ISOQUINOLINE (BioDeep_00001867984)
Main id: BioDeep_00000002906
natural product
代谢物信息卡片
ISOQUINOLINE
化学式: C9H7N (129.0578)
中文名称: 异喹啉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C=NC=CC2=C1
InChI: InChI=1S/C9H7N/c1-2-4-9-7-10-6-5-8(9)3-1/h1-7H
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:16092
- KEGG: C06323
- PubChem: 8405
- DrugBank: DB04329
- ChEMBL: CHEMBL12315
- CAS: 2241982-85-2
- CAS: 119-65-3
- PubChem: 8559
- PDB-CCD: ISQ
- 3DMET: B00931
- NIKKAJI: J43.394B
- RefMet: Isoquinoline
- KNApSAcK: 16092
- LOTUS: LTS0089583
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
11 个相关的物种来源信息
- 4200 - Caprifoliaceae: LTS0089583
- 2759 - Eukaryota: LTS0089583
- 49606 - Lonicera: LTS0089583
- 105884 - Lonicera japonica: 10.3390/MOLECULES18021368
- 105884 - Lonicera japonica: LTS0089583
- 3398 - Magnoliopsida: LTS0089583
- 88149 - Saccharina japonica: 10.3390/MOLECULES200712093
- 35493 - Streptophyta: LTS0089583
- 58023 - Tracheophyta: LTS0089583
- 33090 - Viridiplantae: LTS0089583
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Erika Plazas, Mónica C Avila M, Diego R Muñoz, Luis E Cuca S. Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases.
Pharmacological research.
2022 03; 177(?):106126. doi:
10.1016/j.phrs.2022.106126. [PMID: 35151857] - Emmanoel V Costa, Liviane do N Soares, Jamal da Silva Chaar, Valdenizia R Silva, Luciano de S Santos, Hector H F Koolen, Felipe M A da Silva, Josean F Tavares, Gokhan Zengin, Milena B P Soares, Daniel P Bezerra. Benzylated Dihydroflavones and Isoquinoline-Derived Alkaloids from the Bark of Diclinanona calycina (Annonaceae) and Their Cytotoxicities.
Molecules (Basel, Switzerland).
2021 Jun; 26(12):. doi:
10.3390/molecules26123714. [PMID: 34207059] - Yang Huang, Tiejie Wang, Zhengjin Jiang. Fast analysis of alkaloids from different parts of Mahonia bealei (Fort.) Carr. studied for their anti-Alzheimer's activity using supercritical fluid chromatography.
Journal of separation science.
2021 May; 44(9):2006-2014. doi:
10.1002/jssc.202001079. [PMID: 33650266] - Daniela Marasco, Caterina Vicidomini, Pawel Krupa, Federica Cioffi, Pham Dinh Quoc Huy, Mai Suan Li, Daniele Florio, Kerensa Broersen, Maria Francesca De Pandis, Giovanni N Roviello. Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation.
Chemico-biological interactions.
2021 Jan; 334(?):109300. doi:
10.1016/j.cbi.2020.109300. [PMID: 33098838] - Huan Xia, Yitong Liu, Guiyang Xia, Yi Liu, Sheng Lin, Lijia Guo. Novel Isoquinoline Alkaloid Litcubanine A - A Potential Anti-Inflammatory Candidate.
Frontiers in immunology.
2021; 12(?):685556. doi:
10.3389/fimmu.2021.685556. [PMID: 34163484] - Jun-Yan Xiang, Yan-Yu Chi, Jin-Xin Han, Hongyu Xiang, Qiuhong Xie. The Toxicity and Attenuation Methods of Toxic Chinese Materia Medica for its Reasonable Application: A Review.
The American journal of Chinese medicine.
2021; 49(1):41-67. doi:
10.1142/s0192415x21500038. [PMID: 33416023] - Lin-Hai Chen, Qing Zhang, Xin Xie, Fa-Jun Nan. Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists.
Journal of medicinal chemistry.
2020 12; 63(24):15399-15409. doi:
10.1021/acs.jmedchem.0c01378. [PMID: 33267584] - Zhihui Liu, Zhenru Mi, Panpan Wang, Sheng Chang, Na Han, Jun Yin. Two new alkaloids from the tubers of Corydalis ambigua subsp. amurensis and their anti-proliferative activity.
Natural product research.
2020 Dec; 34(23):3305-3312. doi:
10.1080/14786419.2019.1566821. [PMID: 30908089] - Jing-Jing Xue, Chun-Yu Jiang, De-Li Zou, Bin-Jie Li, Jin-Cai Lu, Da-Hong Li, Bin Lin, Zhan-Lin Li, Hui-Ming Hua. Baicalensines A and B, Two Isoquinoline Alkaloids from the Roots of Thalictrum baicalense.
Organic letters.
2020 10; 22(19):7439-7442. doi:
10.1021/acs.orglett.0c02444. [PMID: 32886519] - Ruifei Zhang, Qiang Guo, Edward J Kennelly, Chunlin Long, Xingyun Chai. Diverse alkaloids and biological activities of Fumaria (Papaveraceae): An ethnomedicinal group.
Fitoterapia.
2020 Oct; 146(?):104697. doi:
10.1016/j.fitote.2020.104697. [PMID: 32739338] - Kaho Hirai, Saiichiro Watanabe, Nozomi Nishijima, Kaoru Shibata, Akane Hase, Tsuyoshi Yamanaka, Masato Inazu. Molecular and Functional Analysis of Choline Transporters and Antitumor Effects of Choline Transporter-Like Protein 1 Inhibitors in Human Pancreatic Cancer Cells.
International journal of molecular sciences.
2020 Jul; 21(15):. doi:
10.3390/ijms21155190. [PMID: 32707889] - Kwangho Song, Jae-Hyeon Oh, Min Young Lee, Seok-Geun Lee, In Jin Ha. Molecular Network-Guided Alkaloid Profiling of Aerial Parts of Papaver nudicaule L. Using LC-HRMS.
Molecules (Basel, Switzerland).
2020 Jun; 25(11):. doi:
10.3390/molecules25112636. [PMID: 32517053] - Erika Plazas, Stefanie Hagenow, Monica Avila Murillo, Holger Stark, Luis Enrique Cuca. Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation.
Bioorganic chemistry.
2020 05; 98(?):103722. doi:
10.1016/j.bioorg.2020.103722. [PMID: 32155491] - Mohamed A Tantawy, Farid M Sroor, Magda F Mohamed, Mostafa E El-Naggar, Fatma M Saleh, Hamdi M Hassaneen, Ismail A Abdelhamid. Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer.
Anti-cancer agents in medicinal chemistry.
2020; 20(1):70-83. doi:
10.2174/1871520619666191024121116. [PMID: 31696811] - Shih-Yi Lee, Ling-Wei Hsin, Ming-Jai Su, Ching-Chia ChangChien, Hui-Chun Ku. A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia.
Pharmacological reports : PR.
2019 Dec; 71(6):1281-1288. doi:
10.1016/j.pharep.2019.06.015. [PMID: 31683199] - Jerald J Nair, Johannes van Staden. Antiprotozoal alkaloid principles of the plant family Amaryllidaceae.
Bioorganic & medicinal chemistry letters.
2019 10; 29(20):126642. doi:
10.1016/j.bmcl.2019.126642. [PMID: 31515186] - Anna Petruczynik, Tomasz Tuzimski, Tomasz Plech, Justyna Misiurek, Karolina Szalast, Grażyna Szymczak. Comparison of Anticancer Activity and HPLC-DAD Determination of Selected Isoquinoline Alkaloids from Thalictrum foetidum, Berberis sp. and Chelidonium majus Extracts.
Molecules (Basel, Switzerland).
2019 Sep; 24(19):. doi:
10.3390/molecules24193417. [PMID: 31547046] - Cai-Feng Ding, Zhi Dai, Hao-Fei Yu, Xu-Dong Zhao, Xiao-Dong Luo. New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum.
Chinese journal of natural medicines.
2019 Sep; 17(9):698-706. doi:
10.1016/s1875-5364(19)30084-6. [PMID: 31526505] - Zhong-Min Zhao, Xiao-Fei Shang, Raymond Kobla Lawoe, Ying-Qian Liu, Rui Zhou, Yu Sun, Yin-Fang Yan, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine.
Pesticide biochemistry and physiology.
2019 Sep; 159(?):51-58. doi:
10.1016/j.pestbp.2019.05.015. [PMID: 31400784] - Yuan Tian, Wei Gui, Philip B Smith, Imhoi Koo, Iain A Murray, Margherita T Cantorna, Gary H Perdew, Andrew D Patterson. Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus).
Journal of agricultural and food chemistry.
2019 Aug; 67(33):9286-9294. doi:
10.1021/acs.jafc.9b03212. [PMID: 31339733] - Wei Li, Guotong Wang, Jixing Lai, Shengkun Li. Multifunctional isoquinoline-oxazoline ligands of chemical and biological importance.
Chemical communications (Cambridge, England).
2019 May; 55(42):5902-5905. doi:
10.1039/c9cc01790a. [PMID: 31045188] - Manju Bala, Shiv Kumar, Kunal Pratap, Praveen Kumar Verma, Yogendra Padwad, Bikram Singh. Bioactive isoquinoline alkaloids from Cissampelos pareira †.
Natural product research.
2019 Mar; 33(5):622-627. doi:
10.1080/14786419.2017.1402319. [PMID: 29126362] - Chunshun Li, Ariel M Sarotti, Xiaohua Wu, Baojun Yang, James Turkson, Yongfei Chen, Qingsong Liu, Shugeng Cao. An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431.
Molecules (Basel, Switzerland).
2019 Jan; 24(1):. doi:
10.3390/molecules24010196. [PMID: 30621059] - Nick Barton, Máire Convery, Anthony W J Cooper, Kenneth Down, J Nicole Hamblin, Graham Inglis, Simon Peace, James Rowedder, Paul Rowland, Jonathan A Taylor, Natalie Wellaway. Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach.
Journal of medicinal chemistry.
2018 12; 61(24):11061-11073. doi:
10.1021/acs.jmedchem.8b01556. [PMID: 30532965] - Shaimaa Fayez, Doris Feineis, Laurent Aké Assi, Marcel Kaiser, Reto Brun, Suresh Awale, Gerhard Bringmann. Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells.
Fitoterapia.
2018 Nov; 131(?):245-259. doi:
10.1016/j.fitote.2018.11.006. [PMID: 30419265] - Séverin Muyisa Kavatsurwa, Blaise Kimbadi Lombe, Doris Feineis, Dya Fita Dibwe, Vinesh Maharaj, Suresh Awale, Gerhard Bringmann. Ancistroyafungines A-D, 5,8'- and 5,1'-coupled naphthylisoquinoline alkaloids from a Congolese Ancistrocladus species, with antiausterity activities against human PANC-1 pancreatic cancer cells.
Fitoterapia.
2018 Oct; 130(?):6-16. doi:
10.1016/j.fitote.2018.07.017. [PMID: 30059720] - Mao-Sheng Zhang, Yan Deng, Shao-Bin Fu, Da-Le Guo, Shi-Ji Xiao. Mahimbrine A, a Novel Isoquinoline Alkaloid Bearing a Benzotropolone Moiety from Mahonia imbricata.
Molecules (Basel, Switzerland).
2018 Jun; 23(7):. doi:
10.3390/molecules23071539. [PMID: 29949909] - Kjell A Svensson, Beverly A Heinz, John M Schaus, James P Beck, Junliang Hao, Joseph H Krushinski, Matthew R Reinhard, Michael P Cohen, Sarah L Hellman, Brian G Getman, Xushan Wang, Michelle M Menezes, Deanna L Maren, Julie F Falcone, Wesley H Anderson, Rebecca A Wright, S Michelle Morin, Kelly L Knopp, Benjamin L Adams, Borys Rogovoy, Ilya Okun, Todd M Suter, Michael A Statnick, Donald R Gehlert, David L Nelson, Virginia L Lucaites, Renee Emkey, Neil W DeLapp, Todd R Wiernicki, Jeffrey W Cramer, Charles R Yang, Robert F Bruns. An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis.
The Journal of pharmacology and experimental therapeutics.
2017 Jan; 360(1):117-128. doi:
10.1124/jpet.116.236372. [PMID: 27811173] - Li-Hong Ye, Xi-De Liu, Jun Cao, Yan-Xu Chang, Mingrui An, Shu-Ling Wang, Jing-Jing Xu, Li-Qing Peng. Analysis of isoquinoline alkaloids using chitosan-assisted liquid-solid extraction followed by microemulsion liquid chromatography employing a sub-2-micron particle stationary phase.
Electrophoresis.
2016 12; 37(23-24):3118-3125. doi:
10.1002/elps.201600114. [PMID: 27699822] - Le Quynh Lien, Tran My Linh, Vu Huong Giang, Nguyen Chi Mai, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Thi Cuc, Hoang Le Tuan Anh, Ninh Khac Ban, Chau Van Minh, Phan Van Kiem. New naphthalene derivatives and isoquinoline alkaloids from Ancistrocladus cochinchinensis with their anti-proliferative activity on human cancer cells.
Bioorganic & medicinal chemistry letters.
2016 08; 26(16):3913-7. doi:
10.1016/j.bmcl.2016.07.014. [PMID: 27423477] - Joshua A Baccile, Joseph E Spraker, Henry H Le, Eileen Brandenburger, Christian Gomez, Jin Woo Bok, Juliane Macheleidt, Axel A Brakhage, Dirk Hoffmeister, Nancy P Keller, Frank C Schroeder. Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus.
Nature chemical biology.
2016 06; 12(6):419-24. doi:
10.1038/nchembio.2061. [PMID: 27065235] - Xianbao Deng, Lingping Zhu, Ting Fang, Sornkanok Vimolmangkang, Dong Yang, Collins Ogutu, Yanling Liu, Yuepeng Han. Analysis of Isoquinoline Alkaloid Composition and Wound-Induced Variation in Nelumbo Using HPLC-MS/MS.
Journal of agricultural and food chemistry.
2016 Feb; 64(5):1130-6. doi:
10.1021/acs.jafc.5b06099. [PMID: 26800445] - Hengjia Ni, Yordan Martínez, Guiping Guan, Román Rodríguez, Dairon Más, Hanhui Peng, Manuel Valdivié Navarro, Gang Liu. Analysis of the Impact of Isoquinoline Alkaloids, Derived from Macleaya cordata Extract, on the Development and Innate Immune Response in Swine and Poultry.
BioMed research international.
2016; 2016(?):1352146. doi:
10.1155/2016/1352146. [PMID: 28042566] - Kaisa A Salminen, Minna Rahnasto-Rilla, Raija Väänänen, Peter Imming, Achim Meyer, Aline Horling, Antti Poso, Tuomo Laitinen, Hannu Raunio, Maija Lahtela-Kakkonen. Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Dec; 43(12):1891-904. doi:
10.1124/dmd.115.065755. [PMID: 26400396] - Valery M Dembitsky, Tatyana A Gloriozova, Vladimir V Poroikov. Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Jan; 22(1):183-202. doi:
10.1016/j.phymed.2014.11.002. [PMID: 25636889] - Tsvetelina Doncheva, Amgalan Solongo, Nadezhda Kostova, Yadamsuren Gerelt-Od, Dangaa Selenge, Stefan Philipov. Leptopyrine, new alkaloid from Leptopyrum fumarioides L. (Ranunculaceae).
Natural product research.
2015; 29(9):853-6. doi:
10.1080/14786419.2014.991322. [PMID: 25529023] - Yali Chen, Min Li, Jianjun Liu, Qian Yan, Mei Zhong, Junxi Liu, Duolong Di, Jinxia Liu. Simultaneous determination of the content of isoquinoline alkaloids in Dicranostigma leptopodum (Maxim) Fedde and the effective fractionation of the alkaloids by high-performance liquid chromatography with diode array detection.
Journal of separation science.
2015 Jan; 38(1):9-17. doi:
10.1002/jssc.201400905. [PMID: 25330407] - Hui-Liang Zou, Hong-Yu Li, Bai-Lian Liu, Guang-Xiong Zhou. A new cytotoxic benzophenanthridine isoquinoline alkaloid from the fruits of Macleaya cordata.
Journal of Asian natural products research.
2015; 17(8):856-60. doi:
10.1080/10286020.2015.1016000. [PMID: 25761206] - Xuelong Yu, Xiaoli Gao, Zhixiang Zhu, Yuan Cao, Qian Zhang, Pengfei Tu, Xingyun Chai. Alkaloids from the tribe Bocconieae (papaveraceae): a chemical and biological review.
Molecules (Basel, Switzerland).
2014 Aug; 19(9):13042-60. doi:
10.3390/molecules190913042. [PMID: 25157468] - Azeana Zahari, Foo Kit Cheah, Jamaludin Mohamad, Syazreen Nadia Sulaiman, Marc Litaudon, Kok Hoong Leong, Khalijah Awang. Antiplasmodial and antioxidant isoquinoline alkaloids from Dehaasia longipedicellata.
Planta medica.
2014 May; 80(7):599-603. doi:
10.1055/s-0034-1368349. [PMID: 24723007] - Sayaree Dhar, Dipak Kumar Rana, Arunava Pal, Subhash Chandra Bhattacharya. Photobehavior and docking simulations of drug within macromolecules: binding of an antioxidative isoquinolindione to a serine protease and albumin proteins.
Journal of photochemistry and photobiology. B, Biology.
2013 Dec; 129(?):69-77. doi:
10.1016/j.jphotobiol.2013.09.007. [PMID: 24177206] - Hong Zhao, H Dorota Halicka, Jiangwei Li, Zbigniew Darzynkiewicz. Berberine suppresses gero-conversion from cell cycle arrest to senescence.
Aging.
2013 Aug; 5(8):623-36. doi:
10.18632/aging.100593. [PMID: 23974852] - Asama Mukherjee, Sushanta Dutta, Utpal Sanyal. Evaluation of antitumor efficacy and toxicity of novel 6-nitro-2-(3-chloropropyl)-1H-benz[de]isoquinoline-1,3-dione in vivo in mouse.
Journal of cancer research and therapeutics.
2013 Jul; 9(3):442-6. doi:
10.4103/0973-1482.119332. [PMID: 24125980] - Robert Domitrović, Hrvoje Jakovac, Vanja Vasiljev Marchesi, Biljana Blažeković. Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression.
Journal of medicinal food.
2013 Jun; 16(6):518-28. doi:
10.1089/jmf.2012.0175. [PMID: 23734997] - Yu Lei, Juan Tan, Michael Wink, Yonggang Ma, Na Li, Guannan Su. An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1.
Food chemistry.
2013 Feb; 136(3-4):1117-21. doi:
10.1016/j.foodchem.2012.09.059. [PMID: 23194502] - Fumihiko Sato, Hidehiko Kumagai. Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research.
Proceedings of the Japan Academy. Series B, Physical and biological sciences.
2013; 89(5):165-82. doi:
10.2183/pjab.89.165. [PMID: 23666088] - Yit-Lai Chow, Fumihiko Sato. Screening of isoquinoline alkaloids for potent lipid metabolism modulation with Caenorhabditis elegans.
Bioscience, biotechnology, and biochemistry.
2013; 77(12):2405-12. doi:
10.1271/bbb.130523. [PMID: 24317056] - Rolf Teschke, Christian Frenzel, Xaver Glass, Johannes Schulze, Axel Eickhoff. Greater Celandine hepatotoxicity: a clinical review.
Annals of hepatology.
2012 Nov; 11(6):838-48. doi:
10.1016/s1665-2681(19)31408-5. [PMID: 23109446] - Wei Zhang, Jin-Feng Hu, Wen-Wen Lv, Qing-Chun Zhao, Guo-Bing Shi. Antibacterial, antifungal and cytotoxic isoquinoline alkaloids from Litsea cubeba.
Molecules (Basel, Switzerland).
2012 Nov; 17(11):12950-60. doi:
10.3390/molecules171112950. [PMID: 23117434] - Eduardo Sobarzo-Sánchez, Patricio González Soto, Cristóbal Valdés Rivera, Georgina Sánchez, María Eliana Hidalgo. Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine.
Molecules (Basel, Switzerland).
2012 Sep; 17(9):10958-70. doi:
10.3390/molecules170910958. [PMID: 22971581] - Mayurkumar B Patel, Shrihari Mishra. Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase.
Phytotherapy research : PTR.
2012 Sep; 26(9):1342-7. doi:
10.1002/ptr.3721. [PMID: 22294283] - Phurpa Wangchuk, Paul A Keller, Stephen G Pyne, Anthony C Willis, Sumalee Kamchonwongpaisan. Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.
Journal of ethnopharmacology.
2012 Aug; 143(1):310-3. doi:
10.1016/j.jep.2012.06.037. [PMID: 22796506] - Lihong Liu, Zilin Chen. Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.
Analytica chimica acta.
2012 Aug; 737(?):99-104. doi:
10.1016/j.aca.2012.05.054. [PMID: 22769040] - Ayami Nakagawa, Hiro Takahashi, Shoko Kojima, Nobuo Sato, Kazuomi Ohga, Byung Yoon Cha, Je-Tae Woo, Kazuo Nagai, Gorou Horiguchi, Hirokazu Tsukaya, Yasunori Machida, Chiyoko Machida. Berberine enhances defects in the establishment of leaf polarity in asymmetric leaves1 and asymmetric leaves2 of Arabidopsis thaliana.
Plant molecular biology.
2012 Aug; 79(6):569-81. doi:
10.1007/s11103-012-9929-7. [PMID: 22684430] - Zhifeng Wei, Fengyun Wang, Jie Song, Qian Lu, Peng Zhao, Yufeng Xia, Guixin Chou, Zhengtao Wang, Yue Dai. Norisoboldine inhibits the production of interleukin-6 in fibroblast-like synoviocytes from adjuvant arthritis rats through PKC/MAPK/NF-κB-p65/CREB pathways.
Journal of cellular biochemistry.
2012 Aug; 113(8):2785-95. doi:
10.1002/jcb.24156. [PMID: 22473817] - K Iwasa, M Moriyasu, W Wiegrebe. Some contributions to the application of LC-NMR, LC-MS, and LC-CD to the biosynthesis of isoquinoline alkaloids using callus cultures.
Die Pharmazie.
2012 Jul; 67(7):571-85. doi:
". [PMID: 22888511] - Lian Chen, Martin Conda-Sheridan, P V Narasimha Reddy, Andrew Morrell, Eun-Jung Park, Tamara P Kondratyuk, John M Pezzuto, Richard B van Breemen, Mark Cushman. Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.
Journal of medicinal chemistry.
2012 Jun; 55(12):5965-81. doi:
10.1021/jm3006806. [PMID: 22712432] - Phurpa Wangchuk, Paul A Keller, Stephen G Pyne, Thanapat Sastraruji, Malai Taweechotipatr, Roonglawan Rattanajak, Aunchalee Tonsomboon, Sumalee Kamchonwongpaisan. Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa.
Natural product communications.
2012 May; 7(5):575-80. doi:
. [PMID: 22799079] - Anirban Basu, Parasuraman Jaisankar, Gopinatha Suresh Kumar. Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects.
Bioorganic & medicinal chemistry.
2012 Apr; 20(8):2498-505. doi:
10.1016/j.bmc.2012.03.006. [PMID: 22459209] - Wei-Han Chueh, Jin-Yuarn Lin. Protective effect of berberine on serum glucose levels in non-obese diabetic mice.
International immunopharmacology.
2012 Mar; 12(3):534-8. doi:
10.1016/j.intimp.2012.01.003. [PMID: 22266065] - Fabien Caillé, Célia S Bonnet, Frédéric Buron, Sandrine Villette, Lothar Helm, Stéphane Petoud, Franck Suzenet, Eva Tóth. Isoquinoline-based lanthanide complexes: bright NIR optical probes and efficient MRI agents.
Inorganic chemistry.
2012 Feb; 51(4):2522-32. doi:
10.1021/ic202446e. [PMID: 22233349] - Jeong-Seok Hong, Yeun-Kyung Chu, Hyung Lee, Byung-Hoon Ahn, Jae-Hyung Park, Mi-Jung Kim, Sunghye Lee, Ho-Sang Ryoo, Jung-Hee Jang, Seong-Ryong Lee, Jong-Wook Park. Effects of berberine on hippocampal neuronal damage and matrix metalloproteinase-9 activity following transient global cerebral ischemia.
Journal of neuroscience research.
2012 Feb; 90(2):489-97. doi:
10.1002/jnr.22756. [PMID: 22052603] - Philip J Jensen, Noemi Halbrendt, Gennaro Fazio, Izabela Makalowska, Naomi Altman, Craig Praul, Siela N Maximova, Henry K Ngugi, Robert M Crassweller, James W Travis, Timothy W McNellis. Rootstock-regulated gene expression patterns associated with fire blight resistance in apple.
BMC genomics.
2012 Jan; 13(?):9. doi:
10.1186/1471-2164-13-9. [PMID: 22229964] - Yaou Shen, Zhou Jiang, Xiadong Yao, Zhiming Zhang, Haijian Lin, Maojun Zhao, Hailan Liu, Huanwei Peng, Shujun Li, Guangtang Pan. Genome expression profile analysis of the immature maize embryo during dedifferentiation.
PloS one.
2012; 7(3):e32237. doi:
10.1371/journal.pone.0032237. [PMID: 22448216] - Angela I Calderón, Johayra Simithy-Williams, Mahabir P Gupta. Antimalarial natural products drug discovery in Panama.
Pharmaceutical biology.
2012 Jan; 50(1):61-71. doi:
10.3109/13880209.2011.602417. [PMID: 22196582] - Takashi Sugane, Takahiko Tobe, Wataru Hamaguchi, Itsuro Shimada, Kyoichi Maeno, Junji Miyata, Takeshi Suzuki, Tetsuya Kimizuka, Takuma Morita, Shuichi Sakamoto, Shin-ichi Tsukamoto. Synthesis and biological evaluation of (4H-1,2,4-triazol-4-yl)isoquinoline derivatives as selective glycine transporter 1 inhibitors.
Bioorganic & medicinal chemistry.
2012 Jan; 20(1):34-41. doi:
10.1016/j.bmc.2011.11.038. [PMID: 22177408] - Wei Wei, Hongmin Zhao, Aili Wang, Ming Sui, Kun Liang, Haiyun Deng, Yukun Ma, Yajuan Zhang, Hongxiu Zhang, Yuanyuan Guan. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome.
European journal of endocrinology.
2012 Jan; 166(1):99-105. doi:
10.1530/eje-11-0616. [PMID: 22019891] - Gabriele Multhoff, Jürgen Radons. Radiation, inflammation, and immune responses in cancer.
Frontiers in oncology.
2012; 2(?):58. doi:
10.3389/fonc.2012.00058. [PMID: 22675673] - Jackson Roberto Guedes da Silva Almeida, Edigênia Cavalcante da Cruz Araújo, Luciano Augusto de Araújo Ribeiro, Julianeli Tolentino de Lima, Xirley Pereira Nunes, Ana Sílvia Suassuna Carneiro Lúcio, Maria de Fátima Agra, José Maria Barbosa Filho. Antinociceptive activity of ethanol extract from Duguetia chrysocarpa Maas (Annonaceae).
TheScientificWorldJournal.
2012; 2012(?):859210. doi:
10.1100/2012/859210. [PMID: 22645460] - Qiao-Qin Huang, Jun-Long Bi, Qian-Yun Sun, Fu-Mei Yang, Yue-Hu Wang, Gui-Hua Tang, Fu-Wei Zhao, Huan Wang, Jin-Jin Xu, Edward J Kennelly, Chun-Lin Long, Ge-Fen Yin. Bioactive isoquinoline alkaloids from Corydalis saxicola.
Planta medica.
2012 Jan; 78(1):65-70. doi:
10.1055/s-0031-1280126. [PMID: 21858757] - Md Sarfaraj Hussain, Sheeba Fareed, Saba Ansari, Md Akhlaquer Rahman, Iffat Zareen Ahmad, Mohd Saeed. Current approaches toward production of secondary plant metabolites.
Journal of pharmacy & bioallied sciences.
2012 Jan; 4(1):10-20. doi:
10.4103/0975-7406.92725. [PMID: 22368394] - Sharanappa M Bagale, Adrienne S Brown, Melissa M Carballosa Gonzalez, Alberto Vitores, Teresa L Micotto, N S Saleesh Kumar, Ian D Hentall, James N Wilson. Fluorescent reporters of monoamine transporter distribution and function.
Bioorganic & medicinal chemistry letters.
2011 Dec; 21(24):7387-91. doi:
10.1016/j.bmcl.2011.10.007. [PMID: 22047697] - Tianjiong Lou, Zhongai Zhang, Zhilei Xi, Kang Liu, Lin Li, Baolin Liu, Fang Huang. Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes.
Inflammation.
2011 Dec; 34(6):659-67. doi:
10.1007/s10753-010-9276-2. [PMID: 21110076] - Chad E Cecil, Jeanine M Davis, Nadja B Cech, Scott M Laster. Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis).
International immunopharmacology.
2011 Nov; 11(11):1706-14. doi:
10.1016/j.intimp.2011.06.002. [PMID: 21683808] - Yasuyuki Yamada, Tomotsugu Koyama, Fumihiko Sato. Basic helix-loop-helix transcription factors and regulation of alkaloid biosynthesis.
Plant signaling & behavior.
2011 Nov; 6(11):1627-30. doi:
10.4161/psb.6.11.17599. [PMID: 22067108] - Z-J Huang, Y Zeng, P Lan, P-H Sun, W-M Chen. Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine.
Mini reviews in medicinal chemistry.
2011 Nov; 11(13):1122-9. doi:
10.2174/138955711797655362. [PMID: 22353221] - Ying Guo, Chad Pope, Xingguo Cheng, Honghao Zhou, Curtis D Klaassen. Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice.
Journal of ethnopharmacology.
2011 Oct; 138(1):111-8. doi:
10.1016/j.jep.2011.08.058. [PMID: 21920422] - Mayurkumar B Patel, Shrihari Mishra. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Sep; 18(12):1045-52. doi:
10.1016/j.phymed.2011.05.006. [PMID: 21665451] - Marianna A Patrauchan, J Jacob Parnell, Michael P McLeod, Christine Florizone, James M Tiedje, Lindsay D Eltis. Genomic analysis of the phenylacetyl-CoA pathway in Burkholderia xenovorans LB400.
Archives of microbiology.
2011 Sep; 193(9):641-50. doi:
10.1007/s00203-011-0705-x. [PMID: 21519854] - Tae Ho Lee, Ki Hyun Kim, Sung Ok Lee, Kang Ro Lee, Miwon Son, Mirim Jin. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function.
The Journal of pharmacology and experimental therapeutics.
2011 Sep; 338(3):917-24. doi:
10.1124/jpet.111.182048. [PMID: 21659472] - Waranya Chatuphonprasert, Thewtas Sangkawat, Nobuo Nemoto, Kanokwan Jarukamjorn. Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine.
Fitoterapia.
2011 Sep; 82(6):889-95. doi:
10.1016/j.fitote.2011.05.002. [PMID: 21624442] - Maria Kulp, Olga Bragina, Priit Kogerman, Mihkel Kaljurand. Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L.
Journal of chromatography. A.
2011 Aug; 1218(31):5298-304. doi:
10.1016/j.chroma.2011.06.016. [PMID: 21726876] - Wei-Han Chueh, Jin-Yuarn Lin. Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice.
Journal of agricultural and food chemistry.
2011 Jul; 59(14):8021-7. doi:
10.1021/jf201627w. [PMID: 21696141] - Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen, Yitao Wang. Anti-cancer natural products isolated from chinese medicinal herbs.
Chinese medicine.
2011 Jul; 6(1):27. doi:
10.1186/1749-8546-6-27. [PMID: 21777476] - Hao Wu, Li-Bing Zhang, Li-Ming Du. Ionic liquid sensitized fluorescence determination of four isoquinoline alkaloids.
Talanta.
2011 Jul; 85(1):787-93. doi:
10.1016/j.talanta.2011.04.076. [PMID: 21645774] - Yasuyuki Yamada, Yasuhisa Kokabu, Kaori Chaki, Tadashi Yoshimoto, Mai Ohgaki, Sayumi Yoshida, Nobuhiko Kato, Tomotsugu Koyama, Fumihiko Sato. Isoquinoline alkaloid biosynthesis is regulated by a unique bHLH-type transcription factor in Coptis japonica.
Plant & cell physiology.
2011 Jul; 52(7):1131-41. doi:
10.1093/pcp/pcr062. [PMID: 21576193] - Qian Hou, Xu Tang, Hanqiang Liu, Junqi Tang, Ying Yang, Xiaohong Jing, Qian Xiao, Wen Wang, Xingchun Gou, Zongren Wang. Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147.
Cancer science.
2011 Jul; 102(7):1287-92. doi:
10.1111/j.1349-7006.2011.01933.x. [PMID: 21443647] - Guo-Ying Zuo, Fan-Yan Meng, Jun Han, Xiao-Yan Hao, Gen-Chun Wang, Yun-Ling Zhang, Qing Zhang. In vitro activity of plant extracts and alkaloids against clinical isolates of extended-spectrum β-lactamase (ESBL)-producing strains.
Molecules (Basel, Switzerland).
2011 Jun; 16(7):5453-9. doi:
10.3390/molecules16075453. [PMID: 21712759] - Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Santosh Tawari, Shaktipal Patil, Pankaj Dixit, Sudhir Umathe, Dharmendra Mundhada. Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Behavioural brain research.
2011 Jun; 220(1):30-41. doi:
10.1016/j.bbr.2011.01.022. [PMID: 21262264] - Ferenc Zsila, Judit Kámán, Borbála Bogányi, Dávid Józsvai. Binding of alkaloids into the S1 specificity pocket of α-chymotrypsin: evidence from induced circular dichroism spectra.
Organic & biomolecular chemistry.
2011 Jun; 9(11):4127-37. doi:
10.1039/c0ob01221a. [PMID: 21483967] - Nan Dong, Li-na Cheng, Xiu-lin Wang, Qin Li, Chuan-yu Dai, Zhu Tao. Significant fluorescence enhancement by supramolecular complex formation between berberine chloride and cucurbit(n=7)uril and its analytical application.
Talanta.
2011 May; 84(3):684-9. doi:
10.1016/j.talanta.2011.01.071. [PMID: 21482268] - Jakub Chlebek, Katerina Macáková, Lucie Cahlíkovi, Milan Kurfürst, Jirí Kunes, Lubomir Opletal. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava (Fumariaceae).
Natural product communications.
2011 May; 6(5):607-10. doi:
. [PMID: 21615017] - D Naveen Chandra, G K Prasanth, Nagendra Singh, Sanjit Kumar, O Jithesh, C Sadasivan, Sujatha Sharma, Tej P Singh, M Haridas. Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93Å and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine.
Biochimica et biophysica acta.
2011 May; 1814(5):657-63. doi:
10.1016/j.bbapap.2011.03.002. [PMID: 21420512] - Kristýna Pěnčíková, Jana Urbanová, Pavel Musil, Eva Táborská, Jana Gregorová. Seasonal variation of bioactive alkaloid contents in Macleaya microcarpa (Maxim.) Fedde.
Molecules (Basel, Switzerland).
2011 Apr; 16(4):3391-401. doi:
10.3390/molecules16043391. [PMID: 21512447] - Kaisa A Salminen, Achim Meyer, Lenka Jerabkova, Laura E Korhonen, Minna Rahnasto, Risto O Juvonen, Peter Imming, Hannu Raunio. Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Apr; 18(6):533-8. doi:
10.1016/j.phymed.2010.08.012. [PMID: 20851588] - Sutapa Mahata, Alok C Bharti, Shirish Shukla, Abhishek Tyagi, Syed A Husain, Bhudev C Das. Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells.
Molecular cancer.
2011 Apr; 10(?):39. doi:
10.1186/1476-4598-10-39. [PMID: 21496227] - Sean M Watts, Craig D Dodson, O J Reichman. The roots of defense: plant resistance and tolerance to belowground herbivory.
PloS one.
2011 Apr; 6(4):e18463. doi:
10.1371/journal.pone.0018463. [PMID: 21494690] - Weicheng Hu, Lingling Yu, Myeong-Hyeon Wang. Antioxidant and antiproliferative properties of water extract from Mahonia bealei (Fort.) Carr. leaves.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Apr; 49(4):799-806. doi:
10.1016/j.fct.2010.12.001. [PMID: 21130829] - Philippe Rasoanaivo, Colin W Wright, Merlin L Willcox, Ben Gilbert. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions.
Malaria journal.
2011 Mar; 10 Suppl 1(?):S4. doi:
10.1186/1475-2875-10-s1-s4. [PMID: 21411015]
