Sophoramine (BioDeep_00000410440)

Main id: BioDeep_00000000909

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(5β)-11,12,13,14-Tetradehydromatridin-15-one

化学式: C15H20N2O (244.1576)
中文名称: 新槐胺, 槐胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC2CN3C(=O)C=CC=C3C4C2N(C1)CCC4
InChI: InChI=1S/C15H20N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,6-7,11-12,15H,2-5,8-10H2/t11-,12+,15-/m0/s1

描述信息

Origin: Plant; SubCategory_DNP: Alkaloids derived from lysine, Quinolizidine alkaloids, Sophora alkaloid

同义名列表

4 个代谢物同义名

(5β)-11,12,13,14-Tetradehydromatridin-15-one; 3,4,5,6-Tetradehydrospartein-2-one; Sophoramine; Sophoramine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

39 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKT1, AXIN2, EGFR, ISG20, NOL3, PTGS2, STAT3, TP53
Peripheral membrane protein 1 PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 CD4, EGFR, PTGS2
Nucleus 6 AKT1, AXIN2, EGFR, ISG20, STAT3, TP53
cytosol 5 AKT1, AXIN2, NOL3, STAT3, TP53
centrosome 2 AXIN2, TP53
nucleoplasm 4 AKT1, ISG20, STAT3, TP53
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 4 AKT1, CD4, EGFR, TNF
Lipid-anchor 1 NOL3
lamellipodium 1 AKT1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 2 EGFR, TNF
glutamatergic synapse 2 AKT1, EGFR
Golgi membrane 1 EGFR
neuronal cell body 1 TNF
postsynapse 1 AKT1
endosome 1 EGFR
plasma membrane 6 AKT1, AXIN2, CD4, EGFR, STAT3, TNF
Membrane 4 AKT1, EGFR, NOL3, TP53
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
endoplasmic reticulum 2 PTGS2, TP53
extracellular space 4 EGFR, IL10, IL4, TNF
perinuclear region of cytoplasm 1 EGFR
mitochondrion 2 NOL3, TP53
protein-containing complex 4 AKT1, EGFR, PTGS2, TP53
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 2 CD4, EGFR
Secreted 2 IL10, IL4
extracellular region 3 IL10, IL4, TNF
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nuclear membrane 1 EGFR
external side of plasma membrane 2 CD4, TNF
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 AKT1
nucleolus 3 ISG20, NOL3, TP53
sarcoplasm 1 NOL3
Cytoplasm, P-body 1 ISG20
P-body 1 ISG20
Early endosome 1 CD4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 3 CD4, EGFR, TNF
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
spindle 1 AKT1
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 NOL3
Nucleus, PML body 1 TP53
PML body 2 ISG20, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 STAT3, TP53
phagocytic cup 1 TNF
Nucleus, nucleolus 1 ISG20
site of double-strand break 1 TP53
germ cell nucleus 1 TP53
replication fork 1 TP53
basal plasma membrane 1 EGFR
[Isoform 3]: Cytoplasm 1 NOL3
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 2 CD4, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
[Isoform 2]: Cytoplasm 1 NOL3
clathrin-coated endocytic vesicle membrane 2 CD4, EGFR
Cajal body 1 ISG20
[Isoform 1]: Nucleus 1 TP53
[Isoform 1]: Nucleus, nucleolus 1 NOL3
Nucleus, Cajal body 1 ISG20
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Li-Jun He, Jun-Shan Liu, Ding Luo, Yuan-Ru Zheng, Yu-Bo Zhang, Guo-Cai Wang, Yao-Lan Li. Quinolizidine alkaloids from Sophora tonkinensis and their anti-inflammatory activities. Fitoterapia. 2019 Nov; 139(?):104391. doi: 10.1016/j.fitote.2019.104391. [PMID: 31682871]
  • Yu-Bo Zhang, Ding Luo, Li Yang, Wen Cheng, Li-Jun He, Guang-Kai Kuang, Man-Mei Li, Yao-Lan Li, Guo-Cai Wang. Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus. Journal of natural products. 2018 10; 81(10):2259-2265. doi: 10.1021/acs.jnatprod.8b00576. [PMID: 30298740]
  • Yuefan Zhang, Shaozhan Wang, Yuanyuan Li, Zhenyu Xiao, Zhenlin Hu, Junping Zhang. Sophocarpine and matrine inhibit the production of TNF-alpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice. International immunopharmacology. 2008 Dec; 8(13-14):1767-72. doi: 10.1016/j.intimp.2008.08.008. [PMID: 18775799]
  • X D Liu, S K Huang, H N Yuan. [Determination of sophoramine and sophocarpine in rabbit plasma by capillary column gas chromatography and their pharmacokinetics]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1987 Sep; 8(5):474-7. doi: . [PMID: 3450185]