Methylisocitric acid (BioDeep_00000005584)

 

Secondary id: BioDeep_00000629073, BioDeep_00001869592

human metabolite


代谢物信息卡片


1-hydroxy-1-methylpropane-1,2,3-tricarboxylic acid

化学式: C7H10O7 (206.0427)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(otcml) 11.02%

分子结构信息

SMILES: CC(C(CC(=O)O)C(=O)O)(C(=O)O)O
InChI: InChI=1S/C7H10O7/c1-7(14,6(12)13)3(5(10)11)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)

描述信息

Methylisocitric acid is a product of bacterial metabolism in the gut. It can be produced by 2-methylisocitrate lyase and by 2-methylisocitrate dehydratase. Methylisocitric acid has also been found to be a metabolite of Candida (https://www.tandfonline.com/doi/pdf/10.1080/00021369.1974.10861293).
Methylisocitric acid is a product of bacterial metabolism in the gut. It can be produced by 2-methylisocitrate lyase and by 2-methylisocitrate dehydratase. [HMDB]

同义名列表

22 个代谢物同义名

1-hydroxy-1-methylpropane-1,2,3-tricarboxylic acid; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylic acid; 3-Carboxy-2,3-dideoxy-4-C-methylpentaric acid; (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate; Threo-alpha-methylisocitrate, (3)H-labeled; 3-Carboxy-2,3-dideoxy-4-C-methylpentarate; 3-Hydroxybutane-1,2,3-tricarboxylic acid; 3-Hydroxy-1,2,3-butanetricarboxylic acid; 3-Hydroxy-1,2,3-butanetricarboxylate; DL-Threo-alpha-methylisocitrate; threo-alpha-Methylisocitrate; alpha-Methylisocitric acid; (2R,3S)2-Methylisocitrate; DL-Methylisocitric acid; Α-methylisocitric acid; a-Methylisocitric acid; alpha-Methylisocitrate; Methylisocitric acid; D.L-methylisocitrate; Α-methylisocitrate; a-Methylisocitrate; Methylisocitrate



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Toshiaki Komatsu, Hinako Morita, Yoko Takayama, Yui Natsume, Yoshinori Tomoda, Hirohisa Miura, Takeo Sato, Takatoshi Nakamura, Masaya Toda, Hirotsugu Okamoto, Hideaki Hanaki, Koichiro Atsuda. Timing of re-dosing based on population pharmacokinetic-pharmacodynamics target attainment analysis of cefmetazole in subjects undergoing lower gastrointestinal surgery. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2022 Aug; 28(8):1105-1111. doi: 10.1016/j.jiac.2022.03.024. [PMID: 35400549]
  • Yoko Takayama, Toshiaki Komatsu, Takatoshi Nakamura, Yoshinori Tomoda, Masaya Toda, Hirohisa Miura, Takeo Sato, Koichiro Atsuda, Hirotsugu Okamoto, Hideaki Hanaki. Association of serum and fat tissue antibiotic concentrations with surgical site infections in lower gastrointestinal surgery. Surgery. 2022 04; 171(4):1000-1005. doi: 10.1016/j.surg.2021.10.013. [PMID: 34772516]
  • Toshiki Etani, Minami Asaoka, Shuhei Kondo, Chiharu Wachino, Kaoru Hori, Nobuhiko Shimizu, Yusuke Noda, Takashi Nagai, Satoshi Nozaki, Keitaro Iida, Taku Naiki, Ryosuke Ando, Noriyasu Kawai, Takeshi Yanagita, Atsushi Nakamura, Takahiro Yasui. Efficacy of fosfomycin in the prevention of postoperative infection following transurethral resection of bladder tumor during periods of limited cefazolin, cefotiam, and cefmetazole supply. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2021 Apr; 27(4):625-631. doi: 10.1016/j.jiac.2020.11.025. [PMID: 33309628]
  • Akiyoshi Horie, Akiyoshi Nariai, Fumihide Katou, Yasuhiro Abe, Yuya Saito, Daisuke Koike, Tomohiro Hirade, Tomoko Ito, Miho Wakuri, Aiko Fukuma. Increased community-acquired upper urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in children and the efficacy of flomoxef and cefmetazole. Clinical and experimental nephrology. 2019 Nov; 23(11):1306-1314. doi: 10.1007/s10157-019-01775-w. [PMID: 31428892]
  • Natsuki Shioji, Minoru Mizutani, Mariko Okayama, Haruna Katayama, Eiko Ooya, Takao Sekine, Masahiro Masuya. [Drug-induced immune hemolytic anemia caused by cefmetazole]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2018 ; 59(7):884-888. doi: 10.11406/rinketsu.59.884. [PMID: 30078798]
  • Toshitaka Sugawara, Junichi Shindoh, Yujiro Nishioka, Masaji Hashimoto. Total bilirubin amount in drainage fluid can be an early predictor for severe biliary fistula after hepatobiliary surgery. Bioscience trends. 2017 Nov; 11(5):588-594. doi: 10.5582/bst.2017.01208. [PMID: 29070759]
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  • Takatoshi Nakamura, Atsushi Tomizawa, Hiroshi Inano, Takeo Sato, Kazuo Yago, Masahiko Watanabe. Tissue concentrations of antibiotics given prophylactically during colorectal cancer surgery. Hepato-gastroenterology. 2013 Sep; 60(126):1371-5. doi: 10.5754/hge13070. [PMID: 23933929]
  • Asako Doi, Toshihiko Shimada, Sohei Harada, Kentaro Iwata, Toru Kamiya. The efficacy of cefmetazole against pyelonephritis caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2013 Mar; 17(3):e159-63. doi: 10.1016/j.ijid.2012.09.010. [PMID: 23140947]
  • Tetsuhiro Owaki, Hiroshi Okumura, Yasuto Uchikado, Ken Sasaki, Masataka Matsumoto, Itaru Omoto, Tetsuro Setoyama, Yoshiaki Kita, Toshihide Sakurai, Daisuke Matsushita, Sumiya Ishigami, Shinichi Ueno, Shoji Natsugoe. Serum concentrations of antibiotics during severe invasive surgery such as esophagectomy for esophageal cancer. International surgery. 2013 Jan; 98(1):1-5. doi: 10.9738/cc164.1. [PMID: 23438269]
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  • Miki Katoh, Chise Tateno, Katsutoshi Yoshizato, Tsuyoshi Yokoi. Chimeric mice with humanized liver. Toxicology. 2008 Apr; 246(1):9-17. doi: 10.1016/j.tox.2007.11.012. [PMID: 18248870]
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