AI3-35128 (BioDeep_00000865951)

Main id: BioDeep_00000001092

 

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


4-01-00-02098 (Beilstein Handbook Reference)

化学式: C6H10S2 (146.02239)
中文名称: 二烯丙基二硫化物, 烯丙基二硫
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCSSCC=C
InChI: InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2

描述信息

D009676 - Noxae > D000988 - Antispermatogenic Agents > D013089 - Spermatocidal Agents
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D020011 - Protective Agents > D016587 - Antimutagenic Agents
D000970 - Antineoplastic Agents
Diallyl disulfide inhibits human squalene monooxygenase with an IC50 of 400 μM for squalene epoxidation[1].
Diallyl disulfide inhibits human squalene monooxygenase with an IC50 of 400 μM for squalene epoxidation[1].

同义名列表

40 个代谢物同义名

4-01-00-02098 (Beilstein Handbook Reference); 3-(prop-2-en-1-yldisulfanyl)prop-1-ene; 3-prop-2-enyldisulfanylprop-1-ene; 3,3-disulfanediylbis(prop-1-ene); 3-(Allyldisulfanyl)-1-propene; 3-allyldisulfanylprop-1-ene; 3,3-dithiobis(prop-1-ene); Disulfide, di-2-propenyl; Di(2-propenyl) disulfide; 4,5-Dithia-1,7-octadiene; 2-Propenyl disulphide; 2-Propenyl disulfide; diallyl disulphide; Diallyl disulfide; Allyl disulphide; EINECS 218-548-6; W202800_ALDRICH; SPECTRUM1505174; NCGC00095294-02; allyl disulfide; NCGC00095294-01; 317691_ALDRICH; FEMA No. 2028; NCI60_002410; ZINC01531082; 32621_FLUKA; AIDS-005092; BRN 1699241; AIDS005092; CHEBI:4488; CCRIS 6290; 2179-57-9; AI3-35128; NSC 29228; NSC29228; HSDB 595; diAllS2; C08369; Diallyl disulfide; Diallyl disulfide



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zeinab Farhat, Tyler Scheving, Diana S Aga, Pamela A Hershberger, Jo L Freudenheim, Rachael Hageman Blair, Manoj J Mammen, Lina Mu. Antioxidant and Antiproliferative Activities of Several Garlic Forms. Nutrients. 2023 Sep; 15(19):. doi: 10.3390/nu15194099. [PMID: 37836382]
  • Jiaqi Zhu, Fu Wang, Youjun Zhang, Yuting Yang, Dengke Hua. Odorant-binding Protein 10 From Bradysia odoriphaga (Diptera: Sciaridae) Binds Volatile Host Plant Compounds. Journal of insect science (Online). 2023 Jan; 23(1):. doi: 10.1093/jisesa/iead004. [PMID: 36729094]
  • Muhammad Ali, Husain Ahmad, Bakht Amin, Muhammad Jawaad Atif, Zhihui Cheng. Induce defense response of DADS in eggplants during the biotrophic phase of Verticillium dahliae. BMC plant biology. 2022 Apr; 22(1):172. doi: 10.1186/s12870-022-03527-7. [PMID: 35379184]
  • Fan Yang, Hui Wang, Chengchen Zhi, Birong Chen, Yujie Zheng, Lijun Qiao, Jingcao Gao, Yupeng Pan, Zhihui Cheng. Garlic Volatile Diallyl Disulfide Induced Cucumber Resistance to Downy Mildew. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212328. [PMID: 34830208]
  • Syed Mohammed Basheeruddin Asdaq, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani. Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175137. [PMID: 34500571]
  • Muhammad Ali, Husain Ahmad, Sikandar Hayat, Muhammad Imran Ghani, Bakht Amin, Muhammad Jawaad Atif, Kashif Wali, Zhihui Cheng. Application of garlic allelochemicals improves growth and induces defense responses in eggplant (Solanum melongena) against Verticillium dahliae. Ecotoxicology and environmental safety. 2021 Jun; 215(?):112132. doi: 10.1016/j.ecoenv.2021.112132. [PMID: 33743403]
  • Emad H M Hassanein, Wafaa R Mohamed, Marwa M Khalaf, Abdel-Gawad S Shalkami, Ahmed M Sayed, Ramadan A M Hemeida. Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis. Journal of food biochemistry. 2021 06; 45(6):e13765. doi: 10.1111/jfbc.13765. [PMID: 33997994]
  • Haiyan He, Yaoying Ma, Huaxing Huang, Chao Huang, Zhuo Chen, Dongjian Chen, Yiming Gu, Xiaohua Wang, Jinliang Chen. A comprehensive understanding about the pharmacological effect of diallyl disulfide other than its anti-carcinogenic activities. European journal of pharmacology. 2021 Feb; 893(?):173803. doi: 10.1016/j.ejphar.2020.173803. [PMID: 33359648]
  • Ya-Ru Wu, Liang Li, Xian-Chang Sun, Jun Wang, Chun-Yan Ma, Yue Zhang, Hui-Lin Qu, Rui-Xia Xu, Jian-Jun Li. Diallyl disulfide improves lipid metabolism by inhibiting PCSK9 expression and increasing LDL uptake via PI3K/Akt-SREBP2 pathway in HepG2 cells. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2021 01; 31(1):322-332. doi: 10.1016/j.numecd.2020.08.012. [PMID: 33500108]
  • Chenghao Lv, Caiqiong Wang, Ping Li, Yiwen Huang, Xiangyang Lu, Meng Shi, Chaoxi Zeng, Si Qin. Effect of Garlic Organic Sulfides on Gene Expression Profiling in HepG2 Cells and Its Biological Function Analysis by Ingenuity Pathway Analysis System and Bio-Plex-Based Assays. Mediators of inflammation. 2021; 2021(?):7681252. doi: 10.1155/2021/7681252. [PMID: 34887701]
  • Wanchao Hu, Liou Huang, Ziyang Zhou, Liping Yin, Jianguo Tang. Diallyl Disulfide (DADS) Ameliorates Intestinal Candida albicans Infection by Modulating the Gut microbiota and Metabolites and Providing Intestinal Protection in Mice. Frontiers in cellular and infection microbiology. 2021; 11(?):743454. doi: 10.3389/fcimb.2021.743454. [PMID: 35071031]
  • You Jeong Lee, Song-Hyun Cha, Hyunjo Kim, Sung Eun Choi, Seonho Cho, Youmie Park. Diallyl disulphide-loaded spherical gold nanoparticles and acorn-like silver nanoparticles synthesised using onion extract: catalytic activity and cytotoxicity. Artificial cells, nanomedicine, and biotechnology. 2020 Dec; 48(1):948-960. doi: 10.1080/21691401.2020.1773485. [PMID: 32496831]
  • Fang Cheng, Muhammad Ali, Ce Liu, Rui Deng, Zhihui Cheng. Garlic Allelochemical Diallyl Disulfide Alleviates Autotoxicity in the Root Exudates Caused by Long-Term Continuous Cropping of Tomato. Journal of agricultural and food chemistry. 2020 Oct; 68(42):11684-11693. doi: 10.1021/acs.jafc.0c03894. [PMID: 32991155]
  • Suzan M Hazzaa, Seham Ahmed Mohamed Abdelaziz, Mabrouk A Abd Eldaim, Mohamed M Abdel-Daim, Ghada E Elgarawany. Neuroprotective Potential of Allium sativum against Monosodium Glutamate-Induced Excitotoxicity: Impact on Short-Term Memory, Gliosis, and Oxidative Stress. Nutrients. 2020 Apr; 12(4):. doi: 10.3390/nu12041028. [PMID: 32290031]
  • Xing Xu, Peili Hu, Yaoying Ma, Lijuan Tong, Dan Wang, Yue Wu, Zhuo Chen, Chao Huang. Identification of a pro-elongation effect of diallyl disulfide, a major organosulfur compound in garlic oil, on microglial process. The Journal of nutritional biochemistry. 2020 04; 78(?):108323. doi: 10.1016/j.jnutbio.2019.108323. [PMID: 32135404]
  • Marimuthu Mathan Kumar, Ramasamy Tamizhselvi. Protective effect of diallyl disulfide against cerulein-induced acute pancreatitis and associated lung injury in mice. International immunopharmacology. 2020 Mar; 80(?):106136. doi: 10.1016/j.intimp.2019.106136. [PMID: 31991372]
  • Hongxing Zhang, Chi Shang, Zhao Tian, Hatem K Amin, Rami B Kassab, Ahmed E Abdel Moneim, Yingang Zhang. Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice. Mediators of inflammation. 2020; 2020(?):8508906. doi: 10.1155/2020/8508906. [PMID: 32377166]
  • Jie Sun, Baoguo Sun, Fazheng Ren, Haitao Chen, Ning Zhang, Yuyu Zhang. Influence of Different Frying Processes on the Flavor Characteristics and Sensory Profile of Garlic Oil. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244456. [PMID: 31817376]
  • Yanhong Yang, Fei Yang, Miaoling Huang, Huijuan Wu, Changyuan Yang, Xinyue Zhang, Lanxiang Yang, Guibin Chen, Shuqi Li, Qianyu Wang, Shaomin Liu, Yanyan Liu, Yuting Lei, Zili Lei, Jiao Guo. Fatty liver and alteration of the gut microbiome induced by diallyl disulfide. International journal of molecular medicine. 2019 Nov; 44(5):1908-1920. doi: 10.3892/ijmm.2019.4350. [PMID: 31573042]
  • Yaochen Wang, Keke Wei, Xiaobin Han, Donglin Zhao, Yanfen Zheng, Jianmin Chao, Jianyu Gou, Fanyu Kong, Cheng-Sheng Zhang. The Antifungal Effect of Garlic Essential Oil on Phytophthora nicotianae and the Inhibitory Component Involved. Biomolecules. 2019 10; 9(10):. doi: 10.3390/biom9100632. [PMID: 31640228]
  • Chen-Hsin Kuo, Yann-Lii Leu, Tong-Hong Wang, Wei-Che Tseng, Chun-Hao Feng, Shu-Huei Wang, Chin-Chuan Chen. A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels. DNA repair. 2019 10; 82(?):102690. doi: 10.1016/j.dnarep.2019.102690. [PMID: 31479843]
  • Fan Yang, Xiaoxue Liu, Hui Wang, Rui Deng, Hanhan Yu, Zhihui Cheng. Identification and Allelopathy of Green Garlic (Allium sativum L.) Volatiles on Scavenging of Cucumber (Cucumis sativus L.) Reactive Oxygen Species. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183263. [PMID: 31500271]
  • Ning Zhang, Yuli Wang, Junli Zhang, Beibei Liu, Guixin Li, Shengliang Xin, Keshu Xu. Diallyl disulfide attenuates non‑alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, lipid peroxidation and inflammation in mice. Molecular medicine reports. 2019 Aug; 20(2):1363-1372. doi: 10.3892/mmr.2019.10316. [PMID: 31173200]
  • Igor A Schepetkin, Liliya N Kirpotina, Andrei I Khlebnikov, Narayanaganesh Balasubramanian, Mark T Quinn. Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091809. [PMID: 31083328]
  • Jaehoon Bae, Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana. Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity. The Journal of nutritional biochemistry. 2019 02; 64(?):152-161. doi: 10.1016/j.jnutbio.2018.10.014. [PMID: 30504007]
  • Kaili Ren, Sikandar Hayat, Xiaofang Qi, Tao Liu, Zhihui Cheng. The garlic allelochemical DADS influences cucumber root growth involved in regulating hormone levels and modulating cell cycling. Journal of plant physiology. 2018 Nov; 230(?):51-60. doi: 10.1016/j.jplph.2018.08.007. [PMID: 30170241]
  • Muammer M Şahin, Mehmet B Uğur, Recep Karamert, Sinem Aytekin, Burak Kabiş, Mehmet Düzlü, Cemile Seymen, Çiğdem Elmas, Çağıl Gökdoğan, Serkan Ünlü. Evaluation of Effect of Garlic Aged Extracts and Vitamin B12 on Noise-Induced Hearing Loss. Noise & health. 2018 Nov; 20(97):232-239. doi: 10.4103/nah.nah_33_18. [PMID: 31823910]
  • Kobra Bahrampour Juybari, Tunku Kamarul, Mohammad Najafi, Davood Jafari, Ali Mohammad Sharifi. Restoring the IL-1β/NF-κB-induced impaired chondrogenesis by diallyl disulfide in human adipose-derived mesenchymal stem cells via attenuation of reactive oxygen species and elevation of antioxidant enzymes. Cell and tissue research. 2018 08; 373(2):407-419. doi: 10.1007/s00441-018-2825-y. [PMID: 29582166]
  • Abdel-Tawab H Mossa, Sahar I Afia, Samia M M Mohafrash, Badawi A Abou-Awad. Formulation and characterization of garlic (Allium sativum L.) essential oil nanoemulsion and its acaricidal activity on eriophyid olive mites (Acari: Eriophyidae). Environmental science and pollution research international. 2018 Apr; 25(11):10526-10537. doi: 10.1007/s11356-017-0752-1. [PMID: 29181754]
  • Tae Hoon Kim, Jin-Chul Kim. Redox-responsive solid lipid microparticles composed of octadecyl acrylate and allyl disulfide. Journal of biomaterials science. Polymer edition. 2018 04; 29(5):476-490. doi: 10.1080/09205063.2017.1422854. [PMID: 29291676]
  • Venkata Talluri Siddhartha, Sai Kiran S S Pindiprolu, Pavan Kumar Chintamaneni, Shashank Tummala, S Nandha Kumar. RAGE receptor targeted bioconjuguate lipid nanoparticles of diallyl disulfide for improved apoptotic activity in triple negative breast cancer: in vitro studies. Artificial cells, nanomedicine, and biotechnology. 2018 Mar; 46(2):387-397. doi: 10.1080/21691401.2017.1313267. [PMID: 28415882]
  • Xiaoran Yin, Cheng Feng, Lili Han, Yinan Ma, Yang Jiao, Jun Wang, Lijun Jia, Fuchun Jing, Xiaoyan Gao, Yinbin Zhang, Jun Zhang. Diallyl disulfide inhibits the metastasis of type Ⅱ esophageal‑gastric junction adenocarcinoma cells via NF-κB and PI3K/AKT signaling pathways in vitro. Oncology reports. 2018 Feb; 39(2):784-794. doi: 10.3892/or.2017.6113. [PMID: 29207122]
  • Yuqing Chen, Rong Xue, Xiaochen Jin, Xiangqi Tan. Antiarthritic Activity of Diallyl Disulfide against Freund's Adjuvant-Induced Arthritic Rat Model. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2018; 37(4):291-303. doi: 10.1615/jenvironpatholtoxicoloncol.2018027078. [PMID: 30806236]
  • Xinhua Xie, Xiaojia Huang, Hailin Tang, Feng Ye, Lu Yang, Xiaofang Guo, Zhi Tian, Xiaofang Xie, Cheng Peng, Xiaoming Xie. Diallyl Disulfide Inhibits Breast Cancer Stem Cell Progression and Glucose Metabolism by Targeting CD44/PKM2/AMPK Signaling. Current cancer drug targets. 2018; 18(6):592-599. doi: 10.2174/1568009617666171024165657. [PMID: 29110616]
  • Javier Morales-López, Mónica Centeno-Álvarez, Antonio Nieto-Camacho, Mercedes G López, Elizabeth Pérez-Hernández, Nury Pérez-Hernández, Eduardo Fernández-Martínez. Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil. Pharmaceutical biology. 2017 Dec; 55(1):233-241. doi: 10.1080/13880209.2016.1258424. [PMID: 27927070]
  • Azam Hosseinzadeh, Davood Jafari, Tunku Kamarul, Abolfazll Bagheri, Ali M Sharifi. Evaluating the Protective Effects and Mechanisms of Diallyl Disulfide on Interlukin-1β-Induced Oxidative Stress and Mitochondrial Apoptotic Signaling Pathways in Cultured Chondrocytes. Journal of cellular biochemistry. 2017 07; 118(7):1879-1888. doi: 10.1002/jcb.25907. [PMID: 28169456]
  • Frank Albrecht, Roman Leontiev, Claus Jacob, Alan J Slusarenko. An Optimized Facile Procedure to Synthesize and Purify Allicin. Molecules (Basel, Switzerland). 2017 May; 22(5):. doi: 10.3390/molecules22050770. [PMID: 28489057]
  • Siddhartha Venkata Talluri, Gowthamarajan Kuppusamy, Veera Venkata Satyanarayana Reddy Karri, Karthik Yamjala, Ashish Wadhwani, SubbaRao V Madhunapantula, Saikiran S S Pindiprolu. Application of quality-by-design approach to optimize diallyl disulfide-loaded solid lipid nanoparticles. Artificial cells, nanomedicine, and biotechnology. 2017 May; 45(3):474-488. doi: 10.3109/21691401.2016.1173046. [PMID: 27112220]
  • Sharon E Mason, Keena A E Mullen, Kevin L Anderson, Steven P Washburn, James L Yeatts, Ronald E Baynes. Pharmacokinetic analysis of thymol, carvacrol and diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2017 May; 34(5):740-749. doi: 10.1080/19440049.2017.1285056. [PMID: 28277182]
  • Hoda S El-Sayed, Remigius Chizzola, Asmaa A Ramadan, Amr E Edris. Chemical composition and antimicrobial activity of garlic essential oils evaluated in organic solvent, emulsifying, and self-microemulsifying water based delivery systems. Food chemistry. 2017 Apr; 221(?):196-204. doi: 10.1016/j.foodchem.2016.10.052. [PMID: 27979186]
  • Je-Won Ko, Jin-Young Shin, Jeong-Won Kim, Sung-Hyeuk Park, Na-Rae Shin, In-Chul Lee, In-Sik Shin, Changjong Moon, Sung-Ho Kim, Sung-Hwan Kim, Jong-Choon Kim. Protective effects of diallyl disulfide against acetaminophen-induced nephrotoxicity: A possible role of CYP2E1 and NF-κB. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Apr; 102(?):156-165. doi: 10.1016/j.fct.2017.02.021. [PMID: 28219698]
  • Fang Cheng, Zhi-Hui Cheng, Huan-Wen Meng. Transcriptomic insights into the allelopathic effects of the garlic allelochemical diallyl disulfide on tomato roots. Scientific reports. 2016 12; 6(?):38902. doi: 10.1038/srep38902. [PMID: 27941943]
  • Yunlong Shan, Zhonghong Wei, Li Tao, Siliang Wang, Feng Zhang, Cunsi Shen, Hongyan Wu, Zhaoguo Liu, Pingting Zhu, Aiyun Wang, Wenxing Chen, Yin Lu. Prophylaxis of Diallyl Disulfide on Skin Carcinogenic Model via p21-dependent Nrf2 stabilization. Scientific reports. 2016 10; 6(?):35676. doi: 10.1038/srep35676. [PMID: 27759091]
  • Nathan L Horn, Frank Ruch, Guy Miller, Kolapo M Ajuwon, Olayiwola Adeola. Determination of the adequate dose of garlic diallyl disulfide and diallyl trisulfide for effecting changes in growth performance, total-tract nutrient and energy digestibility, ileal characteristics, and serum immune parameters in broiler chickens. Poultry science. 2016 Oct; 95(10):2360-5. doi: 10.3382/ps/pew126. [PMID: 27190110]
  • Shakir M Saud, Weidong Li, Zane Gray, Matthias S Matter, Nancy H Colburn, Matthew R Young, Young S Kim. Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF-κB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β. Cancer prevention research (Philadelphia, Pa.). 2016 Jul; 9(7):607-15. doi: 10.1158/1940-6207.capr-16-0044. [PMID: 27138790]
  • Chih-Kwang Chiu, Tai-Yuan Chen, Jou-Hsing Lin, Chen-Ya Wang, Bor-Sen Wang. Protective effects of five allium derived organosulfur compounds against mutation and oxidation. Food chemistry. 2016 Apr; 197(Pt A):829-35. doi: 10.1016/j.foodchem.2015.11.064. [PMID: 26617023]
  • C F Williams, A R Vacca, L Dunham, D Lloyd, M P Coogan, G Evans, M Graz, J Cable. The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens. Molecular and biochemical parasitology. 2016 Mar; 206(1-2):20-8. doi: 10.1016/j.molbiopara.2016.03.001. [PMID: 26968264]
  • Toshiaki Matsutomo, Yukihiro Kodera. Development of an Analytic Method for Sulfur Compounds in Aged Garlic Extract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific Detection. The Journal of nutrition. 2016 Feb; 146(2):450S-455S. doi: 10.3945/jn.114.208520. [PMID: 26764330]
  • Pritha Dasgupta, Sumita Bandyopadhyay Sengupta. Role of diallyl disulfide-mediated cleavage of c-Myc and Sp-1 in the regulation of telomerase activity in human lymphoma cell line U937. Nutrition (Burbank, Los Angeles County, Calif.). 2015 Jul; 31(7-8):1031-7. doi: 10.1016/j.nut.2015.02.016. [PMID: 26059379]
  • In-Chul Lee, Sung-Hwan Kim, Hyung-Seon Baek, Changjong Moon, Sung-Ho Kim, Yun-Bae Kim, Won-Kee Yun, Hyoung-Chin Kim, Jong-Choon Kim. Protective effects of diallyl disulfide on carbon tetrachloride-induced hepatotoxicity through activation of Nrf2. Environmental toxicology. 2015 May; 30(5):538-48. doi: 10.1002/tox.21930. [PMID: 24293383]
  • M Battal, A Kartal, B Citgez, B Yilmaz, A Akcakaya, O Karatepe. Impact of allyl disulfide on oxidative damage and liver regeneration in an experimental hepatectomy model. Chirurgia (Bucharest, Romania : 1990). 2015 Mar; 110(2):117-22. doi: . [PMID: 26011832]
  • I-C Lee, H-S Baek, S-H Kim, C Moon, S-H Park, S-H Kim, I-S Shin, S-C Park, J-C Kim. Effect of diallyl disulfide on acute gastric mucosal damage induced by alcohol in rats. Human & experimental toxicology. 2015 Mar; 34(3):227-39. doi: 10.1177/0960327114537095. [PMID: 24972622]
  • Chuan-yun Zhang, Min-zhen Si, Lun Li, De-qing Zhang. [Research on volatiles of rakkyo (Allium Chinense G. Don) and Chinese chive (Allium Tuberosum Rottl. ex Sprengel) based on headspace and the molecular recognition of SERS]. Guang pu xue yu guang pu fen xi = Guang pu. 2015 Feb; 35(2):394-8. doi: . [PMID: 25970899]
  • Azucena Gándara-Ledezma, Consuelo Corrales-Maldonado, Marisela Rivera-Domínguez, Miguel Ángel Martínez-Téllez, Irasema Vargas-Arispuro. Post-harvest control of gray mold in table grapes using volatile sulfur compounds from Allium sativum. Journal of the science of food and agriculture. 2015 Feb; 95(3):497-503. doi: 10.1002/jsfa.6757. [PMID: 24862582]
  • Simona Casiglia, Maurizio Bruno, Federica Senatore, Felice Senatore. Composition of the Essential Oil of Allium neapolitanum Cirillo Growing Wild in Sicily and its Activity on Microorganisms Affecting Historical Art Crafts. Journal of oleo science. 2015; 64(12):1315-20. doi: 10.5650/jos.ess15188. [PMID: 26632947]
  • Su-Chen Ho, Min-Sheng Su. Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds. Molecules (Basel, Switzerland). 2014 Oct; 19(11):17697-714. doi: 10.3390/molecules191117697. [PMID: 25365295]
  • Shridevi Adaki, Raghavendra Adaki, Kaushal Shah, Amol Karagir. Garlic: Review of literature. Indian journal of cancer. 2014 Oct; 51(4):577-81. doi: 10.4103/0019-509x.175383. [PMID: 26842201]
  • Min-Zhen Si, De-Qing Zhang, Ren-Ming Liu. [Study of volatile organic compounds of fresh allium species using headspace combined with surface-enhanced Raman scattering]. Guang pu xue yu guang pu fen xi = Guang pu. 2014 Sep; 34(9):2449-52. doi: . [PMID: 25532343]
  • Xiaoran Yin, Jun Zhang, Xiaoning Li, Dong Liu, Cheng Feng, Rongrui Liang, Kun Zhuang, Chenlei Cai, Xinghuan Xue, Fuchun Jing, Xijing Wang, Jun Wang, Xinlian Liu, Hongbing Ma. DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways. International journal of molecular sciences. 2014 Jul; 15(7):12422-41. doi: 10.3390/ijms150712422. [PMID: 25026173]
  • Muna Sapkota, Tete K Hottor, Jane M DeVasure, Todd A Wyatt, Michael L McCaskill. Protective role of CYP2E1 inhibitor diallyl disulfide (DADS) on alcohol-induced malondialdehyde-deoxyguanosine (M1dG) adduct formation. Alcoholism, clinical and experimental research. 2014 Jun; 38(6):1550-8. doi: 10.1111/acer.12439. [PMID: 24891074]
  • Ryan Munch, Sheryl A Barringer. Deodorization of garlic breath volatiles by food and food components. Journal of food science. 2014 Apr; 79(4):C526-33. doi: 10.1111/1750-3841.12394. [PMID: 24592995]
  • C J Watson, D Grando, C K Fairley, P Chondros, S M Garland, S P Myers, M Pirotta. The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trial. BJOG : an international journal of obstetrics and gynaecology. 2014 Mar; 121(4):498-506. doi: 10.1111/1471-0528.12518. [PMID: 24308540]
  • D S Prokof'eva, N V Goncharov. [Effects of biogenic and abiogenic disulphides upon endothelial cells in culture: comparison of three methods of viability assessment]. Tsitologiia. 2014; 56(6):410-8. doi: . [PMID: 25696977]
  • In-Chul Lee, Sung-Hwan Kim, Hyung-Seon Baek, Changjong Moon, Seong-Soo Kang, Sung-Ho Kim, Yun-Bae Kim, In-Sik Shin, Jong-Choon Kim. The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Jan; 63(?):174-85. doi: 10.1016/j.fct.2013.11.006. [PMID: 24246655]
  • G Martínez-Fernández, L Abecia, A I Martín-García, E Ramos-Morales, G Hervás, E Molina-Alcaide, D R Yáñez-Ruiz. In vitro-in vivo study on the effects of plant compounds on rumen fermentation, microbial abundances and methane emissions in goats. Animal : an international journal of animal bioscience. 2013 Dec; 7(12):1925-34. doi: 10.1017/s1751731113001699. [PMID: 24237672]
  • Seung Taek Ji, Min-Sun Kim, Hee Ra Park, Eunjin Lee, Yujeong Lee, Young Jung Jang, Hyung Sik Kim, Jaewon Lee. Diallyl disulfide impairs hippocampal neurogenesis in the young adult brain. Toxicology letters. 2013 Jul; 221(1):31-8. doi: 10.1016/j.toxlet.2013.05.013. [PMID: 23732363]
  • J Robyn, G Rasschaert, D Hermans, F Pasmans, M Heyndrickx. Is allicin able to reduce Campylobacter jejuni colonization in broilers when added to drinking water?. Poultry science. 2013 May; 92(5):1408-18. doi: 10.3382/ps.2012-02863. [PMID: 23571353]
  • Sergio Casella, Michele Leonardi, Bernardo Melai, Filippo Fratini, Luisa Pistelli. The role of diallyl sulfides and dipropyl sulfides in the in vitro antimicrobial activity of the essential oil of garlic, Allium sativum L., and leek, Allium porrum L. Phytotherapy research : PTR. 2013 Mar; 27(3):380-3. doi: 10.1002/ptr.4725. [PMID: 22610968]
  • Maroof Alam, Swaleha Zubair, Mohammad Farazuddin, Ejaj Ahmad, Arbab Khan, Qamar Zia, Abida Malik, Owais Mohammad. Development, characterization and efficacy of niosomal diallyl disulfide in treatment of disseminated murine candidiasis. Nanomedicine : nanotechnology, biology, and medicine. 2013 Feb; 9(2):247-56. doi: 10.1016/j.nano.2012.07.004. [PMID: 22858760]
  • Yuko Watanabe, Ryoko Muroi, Haruna Tsuchiya, Yasushi Uda, Kei Hashimoto. Inhibitory effect of methyl methanethiosulfinate on β-glucuronidase activity. Bioscience, biotechnology, and biochemistry. 2013; 77(11):2325-7. doi: 10.1271/bbb.130510. [PMID: 24200790]
  • Zhi Wang, Hong Cao, Yongzhen Sun, Xiaoying Li, Fengying Chen, Annaick Carles, Yong Li, Meng Ding, Cun Zhang, Xin Deng, Wim J J Soppe, Yong-Xiu Liu. Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. The Plant cell. 2013 Jan; 25(1):149-66. doi: 10.1105/tpc.112.108191. [PMID: 23371947]
  • Yoko Hashizume, Ken Shirato, Shogo Sato, Akiko Matsumoto, Kaoru Tachiyashiki, Kazuhiko Imaizumi. Dose-dependent effects of diallyl disulfide on plasma glucose and free fatty acid levels in rats. The Journal of toxicological sciences. 2013; 38(6):879-84. doi: 10.2131/jts.38.879. [PMID: 24213007]
  • Chung-Ren Jan, Horng-Ren Lo, Chung-Yi Chen, Soong-Yu Kuo. Effect of allyl sulfides from garlic essential oil on intracellular ca2+ levels in renal tubular cells. Journal of natural products. 2012 Dec; 75(12):2101-7. doi: 10.1021/np3005248. [PMID: 23163425]
  • Nitin Dubey, Nidhi Dubey, Rajendra Mehta. Validation of HPTLC and HPLC methods for the quantitative determination of allyl disulfide in some polyherbal oils. Journal of AOAC International. 2012 Nov; 95(6):1574-8. doi: 10.5740/jaoacint.11-492. [PMID: 23451371]
  • Andres A Caro, Luke W Adlong, Samuel J Crocker, Michael W Gardner, Emily F Luikart, Liz U Gron. Effect of garlic-derived organosulfur compounds on mitochondrial function and integrity in isolated mouse liver mitochondria. Toxicology letters. 2012 Oct; 214(2):166-74. doi: 10.1016/j.toxlet.2012.08.017. [PMID: 22960305]
  • Dinesh Kumar Sharma, Apra Manral, Vikas Saini, Avninder Singh, B P Srinivasan, Manisha Tiwari. Novel diallyldisulfide analogs ameliorate cardiovascular remodeling in rats with L-NAME-induced hypertension. European journal of pharmacology. 2012 Sep; 691(1-3):198-208. doi: 10.1016/j.ejphar.2012.07.022. [PMID: 22819707]
  • Yang Peng, Li Jiahui, Li Aili, Wang Yong, Shi Zaixiang, Ke Yuannan, Li Xianlun. Garlicin attenuates reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction. Artificial cells, blood substitutes, and immobilization biotechnology. 2012 Aug; 40(4):285-9. doi: 10.3109/10731199.2011.649187. [PMID: 22471597]
  • R Arunkumar, G Sharmila, P Elumalai, K Senthilkumar, S Banudevi, D N Gunadharini, C S Benson, P Daisy, J Arunakaran. Effect of diallyl disulfide on insulin-like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in silico approach through docking analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Jul; 19(10):912-23. doi: 10.1016/j.phymed.2012.04.009. [PMID: 22739413]
  • Patrick Krumm, Teresa Giraldez, Diego Alvarez de la Rosa, Wolfgang G Clauss, Martin Fronius, Mike Althaus. Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC). Bioorganic & medicinal chemistry. 2012 Jul; 20(13):3979-84. doi: 10.1016/j.bmc.2012.05.021. [PMID: 22668601]
  • Kuang-Chi Lai, Chao-Lin Kuo, Heng-Chien Ho, Jai-Sing Yang, Chia-Yu Ma, Hsu-Feng Lu, Hui-Ying Huang, Fu-Shin Chueh, Chien-Chih Yu, Jing-Gung Chung. Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 May; 19(7):625-30. doi: 10.1016/j.phymed.2012.02.004. [PMID: 22397993]
  • Hai-Xiao Zhang, Zai-Xiang Shi, Hai-Zhong Jia. [Garlicin ameliorated pressure overload induced myocardial fibrosis in rats through partial inhibiting TGF-beta1 mediated Smads signal]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2012 May; 32(5):666-70. doi: NULL. [PMID: 22679731]
  • Sunčica Kocić-Tanackov, Gordana Dimić, Jelena Lević, Ilija Tanackov, Aleksandra Tepić, Biserka Vujičić, Jelica Gvozdanović-Varga. Effects of onion (Allium cepa L.) and garlic (Allium sativum L.) essential oils on the Aspergillus versicolor growth and sterigmatocystin production. Journal of food science. 2012 May; 77(5):M278-84. doi: 10.1111/j.1750-3841.2012.02662.x. [PMID: 22497489]
  • Guo Liang, Xuguang Qiao, Yanhong Bi, Baoyu Zou, Zhenjia Zheng. Studies on purification of allicin by molecular distillation. Journal of the science of food and agriculture. 2012 May; 92(7):1475-8. doi: 10.1002/jsfa.4729. [PMID: 22228257]
  • Małgorzata B Iciek, Danuta Kowalczyk-Pachel, Inga Kwiecień, Magdalena B Dudek. Effects of different garlic-derived allyl sulfides on peroxidative processes and anaerobic sulfur metabolism in mouse liver. Phytotherapy research : PTR. 2012 Mar; 26(3):425-31. doi: 10.1002/ptr.3572. [PMID: 21815229]
  • Shih-Hua Lee, Yu-Ting Liu, Ke-Ming Chen, Chong-Kuei Lii, Cheng-Tzu Liu. Effect of garlic sulfur compounds on neutrophil infiltration and damage to the intestinal mucosa by endotoxin in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Mar; 50(3-4):567-74. doi: 10.1016/j.fct.2011.11.027. [PMID: 22138247]
  • Yoko Hashizume, Ken Shirato, Ikumi Abe, Ayumu Kobayashi, Ryosuke Mitsuhashi, Chikako Shiono, Shogo Sato, Kaoru Tachiyashiki, Kazuhiko Imaizumi. Diallyl disulfide reduced dose-dependently the number of lymphocyte subsets and monocytes in rats. Journal of nutritional science and vitaminology. 2012; 58(4):292-6. doi: 10.3177/jnsv.58.292. [PMID: 23132314]
  • Samir Mandal, Sudip Mukherjee, Kaustav Dutta Chowdhury, Avik Sarkar, Kankana Basu, Soumosish Paul, Debasish Karmakar, Mahasweta Chatterjee, Tuli Biswas, Gobinda Chandra Sadhukhan, Gargi Sen. S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead. Biochimica et biophysica acta. 2012 Jan; 1820(1):9-23. doi: 10.1016/j.bbagen.2011.09.019. [PMID: 22033380]
  • Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions. Frontiers in pharmacology. 2012; 3(?):69. doi: 10.3389/fphar.2012.00069. [PMID: 22557968]
  • William W Li, Vincent W Li, Michelle Hutnik, Albert S Chiou. Tumor angiogenesis as a target for dietary cancer prevention. Journal of oncology. 2012; 2012(?):879623. doi: 10.1155/2012/879623. [PMID: 21977033]
  • Mohammed O Altonsy, Tito N Habib, Simon C Andrews. Diallyl disulfide-induced apoptosis in a breast-cancer cell line (MCF-7) may be caused by inhibition of histone deacetylation. Nutrition and cancer. 2012; 64(8):1251-60. doi: 10.1080/01635581.2012.721156. [PMID: 23163853]
  • Mustafa Kiralan, Ali Bayrak, Omar Fawzi Abdulaziz, Tuğba Ozbucak. Essential oil composition and antiradical activity of the oil of Iraq plants. Natural product research. 2012; 26(2):132-9. doi: 10.1080/14786419.2010.535149. [PMID: 21827329]
  • Cui-Li Zhang, Tao Zeng, Xiu-Lan Zhao, Li-Hua Yu, Zhen-Ping Zhu, Ke-Qin Xie. Protective effects of garlic oil on hepatocarcinoma induced by N-nitrosodiethylamine in rats. International journal of biological sciences. 2012; 8(3):363-74. doi: 10.7150/ijbs.3796. [PMID: 22393308]
  • Yasmeen M Nkrumah-Elie, Jayne S Reuben, Alicia M Hudson, Equar Taka, Ramesh Badisa, Tiffany Ardley, Bridg'ette Israel, Sakeenah Y Sadrud-Din, Ebenezer T Oriaku, Selina F Darling-Reed. The attenuation of early benzo(a)pyrene-induced carcinogenic insults by diallyl disulfide (DADS) in MCF-10A cells. Nutrition and cancer. 2012; 64(7):1112-21. doi: 10.1080/01635581.2012.712738. [PMID: 23006051]
  • Ana L Colín-González, Ricardo A Santana, Carlos A Silva-Islas, Maria E Chánez-Cárdenas, Abel Santamaría, Perla D Maldonado. The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Oxidative medicine and cellular longevity. 2012; 2012(?):907162. doi: 10.1155/2012/907162. [PMID: 22685624]
  • Fabien J Cousin, Sandrine Jouan-Lanhouet, Marie-Thérèse Dimanche-Boitrel, Laurent Corcos, Gwénaël Jan. Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells. PloS one. 2012; 7(3):e31892. doi: 10.1371/journal.pone.0031892. [PMID: 22442660]
  • Radu Vasile Bagiu, Brigitha Vlaicu, Monica Butnariu. Chemical composition and in vitro antifungal activity screening of the Allium ursinum L. (Liliaceae). International journal of molecular sciences. 2012; 13(2):1426-1436. doi: 10.3390/ijms13021426. [PMID: 22408399]
  • Akeem O Lawal, Elizabeth M Ellis. The chemopreventive effects of aged garlic extract against cadmium-induced toxicity. Environmental toxicology and pharmacology. 2011 Sep; 32(2):266-74. doi: 10.1016/j.etap.2011.05.012. [PMID: 21843808]
  • M Martinez-Velazquez, R Rosario-Cruz, G Castillo-Herrera, J M Flores-Fernandez, A H Alvarez, E Lugo-Cervantes. Acaricidal effect of essential oils from Lippia graveolens (Lamiales: Verbenaceae), Rosmarinus officinalis (Lamiales: Lamiaceae), and Allium sativum (Liliales: Liliaceae) against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). Journal of medical entomology. 2011 Jul; 48(4):822-7. doi: 10.1603/me10140. [PMID: 21845941]
  • Hyun Soo Park, Gi-Young Kim, Il-Whan Choi, Nam Deuk Kim, Hye Jin Hwang, Young-Whan Choi, Yung Hyun Choi. Inhibition of matrix metalloproteinase activities and tightening of tight junctions by diallyl disulfide in AGS human gastric carcinoma cells. Journal of food science. 2011 May; 76(4):T105-11. doi: 10.1111/j.1750-3841.2011.02114.x. [PMID: 22417372]