ganciclovir (BioDeep_00001867669)
Main id: BioDeep_00000003391
Chemicals and Drugs natural product
代谢物信息卡片
ganciclovir
化学式: C9H13N5O4 (255.0967)
中文名称: 更昔洛韦 水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N
InChI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
描述信息
An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AD - Antivirals
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].
同义名列表
4 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:465284
- KEGG: C07019
- KEGGdrug: D00333
- PubChem: 135398740
- DrugBank: DB01004
- ChEMBL: CHEMBL182
- MeSH: Ganciclovir
- CAS: 82410-32-0
- MetaboLights: MTBLC465284
- PubChem: 9231
- PDB-CCD: GA2
- medchemexpress: HY-13637
- LOTUS: LTS0147632
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
8 个相关的物种来源信息
- 7711 - Chordata: LTS0147632
- 2759 - Eukaryota: LTS0147632
- 9604 - Hominidae: LTS0147632
- 9605 - Homo: LTS0147632
- 9606 - Homo sapiens: 10.1038/NBT.2488
- 9606 - Homo sapiens: LTS0147632
- 40674 - Mammalia: LTS0147632
- 33208 - Metazoa: LTS0147632
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Diana D Wong, Wendy J van Zuylen, Talia Novos, Sophie Stocker, Stephanie E Reuter, Jane Au, Charles S P Foster, Richard O Day, Andrea R Horvath, Zoltan Endre, William D Rawlinson. Detection of Ganciclovir-Resistant Cytomegalovirus in a Prospective Cohort of Kidney Transplant Recipients Receiving Subtherapeutic Valganciclovir Prophylaxis.
Microbiology spectrum.
2022 06; 10(3):e0268421. doi:
10.1128/spectrum.02684-21. [PMID: 35658598] - Mengyun Liu, Hengqian He, Qinkang Lu, Juntao Zhang. CMV retinitis and subsequent acute cystoid macular oedema after treatment with vitreous ganciclovir injection: a case report.
BMC ophthalmology.
2022 Jun; 22(1):284. doi:
10.1186/s12886-022-02500-0. [PMID: 35764964] - Rachel Hellemans, Daniel Abramowicz. Cytomegalovirus after kidney transplantation in 2020: moving towards personalized prevention.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2022 04; 37(5):810-816. doi:
10.1093/ndt/gfaa249. [PMID: 33280028] - Andreas Ärlemalm, Anders Helldén, Louise Karlsson, Björn Carlsson. Rapid determination of acyclovir, its main metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum using LC-MS/MS.
Biomedical chromatography : BMC.
2022 Apr; 36(4):e5315. doi:
10.1002/bmc.5315. [PMID: 34981553] - Mei Meng, Sheng Zhang, Xuan Dong, Wenqing Sun, Yunfeng Deng, Wenzhe Li, Ranran Li, Djillali Annane, Zhixiong Wu, Dechang Chen. COVID-19 associated EBV reactivation and effects of ganciclovir treatment.
Immunity, inflammation and disease.
2022 04; 10(4):e597. doi:
10.1002/iid3.597. [PMID: 35349757] - Aurora Páez-Vega, Belén Gutiérrez-Gutiérrez, Maria L Agüera, Carme Facundo, Dolores Redondo-Pachón, Marta Suñer, Maria O López-Oliva, Jose R Yuste, Miguel Montejo, Cristina Galeano-Álvarez, Juan C Ruiz-San Millan, Ibai Los-Arcos, Domingo Hernández, Mario Fernández-Ruiz, Patricia Muñoz, Jorge Valle-Arroyo, Angela Cano, Alberto Rodríguez-Benot, Marta Crespo, Cristian Rodelo-Haad, María A Lobo-Acosta, Jose C Garrido-Gracia, Elisa Vidal, Luis Guirado, Sara Cantisán, Julian Torre-Cisneros. Immunoguided Discontinuation of Prophylaxis for Cytomegalovirus Disease in Kidney Transplant Recipients Treated With Antithymocyte Globulin: A Randomized Clinical Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 03; 74(5):757-765. doi:
10.1093/cid/ciab574. [PMID: 34228099] - Fernanda Ortiz, Marko Lempinen, Sari Aaltonen, Niina Koivuviita, Ilkka Helanterä. Letermovir treatment for CMV infection in kidney and pancreas transplantation: A valuable option for complicated cases.
Clinical transplantation.
2022 02; 36(2):e14537. doi:
10.1111/ctr.14537. [PMID: 34797574] - Margaret R Jorgenson, Hanna Kleiboeker, Neetika Garg, Sandesh Parajuli, Didier A Mandelbrot, Jon S Odorico, Christopher M Saddler, Jeannina A Smith. Letermovir conversion after valganciclovir treatment in cytomegalovirus high-risk abdominal solid organ transplant recipients may promote development of cytomegalovirus-specific cell mediated immunity.
Transplant infectious disease : an official journal of the Transplantation Society.
2022 Feb; 24(1):e13766. doi:
10.1111/tid.13766. [PMID: 34799964] - Paolo Antonio Grossi, Nassim Kamar, Faouzi Saliba, Fausto Baldanti, Jose M Aguado, Jens Gottlieb, Bernhard Banas, Luciano Potena. Cytomegalovirus Management in Solid Organ Transplant Recipients: A Pre-COVID-19 Survey From the Working Group of the European Society for Organ Transplantation.
Transplant international : official journal of the European Society for Organ Transplantation.
2022; 35(?):10332. doi:
10.3389/ti.2022.10332. [PMID: 35812158] - Narisa Ruenroengbun, Tunlanut Sapankaew, Kamolpat Chaiyakittisopon, Pakpoom Phoompoung, Thundon Ngamprasertchai. Efficacy and Safety of Antiviral Agents in Preventing Allograft Rejection Following CMV Prophylaxis in High-Risk Kidney Transplantation: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Frontiers in cellular and infection microbiology.
2022; 12(?):865735. doi:
10.3389/fcimb.2022.865735. [PMID: 35433502] - Orhan Corum, Kamil Uney, Duygu Durna Corum, Orkun Atik, Devran Coskun, Aidai Zhunushova, Muammer Elmas. Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar).
Journal of veterinary pharmacology and therapeutics.
2022 Jan; 45(1):126-132. doi:
10.1111/jvp.13027. [PMID: 34719792] - Daniel Scotcher, Aleksandra Galetin. PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid Intake.
The AAPS journal.
2021 12; 24(1):13. doi:
10.1208/s12248-021-00654-1. [PMID: 34907479] - Cristina Hernandez, Curtis Mabilangan, Catherine Burton, Karen Doucette, Jutta Preiksaitis. Cytomegalovirus transmission in mismatched solid organ transplant recipients: Are factors other than anti-viral prophylaxis at play?.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2021 12; 21(12):3958-3970. doi:
10.1111/ajt.16734. [PMID: 34174153] - Narisa Ruenroengbun, Pawin Numthavaj, Tunlanut Sapankaew, Kamolpat Chaiyakittisopon, Atiporn Ingsathit, Gareth J Mckay, John Attia, Ammarin Thakkinstian. Efficacy and safety of conventional antiviral agents in preventive strategies for cytomegalovirus infection after kidney transplantation: a systematic review and network meta-analysis.
Transplant international : official journal of the European Society for Organ Transplantation.
2021 12; 34(12):2720-2734. doi:
10.1111/tri.14122. [PMID: 34580930] - Yiyun Shi, Alexis Hope Lerner, Ralph Rogers, Kendra Vieira, Basma Merhi, Krista Mecadon, Adena J Osband, George Bayliss, Reginald Gohh, Paul Morrissey, Dimitrios Farmakiotis. Low-Dose Valganciclovir Prophylaxis Is Safe and Cost-Saving in CMV-Seropositive Kidney Transplant Recipients.
Progress in transplantation (Aliso Viejo, Calif.).
2021 12; 31(4):368-376. doi:
10.1177/15269248211046037. [PMID: 34839729] - Elena Rho, Bettina Näf, Thomas F Müller, Rudolf P Wüthrich, Thomas Schachter, Seraina von Moos. Use of letermovir-valganciclovir combination as a step-down treatment after foscarnet for ganciclovir-resistant CMV infection in kidney transplant recipients.
Clinical transplantation.
2021 11; 35(11):e14401. doi:
10.1111/ctr.14401. [PMID: 34181768] - Bénédicte Franck, Julie Autmizguine, Anders Åsberg, Yves Théorêt, Pierre Marquet, Philippe Ovetchkine, Jean-Baptiste Woillard. Thoroughly Validated Bayesian Estimator and Limited Sampling Strategy for Dose Individualization of Ganciclovir and Valganciclovir in Pediatric Transplant Recipients.
Clinical pharmacokinetics.
2021 11; 60(11):1449-1462. doi:
10.1007/s40262-021-01034-w. [PMID: 34050910] - Alexandra L Bixby, Linda Fitzgerald, Jeong M Park, Daniel Kaul, Sarah Tischer. Comparison of standard versus low-dose valganciclovir regimens for cytomegalovirus prophylaxis in high-risk liver transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Oct; 23(5):e13713. doi:
10.1111/tid.13713. [PMID: 34428337] - Margaret R Jorgenson, Jillian L Descourouez, Glen E Leverson, Christopher M Saddler, Jeannina A Smith, Neetika Garg, Sandesh Parajuli, Didier A Mandelbrot, Jon S Odorico. A pilot study of an intensified ganciclovir dosing strategy for treatment of cytomegalovirus disease in kidney and/or pancreas transplant recipients.
Clinical transplantation.
2021 10; 35(10):e14427. doi:
10.1111/ctr.14427. [PMID: 34263938] - Marta Santos Bravo, Nicolas Plault, Sonsoles Sánchez Palomino, María Mar Mosquera Gutierrez, Francesc Fernández Avilés, María Suarez Lledo, Nuria Sabé Fernández, Montserrat Rovira, Sophie Alain, M Ángeles Marcos Maeso. Phenotype and Genotype Study of Novel C480F Maribavir-Ganciclovir Cross-Resistance Mutation Detected in Hematopoietic Stem Cell and Solid Organ Transplant Recipients.
The Journal of infectious diseases.
2021 09; 224(6):1024-1028. doi:
10.1093/infdis/jiab029. [PMID: 33475730] - Anne-Grete Märtson, Angela E Edwina, Johannes G M Burgerhof, Stefan P Berger, Anoek de Joode, Kevin Damman, Erik A M Verschuuren, Hans Blokzijl, Martijn Bakker, Lambert F Span, Tjip S van der Werf, Daan J Touw, Marieke G G Sturkenboom, Marjolein Knoester, Jan W C Alffenaar. Ganciclovir therapeutic drug monitoring in transplant recipients.
The Journal of antimicrobial chemotherapy.
2021 08; 76(9):2356-2363. doi:
10.1093/jac/dkab195. [PMID: 34160036] - Margaret R Jorgenson, Cynthia Wong, Jillian L Descourouez, Christopher M Saddler, Jeannina A Smith, Didier A Mandelbrot. Conversion from cytomegalovirus universal prophylaxis with valganciclovir to the preemptive monitoring approach to manage leukopenia after kidney or pancreas transplantation.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13617. doi:
10.1111/tid.13617. [PMID: 33866643] - Bénédicte Franck, Jean-Baptiste Woillard, Yves Théorêt, Henrique Bittencourt, Emile Demers, Annabelle Briand, Pierre Marquet, Anne-Laure Lapeyraque, Philippe Ovetchkine, Julie Autmizguine. Population pharmacokinetics of ganciclovir and valganciclovir in paediatric solid organ and stem cell transplant recipients.
British journal of clinical pharmacology.
2021 08; 87(8):3105-3114. doi:
10.1111/bcp.14719. [PMID: 33373493] - Margaret R Jorgenson, Jillian L Descourouez, Neetika Garg, Sandesh Parajuli, Didier A Mandelbrot, Jon S Odorico, Christopher M Saddler, Jeannina A Smith. The addition of adjunctive letermovir to valganciclovir for refractory cytomegalovirus viremia in kidney transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13693. doi:
10.1111/tid.13693. [PMID: 34309158] - Hillary Stamps, Kristin Linder, David M O'Sullivan, Oscar K Serrano, Caroline Rochon, Zeynep Ebcioglu, Joseph Singh, Xiaoyi Ye, Joseph Tremaglio, Patricia Sheiner, Faiqa Cheema, Heather L Kutzler. Evaluation of cytomegalovirus prophylaxis in low and intermediate risk kidney transplant recipients receiving lymphocyte-depleting induction.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13573. doi:
10.1111/tid.13573. [PMID: 33527728] - Isabel Rodríguez-Goncer, María Ruiz-Ruigómez, Francisco López-Medrano, Laura Corbella, Natalia Polanco, Esther González Monte, Rafael San Juan, Tamara Ruiz-Merlo, Patricia Parra, Lola Folgueira, Amado Andrés, José María Aguado, Mario Fernández-Ruiz. CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13597. doi:
10.1111/tid.13597. [PMID: 33751753] - Gaurav Bhandari, Vaibhav Tiwari, Anurag Gupta, Sunila Jain, Pallav Gupta, Vinant Bhargava, Manish Malik, Ashwani Gupta, Anil Kumar Bhalla, Devender Singh Rana. CMV presenting as a skin growth in renal transplant patient.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13590. doi:
10.1111/tid.13590. [PMID: 33641219] - Ute Saunders, Mao Li, Srinivasa R Boddeda, Sonya Maher, Jessica Ghere, Irina Kaptsan, Ravi Dhital, Victoria Velazquez, Lingling Guo, Bo Chen, Qiang Zeng, Trenton R Schoeb, Rachel Cianciolo, Masako Shimamura. Murine Cytomegalovirus-induced Complement-fixing Antibodies Deposit in Murine Renal Allografts During Acute Rejection.
Transplantation.
2021 08; 105(8):1718-1729. doi:
10.1097/tp.0000000000003548. [PMID: 33214535] - Juulia Räihä, Fernanda Ortiz, Laura Mannonen, Raisa Loginov, Marko Lempinen, Irmeli Lautenschlager, Ilkka Helanterä. The burden of cytomegalovirus infection remains high in high-risk kidney transplant recipients despite six-month valganciclovir prophylaxis.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13577. doi:
10.1111/tid.13577. [PMID: 33527660] - Miguel Enrique Cervera-Hernandez, Kenji Ikemura, Margaret E McCort. Cytomegalovirus skin disease in a kidney transplant patient.
BMJ case reports.
2021 Jul; 14(7):. doi:
10.1136/bcr-2020-236903. [PMID: 34226250] - Walter Domingo, Isabelle T Nguyen, Joyce J Johnsrud, Janice Wes Brown. Continuous-Infusion Foscarnet Facilitates Administration in Hematopoietic Stem Cell Transplantation Patients.
Transplantation and cellular therapy.
2021 07; 27(7):622.e1-622.e5. doi:
10.1016/j.jtct.2021.03.018. [PMID: 33891883] - Andrew S Jarrell, Jessica R Crow, Sara E Strout, Rachel M Kruer, Lindsey P Toman, Maria V Dioverti-Prono, Laura Lees, Robin K Avery, Mark A Marzinke. Valganciclovir Dosing for Cytomegalovirus Prophylaxis in Solid-organ Transplant Recipients on Continuous Veno-venous Hemodialysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 07; 73(1):101-106. doi:
10.1093/cid/ciaa537. [PMID: 32379860] - K R Anavi, C Nel, M J Savage-Reid, K E Adzatia, J S Nel. Cytomegalovirus-associated supraglottic mass in a patient on immunosuppressive therapy.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
2021 Jun; 111(7):623-626. doi:
10.7196/samj.2021.v111i7.15614. [PMID: 34382544] - Kaisei Kamatani, Tsuneaki Kenzaka, Ryu Sugimoto, Ayako Kumabe, Akihito Kitao, Hozuka Akita. Multiple thrombosis associated with Cytomegalovirus enterocolitis in an immunocompetent patient: a case report.
BMC infectious diseases.
2021 Jun; 21(1):530. doi:
10.1186/s12879-021-06230-4. [PMID: 34090366] - Jorge Andrade-Sierra, Alejandro Heredia-Pimentel, Enrique Rojas-Campos, Diana Ramírez Flores, José I Cerrillos-Gutierrez, Alejandra G Miranda-Díaz, Luis A Evangelista-Carrillo, Petra Martínez-Martínez, Basilio Jalomo-Martínez, Eduardo Gonzalez-Espinoza, Benjamin Gómez-Navarro, Miguel Medina-Pérez, Juan José Nieves-Hernández. Cytomegalovirus in renal transplant recipients from living donors with and without valganciclovir prophylaxis and with immunosuppression based on anti-thymocyte globulin or basiliximab.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Jun; 107(?):18-24. doi:
10.1016/j.ijid.2021.04.032. [PMID: 33862205] - Montserrat Rodriguez-Reyes, Carmen López-Cabezas, Elena Calvo-Cidoncha, Dolors Soy-Muner. Dose banding of intravenous ganciclovir: Banding scheme proposal and audit of toxicity and efficiency.
Journal of clinical pharmacy and therapeutics.
2021 Jun; 46(3):767-771. doi:
10.1111/jcpt.13347. [PMID: 33421169] - Hugoline Boulay, Emmanuel Oger, Diego Cantarovich, Philippe Gatault, Antoine Thierry, Yannick Le Meur, Agnès Duveau, Cécile Vigneau, Nolwenn Lorcy. Among CMV-positive renal transplant patients receiving non-T-cell depleting induction, the absence of CMV disease prevention is a safe strategy: A retrospective cohort of 372 patients.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Jun; 23(3):e13541. doi:
10.1111/tid.13541. [PMID: 33270341] - Aaron P Pearston, Amanda I Ingemi, Kathryn Ripley, Tyler J Wilson, Jacqueline Gruber, Megan McMahon, Sharon Sutton, Nancy Khardori. Successful Treatment of UL97 Mutation Ganciclovir-Resistant Cytomegalovirus Viremia in a Renal Transplant Recipient With Letermovir and Adjunct Hyperimmune Cytomegalovirus Immunoglobulin: A Case Report.
Transplantation proceedings.
2021 May; 53(4):1284-1287. doi:
10.1016/j.transproceed.2021.02.001. [PMID: 33715819] - Muruj Jumah, Farah Rahman, Mark Figgie, Ankita Prasad, Anthony Zampino, Ali Fadhil, Kaitlin Palmer, Robin Arthur Buerki, Steven Gunzler, Praveen Gundelly, Hesham Abboud. COVID-19, HHV6 and MOG antibody: A perfect storm.
Journal of neuroimmunology.
2021 04; 353(?):577521. doi:
10.1016/j.jneuroim.2021.577521. [PMID: 33607505] - Jhoana Katherine Panez-Gallardo, Noé Atamari-Anahui, Yesenia Limache-Ontiveros, Maycol Suker Ccorahua-Rios, Iveth Miranda-Abarca, Carlos A Orellana-Siuce, John A Cabrera-Enríquez. [Cytomegalovirus hepatitis in a 2-month-old infant: a case report].
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru.
2021 Apr; 41(2):121-125. doi:
NULL. [PMID: 34724695] - Andrew C Lewin, Chin-Chi Liu, Christopher Alling, Pilar Camacho-Luna, Bruna Miessler, Renee T Carter. In vitro efficacy of ganciclovir against feline herpesvirus type 1 and assessment of ocular tolerability in healthy cats.
Journal of feline medicine and surgery.
2021 04; 23(4):400-404. doi:
10.1177/1098612x20944363. [PMID: 32749191] - Rachel Hellemans, Veerle Wijtvliet, Kristof Bergs, Ester Philipse, Rowena Vleut, Annick Massart, Marie-Madeleine Couttenye, Veerle Matheeussen, Daniel Abramowicz. A split strategy to prevent cytomegalovirus after kidney transplantation using prophylaxis in serological high-risk patients and a pre-emptive strategy in intermediate-risk patients: Combining the best of two options?.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Apr; 23(2):e13467. doi:
10.1111/tid.13467. [PMID: 32935909] - Amit D Raval, Kristin D Kistler, Yuexin Tang, Yoshihiko Murata, David R Snydman. Epidemiology, risk factors, and outcomes associated with cytomegalovirus in adult kidney transplant recipients: A systematic literature review of real-world evidence.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Apr; 23(2):e13483. doi:
10.1111/tid.13483. [PMID: 33012092] - Ayumu Kanbe, Tetsuya Ishikawa, Akira Hara, Hiroshi Suemizu, Eri Nanizawa, Yuki Tamaki, Hiroyasu Ito. Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice.
Journal of gastroenterology and hepatology.
2021 Mar; 36(3):782-789. doi:
10.1111/jgh.15142. [PMID: 32515517] - Ender Sirakaya, Mustafa Sahiner, Hatice Aslan Sirakaya. A Patient With Bilateral Conjunctivitis Positive for SARS-CoV-2 RNA in a Conjunctival Sample.
Cornea.
2021 Mar; 40(3):383-386. doi:
10.1097/ico.0000000000002485. [PMID: 32794685] - Bing Chen, Shan-Shan Hu, Wen-Bin Rui, Hui-Min An, Xiao-Hui Zhai, Xi-Han Wang, Jia-Qian Lu, Kun Shao, Pei-Jun Zhou. Population Pharmacokinetics and Bayesian Estimation of the Area Under the Concentration-Time Curve for Ganciclovir in Adult Chinese Renal Allograft Recipients After Valganciclovir Administration.
Journal of clinical pharmacology.
2021 03; 61(3):328-338. doi:
10.1002/jcph.1735. [PMID: 32926418] - Sadid F Khan, Michelle K Yong, Monica A Slavin, Peter Hughes, Joseph Sasadeusz. Very late-onset cytomegalovirus disease with ganciclovir resistance >15 years following renal transplantation.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Feb; 23(1):e13441. doi:
10.1111/tid.13441. [PMID: 32772444] - Joanna Schaenman, Korntip Phonphok, Ittikorn Spanuchart, Tin Duong, Theodore M Sievers, Erik Lum, Elaine F Reed, Suphamai Bunnapradist. Early cytomegalovirus DNAemia and antiviral dose adjustment in high vs intermediate risk kidney transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Feb; 23(1):e13457. doi:
10.1111/tid.13457. [PMID: 32892447] - Eisuke Suganuma, Hideaki Sakata, Nodoka Adachi, Satoshi Asanuma, Mihoko Furuichi, Yoji Uejima, Satoshi Sato, Tomoya Abe, Daigo Matsumoto, Ryohei Takahashi, Sachi Yamamoto, Yutaka Kawano, Takashi Arai, Tsutomu Oh-Ishi. Efficacy, safety, and pharmacokinetics of oral valganciclovir in patients with congenital cytomegalovirus infection.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2021 Feb; 27(2):185-191. doi:
10.1016/j.jiac.2020.08.019. [PMID: 32907793] - Jerica Pleško, Damjan Kovač, Zoran Arsov, Jelka Lindič, Andrej Škoberne, Dušan Ferluga, Nika Kojc. Glomerular and tubulointerstitial foscarnet nephropathy of kidney allograft with emphasis on ultrastructural findings: A case report.
Clinical nephrology.
2021 Sup; 96(1):127-132. doi:
10.5414/cnp96s23. [PMID: 34643504] - Harry W Roberts, Haseeb Akram, James Myerscough. Negative polymerase chain reaction for SARS-CoV-2 in aqueous sample of patient with confirmed SARS-CoV-2 and recurrence of herpetic stromal keratitis.
Journal of cataract and refractive surgery.
2020 12; 46(12):e61-e63. doi:
10.1097/j.jcrs.0000000000000462. [PMID: 33149041] - Pierre-Guillaume Deliège, Justine Bastien, Laetitia Mokri, Charlotte Guyot-Colosio, Carl Arndt, Philippe Rieu. Belatacept associated - cytomegalovirus retinitis in a kidney transplant recipient: a case report and review of the literature.
BMC ophthalmology.
2020 Dec; 20(1):468. doi:
10.1186/s12886-020-01741-1. [PMID: 33256663] - Ambroise Le Pogam, Julien Lopinto, Adrien Pecriaux, Muriel Fartoukh, Juliette Guitard, Guillaume Voiriot. Strongyloides stercoralis disseminated infection in an HIV-infected adult.
PLoS neglected tropical diseases.
2020 11; 14(11):e0008766. doi:
10.1371/journal.pntd.0008766. [PMID: 33151939] - W Zhang, D Y She, X W Xie, H D Zheng, J L Pang, X Y Wei, H Y Wang. [The application of next-generation sequencing in the diagnosis of Pneumocystis pneumonia in non-HIV infected patients].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2020 Oct; 43(10):844-849. doi:
10.3760/cma.j.cn112147-20200416-00510. [PMID: 32992438] - Dominika Jedlińska-Pijanowska, Justyna Czech-Kowalska, Magdalena Kłodzińska, Aleksandra Pietrzyk, Eliza Michalska, Kinga Gradowska, Anna Dobrzańska, Beata Kasztelewicz, Dariusz Gruszfeld. Antiviral treatment in congenital HCMV infection: The six-year experience of a single neonatal center in Poland.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2020 10; 29(10):1161-1167. doi:
10.17219/acem/125427. [PMID: 33053275] - Wei-Jun Zhu, Xuan Zhou, Juan Cao, Yu Shi. The effectiveness and safety of Tanreqing Injection combined with ganciclovir on the treatment of respiratory syncytial virus pneumonia in children: A protocol for systematic review and meta-analysis of randomized controlled trials.
Medicine.
2020 Sep; 99(38):e22356. doi:
10.1097/md.0000000000022356. [PMID: 32957408] - Deepali Kumar, Atul Humar. CMV immune monitoring-Where do we go from here?.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2020 08; 20(8):1961-1962. doi:
10.1111/ajt.15875. [PMID: 32216014] - Phaedon Zavras, Yiqi Su, Jiaqi Fang, Anat Stern, Nitasha Gupta, Yuexin Tang, Amit Raval, Sergio Giralt, Miguel Angel Perales, Ann A Jakubowski, Genovefa A Papanicolaou. Impact of Preemptive Therapy for Cytomegalovirus on Toxicities after Allogeneic Hematopoietic Cell Transplantation in Clinical Practice: A Retrospective Single-Center Cohort Study.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2020 08; 26(8):1482-1491. doi:
10.1016/j.bbmt.2020.03.019. [PMID: 32315708] - Steffen Jockusch, Chuanjuan Tao, Xiaoxu Li, Thomas K Anderson, Minchen Chien, Shiv Kumar, James J Russo, Robert N Kirchdoerfer, Jingyue Ju. A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19.
Antiviral research.
2020 08; 180(?):104857. doi:
10.1016/j.antiviral.2020.104857. [PMID: 32562705] - A Collet, D Baes, A Mambie, K Hembert, C Boulle, I Gana, X Lemaire. VZV meningoencephalitis treated with ganciclovir.
Medecine et maladies infectieuses.
2020 Aug; 50(5):444-445. doi:
10.1016/j.medmal.2020.03.001. [PMID: 32204960] - Tatsuki Noguchi, Takeshi Nishikawa, Soichiro Ishihara. Rectocolic and colocolic fistulas accompanied by cytomegalovirus infection: Two case reports.
Asian journal of surgery.
2020 Jul; 43(7):783-784. doi:
10.1016/j.asjsur.2020.03.004. [PMID: 32199669] - Zhivka Stoykova, Liliya Ivanova, Snejinka Cvetkova, Diana Yordanova. Congenital Cytomegalovirus Infection - Lessons from a Clinical Case.
Folia medica.
2020 Jun; 62(2):403-407. doi:
10.3897/folmed.62.e49840. [PMID: 32666770] - Melissa R Laub, Jennifer Byrns, Jennifer Gommer, Matthew Ellis, Matt Harris. Delayed vs initial cytomegalovirus prophylaxis after kidney transplantation.
Clinical transplantation.
2020 06; 34(6):e13854. doi:
10.1111/ctr.13854. [PMID: 32163619] - Roberto Mondaca, Alberto Fica, Ignacio Delama, Felipe Olivares, Maritza Navarrete. Cytomegalovirus infection in AIDS patients. An illustrative case series.
Revista medica de Chile.
2020 Jun; 148(6):778-786. doi:
10.4067/s0034-98872020000600778. [PMID: 33480376] - Joseph E Rower, Chris Nielson, Kevin Shi, Albert H Park. Validation of an assay for quantifying ganciclovir in dried blood spots.
Journal of pharmaceutical and biomedical analysis.
2020 May; 184(?):113181. doi:
10.1016/j.jpba.2020.113181. [PMID: 32105943] - Izabela Muszalska-Kolos, Monika A Lesniewska-Kowiel, Szymon Plewa, Agnieszka Klupczyńska. Tricyclic Derivative of Acyclovir and Its Esters in Relation to the Esters of Acyclovir Enzymatic Stability: Enzymatic Stability Study.
Molecules (Basel, Switzerland).
2020 May; 25(9):. doi:
10.3390/molecules25092156. [PMID: 32380673] - Stefanie D Krens, Caspar J Hodiamont, Nicole P Juffermans, Ron A A Mathôt, Reinier M van Hest. Population Pharmacokinetics of Ganciclovir in Critically Ill Patients.
Therapeutic drug monitoring.
2020 04; 42(2):295-301. doi:
10.1097/ftd.0000000000000689. [PMID: 31425489] - Scott Pangonis, Grant Paulsen, Heidi Andersen, Francisco Flores, Alexander Miethke, Anna Peters, Samuel Kocoshis, Danielle Lazear, BreAnn Garr, Marc Schecter, Clifford Chin, Trina Hemmelgarn, Lara Danziger-Isakov. Evaluation of a change in cytomegalovirus prevention strategy following pediatric solid organ transplantation.
Transplant infectious disease : an official journal of the Transplantation Society.
2020 Apr; 22(2):e13232. doi:
10.1111/tid.13232. [PMID: 31840369] - Cecilia Botti, Silvia Palma, Maria Federica Roversi, Daniele Monzani, Alberto Berardi, Elisabetta Genovese. Different Audiologic Outcomes in Twins with Congenital Cytomegalovirus Infection.
The journal of international advanced otology.
2020 Apr; 16(1):130-133. doi:
10.5152/iao.2020.6574. [PMID: 32209524] - Mohammad Rubayet Hasan, Manu Somasundaram Sundaram, Sathyavathi Sundararaju, Kin-Ming Tsui, Mohammed Yousuf Karim, Diane Roscoe, Omar Imam, Mohammad A Janahi, Eva Thomas, Simon Dobson, Rusung Tan, Patrick Tang, Andres Perez Lopez. Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
BMC infectious diseases.
2020 Mar; 20(1):237. doi:
10.1186/s12879-020-04966-z. [PMID: 32192451] - Patrick McLeroth, Darius A Paduch, Markus Abt, Richard Hughes, Suzanne Moore, Nadejda Mudie. Effects of valganciclovir on spermatogenesis in renal transplant patients - results of a multicenter prospective nonrandomized study.
Transplant international : official journal of the European Society for Organ Transplantation.
2020 03; 33(3):310-320. doi:
10.1111/tri.13558. [PMID: 31729770] - Victoria Oakes, Dinesh Bahl, Suresh Antony. Cytomegalovirus Retinitis Diagnosis and Treatment in a Kidney Transplant Recipient.
Infectious disorders drug targets.
2020; 20(6):925-928. doi:
10.2174/1871526519666191111100826. [PMID: 31713491] - Andrea Ronchi, Fiker Zeray, Lizette E Lee, Kris E Owen, Angela G Shoup, Fabiana Garcia, Liliana N Vazquez, Joseph B Cantey, Shawn Varghese, Lorenza Pugni, Fabio Mosca, Pablo J Sánchez. Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection.
Journal of perinatology : official journal of the California Perinatal Association.
2020 01; 40(1):89-96. doi:
10.1038/s41372-019-0501-z. [PMID: 31575999] - Sunwen Chou, Jingyang Wu, Kening Song, Tien Bo. Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection.
Antiviral research.
2019 12; 172(?):104616. doi:
10.1016/j.antiviral.2019.104616. [PMID: 31568799] - Kosuke Kato, Michelle Cooper. Small bowel perforation secondary to CMV-positive terminal ileitis postrenal transplant.
BMJ case reports.
2019 Nov; 12(11):. doi:
10.1136/bcr-2019-231662. [PMID: 31772132] - Liliana M E Finocchiaro, Lucrecia Agnetti, Chiara Fondello, Gerardo C Glikin. Combination of cytokine-enhanced vaccine and chemo-gene therapy as surgery adjuvant treatments for spontaneous canine melanoma.
Gene therapy.
2019 11; 26(10-11):418-431. doi:
10.1038/s41434-019-0066-7. [PMID: 30858538] - Yalin Zhou, Fei Hong, Xiaojuan Wang, Jing Feng, Dan Zhu, Yajun Xu, Yong Tao. Abnormal levels of aqueous humor trace elements in patients with cytomegalovirus retinitis.
Eye (London, England).
2019 10; 33(10):1606-1612. doi:
10.1038/s41433-019-0457-4. [PMID: 31065104] - Brandon Chatani, Wendy Glaberson, Zsuzsanna Nemeth, Leonardo Tamariz, Ivan A Gonzalez. GCV/VCVG prophylaxis against CMV DNAemia in pediatric renal transplant patients: A systematic review and meta-analysis.
Pediatric transplantation.
2019 09; 23(6):e13514. doi:
10.1111/petr.13514. [PMID: 31210393] - Adam Uslu, Alpay Ari, Cenk Simsek, Ali Ilgin Olgut, Murat Karatas, Ahmet Aykas, Ismail Can Tercan, Erhan Tatar. Evaluation of a Cytomegalovirus Prophylaxis Protocol in Cytomegalovirus-IgG Positive Renal Transplant Recipients (R+).
Transplantation proceedings.
2019 Sep; 51(7):2350-2354. doi:
10.1016/j.transproceed.2019.01.196. [PMID: 31358453] - Sora Yasri, Viroj Wiwanitkit. Probability of Ganciclovir Resistance in Cytomegalovirus-Infected Pediatric Kidney Transplant Recipients after Cessation of Standard Antiviral Prophylaxis: Estimated Risk on Thai cases.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2019 Jul; 30(4):1000-1001. doi:
10.4103/1319-2442.265448. [PMID: 31464265] - Margaret R Jorgenson, Jillian L Descourouez, Brianna Cardinale, Beini Lyu, Brad C Astor, Neetika Garg, Christopher M Saddler, Jeannina A Smith, Didier A Mandelbrot. Risk of opportunistic infection in kidney transplant recipients with cytomegalovirus infection and associated outcomes.
Transplant infectious disease : an official journal of the Transplantation Society.
2019 Jun; 21(3):e13080. doi:
10.1111/tid.13080. [PMID: 30891915] - Yi Guo, Li Jiang. Cytomegalovirus encephalitis in immunocompetent infants: A 15-year retrospective study at a single center.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2019 May; 82(?):106-110. doi:
10.1016/j.ijid.2019.02.045. [PMID: 30844517] - Ruolin Hou, Jing Wu, Dake He, Yumei Yan, Ling Li. Anti-N-methyl-D-aspartate receptor encephalitis associated with reactivated Epstein-Barr virus infection in pediatric patients: Three case reports.
Medicine.
2019 May; 98(20):e15726. doi:
10.1097/md.0000000000015726. [PMID: 31096528] - Wen-Bin Rui, Hui-Min An, Kun Shao, Xiao-Hui Zhai, Jia-Qian Lu, Shan-Shan Hu, Bing Chen, Pei-Jun Zhou. Limited sampling strategy for the estimation of the area under the concentration-time curve for ganciclovir in Chinese adult renal allograft recipients.
European journal of clinical pharmacology.
2019 May; 75(5):677-686. doi:
10.1007/s00228-018-02613-w. [PMID: 30643927] - Grant Paulsen, Pia Cumagun, Emily Mixon, Karen Fowler, Daniel Feig, Masako Shimamura. Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis.
Pediatric transplantation.
2019 05; 23(3):e13382. doi:
10.1111/petr.13382. [PMID: 30786115] - H Peng, J Xiao, H Wan, J Shi, J Li. Severe Gastric Mycormycosis Infection Followed by Cytomegalovirus Pneumonia in a Renal Transplant Recipient: A Case Report and Concise Review of the Literature.
Transplantation proceedings.
2019 Mar; 51(2):556-560. doi:
10.1016/j.transproceed.2018.12.023. [PMID: 30879589] - Barbora Sporinova, Susanna A McRae, Daniel A Muruve, Marvin J Fritzler, Samih H Nasr, Alex C Chin, Hallgrimur Benediktsson. A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis.
BMC nephrology.
2019 01; 20(1):29. doi:
10.1186/s12882-019-1227-z. [PMID: 30704432] - Raymund R Razonable, Hatem Amer, Samir Mardini. Application of a New Paradigm for Cytomegalovirus Disease Prevention in Mayo Clinic's First Face Transplant.
Mayo Clinic proceedings.
2019 01; 94(1):166-170. doi:
10.1016/j.mayocp.2018.09.017. [PMID: 30611443] - Yiping Wang, Rupkatha Mukhopadhyay, Sujayita Roy, Arun Kapoor, Yu-Pin Su, Susan A Charman, Gong Chen, Jianbo Wu, Xiaofang Wang, Jonathan L Vennerstrom, Ravit Arav-Boger. Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides.
Antimicrobial agents and chemotherapy.
2019 01; 63(1):. doi:
10.1128/aac.01735-18. [PMID: 30373792] - Lauren Cherrier, Aasya Nasar, Kellie J Goodlet, Michael D Nailor, Sofya Tokman, Sunwen Chou. Emergence of letermovir resistance in a lung transplant recipient with ganciclovir-resistant cytomegalovirus infection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2018 12; 18(12):3060-3064. doi:
10.1111/ajt.15135. [PMID: 30286286] - Miguel Moyses Neto, Roberto Silva Costa, Gustavo Frezza, Tania M Garcia, Maria Estela Papini Nardin, Elen Almeida Romao. Cytomegalovirus-Associated Glomerulonephritis in a Kidney Transplant Recipient.
Progress in transplantation (Aliso Viejo, Calif.).
2018 12; 28(4):398-399. doi:
10.1177/1526924818800034. [PMID: 30244653] - Y Nawashiro, K Shiraki, S Yamamoto, K Takizawa, Y Sasada, M Suehiro, K Miura, M Hattori, T Daikoku, M Hisano. Persistent Primary Cytomegalovirus Infection After Deceased Donor Kidney Transplant: Ganciclovir Susceptibility of Human Cytomegalovirus With UL97 D605E Mutation: A Case Report.
Transplantation proceedings.
2018 Dec; 50(10):3932-3936. doi:
10.1016/j.transproceed.2018.09.010. [PMID: 30577289] - Eisuke Suganuma, Akira Oka, Hideaki Sakata, Nodoka Adachi, Satoshi Asanuma, Eiji Oguma, Akira Yamaguchi, Mihoko Furuichi, Yoji Uejima, Satoshi Sato, Tadamasa Takano, Yutaka Kawano, Risa Tanaka, Takashi Arai, Tsutomu Oh-Ishi. 10-year follow-up of congenital cytomegalovirus infection complicated with severe neurological findings in infancy: a case report.
BMC pediatrics.
2018 11; 18(1):369. doi:
10.1186/s12887-018-1348-8. [PMID: 30470211] - Joshua Aiden Hill, Steven A Pergam, Emily Cox, Hu Xie, Wendy M Leisenring, Michael Boeckh, Colleen Delaney, Filippo Milano. A Modified Intensive Strategy to Prevent Cytomegalovirus Disease in Seropositive Umbilical Cord Blood Transplantation Recipients.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2018 10; 24(10):2094-2100. doi:
10.1016/j.bbmt.2018.05.008. [PMID: 29753836] - Lúcio R Requião-Moura, Ana C C Matos, Kikumi S Ozaki, Niels O S Câmara, Alvaro Pacheco-Silva. A high level of urinary retinol-binding protein is associated with cytomegalovirus infection in kidney transplantation.
Clinical science (London, England : 1979).
2018 09; 132(18):2059-2069. doi:
10.1042/cs20180390. [PMID: 30171051] - Marianne C Jacobsen, Maria D I Manunta, Emma S Pincott, Matthew Fenton, Gavin L Simpson, Nigel J Klein, Michael Burch. Specific Immunity to Cytomegalovirus in Pediatric Cardiac Transplantation.
Transplantation.
2018 09; 102(9):1569-1575. doi:
10.1097/tp.0000000000002157. [PMID: 29509573] - Matthew P Soape, Robert S Rahimi, Cedric W Spak, James F Trotter. Case Report of a Rare Presentation of Isolated Cytomegalovirus Hepatitis After Renal Transplantation.
Progress in transplantation (Aliso Viejo, Calif.).
2018 09; 28(3):296-298. doi:
10.1177/1526924818781573. [PMID: 29898621] - Maria-Eugenia Palacio-Lacambra, Immaculada Comas-Reixach, Albert Blanco-Grau, Josep-Maria Suñé-Negre, Alfonso Segarra-Medrano, José-Bruno Montoro-Ronsano. Comparison of the Cockcroft-Gault, MDRD and CKD-EPI equations for estimating ganciclovir clearance.
British journal of clinical pharmacology.
2018 09; 84(9):2120-2128. doi:
10.1111/bcp.13647. [PMID: 29791023] - Ignacio A Echenique, Michael P Angarone, Jonathan D Rich, Allen S Anderson, Valentina Stosor. Cytomegalovirus infection in heart transplantation: A single center experience.
Transplant infectious disease : an official journal of the Transplantation Society.
2018 Aug; 20(4):e12896. doi:
10.1111/tid.12896. [PMID: 29602266]
