7-a,25-Dihydroxycholesterol (BioDeep_00000010757)
Main id: BioDeep_00000636711
human metabolite Endogenous
代谢物信息卡片
3beta,7alpha,25-Trihydroxycholest-5-ene
化学式: C27H46O3 (418.3447)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 28.98%
分子结构信息
SMILES: CC(CCCC(C)(C)O)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C
InChI: InChI=1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1
描述信息
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:37623
- KEGG: C15520
- PubChem: 11954197
- PubChem: 14077700
- HMDB: HMDB0006280
- Metlin: METLIN57927
- ChEMBL: CHEMBL4788348
- LipidMAPS: LMST04030166
- CAS: 64907-22-8
- PMhub: MS000024642
- PubChem: 17396512
- PDB-CCD: KJX
- NIKKAJI: J652.922D
- RefMet: 7alpha,25-Dihydroxycholesterol
- medchemexpress: HY-113962
分类词条
相关代谢途径
Reactome(15)
- Metabolism
- Biological oxidations
- Phase I - Functionalization of compounds
- Metabolism of lipids
- Metabolism of steroids
- Cytochrome P450 - arranged by substrate type
- Signaling Pathways
- Bile acid and bile salt metabolism
- Synthesis of bile acids and bile salts
- Endogenous sterols
- Signaling by GPCR
- GPCR ligand binding
- Class A/1 (Rhodopsin-like receptors)
- GPCR downstream signalling
- G alpha (i) signalling events
BioCyc(0)
PlantCyc(0)
代谢反应
159 个相关的代谢反应过程信息。
Reactome(137)
- Signaling Pathways:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Signaling by GPCR:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (i) signalling events:
ATP ⟶ PPi + cAMP - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP - Signaling by GPCR:
H2O + cAMP ⟶ AMP - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (i) signalling events:
H2O + cAMP ⟶ AMP - GPCR ligand binding:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR ligand binding:
Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
Ade-Rib ⟶ ADORA1,3:Ade-Rib - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR ligand binding:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR ligand binding:
Ade-Rib + H0YT13 ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
Ade-Rib + H0YT13 ⟶ ADORA1,3:Ade-Rib - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Endogenous sterols:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of steroids:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Endogenous sterols:
EST17b + H+ + Oxygen + TPNH ⟶ 4OH-EST17b + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - GPCR downstream signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (i) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(22)
- Bile Acid Biosynthesis:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type II:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type III:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Familial Hypercholanemia (FHCA):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Zellweger Syndrome:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Cerebrotendinous Xanthomatosis (CTX):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - 27-Hydroxylase Deficiency:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Bile Acid Biosynthesis:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - 27-Hydroxylase Deficiency:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Cerebrotendinous Xanthomatosis (CTX):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type II:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type III:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Familial Hypercholanemia (FHCA):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Zellweger Syndrome:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - 27-Hydroxylase Deficiency:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Bile Acid Biosynthesis:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Bile Acid Biosynthesis:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Cerebrotendinous Xanthomatosis (CTX):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type II:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type III:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Familial Hypercholanemia (FHCA):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Zellweger Syndrome:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jin Huang, Seung-Jin Lee, Saeromi Kang, Man Ho Choi, Dong-Soon Im. 7α,25-Dihydroxycholesterol Suppresses Hepatocellular Steatosis through GPR183/EBI2 in Mouse and Human Hepatocytes.
The Journal of pharmacology and experimental therapeutics.
2020 07; 374(1):142-150. doi:
10.1124/jpet.120.264960. [PMID: 32341017] - Tau Benned-Jensen, Christoffer Norn, Stephane Laurent, Christian M Madsen, Hjalte M Larsen, Kristine N Arfelt, Romain M Wolf, Thomas Frimurer, Andreas W Sailer, Mette M Rosenkilde. Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).
The Journal of biological chemistry.
2012 Oct; 287(42):35470-35483. doi:
10.1074/jbc.m112.387894. [PMID: 22875855] - Lisa M Kelly, João P Pereira, Tangsheng Yi, Ying Xu, Jason G Cyster. EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues.
Journal of immunology (Baltimore, Md. : 1950).
2011 Sep; 187(6):3026-32. doi:
10.4049/jimmunol.1101262. [PMID: 21844396] - Sébastien Hannedouche, Juan Zhang, Tangsheng Yi, Weijun Shen, Deborah Nguyen, João P Pereira, Danilo Guerini, Birgit U Baumgarten, Silvio Roggo, Ben Wen, Richard Knochenmuss, Sophie Noël, Francois Gessier, Lisa M Kelly, Mirka Vanek, Stephane Laurent, Inga Preuss, Charlotte Miault, Isabelle Christen, Ratna Karuna, Wei Li, Dong-In Koo, Thomas Suply, Christian Schmedt, Eric C Peters, Rocco Falchetto, Andreas Katopodis, Carsten Spanka, Marie-Odile Roy, Michel Detheux, Yu Alice Chen, Peter G Schultz, Charles Y Cho, Klaus Seuwen, Jason G Cyster, Andreas W Sailer. Oxysterols direct immune cell migration via EBI2.
Nature.
2011 Jul; 475(7357):524-7. doi:
10.1038/nature10280. [PMID: 21796212]
