acebutolol (BioDeep_00000408831)
Main id: BioDeep_00000001879
代谢物信息卡片
acebutolol
化学式: C18H28N2O4 (336.2049)
中文名称: 醋丁洛尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC(=O)Nc(c1)cc(C(C)=O)c(OCC(O)CNC(C)C)c1
InChI: InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23)
描述信息
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
同义名列表
2 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:2379
- KEGG: C06803
- KEGGdrug: D02338
- PubChem: 1978
- DrugBank: DB01193
- ChEMBL: CHEMBL642
- MeSH: Acebutolol
- CAS: 1189500-68-2
- CAS: 37517-30-9
- CAS: 28197-63-9
- MoNA: WA000900
- MoNA: WA000899
- MoNA: WA000898
- MoNA: WA000897
- PubChem: 9022
- NIKKAJI: J252.821E
- RefMet: Acebutolol
- KNApSAcK: 2379
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- E Bokri, H Felfel, S Bahri. Prediction of plasma concentrations using in silico modelling and simulation approach: Case of Acebutolol.
Annales pharmaceutiques francaises.
2021 Sep; 79(5):530-538. doi:
10.1016/j.pharma.2021.02.004. [PMID: 33675740] - Chung-Yi Lee, Adhimoorthy Prasannan, Varghese Lincy, Subash Vetri Selvi, Shen Ming Chen, Po-Da Hong. Highly exfoliated functionalized MoS2 with sodium alginate-polydopamine conjugates for electrochemical sensing of cardio-selective β-blocker by voltammetric methods.
Mikrochimica acta.
2021 03; 188(3):103. doi:
10.1007/s00604-021-04717-0. [PMID: 33646401] - Brendan Le Daré, Sophie Allard, Renaud Bouvet, Alain Baert, Pierre-Marie Allard, Isabelle Morel, Thomas Gicquel. A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking.
International journal of legal medicine.
2020 Jan; 134(1):251-256. doi:
10.1007/s00414-019-02062-9. [PMID: 30997571] - Manuel Röhrich, Anastasia Loktev, Annika K Wefers, Annette Altmann, Daniel Paech, Sebastian Adeberg, Paul Windisch, Thomas Hielscher, Paul Flechsig, Ralf Floca, Dominik Leitz, Julius P Schuster, Peter E Huber, Jürgen Debus, Andreas von Deimling, Thomas Lindner, Uwe Haberkorn. IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein-specific PET/CT.
European journal of nuclear medicine and molecular imaging.
2019 Nov; 46(12):2569-2580. doi:
10.1007/s00259-019-04444-y. [PMID: 31388723] - Changting Cui, Chuanbo Huang, Kejia Liu, Guoheng Xu, Jichun Yang, Yong Zhou, Yingmei Feng, Georgios Kararigas, Bin Geng, Qinghua Cui. Large-scale in silico identification of drugs exerting sex-specific effects in the heart.
Journal of translational medicine.
2018 08; 16(1):236. doi:
10.1186/s12967-018-1612-6. [PMID: 30157868] - Yousif Nijim, Amin Adawi, Bishara Bisharat, Abdalla Bowirrat. First Case Report of Smith-Magenis Syndrome (SMS) Among the Arab Community in Nazareth: View and Overview.
Medicine.
2016 Jan; 95(3):e2362. doi:
10.1097/md.0000000000002362. [PMID: 26817868] - Kyotaka Muta, Tatsuki Fukami, Miki Nakajima. A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production.
Biochemical pharmacology.
2015 Dec; 98(4):659-70. doi:
10.1016/j.bcp.2015.09.016. [PMID: 26408002] - Thana Abuzooda, Ahmad Amini, Mohamed Abdel-Rehim. Graphite-based microextraction by packed sorbent for online extraction of β-blockers from human plasma samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jun; 992(?):86-90. doi:
10.1016/j.jchromb.2015.04.027. [PMID: 25958323] - Gesche Först, Lukasz Cwiklik, Piotr Jurkiewicz, Rolf Schubert, Martin Hof. Interactions of beta-blockers with model lipid membranes: molecular view of the interaction of acebutolol, oxprenolol, and propranolol with phosphatidylcholine vesicles by time-dependent fluorescence shift and molecular dynamics simulations.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2014 Aug; 87(3):559-69. doi:
10.1016/j.ejpb.2014.03.013. [PMID: 24681296] - Travis E Huxman, Sarah Kimball, Amy L Angert, Jennifer R Gremer, Greg A Barron-Gafford, D Lawrence Venable. Understanding past, contemporary, and future dynamics of plants, populations, and communities using Sonoran Desert winter annuals.
American journal of botany.
2013 Jul; 100(7):1369-80. doi:
10.3732/ajb.1200463. [PMID: 23838034] - Akiko Itohda, Kimiko Tsutsumi, Hiromitsu Imai, Miyuki Iwao, Tsutomu Kotegawa, Kyoichi Ohashi. Determination of celiprolol in human plasma using high performance liquid chromatography with fluorescence detection for clinical application.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Sep; 904(?):88-92. doi:
10.1016/j.jchromb.2012.07.026. [PMID: 22889991] - Ali F Al-Ghamdi, Mohamed M Hefnawy, Abdulrahman A Al-Majed, Fatallah F Belal. Development of square-wave adsorptive stripping voltammetric method for determination of acebutolol in pharmaceutical formulations and biological fluids.
Chemistry Central journal.
2012 Feb; 6(?):15. doi:
10.1186/1752-153x-6-15. [PMID: 22353684] - Darren P Martin, Rob W Briddon, Arvind Varsani. Recombination patterns in dicot-infecting mastreviruses mirror those found in monocot-infecting mastreviruses.
Archives of virology.
2011 Aug; 156(8):1463-9. doi:
10.1007/s00705-011-0994-z. [PMID: 21484422] - Konstantinos Tziomalos, Vasilios G Athyros, Asterios Karagiannis, Dimitri P Mikhailidis. Dyslipidemia induced by drugs used for the prevention and treatment of vascular diseases.
The open cardiovascular medicine journal.
2011; 5(?):85-9. doi:
10.2174/1874192401105010085. [PMID: 21769302] - Suguru Kurokawa, Masanori Takehashi, Hiromitsu Tanaka, Hisaaki Mihara, Tatsuo Kurihara, Seigo Tanaka, Kristina Hill, Raymond Burk, Nobuyoshi Esaki. Mammalian selenocysteine lyase is involved in selenoprotein biosynthesis.
Journal of nutritional science and vitaminology.
2011; 57(4):298-305. doi:
10.3177/jnsv.57.298. [PMID: 22041913] - Khaled M Elokely, Mohamed A Eldawy, Mohamed A Elkersh, Tarek F El-Moselhy. Fluorescence Spectrometric Determination of Drugs Containing α-Methylene Sulfone/Sulfonamide Functional Groups Using N-Methylnicotinamide Chloride as a Fluorogenic Agent.
International journal of analytical chemistry.
2011; 2011(?):840178. doi:
10.1155/2011/840178. [PMID: 21647288] - Brent M McGrath, John Paul Harmon, Graham Bishop. Palmaria palmata (Dulse) as an unusual maritime aetiology of hyperkalemia in a patient with chronic renal failure: a case report.
Journal of medical case reports.
2010 Sep; 4(?):301. doi:
10.1186/1752-1947-4-301. [PMID: 20825630] - Ana Maria Abreu-Velez, Vickie M Brown, Michael S Howard. Antibodies to piloerector muscle in a patient with lupus-lichen planus overlap syndrome.
North American journal of medical sciences.
2010 Jun; 2(6):276-80. doi:
. [PMID: 22574303] - Atlasi Daneshvar, Jesper Svanfelt, Leif Kronberg, Michèle Prévost, Gesa A Weyhenmeyer. Seasonal variations in the occurrence and fate of basic and neutral pharmaceuticals in a Swedish river-lake system.
Chemosphere.
2010 Jun; 80(3):301-9. doi:
10.1016/j.chemosphere.2010.03.060. [PMID: 20430415] - E Pujos, C Cren-Olivé, O Paisse, M M Flament-Waton, M F Grenier-Loustalot. Comparison of the analysis of beta-blockers by different techniques.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Dec; 877(31):4007-14. doi:
10.1016/j.jchromb.2009.10.014. [PMID: 19879818] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Yukio Kato, Tatsuya Miyazaki, Takashi Kano, Tomoko Sugiura, Yoshiyuki Kubo, Akira Tsuji. Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol.
Journal of pharmaceutical sciences.
2009 Jul; 98(7):2529-39. doi:
10.1002/jps.21618. [PMID: 19067419] - Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
10.1021/jm801441s. [PMID: 19256501] - M A Alam, M A Awal, N Subhan, M Mostofa. In-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic.
Journal of health, population, and nutrition.
2009 Feb; 27(1):20-30. doi:
10.3329/jhpn.v27i1.3315. [PMID: 19248645] - Hongliang Jiang, Christopher Randlett, Heiko Junga, Xiangyu Jiang, Qin C Ji. Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jan; 877(3):173-80. doi:
10.1016/j.jchromb.2008.12.006. [PMID: 19109073] - Bogusław Buszewski, Tomasz Welerowicz, Eugenia Tegowska, Tadeusz F Krzemiński. Determination of selected beta-receptor antagonists in biological samples by solid-phase extraction with cholesterolic phase and LC/MS.
Analytical and bioanalytical chemistry.
2009 Jan; 393(1):263-72. doi:
10.1007/s00216-008-2369-1. [PMID: 18781297] - Hironobu Umezawa, Xiao-Pen Lee, Yoshiko Arima, Chika Hasegawa, Hikaru Izawa, Takeshi Kumazawa, Keizo Sato. Simultaneous determination of beta-blockers in human plasma using liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2008 Jul; 22(7):702-11. doi:
10.1002/bmc.987. [PMID: 18318013] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - N Vieno, T Tuhkanen, L Kronberg. Elimination of pharmaceuticals in sewage treatment plants in Finland.
Water research.
2007 Mar; 41(5):1001-12. doi:
10.1016/j.watres.2006.12.017. [PMID: 17261324] - Mohamed Abdelfattah El Dawya, Mokhtar Mohamed Mabrouk, Riad Ahmed El Barbary. Spectrofluorimetric determination of drugs containing active methylene group using N1-methyl nicotinamide chloride as a fluorigenic agent.
Chemical & pharmaceutical bulletin.
2006 Jul; 54(7):1026-9. doi:
10.1248/cpb.54.1026. [PMID: 16819224] - Jari J Lilja, Kari Raaska, Pertti J Neuvonen. Effects of grapefruit juice on the pharmacokinetics of acebutolol.
British journal of clinical pharmacology.
2005 Dec; 60(6):659-63. doi:
10.1111/j.1365-2125.2005.02489.x. [PMID: 16305592] - Giuseppe Ermondi, Miriam Lorenti, Giulia Caron. Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction.
Journal of medicinal chemistry.
2004 Jul; 47(16):3949-61. doi:
10.1021/jm040760a. [PMID: 15267234] - Pirkko Kriikku, Benedikt Grass, Ari Hokkanen, Ingmar Stuns, Heli Sirén. Isotachophoresis of beta-blockers in a capillary and on a poly(methyl methacrylate) chip.
Electrophoresis.
2004 Jun; 25(10-11):1687-94. doi:
10.1002/elps.200305872. [PMID: 15188258] - Magali Delamoye, Charlotte Duverneuil, François Paraire, Philippe de Mazancourt, Jean-Claude Alvarez. Simultaneous determination of thirteen beta-blockers and one metabolite by gradient high-performance liquid chromatography with photodiode-array UV detection.
Forensic science international.
2004 Apr; 141(1):23-31. doi:
10.1016/j.forsciint.2003.12.008. [PMID: 15066710] - Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
10.1021/jm0309001. [PMID: 15027870] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h. [PMID: 14971904] - J Hu, Z Chen, C P Gorczynski, L Y Gorczynski, Y Kai, L Lee, J Manuel, R M Gorczynski. Sleep-deprived mice show altered cytokine production manifest by perturbations in serum IL-1ra, TNFa, and IL-6 levels.
Brain, behavior, and immunity.
2003 Dec; 17(6):498-504. doi:
10.1016/j.bbi.2003.03.001. [PMID: 14583241] - Matthew D Troutman, Dhiren R Thakker. Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Pharmaceutical research.
2003 Aug; 20(8):1210-24. doi:
10.1023/a:1025001131513. [PMID: 12948019] - Djamil Krouf, Malika Bouchenak, Bachir Mohammedi, Allaoua Cherrad, Jacques L Belleville, Josiane L Prost. Changes in serum lipids and antioxidant status in west Algerian patients with essential hypertension treated with acebutolol compared to healthy subjects.
Medical science monitor : international medical journal of experimental and clinical research.
2003 Aug; 9(8):PI109-15. doi:
. [PMID: 12942043] - Dong Hyun Choi, Hak Yeon Bae, Jun Shik Choi. Pharmacokinetic changes of acebutolol after oral administration in rabbits with diabetes mellitus induced by alloxan.
Archives of pharmacal research.
2003 Jun; 26(6):499-503. doi:
10.1007/bf02976870. [PMID: 12877562] - S Abolfazl Mostafavi, Robert T Foster. Influence of cimetidine co-administration on the pharmacokinetics of acebutolol enantiomers and its metabolite diacetolol in a rat model: the effect of gastric pH on double-peak phenomena.
International journal of pharmaceutics.
2003 Apr; 255(1-2):81-6. doi:
10.1016/s0378-5173(03)00037-1. [PMID: 12672604] - Jun Shik Choi, Jin Pil Burm. Pharmacokinetics of acebutolol and its main metabolite, diacetolol after oral administration of acebutolol in rabbits with carbon tetrachloride-induced hepatic failure.
Archives of pharmacal research.
2002 Aug; 25(4):541-5. doi:
10.1007/bf02976615. [PMID: 12214869] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Journal of medicinal chemistry.
2002 Jun; 45(13):2867-76. doi:
10.1021/jm0200409. [PMID: 12061889] - Elzbieta Luchowska, Piotr Luchowski, Marian Wielosz, Zdzisław Kleinrok, Stanisław J Czuczwar, Ewa M Urbańska. Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock.
Pharmacology, biochemistry, and behavior.
2002 Jan; 71(1-2):223-31. doi:
10.1016/s0091-3057(01)00654-2. [PMID: 11812526] - G Colmenarejo, A Alvarez-Pedraglio, J L Lavandera. Cheminformatic models to predict binding affinities to human serum albumin.
Journal of medicinal chemistry.
2001 Dec; 44(25):4370-8. doi:
10.1021/jm010960b. [PMID: 11728183] - H De Leersnyder, M C de Blois, M Vekemans, D Sidi, E Villain, C Kindermans, A Munnich. beta(1)-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome.
Journal of medical genetics.
2001 Sep; 38(9):586-90. doi:
10.1136/jmg.38.9.586. [PMID: 11546826] - Y Tashiro, M Sami, S Shichibe, Y Kato, E Hayakawa, K Itoh. Effect of lipophilicity on in vivo iontophoretic delivery. II. Beta-blockers.
Biological & pharmaceutical bulletin.
2001 Jun; 24(6):671-7. doi:
10.1248/bpb.24.671. [PMID: 11411557] - A Chiffoleau, H Huguenin, G Veyrac, V Argaiz, D Dupe, M Kayser, M Bourin, P Jolliet. [Interaction between melilot and acenocoumarol? (Melilotruscus aculeatus)].
Therapie.
2001 May; 56(3):321-2. doi:
". [PMID: 11475815] - S Mostafavi, R Lewanczuk, R Foster. Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats.
Biopharmaceutics & drug disposition.
2000 May; 21(4):121-8. doi:
10.1002/1099-081x(200005)21:4<121::aid-bdd216>3.0.co;2-y. [PMID: 11180190] - J Szymura-Oleksiak, M Walczak, J Bojarski, H Y Aboul-Enein. Enantioselective high performance liquid chromatographic assay of acebutolol and its active metabolite diacetolol in human serum.
Chirality.
1999; 11(4):267-71. doi:
10.1002/(sici)1520-636x(1999)11:4<267::aid-chir2>3.0.co;2-j. [PMID: 10224653] - S A Mostafavi, R T Foster. Pharmacokinetics of single oral and multiple intravenous and oral administration of acebutolol enantiomers in a rat model.
Biopharmaceutics & drug disposition.
1998 Oct; 19(7):425-31. doi:
10.1002/(sici)1099-081x(199810)19:7<425::aid-bdd121>3.0.co;2-x. [PMID: 9818708] - L Zhang, M E Schaner, K M Giacomini. Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
The Journal of pharmacology and experimental therapeutics.
1998 Jul; 286(1):354-61. doi:
NULL. [PMID: 9655880] - I Mahmood. Prediction of absolute bioavailability for drugs using oral and renal clearance following a single oral dose: a critical view.
Biopharmaceutics & drug disposition.
1997 Aug; 18(6):465-73. doi:
10.1002/(sici)1099-081x(199708)18:6<465::aid-bdd41>3.0.co;2-c. [PMID: 9267680] - M Piquette-Miller, F Jamali. Pharmacokinetics and multiple peaking of acebutolol enantiomers in rats.
Biopharmaceutics & drug disposition.
1997 Aug; 18(6):543-56. doi:
10.1002/(sici)1099-081x(199708)18:6<543::aid-bdd52>3.0.co;2-f. [PMID: 9267686] - S A Mostafavi, R T Foster. Pharmacokinetics of acebutolol enantiomers after intravenous administration of racemate in a rat model: a dosing range comparison.
Biopharmaceutics & drug disposition.
1997 Jul; 18(5):397-408. doi:
10.1002/(sici)1099-081x(199707)18:5<397::aid-bdd27>3.0.co;2-r. [PMID: 9210978] - T Seifert, O Zschörnig, J Arnhold, K Arnold. Beta-blockers inhibit the modification of low-density lipoproteins by sodium hypochlorite in vitro.
Chemistry and physics of lipids.
1997 Jan; 85(1):13-21. doi:
10.1016/s0009-3084(96)02637-0. [PMID: 9032944] - R Verbesselt, A Zugravu, T B Tjandramaga, P J De Schepper. Liquid chromatographic determination of total celiprolol or (S)-celiprolol and (R)-celiprolol simultaneously in human plasma.
Journal of chromatography. B, Biomedical applications.
1996 Aug; 683(2):231-6. doi:
10.1016/0378-4347(96)00110-7. [PMID: 8891920] - R H Grimm, J M Flack, G A Grandits, P J Elmer, J D Neaton, J A Cutler, C Lewis, R McDonald, J Schoenberger, J Stamler. Long-term effects on plasma lipids of diet and drugs to treat hypertension. Treatment of Mild Hypertension Study (TOMHS) Research Group.
JAMA.
1996 May; 275(20):1549-56. doi:
10.1001/jama.1996.03530440029033. [PMID: 8622245] - J V Gobburu, W H Shelver. Quantitative structure-pharmacokinetic relationships (QSPR) of beta blockers derived using neural networks.
Journal of pharmaceutical sciences.
1995 Jul; 84(7):862-5. doi:
10.1002/jps.2600840715. [PMID: 7562438] - L Hovgaard, H Brøndsted, A Buur, H Bundgaard. Drug delivery studies in Caco-2 monolayers. Synthesis, hydrolysis, and transport of O-cyclopropane carboxylic acid ester prodrugs of various beta-blocking agents.
Pharmaceutical research.
1995 Mar; 12(3):387-92. doi:
10.1023/a:1016204602471. [PMID: 7617526] - A Górecki, A Januszewicz, G Opolski, M Lapiński, B Wocial, H Ignatowska-Switalska, K Słomka, J Kochanowski, P Stolarz. Elevated plasma atrial natriuretic peptide concentrations in hypertensive patients with acute myocardial infarction.
Journal of cardiovascular risk.
1995 Feb; 2(1):45-50. doi:
NULL. [PMID: 7606640] - T Hannedouche, P Landais, B Goldfarb, N el Esper, A Fournier, M Godin, D Durand, J Chanard, F Mignon, J M Suo. Randomised controlled trial of enalapril and beta blockers in non-diabetic chronic renal failure.
BMJ (Clinical research ed.).
1994 Oct; 309(6958):833-7. doi:
10.1136/bmj.309.6958.833. [PMID: 7950612] - T Gasińska, S Nowak, A Beldzik, L Wawrzyniak. [Levels of free fatty acids in plasma, K coefficient and insulin secretion stimulated by intravenous glucose load in patients with hyperthyroidism taking propranolol or acebutolol].
Polskie Archiwum Medycyny Wewnetrznej.
1994 May; 91(5):324-31. doi:
. [PMID: 8084808] - C Napoli, G Ambrosio, P Chiariello, G Palumbo, M Chiariello. [Protection by blockers against human low density lipoprotein peroxidation induced by oxygen free radicals].
Giornale italiano di cardiologia.
1994 Apr; 24(4):361-6. doi:
". [PMID: 7914499] - T Gasińska, S Nowak, A Beldzik, L Wawrzyniak. [Levels of free fatty acids in plasma, tissue utilization coefficient of glucose K and insulin secretion following intravenous glucose load in hyperthyroid patients treated with propranolol or acebutolol].
Polski tygodnik lekarski (Warsaw, Poland : 1960).
1994 Jan; 49(1-3):7-10. doi:
. [PMID: 8008680] - T Kaila, E Iisalo. Selectivity of acebutolol, atenolol, and metoprolol in healthy volunteers estimated by the extent the drugs occupy beta 2-receptors in the circulating plasma.
Journal of clinical pharmacology.
1993 Oct; 33(10):959-66. doi:
10.1002/j.1552-4604.1993.tb01930.x. [PMID: 8227468] - M Murai-Kushiya, S Okada, T Kimura, R Hasegawa. Effects of turpentine oil pretreatment on beta-blocker pharmacokinetic parameters in rats.
The Journal of pharmacy and pharmacology.
1993 Sep; 45(9):836-8. doi:
10.1111/j.2042-7158.1993.tb05696.x. [PMID: 7903375] - J D Neaton, R H Grimm, R J Prineas, J Stamler, G A Grandits, P J Elmer, J A Cutler, J M Flack, J A Schoenberger, R McDonald. Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group.
JAMA.
1993 Aug; 270(6):713-24. doi:
NULL. [PMID: 8336373] - J Segura, J A Pascual, R Ventura, J I Ustaran, A Cuevas, R Gonzalez. International cooperation in analytical chemistry: experience of antidoping control at the XI Pan American Games.
Clinical chemistry.
1993 May; 39(5):836-45. doi:
NULL. [PMID: 8485874] - M Murai-Kushiya, S Okada, T Kimura, R Hasegawa. Stereoselective binding of beta-blockers to purified rat alpha 1-acid glycoprotein.
The Journal of pharmacy and pharmacology.
1993 Mar; 45(3):225-8. doi:
10.1111/j.2042-7158.1993.tb05539.x. [PMID: 8097783] - E Cichocka, P Januszewicz, T Wyszynska. [Evaluation of the efficacy and tolerance of three antihypertensive agents used as single-drug therapy, nifedipine, prazosin and acebutolol in severe, idiopathic hypertension in adolescents].
Annales de pediatrie.
1993 Feb; 40(2):119-26. doi:
NULL. [PMID: 8457132] - N G Filippenko, S V Povetkin, I I Smirnova, N G Dementéva, V T Bredikhin. [Pharmaco -- genetic approach to the improvement of beta-adrenoblocker therapy in the treatment of hypertension].
Kardiologiia.
1993; 33(5):30-2. doi:
". [PMID: 7967324] - M Piquette-Miller, F Jamali. Effect of adjuvant arthritis on the disposition of acebutolol enantiomers in rats.
Agents and actions.
1992 Nov; 37(3-4):290-6. doi:
10.1007/bf02028122. [PMID: 1295378] - H Yassen, M J Boutroy, P Monin, P Vert. [Hemodynamic and renal adaptation of newborn infants of hypertensive mothers treated with acebutolol].
Archives francaises de pediatrie.
1992 Apr; 49(4):351-5. doi:
NULL. [PMID: 1497424] - M Piquette-Miller, R T Foster, C T Kappagoda, F Jamali. Effect of aging on the pharmacokinetics of acebutolol enantiomers.
Journal of clinical pharmacology.
1992 Feb; 32(2):148-56. doi:
10.1002/j.1552-4604.1992.tb03820.x. [PMID: 1613125] - S Yoneda, T Kako, M Koketsu, J Hayano, T Asakawa, T Fujinami, T Kato. Single administration of captopril and combined use with beta-blocker and/or thiazide diuretic in the treatment of essential hypertension.
Angiology.
1991 Nov; 42(11):914-23. doi:
10.1177/000331979104201107. [PMID: 1683186] - M S Leloux, W M Niessen, R A van der Hoeven. Thermospray liquid chromatography/mass spectrometry of polar beta-blocking drugs: preliminary results.
Biological mass spectrometry.
1991 Oct; 20(10):647-9. doi:
10.1002/bms.1200201010. [PMID: 1686558] - M Sznajderman, M Bednarska-Makaruk, J Niegowska, M Makowiecka-Cieśla. [Comparative studies on the effects of propranolol and acebutolol on blood pressure, serum lipids and lipoproteins in patients with primary hypertension].
Polski tygodnik lekarski (Warsaw, Poland : 1960).
1991 Aug; 46(32-34):601-4. doi:
NULL. [PMID: 1669122] - V M Ermolenko, N L Lifshits, S B Zisel'man, V A Tatsievskiĭ. [The treatment of severe arterial hypertension in patients with chronic kidney failure with captopril and beta-adrenoblockaders].
Urologiia i nefrologiia.
1991 May; ?(3):41-8. doi:
NULL. [PMID: 1871923] - M Piquette-Miller, R T Foster, C T Kappagoda, F Jamali. Pharmacokinetics of acebutolol enantiomers in humans.
Journal of pharmaceutical sciences.
1991 Apr; 80(4):313-6. doi:
10.1002/jps.2600800405. [PMID: 1865329] - V L Esnault, M Potiron-Josse, A Testa, J D Ginet, D Le Carrer, J Guenel. Captopril but not acebutolol, prazosin or indomethacin decreases postexercise proteinuria.
Nephron.
1991; 58(4):437-42. doi:
10.1159/000186476. [PMID: 1922609] - V G Kukes, E T Gneushev, T Sh Mamedov, I A Gneusheva. [Acebutolol and diacetolol: their binding to plasma proteins and erythrocytes and secretion with the saliva].
Farmakologiia i toksikologiia.
1991 Jan; 54(1):53-5. doi:
NULL. [PMID: 1860501] - O Fleurot, B Lecocq, V Lecocq, A Le Liboux, G Montay, A Frydman, P Jaillon. A comparative pharmacokinetic and pharmacodynamic study of conventional and sustained-release preparations of acebutolol in healthy volunteers.
Fundamental & clinical pharmacology.
1991; 5(7):601-9. doi:
10.1111/j.1472-8206.1991.tb00749.x. [PMID: 1778538] - M Witkowska, G Kübler, E Kopel, B Karolko. [Does chronic therapy of hypertension with acebutolol or hydrochlorothiazide effect coronary risk factors?].
Kardiologia polska.
1991; 34(3):143-50. doi:
NULL. [PMID: 2046225] - M Piquette-Miller, R T Foster. High-performance liquid chromatographic determination of diacetolol enantiomers.
Journal of chromatography.
1990 Nov; 533(?):300-3. doi:
10.1016/s0378-4347(00)82218-5. [PMID: 2081779] - J Mantz, G Blanchot, J Marty, R Farinotti, J H Trouvin, J Hazebroucq, J M Desmonts. Acebutolol and diacetolol plasma levels in patients undergoing myocardial revascularization with hypothermic cardiopulmonary bypass.
Journal of cardiothoracic anesthesia.
1990 Oct; 4(5):577-81. doi:
10.1016/0888-6296(90)90407-7. [PMID: 2132136] - H W Schnaper. Acebutolol effects on lipid profile.
The American journal of cardiology.
1990 Sep; 66(9):49C-54C. doi:
10.1016/0002-9149(90)90764-r. [PMID: 2220651] - P Jaillon. Relevance of intrinsic sympathomimetic activity for beta blockers.
The American journal of cardiology.
1990 Sep; 66(9):21C-23C. doi:
10.1016/0002-9149(90)90758-s. [PMID: 1977302] - A Overlack, H M Müller, R Kolloch, K O Stumpe. [Therapy of moderate hypertension with the calcium antagonist nitrendipine in combination with beta receptor blocker or diuretic].
Medizinische Klinik (Munich, Germany : 1983).
1990 Aug; 85(8):467-71. doi:
. [PMID: 2233598] - L Kayser, H Perrild, P H Petersen, L Skovsted, J E Hansen. Acute beta-blockade changes the extracellular distribution of thyroid hormones.
Journal of endocrinological investigation.
1990 Apr; 13(4):277-81. doi:
10.1007/bf03349560. [PMID: 1695234] - A Bossini, C Di Veroli. [Effects of medium-term treatment of acebutolol on lipid profile].
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques.
1990 Apr; 12(2):91-8. doi:
NULL. [PMID: 2080313] - M Piquette-Miller, R T Foster, F M Pasutto, F Jamali. Stereospecific high-performance liquid chromatographic assay of acebutolol in human plasma and urine.
Journal of chromatography.
1990 Mar; 526(1):129-37. doi:
10.1016/s0378-4347(00)82490-1. [PMID: 2341525] - S Tyagi, M Bhargava, J Bhattacharya, M Khalilullah. Randomised two way crossover comparison of the effects of six weeks propranolol and acebutolol therapy on plasma lipid profiles in patients with hypertension or ischaemic heart disease.
Indian heart journal.
1990 Mar; 42(2):117-9. doi:
NULL. [PMID: 2081608] - J M Bouvier, D Rabot, G Herrero. Effect of bisoprolol and acebutolol on resting blood pressure and on exercise blood pressure profile in hypertensive patients: a comparative, single-blind study.
Journal of cardiovascular pharmacology.
1990; 16 Suppl 5(?):S179-83. doi:
. [PMID: 11527124] - J Leowski, A Czech, P Lastowiecki, K Jaskóła, J Tatoń. [Monotherapy with acebutolol in hypertensive diabetic patients].
Polski tygodnik lekarski (Warsaw, Poland : 1960).
1990 Jan; 45(1-3):30-5. doi:
. [PMID: 2399187] - D C Ghosh, S Dutta, N Sarkar. A cross-over trial comparing the effects of acebutolol and propranolol on the serum lipids and hypertension.
Indian heart journal.
1989 Sep; 41(5):292-5. doi:
NULL. [PMID: 2599537] - H Matsuura, S Masaoka, I Kanazawa, S Murano, Y Tsuchioka, G Kajiyama. Comparison of the acute effects of acebutolol and propranolol on blood pressure, heart rate and hormonal changes during graded treadmill exercise in patients with essential hypertension.
Japanese journal of medicine.
1989 Jan; 28(1):8-15. doi:
10.2169/internalmedicine1962.28.8. [PMID: 2657144] - I Lewandowska, J Tyfczyńska, M Bujak. [Determining acebutolol level in the blood serum].
Acta poloniae pharmaceutica.
1989; 46(4):350-3. doi:
NULL. [PMID: 2635806] - A H van den Meiracker, A J Man in 't Veld, H J van Eck, F Boomsma, M A Schalekamp. Hemodynamic and hormonal adaptations to beta-adrenoceptor blockade. A 24-hour study of acebutolol, atenolol, pindolol, and propranolol in hypertensive patients.
Circulation.
1988 Oct; 78(4):957-68. doi:
10.1161/01.cir.78.4.957. [PMID: 3048776]
