2584. doi:
10.1002/jssc.201701555. [PMID: 29603663] - Feng Peng, Yingzi Liu, Chenjie He, Yi Kong, Qianying Ouyang, Xiaonv Xie, Tong Liu, Zhaoqian Liu, Jingbo Peng. Prediction of platinum-based chemotherapy efficacy in lung cancer based on LC-MS metabolomics approach.
Journal of pharmaceutical and biomedical analysis.
2018 May; 154(?):95-101. doi:
10.1016/j.jpba.2018.02.051. [PMID: 29544107] - Manman Zhang, Chao Gao, Xiaoting Guo, Shiting Guo, Zhaoqi Kang, Dan Xiao, Jinxin Yan, Fei Tao, Wen Zhang, Wenyue Dong, Pan Liu, Chen Yang, Cuiqing Ma, Ping Xu. Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.
Nature communications.
2018 05; 9(1):2114. doi:
10.1038/s41467-018-04513-0. [PMID: 29844506] - Esther Fernández-Galán, Núria Massana, Marina Parra-Robert, Susana Hidalgo, Gregori Casals, Jordi Esteve, Wladimiro Jiménez. Validation of a routine gas chromatography mass spectrometry method for 2-hydroxyglutarate quantification in human serum as a screening tool for detection of idh mutations.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Apr; 1083(?):28-34. doi:
10.1016/j.jchromb.2018.02.038. [PMID: 29522955] - Rafael Teixeira Ribeiro, Ângela Zanatta, Alexandre Umpierrez Amaral, Guilhian Leipnitz, Francine Hehn de Oliveira, Bianca Seminotti, Moacir Wajner. Experimental Evidence that In Vivo Intracerebral Administration of L-2-Hydroxyglutaric Acid to Neonatal Rats Provokes Disruption of Redox Status and Histopathological Abnormalities in the Brain.
Neurotoxicity research.
2018 04; 33(3):681-692. doi:
10.1007/s12640-018-9874-6. [PMID: 29411290] - Ana Pop, Monique Williams, Eduard A Struys, Magnus Monné, Erwin E W Jansen, Anna De Grassi, Warsha A Kanhai, Pasquale Scarcia, Matilde R Fernandez Ojeda, Vito Porcelli, Silvy J M van Dooren, Pascal Lennertz, Benjamin Nota, Jose E Abdenur, David Coman, Anibh Martin Das, Areeg El-Gharbawy, Jean-Marc Nuoffer, Branka Polic, René Santer, Natalie Weinhold, Britton Zuccarelli, Ferdinando Palmieri, Luigi Palmieri, Gajja S Salomons. An overview of combined D-2- and L-2-hydroxyglutaric aciduria: functional analysis of CIC variants.
Journal of inherited metabolic disease.
2018 03; 41(2):169-180. doi:
10.1007/s10545-017-0106-7. [PMID: 29238895] - Julia Delahousse, Loic Verlingue, Sophie Broutin, Clémence Legoupil, Mehdi Touat, Ludovic Doucet, Samy Ammari, Ludovic Lacroix, Michel Ducreux, Jean-Yves Scoazec, David Malka, Angelo Paci, Antoine Hollebecque. Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase-mutated intrahepatic cholangiocarcinomas.
European journal of cancer (Oxford, England : 1990).
2018 02; 90(?):83-91. doi:
10.1016/j.ejca.2017.11.024. [PMID: 29274619] - Jie Han, Dakota Jackson, Janette Holm, Kevin Turner, Paula Ashcraft, Xuan Wang, Beth Cook, Erland Arning, Robert M Genta, K Venuprasad, Rhonda F Souza, Lawrence Sweetman, Arianne L Theiss. Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2018 01; 115(5):1057-1062. doi:
10.1073/pnas.1712625115. [PMID: 29339485] - Wilson I Gonsalves, Vijay Ramakrishnan, Taro Hitosugi, Toshi Ghosh, Dragan Jevremovic, Tumpa Dutta, Dhananjay Sakrikar, Xuan-Mai Petterson, Linda Wellik, Shaji K Kumar, K Sreekumaran Nair. Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies.
JCI insight.
2018 01; 3(1):. doi:
10.1172/jci.insight.94543. [PMID: 29321378] - Hisakuni Obayashi, Naoko Kobayashi, Yoshikazu Nezu, Takashi Yamoto, Mitsuyuki Shirai, Fumitoshi Asai. Plasma 2-hydroxyglutarate, a promising prognostic biomarker candidate for skeletal muscle injury in Fischer 344 rats.
The Journal of toxicological sciences.
2018; 43(10):601-610. doi:
10.2131/jts.43.601. [PMID: 30298848] - Daiane Grigolo Bardemaker Rodrigues, Daniella de Moura Coelho, Ângela Sitta, Carlos Eduardo Diaz Jacques, Tatiane Hauschild, Vanusa Manfredini, Abdellatif Bakkali, Eduard A Struys, Cornelis Jakobs, Moacir Wajner, Carmen Regla Vargas. Experimental evidence of oxidative stress in patients with l-2-hydroxyglutaric aciduria and that l-carnitine attenuates in vitro DNA damage caused by d-2-hydroxyglutaric and l-2-hydroxyglutaric acids.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Aug; 42(?):47-53. doi:
10.1016/j.tiv.2017.04.006. [PMID: 28396261] - Shahab Babakoohi, Rena G Lapidus, Rawan Faramand, Edward A Sausville, Ashkan Emadi. Comparative Analysis of Methods for Detecting Isocitrate Dehydrogenase 1 and 2 Mutations and Their Metabolic Consequence, 2-Hydroxyglutarate, in Different Neoplasms.
Applied immunohistochemistry & molecular morphology : AIMM.
2017 May; 25(5):334-337. doi:
10.1097/pai.0000000000000342. [PMID: 26945443] - Bin Jiang, Jia Zhang, Jinmei Xia, Wentao Zhao, Yanan Wu, Minggang Shi, Lianzhong Luo, Huamin Zhou, Ai Chen, Huanhuan Ma, Qingwen Zhao, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Ying He, Xiaotong Li, Li-Man Hung, Tak Wah Mak, Qinxi Li. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation.
Cell reports.
2017 04; 19(2):389-400. doi:
10.1016/j.celrep.2017.03.053. [PMID: 28402860] - Hisakuni Obayashi, Naoko Kobayashi, Yoshikazu Nezu, Takashi Yamoto, Mitsuyuki Shirai, Fumitoshi Asai. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats.
The Journal of toxicological sciences.
2017; 42(4):385-396. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2016 12; 113(52):15084-15089. doi:
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Oncotarget.
2016 Nov; 7(48):79722-79735. doi:
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Journal of chromatography. A.
2016 Oct; 1467(?):383-390. doi:
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Brain research.
2016 10; 1648(Pt A):506-511. doi:
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Molecular and cellular biology.
2016 09; 36(18):2384-95. doi:
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The oncologist.
2016 08; 21(8):1026. doi:
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Leukemia.
2016 Apr; 30(4):782-8. doi:
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The oncologist.
2016 Feb; 21(2):214-9. doi:
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2016 Jan; 25(1):180-7. doi:
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Molecular cell.
2015 Nov; 60(4):661-75. doi:
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Scientific reports.
2015 Oct; 5(?):15217. doi:
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American journal of physiology. Renal physiology.
2015 Sep; 309(6):F492-8. doi:
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Plant & cell physiology.
2015 Sep; 56(9):1820-30. doi:
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The international journal of biochemistry & cell biology.
2015 Aug; 65(?):125-33. doi:
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eLife.
2015 Jul; 4(?):e07420. doi:
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BMC neurology.
2015 Jul; 15(?):117. doi:
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Free radical biology & medicine.
2015 Jun; 83(?):201-13. doi:
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The oncologist.
2015 May; 20(5):562-7. doi:
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Human pathology.
2015 Feb; 46(2):322-6. doi:
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International journal of clinical and experimental pathology.
2015; 8(9):11753-9. doi:
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PloS one.
2015; 10(9):e0133813. doi:
10.1371/journal.pone.0133813. [PMID: 26368816] - Eun-Hee Shim, Carolina B Livi, Dinesh Rakheja, Jubilee Tan, Daniel Benson, Vishwas Parekh, Eun-Young Kho, Arindam P Ghosh, Richard Kirkman, Sadanan Velu, Shilpa Dutta, Balachandra Chenna, Shane L Rea, Robert J Mishur, Qiuhua Li, Teresa L Johnson-Pais, Lining Guo, Sejong Bae, Shi Wei, Karen Block, Sunil Sudarshan. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.
Cancer discovery.
2014 Nov; 4(11):1290-8. doi:
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Mitochondrion.
2014 Nov; 19 Pt B(?):275-81. doi:
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Neuroscience.
2014 Sep; 277(?):281-93. doi:
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British journal of haematology.
2014 Jul; 166(1):145-8. doi:
10.1111/bjh.12826. [PMID: 24606602] - Amir T Fathi, Hossein Sadrzadeh, Amy H Comander, Michaela J Higgins, Aditya Bardia, Ashley Perry, Meghan Burke, Regina Silver, Christina R Matulis, Kimberly S Straley, Katharine E Yen, Sam Agresta, Hyeryun Kim, David P Schenkein, Darrell R Borger. Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.
The oncologist.
2014 Jun; 19(6):602-7. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2014 Apr; 20(7):1884-90. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2014 Feb; 32(4):297-305. doi:
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Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.
2014 Feb; 14(1):92-3. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2013 Oct; 110(42):17017-22. doi:
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Plant biology (Stuttgart, Germany).
2013 Jul; 15(4):776-84. doi:
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Blood.
2013 Jun; 121(24):4917-24. doi:
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American journal of human genetics.
2013 Apr; 92(4):627-31. doi:
10.1016/j.ajhg.2013.03.009. [PMID: 23561848] - Jörg Balss, Stefan Pusch, Ann-Christin Beck, Christel Herold-Mende, Alwin Krämer, Christian Thiede, Wolfgang Buckel, Claus-Dieter Langhans, Jürgen G Okun, Andreas von Deimling. Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate.
Acta neuropathologica.
2012 Dec; 124(6):883-91. doi:
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Blood.
2012 Nov; 120(23):4649-52. doi:
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Biochimica et biophysica acta.
2012 Oct; 1822(10):1544-52. doi:
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International journal of cancer.
2012 Aug; 131(3):766-8. doi:
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Biochemical and biophysical research communications.
2012 Jul; 423(3):553-6. doi:
10.1016/j.bbrc.2012.06.002. [PMID: 22683334] - C Marcel, M Mallaret, O Lagha-Boukbiza, S Kremer, A Echaniz-Laguna, C Tranchant. L-2-hydroxyglutaric aciduria diagnosed in a young adult with progressive cerebellar ataxia and facial dyskinesia.
Revue neurologique.
2012 Feb; 168(2):187-91. doi:
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American journal of medical genetics. Part A.
2011 Nov; 155A(11):2609-16. doi:
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Journal of inherited metabolic disease.
2011 Apr; 34(2):477-82. doi:
10.1007/s10545-010-9268-2. [PMID: 21264516] - Martin K M Engqvist, Anke Kuhn, Judith Wienstroer, Katrin Weber, Erwin E W Jansen, Cornelis Jakobs, Andreas P M Weber, Veronica G Maurino. Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence.
The Journal of biological chemistry.
2011 Apr; 286(13):11382-90. doi:
10.1074/jbc.m110.194175. [PMID: 21296880] - Dinesh Rakheja, Midori Mitui, Richard L Boriack, Ralph J DeBerardinis. Isocitrate dehydrogenase 1/2 mutational analyses and 2-hydroxyglutarate measurements in Wilms tumors.
Pediatric blood & cancer.
2011 Mar; 56(3):379-83. doi:
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Science (New York, N.Y.).
2010 Oct; 330(6002):336. doi:
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Journal of the National Cancer Institute.
2010 Jul; 102(13):932-41. doi:
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Journal of pediatric hematology/oncology.
2010 May; 32(4):339-40; author reply 340. doi:
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Human mutation.
2010 Mar; 31(3):279-83. doi:
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Journal of pediatric hematology/oncology.
2010 Mar; 32(2):169-70. doi:
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Journal of neurology.
2010 Jan; 257(1):146-8. doi:
10.1007/s00415-009-5319-8. [PMID: 19760480]