Calcein AM (BioDeep_00000008566)

 

Secondary id: BioDeep_00001876741

human metabolite blood metabolite


代谢物信息卡片


(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}({[3,6-bis(acetyloxy)-2-{[bis({2-[(acetyloxy)methoxy]-2-oxoethyl})amino]methyl}-3-oxo-3H-spiro[2-benzofuran-1,9-xanthene]-7-yl]methyl})amino)acetate

化学式: C46H46N2O23 (994.2491246000001)
中文名称: 钙黄绿素乙酰氧基甲酯
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)CC1=C(OC(C)=O)C=C2OC3=CC(OC(C)=O)=C(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C=C3C3(OC(=O)C4=CC=CC=C34)C2=C1
InChI: InChI=1S/C46H46N2O23/c1-25(49)60-21-64-41(55)17-47(18-42(56)65-22-61-26(2)50)15-31-11-35-39(13-37(31)68-29(5)53)70-40-14-38(69-30(6)54)32(12-36(40)46(35)34-10-8-7-9-33(34)45(59)71-46)16-48(19-43(57)66-23-62-27(3)51)20-44(58)67-24-63-28(4)52/h7-14H,15-24H2,1-6H3

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D004396 - Coloring Agents > D005456 - Fluorescent Dyes > D005452 - Fluoresceins
D000970 - Antineoplastic Agents

同义名列表

11 个代谢物同义名

(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}({[3,6-bis(acetyloxy)-2-{[bis({2-[(acetyloxy)methoxy]-2-oxoethyl})amino]methyl}-3-oxo-3H-spiro[2-benzofuran-1,9-xanthene]-7-yl]methyl})amino)acetate; (acetyloxy)methyl ({2-[(acetyloxy)methoxy]-2-oxoethyl}[3,6-bis(acetyloxy)-2-{[bis({2-[(acetyloxy)methoxy]-2-oxoethyl})amino]methyl}-3-oxospiro[2-benzofuran-1,9-xanthene]-7-ylmethyl]amino)acetate; [({[3,6-bis(acetyloxy)-3-oxo-3H-spiro[[2]benzofuran-1,9-xanthene]-2,7-diyl]bis(methylene)nitrilo}bis[(1-oxoethane-2,1-diyl)oxy]methylene)] tetraacetic acid; [({[3,6-bis(acetyloxy)-3-oxo-3H-spiro[[2]benzofuran-1,9-xanthene]-2,7-diyl]bis(methylene)nitrilo}bis[(1-oxoethane-2,1-diyl)oxy]methylene)] tetraacetate; 4,5-Bis(N,N-bis(carboxymethyl)aminomethyl)fluorescein acetoxymethyl ester; Calcein O,o-diacetic acid tetrakis(acetoxymethyl) ester; Calcein O,o-diacetate tetrakis(acetoxymethyl) ester; Calcein-acetoxymethyl ester; Calcein-AM; Calcein AM; Calcein AM



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jing Yan, Zehua Li, Yu Liang, Chaobo Yang, Wen Ou, Huaqiang Mo, Min Tang, Deshu Chen, Chongbin Zhong, Dongdong Que, Liyun Feng, Hua Xiao, Xudong Song, Pingzhen Yang. Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway. Food & function. 2023 Nov; 14(22):10052-10068. doi: 10.1039/d3fo02633g. [PMID: 37861458]
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  • Safaa Yehia Eid, Mahmoud Zaki El-Readi, Essam Eldin Mohamed Nour Eldin, Sameer Hassan Fatani, Michael Wink. Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Dec; 21(1):47-61. doi: 10.1016/j.phymed.2013.07.019. [PMID: 23999162]
  • Yumi Hashiguchi, Akinobu Hamada, Takashi Shinohara, Kiyoto Tsuchiya, Hirofumi Jono, Hideyuki Saito. Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents. Biochemical and biophysical research communications. 2013 Sep; 439(2):221-7. doi: 10.1016/j.bbrc.2013.08.054. [PMID: 23981805]
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  • Siyuan Sun, Zhongjian Chen, Liping Li, Dongli Sun, Ye Tian, Hao Pan, Huichang Bi, Min Huang, Su Zeng, Huidi Jiang. The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP. Xenobiotica; the fate of foreign compounds in biological systems. 2012 Dec; 42(12):1197-205. doi: 10.3109/00498254.2012.702247. [PMID: 22900779]
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  • Pornsiri Pitchakarn, Shinobu Ohnuma, Komsak Pintha, Wilart Pompimon, Suresh V Ambudkar, Pornngarm Limtrakul. Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance. The Journal of nutritional biochemistry. 2012 Jan; 23(1):76-84. doi: 10.1016/j.jnutbio.2010.11.005. [PMID: 21414769]
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  • Yong Long, Qing Li, Shan Zhong, Youhui Wang, Zongbin Cui. Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2011 May; 153(4):381-91. doi: 10.1016/j.cbpc.2011.01.002. [PMID: 21266201]
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  • Joerg Hauser, Manfred Koeller, Sebastian Bensch, Helmut Halfmann, Peter Awakowicz, Hans-Ulrich Steinau, Stefan Esenwein. Plasma mediated collagen-I-coating of metal implant materials to improve biocompatibility. Journal of biomedical materials research. Part A. 2010 Jul; 94(1):19-26. doi: 10.1002/jbm.a.32672. [PMID: 20091709]
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