dapsone (BioDeep_00000408881)

Main id: BioDeep_00000001703

 


代谢物信息卡片


4,4-Diaminodiphenylsulfone

化学式: C12H12N2O2S (248.0619)
中文名称: 4,4-二氨基二苯砜
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2

描述信息

J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04B - Drugs for treatment of lepra > J04BA - Drugs for treatment of lepra
D - Dermatologicals > D10 - Anti-acne preparations > D10A - Anti-acne preparations for topical use
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007917 - Leprostatic Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C254 - Anti-Infective Agent > C849 - Sulfone Anti-Infective Agent
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

3 个代谢物同义名

4,4-Diaminodiphenylsulfone; dapsone; Dapsone



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, AXIN2, CAT, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, DHFR, G6PD, NAT2
Peripheral membrane protein 3 CYP1B1, CYP2E1, G6PD
Endosome membrane 1 HLA-B
Endoplasmic reticulum membrane 8 CD4, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, HLA-B
Nucleus 4 ALB, AXIN2, MPO, NAT2
cytosol 6 ALB, AXIN2, CAT, DHFR, G6PD, NAT2
centrosome 2 ALB, AXIN2
nucleoplasm 1 MPO
Cell membrane 5 CD4, HLA-B, MPL, NAT2, TNF
Early endosome membrane 1 HLA-B
Multi-pass membrane protein 1 NAT2
cell surface 3 HLA-B, MPL, TNF
Golgi apparatus 3 ALB, HLA-B, MPL
Golgi membrane 1 HLA-B
lysosomal membrane 1 HLA-B
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 3 MPL, NAT2, TNF
Cytoplasm, cytosol 1 G6PD
Lysosome 1 MPO
plasma membrane 9 AXIN2, CD4, COL17A1, CYP2C19, CYP2C9, HLA-B, MPL, NAT2, TNF
Membrane 9 CAT, COL17A1, CYP1B1, CYP2D6, CYP3A4, G6PD, HLA-B, MPL, NAT2
axon 1 NAT2
basolateral plasma membrane 1 NAT2
extracellular exosome 6 ALB, CAT, G6PD, HLA-B, MPO, NAT2
Lysosome membrane 1 HLA-B
endoplasmic reticulum 3 ALB, CYP2D6, HLA-B
extracellular space 7 ALB, COL17A1, CRP, CXCL8, HLA-B, MPO, TNF
mitochondrion 4 CAT, CYP1B1, CYP2D6, DHFR
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 9 CAT, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, G6PD, MPO
Microsome membrane 5 CYP1B1, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Single-pass type I membrane protein 3 CD4, HLA-B, MPL
Secreted 3 ALB, CRP, CXCL8
extracellular region 7 ALB, CAT, COL17A1, CRP, CXCL8, MPO, TNF
cytoplasmic side of plasma membrane 1 G6PD
Single-pass membrane protein 2 CYP2D6, HLA-B
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 1 NAT2
centriolar satellite 1 G6PD
nuclear membrane 1 MPL
external side of plasma membrane 4 CD4, HLA-B, MPL, TNF
beta-catenin destruction complex 1 AXIN2
Early endosome 1 CD4
cell-cell junction 1 COL17A1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 2 CD4, TNF
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 COL17A1
collagen trimer 1 COL17A1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 COL17A1
secretory granule 1 MPO
ciliary basal body 1 ALB
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 HLA-B
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Recycling endosome membrane 1 HLA-B
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
secretory granule membrane 1 HLA-B
endoplasmic reticulum lumen 3 ALB, CD4, COL17A1
platelet alpha granule lumen 1 ALB
azurophil granule lumen 1 MPO
ER to Golgi transport vesicle membrane 1 HLA-B
clathrin-coated endocytic vesicle membrane 1 CD4
phagocytic vesicle lumen 1 MPO
external side of apical plasma membrane 1 NAT2
lumenal side of endoplasmic reticulum membrane 1 HLA-B
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
MHC class I protein complex 1 HLA-B
MHC class II protein complex 1 HLA-B
catalase complex 1 CAT
hemidesmosome 1 COL17A1
NatA complex 1 NAT2
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Thakur Rohit Singh, Devaraj Ezhilarasan. Lagerstroemia speciosa (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats. Drug and chemical toxicology. 2022 Sep; 45(5):2361-2370. doi: 10.1080/01480545.2021.1945079. [PMID: 34225555]
  • Mohammad Reza Madanipour, Mortaza Fatehi-Zardalou, Nastaran Rahimi, Sara Hemmati, Mojgan Alaeddini, Shahroo Etemad-Moghadam, Maryam Shayan, Sasan Dabiri, Ahmad Reza Dehpour. The anti-inflammatory effect of dapsone on ovalbumin-induced allergic rhinitis in balb/c mice. Life sciences. 2022 May; 297(?):120449. doi: 10.1016/j.lfs.2022.120449. [PMID: 35245518]
  • G S Basavaraj, Riddhi Das Gupta, Bhavesh Patel, Felix Jebasingh, Anu Anna George, Dincy Peter, Leni George, Thomas V Paul, Nihal Thomas. Erroneous reduction of HbA1c levels in patients with type 2 diabetes mellitus on dapsone treatment for Hansen's disease - a single-center retrospective cohort study. Indian journal of dermatology, venereology and leprology. 2022 May; 88(4):519-522. doi: 10.25259/ijdvl_527_18. [PMID: 33871212]
  • Akshay Khatri, Sarath Lal M R, Madhu C Bhaskaran. Dapsone-Associated Hemolytic Anemia in Renal Transplant Recipients With Normal Glucose-6-Phosphate-Dehydrogenase Levels. American journal of therapeutics. 2022 May; 29(3):e369-e372. doi: 10.1097/mjt.0000000000001252. [PMID: 32947344]
  • Xuesong Wang, Zhenzhen Wang, Lulu Sun, Hong Liu, Furen Zhang. Efficacy and safety of dapsone gel for acne: a systematic review and meta-analysis. Annals of palliative medicine. 2022 Feb; 11(2):611-620. doi: 10.21037/apm-21-3935. [PMID: 35249339]
  • Marco Andrey Cipriani Frade, Fred Bernardes Filho, Ana Laura Quirino de Lima, Marcelo Bezerra de Menezes, Helena Barbosa Lugão. Asymptomatic low pulse oximetry measurements in leprosy patients in the time of COVID-19: Dapsone side effect. Revista da Sociedade Brasileira de Medicina Tropical. 2022; 55(?):e0491. doi: 10.1590/0037-8682-0491-2021. [PMID: 35239908]
  • Shasank Sekhar Swain, Gunanidhi Sahoo, Pravati Kumari Mahapatra, Sujogya Kumar Panda. Disease Burden and Current Therapeutical Status of Leprosy with Special Emphasis on Phytochemicals. Current topics in medicinal chemistry. 2022; 22(19):1611-1625. doi: 10.2174/1568026621666210909162435. [PMID: 34503409]
  • Samira Shirooie, Ehsan Khaledi, Ahmad Reza Dehpour, Tayebeh Noori, Mozafar Khazaei, Faezeh Sadeghi, Eduardo Sobarzo-Sánchez. The effect of dapsone in testosterone enanthate-induced polycystic ovary syndrome in rat. The Journal of steroid biochemistry and molecular biology. 2021 11; 214(?):105977. doi: 10.1016/j.jsbmb.2021.105977. [PMID: 34428594]
  • Alfonso Mata-Bermudez, Araceli Diaz-Ruiz, Masha Burelo, Betzabeth Anali García-Martínez, Gustavo Jardon-Guadarrama, Francisco Calderón-Estrella, Andrea Rangel-Hernández, Cuauhtémoc Pérez-González, Rios Camilo. Dapsone Prevents Allodynia and Hyperalgesia and Decreased Oxidative Stress After Spinal Cord Injury in Rats. Spine. 2021 Oct; 46(19):1287-1294. doi: 10.1097/brs.0000000000004015. [PMID: 34517396]
  • T Tripathi, A R Singh, R Kapoor, A Sinha, S Ghosh, K Kaur, D Pokhariya, S Maity, A Tapadar, A Chandra. Dapsone-induced methaemoglobinaemia in leprosy: a close mimic of 'happy hypoxia' in the COVID-19 pandemic. Journal of the European Academy of Dermatology and Venereology : JEADV. 2021 09; 35(9):e568-e571. doi: 10.1111/jdv.17394. [PMID: 34037283]
  • Chiara Sabbadin, Alessandra Andrisani, Gabriella Donà, Elena Tibaldi, Anna Maria Brunati, Stefano Dall'Acqua, Eugenio Ragazzi, Guido Ambrosini, Decio Armanini, Luciana Bordin. Endometriosis Susceptibility to Dapsone-Hydroxylamine-Induced Alterations Can Be Prevented by Licorice Intake: In Vivo and In Vitro Study. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22168476. [PMID: 34445180]
  • Sai Sudha Mannemuddhu, Rozina Ali, Salam Kadhem, Rupam Ruchi. Unusual cause of persistent dyspnea in a patient with nephrotic syndrome: dapsone-induced methemoglobinemia. CEN case reports. 2021 08; 10(3):336-340. doi: 10.1007/s13730-020-00565-8. [PMID: 33417185]
  • Selma Regina Penha Silva Cerqueira, Patrícia Duarte Deps, Débora Vilela Cunha, Natanael Victor Furtunato Bezerra, Daniel Holanda Barroso, Ana Bárbara Sapienza Pinheiro, Gecilmara Salviato Pillegi, Taynah Alves Rocha Repsold, Patrícia Shu Kurizky, Simon M Collin, Ciro Martins Gomes. The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study. PLoS neglected tropical diseases. 2021 07; 15(7):e0009635. doi: 10.1371/journal.pntd.0009635. [PMID: 34319982]
  • Aditi Hindka, Dao Huynh, Priya S Verghese. Dapsone-induced methemoglobinemia in pediatrics post-renal transplant. Pediatric transplantation. 2021 May; 25(3):e13921. doi: 10.1111/petr.13921. [PMID: 33280223]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Sriram Sriperumbuduri, Caitlin Hesketh, Edward G Clark. A Transplant Patient with Blue Lips, Tongue, and Fingertips. Kidney360. 2021 02; 2(2):398-399. doi: 10.34067/kid.0005102020. [PMID: 35373029]
  • Rita Sampaio, Leandro Silva, Goreti Catorze, Isabel Viana. Cutaneous Rosai-Dorfman disease: a challenging diagnosis. BMJ case reports. 2021 Feb; 14(2):. doi: 10.1136/bcr-2020-239244. [PMID: 33541998]
  • Sunmeet Sandhu, Shekhar Neema, Deepak Vashisht, Ruby Venugopal, Prashant Sengupta, Subramaniyan Radhakrishnan. Drug reaction with eosinophilia and systemic symptoms: A single center descriptive observational study. Dermatologic therapy. 2021 01; 34(1):e14670. doi: 10.1111/dth.14670. [PMID: 33314590]
  • Gabriela Schneider-Rauber, Debora Fretes Argenta, Thiago Caon. Emerging Technologies to Target Drug Delivery to the Skin - the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone. Pharmaceutical research. 2020 Nov; 37(12):240. doi: 10.1007/s11095-020-02951-4. [PMID: 33169237]
  • Ömer Faruk Elmas, Abdullah Demirbaş, Ümit Türsen, Mustafa Atasoy, Torello Lotti. Pemphigus and COVID-19: Critical overview of management with a focus on treatment choice. Dermatologic therapy. 2020 11; 33(6):e14265. doi: 10.1111/dth.14265. [PMID: 32882079]
  • Jong-Hoon Lee, Ha Kyeu An, Mun-Gi Sohn, Paul Kivela, Sangsuk Oh. 4,4'-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor. International journal of molecular sciences. 2020 Aug; 21(17):. doi: 10.3390/ijms21175953. [PMID: 32824985]
  • Eric L Altschuler, Richard E Kast. Dapsone, colchicine and olanzapine as treatment adjuncts to prevent COVID-19 associated adult respiratory distress syndrome (ARDS). Medical hypotheses. 2020 08; 141(?):109774. doi: 10.1016/j.mehy.2020.109774. [PMID: 32344275]
  • Ahmed Farouk, Samar Salman. Dapsone and doxycycline could be potential treatment modalities for COVID-19. Medical hypotheses. 2020 07; 140(?):109768. doi: 10.1016/j.mehy.2020.109768. [PMID: 32339778]
  • Joseph George. Metabolism and interactions of antileprosy drugs. Biochemical pharmacology. 2020 07; 177(?):113993. doi: 10.1016/j.bcp.2020.113993. [PMID: 32339493]
  • Sadaf Nezamoleslami, Mohammad Sheibani, Fatemeh Jahanshahi, Faiza Mumtaz, Ata Abbasi, Ahmad Reza Dehpour. Protective effect of dapsone against renal ischemia-reperfusion injury in rat. Immunopharmacology and immunotoxicology. 2020 Jun; 42(3):272-279. doi: 10.1080/08923973.2020.1755308. [PMID: 32321337]
  • Mohammad Sheibani, Sadaf Nezamoleslami, Hedyeh Faghir-Ghanesefat, Amir Hossein Emami, Ahmad Reza Dehpour. Cardioprotective effects of dapsone against doxorubicin-induced cardiotoxicity in rats. Cancer chemotherapy and pharmacology. 2020 03; 85(3):563-571. doi: 10.1007/s00280-019-04019-6. [PMID: 31915967]
  • Gurinder Kumar, Hanan Khalid AlHadhrami. Bullous lesions in a young adolescent postrenal transplant. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2020 Mar; 31(2):553-555. doi: 10.4103/1319-2442.284037. [PMID: 32394935]
  • Christopher Evernden, Michelle Dowhan, Rosy Dabas, Ahsan Chaudhry, Amit Kalra, Poonam Dharmani-Khan, Daniel Gregson, Andrew Johnson, Jennifer Jupp, Victor Jimenez-Zepeda, Kareem Jamani, Peter Duggan, Jason Tay, Faisal Khan, Andrew Daly, Jan Storek. High incidence of Pneumocystis jirovecii pneumonia in allogeneic hematopoietic cell transplant recipients in the modern era. Cytotherapy. 2020 01; 22(1):27-34. doi: 10.1016/j.jcyt.2019.11.002. [PMID: 31889628]
  • Mohammed Elmowafy, Khaled Shalaby, Hazim M Ali, Nabil K Alruwaili, Ayman Salama, Mohamed F Ibrahim, Mohamed A Akl, Tarek A Ahmed. Impact of nanostructured lipid carriers on dapsone delivery to the skin: in vitro and in vivo studies. International journal of pharmaceutics. 2019 Dec; 572(?):118781. doi: 10.1016/j.ijpharm.2019.118781. [PMID: 31715347]
  • Rohini Kanwar, Michael Gradzielski, Sylvain Prevost, Gurpreet Kaur, Marie-Sousai Appavou, S K Mehta. Physicochemical stimuli as tuning parameters to modulate the structure and stability of nanostructured lipid carriers and release kinetics of encapsulated antileprosy drugs. Journal of materials chemistry. B. 2019 11; 7(42):6539-6555. doi: 10.1039/c9tb01330j. [PMID: 31584603]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Julia Torabi, Alesa Campbell, Gayatri Nair, Gauravkumar L Patel, Yoshifumi Miura, Jay A Graham. Dapsone-Induced Methemoglobinemia in Two Renal Transplant Recipients. Progress in transplantation (Aliso Viejo, Calif.). 2019 09; 29(3):289-290. doi: 10.1177/1526924819855365. [PMID: 31167609]
  • Céline Roman, Bogdan Dima, Laurence Muyshont, Thierry Schurmans, Olivier Gilliaux. Indications and efficiency of dapsone in IgA vasculitis (Henoch-Schonlein purpura): case series and a review of the literature. European journal of pediatrics. 2019 Aug; 178(8):1275-1281. doi: 10.1007/s00431-019-03409-5. [PMID: 31230197]
  • Sherrie J Divito. Screening HLA to Prevent Severe Drug Reactions-A Devil's Advocate Perspective. JAMA dermatology. 2019 06; 155(6):655-656. doi: 10.1001/jamadermatol.2018.5336. [PMID: 30916720]
  • Ekta Varshney, Monika Tandon, Nilanjan Saha, Shakir Ali. In vivo phenotyping of cytochrome 450 isoforms involved in the metabolism of anti-HIV and anti-tubercular drugs in human using cocktail approach: An LC-MS/MS analysis. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 164(?):698-705. doi: 10.1016/j.jpba.2018.11.026. [PMID: 30472588]
  • Yuri de Deus Mont'alverne Parente, Amanda Lopes de Castro, Flávio Bezerra de Araújo, André Costa Teixeira, Ítalo Criszostomo Lima, Elizabeth De Francesco Daher. Acute renal failure by rapidly progressive glomerulonephritis with IgA deposition in a patient concomitantly diagnosed with multibacillary Hansen's disease: a case report. Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia. 2019 Jan; 41(1):152-156. doi: 10.1590/2175-8239-jbn-2018-0056. [PMID: 30160772]
  • Franziska Hübner, Michael Kasperkiewicz, Diana Knuth-Rehr, Iakov Shimanovich, Joachim Hübner, Sven Süfke, Philip Muck, Detlef Zillikens, Enno Schmidt. Adjuvant treatment of severe/refractory bullous pemphigoid with protein A immunoadsorption. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. 2018 Sep; 16(9):1109-1118. doi: 10.1111/ddg.13642. [PMID: 30179319]
  • Emma F Johnson, Stanislav N Tolkachjov, Lawrence E Gibson. Alpha-1 antitrypsin deficiency panniculitis: clinical and pathologic characteristics of 10 cases. International journal of dermatology. 2018 Aug; 57(8):952-958. doi: 10.1111/ijd.14012. [PMID: 29707779]
  • Rohini Kanwar, Michael Gradzielski, S K Mehta. Biomimetic Solid Lipid Nanoparticles of Sophorolipids Designed for Antileprosy Drugs. The journal of physical chemistry. B. 2018 07; 122(26):6837-6845. doi: 10.1021/acs.jpcb.8b03081. [PMID: 29874078]
  • Wei-Ti Chen, Chuang-Wei Wang, Chun-Wei Lu, Chun-Bing Chen, Hua-En Lee, Shuen-Iu Hung, Siew-Eng Choon, Chih-Hsun Yang, Ming-Tsan Liu, Ting Jui Chen, Wen-Lang Fan, Shih-Chi Su, Yang Yu-Wei Lin, Ya-Ching Chang, Wen-Hung Chung. The Function of HLA-B*13:01 Involved in the Pathomechanism of Dapsone-Induced Severe Cutaneous Adverse Reactions. The Journal of investigative dermatology. 2018 07; 138(7):1546-1554. doi: 10.1016/j.jid.2018.02.004. [PMID: 29458119]
  • Rui Zhan, Mingming Zhao, Ting Zhou, Yue Chen, Weiwei Yu, Lei Zhao, Tao Zhang, Hecheng Wang, Huan Yang, Yinglan Jin, Qihua He, Xiaoda Yang, Xiangyang Guo, Belinda Willard, Bing Pan, Yining Huang, Yingyu Chen, Dehua Chui, Lemin Zheng. Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation. Cell death & disease. 2018 06; 9(6):683. doi: 10.1038/s41419-018-0739-y. [PMID: 29880899]
  • Hendra Gunawan, Muljaningsih Sasmojo, Helena Eka Putri, Erda Avriyanti, Reti Hindritiani, Oki Suwarsa. Clinical pilot study: Clarithromycin efficacy in multibacillary leprosy therapy. International journal of mycobacteriology. 2018 Apr; 7(2):152-155. doi: 10.4103/ijmy.ijmy_58_18. [PMID: 29900892]
  • Sanjeevani Shekhar Deshkar, Shyam Gangadhar Bhalerao, Monali Shivaji Jadhav, Satish Vasudeo Shirolkar. Formulation and Optimization of Topical Solid Lipid Nanoparticles based Gel of Dapsone Using Design of Experiment. Pharmaceutical nanotechnology. 2018; 6(4):264-275. doi: 10.2174/2211738506666181105141522. [PMID: 30394227]
  • M Sticherling, A Franke, E Aberer, R Gläser, M Hertl, C Pfeiffer, B Rzany, S Schneider, I Shimanovich, T Werfel, A Wilczek, D Zillikens, E Schmidt. An open, multicentre, randomized clinical study in patients with bullous pemphigoid comparing methylprednisolone and azathioprine with methylprednisolone and dapsone. The British journal of dermatology. 2017 Nov; 177(5):1299-1305. doi: 10.1111/bjd.15649. [PMID: 28494097]
  • Keum Hwa Lee, Jae Hyon Park, Dong Hyun Kim, Jimin Hwang, Goeun Lee, Jae Seok Hyun, Sung Taik Heo, Ji Hoon Choi, Minwoo Kim, Minhye Kim, Seong Il Kim, Michael Eisenhut, Andreas Kronbichler, Jae Il Shin. Dapsone as a potential treatment option for Henoch-Schönlein Purpura (HSP). Medical hypotheses. 2017 Oct; 108(?):42-45. doi: 10.1016/j.mehy.2017.07.018. [PMID: 29055398]
  • Sohail Abdul Salim, Lakshmi Ramachandran Nair, Venkataraman Palabindala, Iasmina Craici. Upward trend of dapsone-induced methemoglobinemia in renal transplant community
. Clinical nephrology. 2017 Sep; 88(9):156-161. doi: 10.5414/cn109181. [PMID: 28699887]
  • Coralie Lheure, Saskia Ingen-Housz-Oro, Sandra Guignard, Rachida Inaoui, Brigitte Jolivet, Xavier Chevalier, Pierre Wolkenstein, Bruno Fautrel, Oliver Chosidow. Dermatitis herpetiformis and bone mineral density: analysis of a French cohort of 53 patients. European journal of dermatology : EJD. 2017 Aug; 27(4):353-358. doi: 10.1684/ejd.2017.3029. [PMID: 28524056]
  • Juliana Atallah, Juan C Garces, Enrique Loayza, John A Carlson. Chronic Localized Fibrosing Leukocytoclastic Vasculitis Associated With Lymphedema, Intralymphatic and Intravascular Lymphocytosis, and Chronic Myelogenous Leukemia: A Case Report of Unilateral Erythema Elevatum Diutinum. The American Journal of dermatopathology. 2017 Jun; 39(6):479-484. doi: 10.1097/dad.0000000000000802. [PMID: 27930381]
  • P A von dem Borne, M F Jonkman, R van Doorn. Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy: association with disappearance of M-protein. The British journal of dermatology. 2017 May; 176(5):1341-1344. doi: 10.1111/bjd.14954. [PMID: 27516004]
  • Richard E Kast, Quentin A Hill, Didier Wion, Håkan Mellstedt, Daniele Focosi, Georg Karpel-Massler, Tim Heiland, Marc-Eric Halatsch. Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2017 May; 39(5):1010428317699797. doi: 10.1177/1010428317699797. [PMID: 28459367]
  • Ana Paula Vieira, Maria Angela Bianconcini Trindade, Flávio Jota de Paula, Neusa Yurico Sakai-Valente, Alberto José da Silva Duarte, Francine Brambate Carvalhinho Lemos, Gil Benard. Severe type 1 upgrading leprosy reaction in a renal transplant recipient: a paradoxical manifestation associated with deficiency of antigen-specific regulatory T-cells?. BMC infectious diseases. 2017 04; 17(1):305. doi: 10.1186/s12879-017-2406-9. [PMID: 28438129]
  • Anna Görög, Krisztián Németh, László Szabó, Balázs Mayer, Pálma Silló, Krasimir Kolev, Sarolta Kárpáti. Decreased fibrinolytic potential and morphological changes of fibrin structure in dermatitis herpetiformis. Journal of dermatological science. 2016 Oct; 84(1):17-23. doi: 10.1016/j.jdermsci.2016.07.005. [PMID: 27440075]
  • Rachumallu Ramakrishna, Manisha Bhateria, Rajbir Singh, Rabi Sankar Bhatta. Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes. The Journal of steroid biochemistry and molecular biology. 2016 10; 163(?):183-92. doi: 10.1016/j.jsbmb.2016.05.018. [PMID: 27224941]
  • Yong Sung Cha, Hyun Kim, Juwon Kim, Oh Hyun Kim, Hyung Il Kim, KyoungChul Cha, Kang Hyun Lee, Sung Oh Hwang. Incidence and patterns of hemolytic anemia in acute dapsone overdose. The American journal of emergency medicine. 2016 Mar; 34(3):366-9. doi: 10.1016/j.ajem.2015.09.021. [PMID: 26830387]
  • Alexandre Cc Vieira, Luíse L Chaves, Marina Pinheiro, Domingos Ferreira, Bruno Sarmento, Salette Reis. Design and statistical modeling of mannose-decorated dapsone-containing nanoparticles as a strategy of targeting intestinal M-cells. International journal of nanomedicine. 2016; 11(?):2601-17. doi: 10.2147/ijn.s104908. [PMID: 27354792]
  • R A Evans, T M Clifford, S Tang, T Au, A M Fugit. Efficacy of once-weekly dapsone dosing for Pneumocystis jirovecii pneumonia prophylaxis post transplantation. Transplant infectious disease : an official journal of the Transplantation Society. 2015 Dec; 17(6):816-21. doi: 10.1111/tid.12457. [PMID: 26369753]
  • Camilo Ríos, Sandra Orozco-Suarez, Hermelinda Salgado-Ceballos, Marisela Mendez-Armenta, Concepción Nava-Ruiz, Iván Santander, Veronica Barón-Flores, Nadia Caram-Salas, Araceli Diaz-Ruiz. Anti-Apoptotic Effects of Dapsone After Spinal Cord Injury in Rats. Neurochemical research. 2015 Jun; 40(6):1243-51. doi: 10.1007/s11064-015-1588-z. [PMID: 25931161]
  • Delphine Hanuschk, Alexandra Kozyreff, Naima Tafzi, Dominique Tennstedt, Philippe Hantson, Franck Saint-Marcoux. Acute visual loss following dapsone-induced methemoglobinemia and hemolysis. Clinical toxicology (Philadelphia, Pa.). 2015 Jun; 53(5):489-92. doi: 10.3109/15563650.2015.1033631. [PMID: 25858136]
  • Yuhei Kinehara, Takashi Kijima, Koji Inoue, Haruhiko Hirata, Yoshiko Takeuchi, Kiyoharu Fukushima, Yoshitomo Hayama, Masayoshi Higashiguchi, Osamu Morimura, Kotaro Miyake, Toshiyuki Minami, Izumi Nagatomo, Yoshito Takeda, Hiroshi Kida, Atsushi Kumanogoh. Dapsone hypersensitivity syndrome-related lung injury without eosinophilia in the bronchoalveolar lavage fluid. Internal medicine (Tokyo, Japan). 2015; 54(7):827-31. doi: 10.2169/internalmedicine.54.3406. [PMID: 25832951]
  • Zhi-Qiang Chang, Jian Li, Qian-Qian Zhai. Evaluation on activity of cytochrome p450 enzymes in turbot via a probe drug cocktail. Journal of aquatic animal health. 2014 Dec; 26(4):272-7. doi: 10.1080/08997659.2014.938868. [PMID: 25369285]
  • Roshini Malasingam, Dwarakanathan Ranganathan, Lakshmanan Jeyaseelan, Kavitha Ramanathan, Margaret Jacks, Julie Owens, George T John. An audit of dapsone-associated methaemoglobinaemia in renal transplant recipients. Nephrology (Carlton, Vic.). 2014 Sep; 19(9):594-5. doi: 10.1111/nep.12291. [PMID: 25156437]
  • Fernanda M L Moura, Rosa M Dias, Eliete C Araujo, Laélia M B F Brasil, Michelle V D Ferreira, Jose L F Vieira. Dapsone and body mass index in subjects with multibacillary leprosy. Therapeutic drug monitoring. 2014 Apr; 36(2):261-3. doi: 10.1097/ftd.0b013e3182a8f0c8. [PMID: 24232126]
  • N Mitsides, D Green, R Middleton, D New, E Lamerton, J Allen, J Redshaw, P R Chadwick, C P K Subudhi, G Wood. Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought. Transplant infectious disease : an official journal of the Transplantation Society. 2014 Feb; 16(1):37-43. doi: 10.1111/tid.12161. [PMID: 24215452]
  • André Laureano, Rodrigo Carvalho, Alexandra Chaveiro, Jorge Cardoso. Alpha-1-antitrypsin deficiency-associated panniculitis: a case report. Dermatology online journal. 2014 Jan; 20(1):21245. doi: NULL. [PMID: 24456948]
  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Taysa Ribeiro Schalcher, Rosivaldo S Borges, Michael D Coleman, João Batista Júnior, Claudio G Salgado, Jose Luiz F Vieira, Pedro R T Romão, Fabio R Oliveira, Marta Chagas Monteiro. Clinical oxidative stress during leprosy multidrug therapy: impact of dapsone oxidation. PloS one. 2014; 9(1):e85712. doi: 10.1371/journal.pone.0085712. [PMID: 24465659]
  • Araceli Diaz-Ruiz, Marisela Mendez-Armenta, Sonia Galván-Arzate, Joaquín Manjarrez, Concepción Nava-Ruiz, Iván Santander, Gustavo Balderas, Camilo Ríos. Antioxidant, anticonvulsive and neuroprotective effects of dapsone and phenobarbital against kainic acid-induced damage in rats. Neurochemical research. 2013 Sep; 38(9):1819-27. doi: 10.1007/s11064-013-1087-z. [PMID: 23729301]
  • Tao Su, Chunqin Mao, Fangzhou Yin, Zhiling Yu, Ying Lin, Yu Song, Tulin Lu. Effects of unprocessed versus vinegar-processed Schisandra chinensis on the activity and mRNA expression of CYP1A2, CYP2E1 and CYP3A4 enzymes in rats. Journal of ethnopharmacology. 2013 Apr; 146(3):734-43. doi: 10.1016/j.jep.2013.01.028. [PMID: 23376044]
  • Wensi Lin, Jianmei Zhang, Xiaomei Ling, Ning Yu, Jing Li, Haisong Yang, Runtao Li, Jingrong Cui. Evaluation of the effect of TM208 on the activity of five cytochrome P450 enzymes using on-line solid-phase extraction HPLC-DAD: a cocktail approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Apr; 923-924(?):29-36. doi: 10.1016/j.jchromb.2013.01.031. [PMID: 23466445]
  • Jingwen Gao, Zhan Shi, Shuzhen Zhu, George Q Li, Ru Yan, Meicun Yao. Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches. Journal of ethnopharmacology. 2013 Jan; 145(2):566-72. doi: 10.1016/j.jep.2012.11.030. [PMID: 23207062]
  • Yan Liu, Xiang Li, Chunjuan Yang, Sheng Tai, Xiangning Zhang, Gaofeng Liu. UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats. Journal of chromatographic science. 2013 Jan; 51(1):26-32. doi: 10.1093/chromsci/bms100. [PMID: 22695883]
  • Silvia Méndez-Flores, Yann Charli-Joseph, Marcela Saeb-Lima, Rocío Orozco-Topete, Mónica Fernández Sánchez. Amicrobial pustulosis of the folds associated with autoimmune disorders: systemic lupus erythematosus case series and first report on the association with autoimmune hepatitis. Dermatology (Basel, Switzerland). 2013; 226(1):1-4. doi: 10.1159/000343595. [PMID: 23467024]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Sudipta Basu, Abdul Basit, Selvan Ravindran, Vandana B Patel, Subrahmanyam Vangala, Hitesh Patel. Split calibration curve: an approach to avoid repeat analysis of the samples exceeding ULOQ. Bioanalysis. 2012 Oct; 4(19):2375-89. doi: 10.4155/bio.12.219. [PMID: 23088464]
  • Fuguang Lu, Jinlong Yang, Min Sun, Lulu Fan, Huamin Qiu, Xiangjun Li, Chuannan Luo. Flow injection chemiluminescence sensor using core-shell molecularly imprinted polymers as recognition element for determination of dapsone. Analytical and bioanalytical chemistry. 2012 Jul; 404(1):79-88. doi: 10.1007/s00216-012-6088-2. [PMID: 22653423]
  • Ying-Chuen Lai, Chou-Shiang Wang, Yi-Ching Wang, Yu-Ling Hsu, Lee-Ming Chuang. Falsely decreased HbA1c in a type 2 diabetic patient treated with dapsone. Journal of the Formosan Medical Association = Taiwan yi zhi. 2012 Feb; 111(2):109-12. doi: 10.1016/j.jfma.2012.01.007. [PMID: 22370290]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Yang Degang, Takeshi Akama, Takeshi Hara, Kazunari Tanigawa, Yuko Ishido, Masaichi Gidoh, Masahiko Makino, Norihisa Ishii, Koichi Suzuki. Clofazimine modulates the expression of lipid metabolism proteins in Mycobacterium leprae-infected macrophages. PLoS neglected tropical diseases. 2012; 6(12):e1936. doi: 10.1371/journal.pntd.0001936. [PMID: 23236531]
  • Mario López-Gómez, Teresa Corona, Araceli Diaz-Ruiz, Camilo Ríos. Safety and tolerability of dapsone for the treatment of patients with drug-resistant, partial-onset seizures: an open-label trial. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2011 Dec; 32(6):1063-7. doi: 10.1007/s10072-011-0612-6. [PMID: 21584739]
  • John W Frew, Linda K Martin, Dédée F Murrell. Evidence-based treatments in pemphigus vulgaris and pemphigus foliaceus. Dermatologic clinics. 2011 Oct; 29(4):599-606. doi: 10.1016/j.det.2011.07.001. [PMID: 21925004]
  • Nawaf Al-Mutairi. Nosology and therapeutic options for lupus miliaris disseminatus faciei. The Journal of dermatology. 2011 Sep; 38(9):864-73. doi: 10.1111/j.1346-8138.2011.01244.x. [PMID: 21714812]
  • P Bernard, J Charneux. [Bullous pemphigoid: a review]. Annales de dermatologie et de venereologie. 2011 Mar; 138(3):173-81. doi: 10.1016/j.annder.2011.01.004. [PMID: 21397147]
  • Araceli Diaz-Ruiz, Hermelinda Salgado-Ceballos, Sergio Montes, Gabriel Guizar-Sahagún, Noemi Gelista-Herrera, Marisela Mendez-Armenta, Sofia Diaz-Cintra, Camilo Ríos. Delayed administration of dapsone protects from tissue damage and improves recovery after spinal cord injury. Journal of neuroscience research. 2011 Mar; 89(3):373-80. doi: 10.1002/jnr.22555. [PMID: 21259324]
  • Robert L Clark, William E Gristwood, Richard Lewsley, Robert Wilson, Andrew W Harrell. Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity. Birth defects research. Part B, Developmental and reproductive toxicology. 2010 Oct; 89(5):364-75. doi: 10.1002/bdrb.20256. [PMID: 20717981]
  • Jeffrey Allen Giullian, Kerri Cavanaugh, Heidi Schaefer. Lower risk of urinary tract infection with low-dose trimethoprim/sulfamethoxazole compared to dapsone prophylaxis in older renal transplant patients on a rapid steroid-withdrawal immunosuppression regimen. Clinical transplantation. 2010 Sep; 24(5):636-42. doi: 10.1111/j.1399-0012.2009.01129.x. [PMID: 19925478]
  • Sharon J Nessim, Mark L Lipman. The case/ cyanosis in a hemodialysis patient. Kidney international. 2010 Aug; 78(3):327-8. doi: 10.1038/ki.2010.152. [PMID: 20631737]
  • Vanessa Amaral Mendonça, Rosane Dias Costa, Sandra Lyon, Rachel Adriana Penido, Valdinéria Oliveira Borges, Thales Lage Bretas, Carlos Mauricio Antunes, Mauro Martins Teixeira, Antonio Lúcio Teixeira. Plasma levels of chemokines during leprosy specific treatment. Acta tropica. 2010 Feb; 113(2):151-4. doi: 10.1016/j.actatropica.2009.10.010. [PMID: 19874796]
  • Larry Becker, Cathy Kowalewski, John M Martin. Nonpruritic erythematous plaques. The Journal of family practice. 2009 Dec; 58(12):657-9. doi: NULL. [PMID: 19961820]
  • Yukitaka Yoshikawa, Hiroko Hosomi, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity. Toxicology in vitro : an international journal published in association with BIBRA. 2009 Sep; 23(6):1179-87. doi: 10.1016/j.tiv.2009.05.024. [PMID: 19501153]
  • David J Bell, Dan Wootton, Mavuto Mukaka, Jacqui Montgomery, Noel Kayange, Phillips Chimpeni, Dyfrig A Hughes, Malcolm E Molyneux, Steve A Ward, Peter A Winstanley, David G Lalloo. Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malaria journal. 2009 Aug; 8(?):204. doi: 10.1186/1475-2875-8-204. [PMID: 19709418]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Hai Jia, Aixia Xu, Jiyong Yuan, Xiang Gao, Jun Gao. [Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Aug; 34(16):2079-82. doi: . [PMID: 19938551]
  • Motoaki Ozaki. [Trends in therapy for Hansen disease]. Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association. 2009 Feb; 78(1):1-2. doi: 10.5025/hansen.78.89. [PMID: 19348088]
  • Ting-Jui Chen, Ping-Chin Lai, Li-Cheng Yang, Tseng-Tong Kuo, Hong-Shang Hong. Bullous pemphigoid in a renal transplant recipient: a case report and review of the literature. American journal of clinical dermatology. 2009; 10(3):197-200. doi: 10.2165/00128071-200910030-00007. [PMID: 19354335]
  • Sabiha Kausar, Aparna Yalamanchili. Management of haemorrhagic bullous lesions in Henoch-Schonlein purpura: is there any consensus?. The Journal of dermatological treatment. 2009; 20(2):88-90. doi: 10.1080/09546630802314670. [PMID: 18728921]
  • Warren W Piette, Susan Taylor, David Pariser, Michael Jarratt, Pranav Sheth, David Wilson. Hematologic safety of dapsone gel, 5\%, for topical treatment of acne vulgaris. Archives of dermatology. 2008 Dec; 144(12):1564-70. doi: 10.1001/archdermatol.2008.518. [PMID: 19075138]
  • Araceli Diaz-Ruiz, Carlos Zavala, Sergio Montes, Alma Ortiz-Plata, Hermelinda Salgado-Ceballos, Sandra Orozco-Suarez, Concepción Nava-Ruiz, Iván Pérez-Neri, Francisca Perez-Severiano, Camilo Ríos. Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. Journal of neuroscience research. 2008 Nov; 86(15):3410-9. doi: 10.1002/jnr.21775. [PMID: 18615706]
  • Priyumvada M Naik, G Marshall Lyon, Allan Ramirez, E Clinton Lawrence, David C Neujahr, Seth Force, Andres Pelaez. Dapsone-induced hemolytic anemia in lung allograft recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2008 Nov; 27(11):1198-202. doi: 10.1016/j.healun.2008.07.025. [PMID: 18971091]
  • Martha Pardo, Alexandro Bonifaz, Adriana Valencia, Javier Araiza, Silvia Anett Mejia, Carlos Mena-Cedillos. Actinomycetoma by Nocardia brasiliensis in a girl with Down syndrome. Dermatology online journal. 2008 Aug; 14(8):9. doi: ". [PMID: 19061569]