FA 7:2;O5 (BioDeep_00000629073)
Main id: BioDeep_00000005584
代谢物信息卡片
(2R,3S)-2-hydroxybutane-1,2,3-tricarboxylic acid;3-C-carboxy-2,4-dideoxy-2-methyl-D-threo-pentaric acid
化学式: C7H10O7 (206.042651)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(O)=O)[C@H](C(O)=O)[C@@](O)(C(O)=O)C
InChI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/t3-,7-/m1/s1
描述信息
同义名列表
5 个代谢物同义名
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylic acid; FA 7:2;O5; (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylic acid;3-C-carboxy-2,4-dideoxy-2-methyl-D-threo-pentaric acid; (2R, 3S)-2-Hydroxybutane-1,2,3-tricarboxylate;2-Hydroxybutane-1,2,3-tricarboxylate;2-Methylcitrate; (2R,3S)-2-methylcitric acid
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:15607
- ChEBI: CHEBI:30836
- KEGG: C04593
- PubChem: 5459784
- PubChem: 439681
- DrugBank: DB04072
- LipidMAPS: LMFA01050444
- LipidMAPS: LMFA01050442
- CAS: 64815-79-8
- PubChem: 7191
- PDB-CCD: MIC
- 3DMET: B01764
- NIKKAJI: J1.534.785F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiaqi Sun, Jun Ding, Qingsong Shen, Xiyang Wang, Min Wang, Yongping Huang, Xuechun Zhang, Huan Zhu, Feng Zhang, Dongde Wu, Min Peng, Zhonglin Zhang, Yufeng Yuan, Wenhua Li, Zhi-Gang She, Xiao-Jing Zhang, Hongliang Li, Peng Zhang, Zan Huang. Decreased propionyl-CoA metabolism facilitates metabolic reprogramming and promotes hepatocellular carcinoma.
Journal of hepatology.
2023 Mar; 78(3):627-642. doi:
10.1016/j.jhep.2022.11.017. [PMID: 36462680] - Toshiaki Komatsu, Hinako Morita, Yoko Takayama, Yui Natsume, Yoshinori Tomoda, Hirohisa Miura, Takeo Sato, Takatoshi Nakamura, Masaya Toda, Hirotsugu Okamoto, Hideaki Hanaki, Koichiro Atsuda. Timing of re-dosing based on population pharmacokinetic-pharmacodynamics target attainment analysis of cefmetazole in subjects undergoing lower gastrointestinal surgery.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Aug; 28(8):1105-1111. doi:
10.1016/j.jiac.2022.03.024. [PMID: 35400549] - Yoko Takayama, Toshiaki Komatsu, Takatoshi Nakamura, Yoshinori Tomoda, Masaya Toda, Hirohisa Miura, Takeo Sato, Koichiro Atsuda, Hirotsugu Okamoto, Hideaki Hanaki. Association of serum and fat tissue antibiotic concentrations with surgical site infections in lower gastrointestinal surgery.
Surgery.
2022 04; 171(4):1000-1005. doi:
10.1016/j.surg.2021.10.013. [PMID: 34772516] - Michelle R Denburg, Yunwen Xu, Alison G Abraham, Josef Coresh, Jingsha Chen, Morgan E Grams, Harold I Feldman, Paul L Kimmel, Casey M Rebholz, Eugene P Rhee, Ramachandran S Vasan, Bradley A Warady, Susan L Furth. Metabolite Biomarkers of CKD Progression in Children.
Clinical journal of the American Society of Nephrology : CJASN.
2021 08; 16(8):1178-1189. doi:
10.2215/cjn.00220121. [PMID: 34362785] - Toshiki Etani, Minami Asaoka, Shuhei Kondo, Chiharu Wachino, Kaoru Hori, Nobuhiko Shimizu, Yusuke Noda, Takashi Nagai, Satoshi Nozaki, Keitaro Iida, Taku Naiki, Ryosuke Ando, Noriyasu Kawai, Takeshi Yanagita, Atsushi Nakamura, Takahiro Yasui. Efficacy of fosfomycin in the prevention of postoperative infection following transurethral resection of bladder tumor during periods of limited cefazolin, cefotiam, and cefmetazole supply.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2021 Apr; 27(4):625-631. doi:
10.1016/j.jiac.2020.11.025. [PMID: 33309628] - Evelina Maines, Giulio Catesini, Sara Boenzi, Antonella Mosca, Manila Candusso, Luca Dello Strologo, Diego Martinelli, Arianna Maiorana, Alessandra Liguori, Giorgia Olivieri, Roberta Taurisano, Fiorella Piemonte, Cristiano Rizzo, Marco Spada, Carlo Dionisi-Vici. Plasma methylcitric acid and its correlations with other disease biomarkers: The impact in the follow up of patients with propionic and methylmalonic acidemia.
Journal of inherited metabolic disease.
2020 11; 43(6):1173-1185. doi:
10.1002/jimd.12287. [PMID: 32681732] - Osama Y Al-Dirbashi, Charu Sharma, Nahid Al Dahouri, Anas Al Aidaros, Shamma Al-Muhairi, Rami Beiram, Salah Gariballa, Juma Al Kaabi. Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study.
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2019 Nov; 23(11):1306-1314. doi:
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Pediatric transplantation.
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The Journal of nutrition.
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2011 Apr; 22(4):477-81. doi:
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The Journal of biological chemistry.
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The Japanese journal of antibiotics.
1990 Sep; 43(9):1530-7. doi:
. [PMID: 2262960] - C E Halstenson, D R Guay, J A Opsahl, C A Hirata, L S Olanoff, E Novak, H Ko, K S Cathcart, G R Matzke. Disposition of cefmetazole in healthy volunteers and patients with impaired renal function.
Antimicrobial agents and chemotherapy.
1990 Apr; 34(4):519-23. doi:
10.1128/aac.34.4.519. [PMID: 2344159] - J Igari, M Shitara, M Shitara, K Yoshimoto, Y Hayashi. [In vitro susceptibility of Escherichia coli and Klebsiella sp. to antibiotics].
The Japanese journal of antibiotics.
1990 Apr; 43(4):659-69. doi:
NULL. [PMID: 2199690] - J Morisaki, N Morisaki, T Chimura. [A study of tissue transfer of cefmetazole in the blood and uterus in pregnant rabbits].
The Japanese journal of antibiotics.
1990 Feb; 43(2):318-20. doi:
NULL. [PMID: 2362353] - R N Jones. Cefmetazole (CS-1170), a "new" cephamycin with a decade of clinical experience.
Diagnostic microbiology and infectious disease.
1989 Sep; 12(5):367-79. doi:
10.1016/0732-8893(89)90106-5. [PMID: 2692950] - J S Tan, S J Salstrom, S A Signs, H E Hoffman, T M File. Pharmacokinetics of intravenous cefmetazole with emphasis on comparison between predicted theoretical levels in tissue and actual skin window fluid levels.
Antimicrobial agents and chemotherapy.
1989 Jun; 33(6):924-7. doi:
10.1128/aac.33.6.924. [PMID: 2764542] - M Sugimoto, K Saito, M Hashimoto, S Horie, Y Wakabayashi, S Hirose, Y Murata, M Kobayashi. [Antibiotics-induced agranulocytosis. Patient's IgG inhibits a GM colony formation].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
1989 May; 30(5):768-73. doi:
NULL. [PMID: 2795889] - H Takeuchi, Y Okada, O Yoshida, T Konishi, T Tomoyoshi, S Nakahara. [Urinary tract infection associated with urinary calculi. 2. Effects of antibiotics on bacteria within infected stones].
Hinyokika kiyo. Acta urologica Japonica.
1989 May; 35(5):755-61. doi:
NULL. [PMID: 2801373] - J B Moe, R C Piper, H Tanase, K Sotani, J Manabe. Preclinical safety studies of cefmetazole.
The Journal of antimicrobial chemotherapy.
1989 Apr; 23 Suppl D(?):125-9. doi:
10.1093/jac/23.suppl_d.125. [PMID: 2722719] - H Ko, E Novak, G R Peters, W M Bothwell, J D Hosley, S K Closson, W J Adams. Pharmacokinetics of single-dose cefmetazole following intramuscular administration of cefmetazole sodium to healthy male volunteers.
Antimicrobial agents and chemotherapy.
1989 Apr; 33(4):508-12. doi:
10.1128/aac.33.4.508. [PMID: 2729944] - J T DiPiro, J E Connors, T A Bowden, J A Stanfield, B M Lampert, J T Stewart. Comparative intraoperative concentrations of two cephalosporins with activity against anaerobic bacteria.
The Journal of antimicrobial chemotherapy.
1989 Apr; 23 Suppl D(?):89-95. doi:
10.1093/jac/23.suppl_d.89. [PMID: 2722728] - H Ko, K S Cathcart, D L Griffith, G R Peters, W J Adams. Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination.
Antimicrobial agents and chemotherapy.
1989 Mar; 33(3):356-61. doi:
10.1128/aac.33.3.356. [PMID: 2729930] - W M Bothwell, K S Cathcart, P A Bombardt. An on-line, column-switching high-performance liquid chromatographic procedure for the removal of probenecid from human plasma, serum, or urine in the quantitative determination of cefmetazole or cefoxitin.
Journal of pharmaceutical and biomedical analysis.
1989; 7(8):987-95. doi:
10.1016/0731-7085(89)80024-x. [PMID: 2490108] - T Hayashi, A Maruden, K Irimura, M Kuwata, K Morita. [Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].
The Journal of toxicological sciences.
1988 Jun; 13 Suppl 1(?):285-327. doi:
10.2131/jts.13.supplementi_285. [PMID: 3172294] - F Soriano, M Santamaría, C Ponte, C Castilla, R Fernández-Roblas. In vivo significance of the inoculum effect of antibiotics on Escherichia coli.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
1988 Jun; 7(3):410-2. doi:
10.1007/bf01962350. [PMID: 3137046] - M K Ito, M A Gill, F C Chenella, T V Berne, A E Yellin, P N Heseltine, M D Appleman. Intraoperative serum, bile, and gallbladder-wall concentrations of cefmetazole in patients undergoing cholecystectomy.
Clinical pharmacy.
1988 Jun; 7(6):467-8. doi:
NULL. [PMID: 3165314] - K Yoshino, K Fujita, M Takemoto, M Suga. [Penetration of cefmetazole and netilmicin into the cerebrospinal fluid].
The Japanese journal of antibiotics.
1988 May; 41(5):563-6. doi:
NULL. [PMID: 3216478] - R E Kretschmer, C Bachmann. Methylcitric acid determination in amniotic fluid by electron-impact mass fragmentography.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1988 May; 26(5):345-8. doi:
10.1515/cclm.1988.26.5.345. [PMID: 3404093] - J A Stanfield, J T DiPiro. Interference of cefmetazole sodium and cefotetan disodium with urine-glucose testing systems.
American journal of hospital pharmacy.
1988 Mar; 45(3):625-6. doi:
10.1093/ajhp/45.3.625. [PMID: 3163470] - T Miura, I Hashimoto, Y Sawada, T Nakamura, M Nakahara. [Pharmacokinetics of cefmetazole during and after surgical operations].
The Japanese journal of antibiotics.
1987 Nov; 40(11):1923-36. doi:
NULL. [PMID: 3481836] - S Asari, M Horikawa, H Tsukamoto, K Kouda, C Hayashi, K Miyai. [Susceptibility of clinical isolates to aztreonam].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1317-31. doi:
. [PMID: 3479624] - H Nakahata, Y Hirai, Y Kumasaka, T Miyazawa, T Nakamura, K Imamura, I Makino, K Takebe, H Kudo. [Free methyltetrazolethiol concentrations in men subjected to intravenous administration of cephems with methyltetrazolethiol].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1294-8. doi:
NULL. [PMID: 3479623] - M Shiga, M Hayashi, T Horie, S Awazu. Differences in the promotion mechanism of the colonic absorption of antipyrine, phenol red and cefmetazole.
The Journal of pharmacy and pharmacology.
1987 Feb; 39(2):118-23. doi:
10.1111/j.2042-7158.1987.tb06956.x. [PMID: 2881996] - J Igari, M Shitara, M Morimoto, N Shiga, N Kosakai. [A nationwide study of the antimicrobial susceptibility of clinical isolates of Klebsiella sp. in Japan].
The Japanese journal of antibiotics.
1986 Nov; 39(11):3110-24. doi:
NULL. [PMID: 3469423] - J Igari, M Shitara, M Morimoto, N Shiga, N Kosakai. [A nationwide study of the antimicrobial susceptibility of clinical isolates of Escherichia coli in Japan].
The Japanese journal of antibiotics.
1986 Nov; 39(11):3094-109. doi:
NULL. [PMID: 3546776] - H Takahagi, K Inoue, M Horiguchi. Drug monitoring by a fully automated high-performance liquid chromatographic technique, involving direct injection of plasma.
Journal of chromatography.
1986 Feb; 352(?):369-79. doi:
10.1016/s0021-9673(01)83394-x. [PMID: 3457796] - Y Kumasaka, H Nakahata, Y Hirai, K Imamura, K Takebe, I Suzuki, H Senda. [In vivo antibacterial activity of cefbuperazone. Synergy of cefbuperazone for bactericidal effect with human polymorphonuclear leukocytes].
The Japanese journal of antibiotics.
1986 Jan; 39(1):154-8. doi:
NULL. [PMID: 3517405] - J Rodriguez-Barbero, E L Mariño, A Dominguez-Gil. Pharmacokinetics of cefmetazole administered intramuscularly and intravenously to healthy adults.
Antimicrobial agents and chemotherapy.
1985 Oct; 28(4):544-7. doi:
10.1128/aac.28.4.544. [PMID: 3865631] - D M Mock, D L Baswell, H Baker, R T Holman, L Sweetman. Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment.
The Journal of pediatrics.
1985 May; 106(5):762-9. doi:
10.1016/s0022-3476(85)80350-4. [PMID: 3923177] - J Rodriquez Barbero, E L Mariño, A Dominquez-Gil, J Garcia Garcia, J M Rodriquez Rodriquez, A Gomez Alonso. Cefmetazole plasma levels after intraincisional administration.
Drug intelligence & clinical pharmacy.
1985 May; 19(5):394-6. doi:
10.1177/106002808501900516. [PMID: 3859398] - M Sekine, H Terashima, K Sasahara, K Nishimura, R Okada, S Awazu. Improvement of bioavailability of poorly absorbed drugs. II. Effect of medium chain glyceride base on the intestinal absorption of cefmetazole sodium in rats and dogs.
Journal of pharmacobio-dynamics.
1985 Apr; 8(4):286-95. doi:
10.1248/bpb1978.8.286. [PMID: 3861846] - J Shimada, Y Hayashi, K Nakamura. Cefmetazole: clinical evaluation of efficacy and safety in Japan.
Drugs under experimental and clinical research.
1985; 11(3):181-94. doi:
. [PMID: 3869805] - T Ueda, K Sakai, M Fujimoto. Studies of cefotaxime serum concentrations during surgery under general anaesthesia and its passage to the wound fluid after surgery for breast cancer.
Infection.
1985; 13 Suppl 1(?):S43-5. doi:
10.1007/bf01644217. [PMID: 3863795] - J R Rodríguez, E L Mariño, M J Otero, J R Commes, J Garcia, J M Rodriguez, F Lozano, A Dominguez-Gil, A G Alonso. Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy.
Antimicrobial agents and chemotherapy.
1984 Nov; 26(5):787-8. doi:
10.1128/aac.26.5.787. [PMID: 6595964] - K Fujita, M Sugimoto, T Hara, T Murayama. [Concentration of antibiotics in the prostate: cefmetazole].
The Japanese journal of antibiotics.
1984 Sep; 37(9):1694-6. doi:
NULL. [PMID: 6210377] - T Watanabe, T Hara, T Kasai, T Ishii, K Miyauchi, H Date, M Jinzaki, H Shindo, A Matsugami, H Goi. [Antibacterial activity of MT-141 against anaerobic bacteria].
The Japanese journal of antibiotics.
1984 Jun; 37(6):1058-69. doi:
. [PMID: 6092738] - T Miyano, T Arai, H Shimomura, T Ogawa, K Sasaki, E Deguchi, K Suruga, H Nittono. [The correlation between the biliary excretion of cefmetazole and the bile acid metabolism in postoperative patients with biliary atresia].
The Japanese journal of antibiotics.
1984 Feb; 37(2):243-6. doi:
NULL. [PMID: 6588213] - T Miyano, H Shimomura, T Arai, K Sasaki, T Ogawa, E Deguchi, K Suruga. [Postoperative evaluation of renal function from the aspect of urinary concentration of cefmetazole in infants and children with vesicoureteral reflux and hydronephrosis. I].
The Japanese journal of antibiotics.
1984 Feb; 37(2):237-42. doi:
NULL. [PMID: 6588212]