Acebutolol (BioDeep_00000001879)

 

Secondary id: BioDeep_00000408831

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide

化学式: C18H28N2O4 (336.2049)
中文名称: 醋丁洛尔
谱图信息: 最多检出来源 Homo sapiens(plant) 8.56%

分子结构信息

SMILES: CCCC(=O)NC1=CC(=C(C=C1)OCC(CNC(C)C)O)C(=O)C
InChI: InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23)

描述信息

Acebutolol is only found in individuals that have used or taken this drug. It is a cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. [PubChem]Acebutolol is a selective β1-receptor antagonist. Activation of β1-receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Acebutolol blocks these receptors, lowering the heart rate and blood pressure. This drug then has the reverse effect of epinephrine. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
CONFIDENCE standard compound; INTERNAL_ID 2281

同义名列表

50 个代谢物同义名

N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide; N-(3-acetyl-4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butanamide; N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide; 5-Butyramido-2-(2-hydroxy-3-isopropylaminopropoxy)acetophenone; 3-Acetyl-4-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide; Rhône poulenc rorer brand OF acebutolol hydrochloride; Rhône-poulenc rorer brand OF acebutolol hydrochloride; Proctor and gamble brand OF acebutolol hydrochloride; Lafon ratiopharm brand OF acebutolol hydrochloride; Lafon-ratiopharm brand OF acebutolol hydrochloride; Rhodiapharm brand OF acebutolol hydrochloride; Italfarmaco brand OF acebutolol hydrochloride; Novopharm brand OF acebutolol hydrochloride; Heumann brand OF acebutolol hydrochloride; Specia brand OF acebutolol hydrochloride; Apotex brand OF acebutolol hydrochloride; Bayer brand OF acebutolol hydrochloride; Wyeth brand OF acebutolol hydrochloride; Gepepharm brand OF acebutolol; Acebutolol gepepharm brand; Hydrochloride, acebutolol; Acebutolol hydrochloride; Acébutolol ratiopharm; Acébutolol-ratiopharm; Acébutololratiopharm; Heumann, acebutolol; Acebutolol heumann; Novo-acebutolol; Novo acebutolol; (+-)-Acebutolol; m And b 17803 a; m And b-17803 a; m And b17803 a; m And b 17803a; NovoAcebutolol; Apo acebutolol; Apo-acebutolol; Acebutolol HCl; ApoAcebutolol; DL-Acebutolol; Acebutololum; Acetobutolol; Acebutololo; acebutolol; Monitan; Sectral; Rhotral; Neptal; Prent; Acebutolol



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, ACE, ALB, AXIN2, CAT, CES2
Peripheral membrane protein 2 CYP1B1, LPL
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 3 ALB, AXIN2, TBX1
cytosol 6 ALB, APOA1, AXIN2, CAT, CES2, TNNI3
centrosome 2 ALB, AXIN2
nucleoplasm 1 ATP2B1
Cell membrane 5 ABCB1, ACE, ADRB3, ATP2B1, LPL
Multi-pass membrane protein 4 ABCB1, ADRB3, ATP2B1, CACNA1I
Synapse 1 ATP2B1
cell surface 2 ABCB1, LPL
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 ALB
Golgi membrane 1 INS
presynaptic membrane 1 ATP2B1
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 12 ABCB1, ACE, ADRB3, APOA1, ATP2B1, AXIN2, CACNA1I, EDNRA, GCG, KNG1, LPL, REN
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ABCB1, ACE, ATP2B1, CACNA1I, CAT, CYP1B1, LCAT, REN
apical plasma membrane 1 ABCB1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 9 ABCB1, ACE, ALB, APOA1, ATP2B1, CAT, CES2, KNG1, LCAT
endoplasmic reticulum 2 ALB, CES2
extracellular space 9 ACE, ALB, APOA1, GCG, INS, KNG1, LCAT, LPL, REN
mitochondrion 2 CAT, CYP1B1
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 4 ATP2B1, CAT, CES2, CYP1B1
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 ACE
Secreted 8 ACE, ALB, APOA1, GCG, INS, LCAT, LPL, REN
extracellular region 10 ACE, ALB, APOA1, CAT, GCG, INS, KNG1, LCAT, LPL, REN
mitochondrial matrix 1 CAT
Extracellular side 1 LPL
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ACE
Extracellular vesicle 1 APOA1
Secreted, extracellular space, extracellular matrix 1 LPL
chylomicron 2 APOA1, LPL
high-density lipoprotein particle 2 APOA1, LCAT
low-density lipoprotein particle 1 APOA1
very-low-density lipoprotein particle 2 APOA1, LPL
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 APOA1
Early endosome 1 APOA1
apical part of cell 1 REN
Apical cell membrane 1 ABCB1
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 APOA1, KNG1
lateral plasma membrane 1 ATP2B1
sarcomere 1 TNNI3
receptor complex 1 ADRB3
ciliary basal body 1 ALB
chromatin 1 TBX1
cell projection 1 ATP2B1
centriole 1 ALB
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 3 ALB, APOA1, KNG1
sperm midpiece 1 ACE
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Lipid droplet 1 CES2
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 ACE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 4 APOA1, CAT, GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 6 ALB, APOA1, CES2, GCG, INS, KNG1
platelet alpha granule lumen 2 ALB, KNG1
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 APOA1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
external side of apical plasma membrane 1 ABCB1
spherical high-density lipoprotein particle 1 APOA1
endocytic vesicle lumen 1 APOA1
[Glucagon-like peptide 1]: Secreted 1 GCG
cardiac myofibril 1 TNNI3
troponin complex 1 TNNI3
catalase complex 1 CAT
catalytic complex 1 LPL
photoreceptor ribbon synapse 1 ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
cardiac Troponin complex 1 TNNI3
ciliary transition fiber 1 ALB


文献列表

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