D-Mannitol (BioDeep_00000231048)

Main id: BioDeep_00000000355

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


D-glycero-Hexitol

化学式: C6H14O6 (182.079)
中文名称: 甘露醇, 甘露糖, D-甘露糖醇
谱图信息: 最多检出来源 Homo sapiens(otcml) 19.49%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

D-Mannitol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/d-mannitol (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000231048). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(C(C(CO)O)O)O)O)O
InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

描述信息

Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.

Mannitol, a type of sugar alcohol, serves several important biological functions:

Osmotic Diuretic: Mannitol is used medically as an osmotic diuretic to reduce intracranial and intraocular pressure. By increasing urine production, it helps to draw excess fluid from the brain and eyes, which is beneficial in conditions like cerebral edema and glaucoma.
Sweetener and Sugar Substitute: In the food industry, mannitol is used as a sweetener and sugar substitute. It provides sweetness without contributing to tooth decay and is often used in products for diabetics because it has a minimal impact on blood sugar levels.
Preservative: Mannitol’s hygroscopic properties make it useful as a preservative in various products, including pharmaceuticals and foods, to prevent moisture absorption and maintain product stability.
Laxative: In high concentrations, mannitol can act as a laxative due to its osmotic effect in the intestine, drawing water into the bowel and stimulating bowel movements.
Tissue Protectant: In cryopreservation, mannitol is used to protect tissues from damage caused by freezing and thawing processes.
Cell Culture Medium Component: Mannitol is often included in cell culture media to maintain osmotic balance and provide a stable environment for cell growth.
Pharmaceutical Excipient: It is used as an excipient in the pharmaceutical industry, helping to enhance the stability and bioavailability of drugs.

Mannitol. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=69-65-8 (retrieved 2024-07-01) (CAS RN: 69-65-8). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
DL-Mannitol is obtained by combining D-mannitol with a sample of Lmannitol obtained by reduction of L-mannono-1, Clactone[1].
DL-Mannitol is obtained by combining D-mannitol with a sample of Lmannitol obtained by reduction of L-mannono-1, Clactone[1].
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7].
D-Mannitol is an osmotic diuretic with weak renal vasodilatory activity.
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7].
D-Mannitol is an osmotic diuretic with weak renal vasodilatory activity.

同义名列表

7 个代谢物同义名

Mannitol; D-mannitol; D-glycero-Hexitol; DL-Mannitol; Mannite; Mannitol; Mannitol



数据库引用编号

58 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

152 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKT1, ALB, CA1, CAT, MAPK14, PTGS2, TJP1, VEGFA
Peripheral membrane protein 2 PTGS2, TJP1
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 6 AKT1, ALB, MAPK14, MPO, TJP1, VEGFA
cytosol 8 AKT1, ALB, AVP, CA1, CAT, MAPK14, MB, TJP1
dendrite 1 AVP
centrosome 1 ALB
nucleoplasm 3 AKT1, MAPK14, MPO
Cell membrane 4 AKT1, TJP1, TNF, TNFRSF1A
Cytoplasmic side 1 TJP1
lamellipodium 1 AKT1
Golgi apparatus membrane 1 TNFRSF1A
cell cortex 1 AKT1
cell junction 1 TJP1
cell surface 3 TNF, TNFRSF1A, VEGFA
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 2 ALB, VEGFA
Golgi membrane 2 INS, TNFRSF1A
neuronal cell body 1 TNF
postsynapse 1 AKT1
Lysosome 1 MPO
plasma membrane 6 AKT1, IGHE, REN, TJP1, TNF, TNFRSF1A
Membrane 5 AKT1, CAT, REN, TNFRSF1A, VEGFA
apical plasma membrane 1 TJP1
basolateral plasma membrane 1 TJP1
caveola 1 PTGS2
extracellular exosome 6 ALB, CA1, CAT, LYZ, MB, MPO
endoplasmic reticulum 3 ALB, PTGS2, VEGFA
extracellular space 13 ALB, AVP, CRP, CXCL8, IGHE, IL6, INS, LYZ, MPO, REN, TNF, TNFRSF1A, VEGFA
Cell junction, tight junction 1 TJP1
adherens junction 2 TJP1, VEGFA
apicolateral plasma membrane 1 TJP1
bicellular tight junction 1 TJP1
gap junction 1 TJP1
intercalated disc 1 TJP1
intercellular canaliculus 1 TJP1
mitochondrion 3 CAT, MAPK14, TJP1
protein-containing complex 5 AKT1, ALB, CAT, PTGS2, TJP1
intracellular membrane-bounded organelle 2 CAT, MPO
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 2 IGHE, TNFRSF1A
Secreted 9 ALB, AVP, CRP, CXCL8, IL6, INS, REN, TNFRSF1A, VEGFA
extracellular region 15 ALB, AVP, CAT, CRP, CXCL8, IGHE, IL6, INS, LYZ, MAPK14, MPO, REN, TNF, TNFRSF1A, VEGFA
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
sarcoplasm 1 MB
apical part of cell 2 REN, TJP1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 2 TNF, TNFRSF1A
focal adhesion 1 CAT
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 3 AVP, MPO, VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 TNFRSF1A
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, ALB
IgE immunoglobulin complex 1 IGHE
cell projection 1 TJP1
phagocytic cup 1 TNF
Cell projection, podosome 1 TJP1
podosome 1 TJP1
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 1 ALB
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, IL6, INS, PTGS2
platelet alpha granule lumen 2 ALB, VEGFA
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
tight junction 1 TJP1
azurophil granule lumen 2 LYZ, MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 AVP
clathrin-coated endocytic vesicle membrane 1 AVP
phagocytic vesicle lumen 1 MPO
apical junction complex 1 TJP1
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
Cytoplasm, sarcoplasm 1 MB
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
tumor necrosis factor receptor superfamily complex 1 TNFRSF1A
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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  • Hye-Yeon Seok, Sun-Young Lee, Swarnali Sarker, Md Bayzid, Yong-Hwan Moon. Genome-Wide Analysis of Stress-Responsive Genes and Alternative Splice Variants in Arabidopsis Roots under Osmotic Stresses. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914580. [PMID: 37834024]
  • Ashish Sarode, Priyal Patel, Natalia Vargas-Montoya, Ayed Allawzi, Alisa Zhilin-Roth, Saswata Karmakar, Lianne Boeglin, Hongfeng Deng, Shrirang Karve, Frank DeRosa. Inhalable dry powder product (DPP) of mRNA lipid nanoparticles (LNPs) for pulmonary delivery. Drug delivery and translational research. 2023 Aug; ?(?):. doi: 10.1007/s13346-023-01402-y. [PMID: 37526881]
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  • Sara Sangi, Geovanna Vitória Olimpio, Fernanda Silva Coelho, Camilla R Alexandrino, Maura Da Cunha, Clícia Grativol. Flagellin and mannitol modulate callose biosynthesis and deposition in soybean seedlings. Physiologia plantarum. 2023 Feb; ?(?):e13877. doi: 10.1111/ppl.13877. [PMID: 36811487]
  • Arun Narota, Ranjit Singh, Ranju Bansal, Ashwani Kumar, Amarjit S Naura. Isolation & identification of anti-inflammatory constituents of Randia dumetorum lamk. fruit: Potential beneficial effects against acute lung injury. Journal of ethnopharmacology. 2023 Jan; 301(?):115759. doi: 10.1016/j.jep.2022.115759. [PMID: 36216197]
  • Qian Chen, Lu Peng, Anhu Wang, Lingzhi Yu, Yu Liu, Xinrong Zhang, Ruolin Wang, Xiaoyi Li, Yi Yang, Xufeng Li, Jianmei Wang. An R2R3-MYB FtMYB11 from Tartary buckwheat has contrasting effects on abiotic tolerance in Arabidopsis. Journal of plant physiology. 2023 Jan; 280(?):153842. doi: 10.1016/j.jplph.2022.153842. [PMID: 36434991]
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