GLUTARIC ACID (BioDeep_00000400407)

Main id: BioDeep_00000001619

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


GLUTARIC ACID

化学式: C5H8O4 (132.0423)
中文名称: 戊二酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)O)CC(=O)O
InChI: InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)

描述信息

An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

同义名列表

3 个代谢物同义名

GLUTARIC ACID; Glutaric acid; Glutarate



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ANXA5, CAT, FOLH1, GFAP, GLUL, RBFOX3
Peripheral membrane protein 2 ANXA5, HSD17B6
Nucleus 2 GLUL, RBFOX3
cytosol 7 ANXA5, CAT, GFAP, GLUL, LIPE, PRKCQ, SLC22A7
Cell membrane 5 FOLH1, GLUL, LIPE, SLC22A11, SLC22A7
Lipid-anchor 1 GLUL
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 6 ABCC3, SLC13A2, SLC22A11, SLC22A6, SLC22A7, SLC22A8
Synapse 1 ALDH5A1
cell surface 1 FOLH1
Golgi membrane 1 INS
sarcolemma 1 ANXA5
Cytoplasm, cytosol 2 GLUL, LIPE
plasma membrane 9 ABCC3, FOLH1, GLUL, PRKCQ, SLC13A2, SLC22A11, SLC22A6, SLC22A7, SLC22A8
Membrane 9 ABCC3, ANXA5, CAT, FOLH1, LIPE, SLC13A2, SLC22A11, SLC22A6, SLC22A7
apical plasma membrane 4 SLC13A2, SLC22A11, SLC22A7, SLC22A8
basolateral plasma membrane 4 ABCC3, SLC22A6, SLC22A7, SLC22A8
caveola 2 LIPE, SLC22A6
extracellular exosome 8 ANXA5, CAT, FOLH1, GLUL, SLC13A2, SLC22A11, SLC22A6, SLC22A8
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 GLUL, HSD17B6
extracellular space 1 INS
mitochondrion 6 ABAT, ALDH5A1, CAT, GCDH, GLUL, SUGCT
protein-containing complex 2 CAT, SLC22A6
intracellular membrane-bounded organelle 2 CAT, HSD17B6
Microsome membrane 1 HSD17B6
Secreted 1 INS
extracellular region 3 ANXA5, CAT, INS
astrocyte end-foot 1 GFAP
Mitochondrion matrix 1 GCDH
mitochondrial matrix 4 ABAT, ALDH5A1, CAT, GCDH
centriolar satellite 1 PRKCQ
external side of plasma membrane 2 ANXA5, SLC22A11
perikaryon 1 RBFOX3
Single-pass type II membrane protein 1 FOLH1
Apical cell membrane 3 SLC13A2, SLC22A11, SLC22A7
focal adhesion 2 ANXA5, CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ANXA5
intermediate filament 1 GFAP
lateral plasma membrane 1 SLC22A8
Zymogen granule membrane 1 ANXA5
cell projection 1 GFAP
Basolateral cell membrane 4 ABCC3, SLC22A6, SLC22A7, SLC22A8
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
cell body 2 GFAP, GLUL
intermediate filament cytoskeleton 1 GFAP
basal plasma membrane 4 ABCC3, SLC22A11, SLC22A6, SLC22A7
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
vesicle membrane 1 ANXA5
Basal cell membrane 3 ABCC3, SLC22A11, SLC22A6
[Isoform 1]: Cytoplasm, cytosol 1 SLC22A7
cytoplasmic side of lysosomal membrane 1 GFAP
glial cell projection 1 GLUL
catalase complex 1 CAT
endothelial microparticle 1 ANXA5
4-aminobutyrate transaminase complex 1 ABAT
[Isoform PSMA']: Cytoplasm 1 FOLH1
[Isoform 2]: Basolateral cell membrane 1 SLC22A7


文献列表

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  • Tanyel Zubarioglu, Saffa Ahmadzada, Cengiz Yalcinkaya, Ertugrul Kiykim, Cigdem Aktuglu-Zeybek. COVID-19 triggered encephalopathic crisis in a patient with glutaric aciduria type 1. Journal of pediatric endocrinology & metabolism : JPEM. 2021 Dec; 34(12):1611-1614. doi: 10.1515/jpem-2021-0474. [PMID: 34517439]
  • Mary Gonzalez Melo, Andrea Orlando Fontana, David Viertl, Gilles Allenbach, John O Prior, Samuel Rotman, René Günther Feichtinger, Johannes Adalbert Mayr, Michele Costanzo, Marianna Caterino, Margherita Ruoppolo, Olivier Braissant, Frederic Barbey, Diana Ballhausen. A knock-in rat model unravels acute and chronic renal toxicity in glutaric aciduria type I. Molecular genetics and metabolism. 2021 12; 134(4):287-300. doi: 10.1016/j.ymgme.2021.10.003. [PMID: 34799272]
  • E M Charlotte Märtner, Eva Thimm, Philipp Guder, Katharina A Schiergens, Frank Rutsch, Sylvia Roloff, Iris Marquardt, Anibh M Das, Peter Freisinger, Sarah C Grünert, Johannes Krämer, Matthias R Baumgartner, Skadi Beblo, Claudia Haase, Andrea Dieckmann, Martin Lindner, Andrea Näke, Georg F Hoffmann, Chris Mühlhausen, Magdalena Walter, Sven F Garbade, Esther M Maier, Stefan Kölker, Nikolas Boy. The biochemical subtype is a predictor for cognitive function in glutaric aciduria type 1: a national prospective follow-up study. Scientific reports. 2021 09; 11(1):19300. doi: 10.1038/s41598-021-98809-9. [PMID: 34588557]
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  • João Leandro, Aaron Bender, Tetyana Dodatko, Carmen Argmann, Chunli Yu, Sander M Houten. Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains. Molecular genetics and metabolism. 2021 02; 132(2):139-145. doi: 10.1016/j.ymgme.2021.01.004. [PMID: 33483254]
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