2-Nitrofluorene (BioDeep_00000008403)
Secondary id: BioDeep_00001873694
human metabolite blood metabolite Industrial Pollutants
代谢物信息卡片
2-Nitro-9H-fluorene
化学式: C13H9NO2 (211.0633)
中文名称: 2-硝基芴
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2=CC=CC=C2C3=C1C=C(C=C3)[N+](=O)[O-]
InChI: InChI=1S/C13H9NO2/c15-14(16)11-5-6-13-10(8-11)7-9-3-1-2-4-12(9)13/h1-6,8H,7H2
描述信息
D004785 - Environmental Pollutants > D000393 - Air Pollutants
D009676 - Noxae > D009153 - Mutagens
同义名列表
6 个代谢物同义名
2-Nitro-9H-fluorene; 2-Nitrofluorene; Nitrofluorene; NF; 2-Nitrofluorene; 2-Nitrofluorene
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:1224
- KEGG: C10923
- PubChem: 11831
- HMDB: HMDB0245257
- Metlin: METLIN68692
- ChEMBL: CHEMBL351487
- Wikipedia: 2-Nitrofluorene
- chemspider: 11338
- CAS: 607-57-8
- PMhub: MS000022022
- PubChem: 13106
- NIKKAJI: J2.988B
- RefMet: 2-Nitrofluorene
- RefMet: Nitrofluorene
- KNApSAcK: 1224
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yanlin Jian, He Eun Forbes, Fabian Hulpia, Martijn D P Risseeuw, Guy Caljon, Hélène Munier-Lehmann, Helena I M Boshoff, Serge Van Calenbergh. 2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn).
Journal of medicinal chemistry.
2021 01; 64(1):440-457. doi:
10.1021/acs.jmedchem.0c01374. [PMID: 33347317] - Youngsu You, Hee Sun Kim, Il Hak Bae, Seung Gi Lee, Min Hyeok Jee, Gyochang Keum, Sung Key Jang, B Moon Kim. New potent biaryl sulfate-based hepatitis C virus inhibitors.
European journal of medicinal chemistry.
2017 Jan; 125(?):87-100. doi:
10.1016/j.ejmech.2016.09.031. [PMID: 27657807] - Il Hak Bae, Hee Sun Kim, Youngsu You, Chieyeon Chough, Weonu Choe, Min Kyung Seon, Seung Gi Lee, Gyochang Keum, Sung Key Jang, B Moon Kim. Novel benzidine and diaminofluorene prolinamide derivatives as potent hepatitis C virus NS5A inhibitors.
European journal of medicinal chemistry.
2015 Aug; 101(?):163-78. doi:
10.1016/j.ejmech.2015.06.033. [PMID: 26134551] - Laia Tolosa, Sandra Pinto, M Teresa Donato, Agustín Lahoz, José V Castell, J Enrique O'Connor, M José Gómez-Lechón. Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 May; 127(1):187-98. doi:
10.1093/toxsci/kfs083. [PMID: 22331495] - Halmurat Upur, Abdiryim Yusup, Isabelle Baudrimont, Anwar Umar, Benedicte Berke, Dilxat Yimit, Jaya Conser Lapham, Edmon E Creppy, Nicholas Moore. Inhibition of Cell Growth and Cellular Protein, DNA and RNA Synthesis in Human Hepatoma (HepG2) Cells by Ethanol Extract of Abnormal Savda Munziq of Traditional Uighur Medicine.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):251424. doi:
10.1093/ecam/nen062. [PMID: 18955370] - Michael Zhuo Wang, Xiaohua Zhu, Anuradha Srivastava, Qiang Liu, J Mark Sweat, Trupti Pandharkar, Chad E Stephens, Ed Riccio, Toufan Parman, Manoj Munde, Swati Mandal, Rentala Madhubala, Richard R Tidwell, W David Wilson, David W Boykin, James Edwin Hall, Dennis E Kyle, Karl A Werbovetz. Novel arylimidamides for treatment of visceral leishmaniasis.
Antimicrobial agents and chemotherapy.
2010 Jun; 54(6):2507-16. doi:
10.1128/aac.00250-10. [PMID: 20368397] - A Di Sotto, A Vitalone, M Nicoletti, A Piccin, G Mazzanti. Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract.
Journal of ethnopharmacology.
2010 Feb; 127(3):731-6. doi:
10.1016/j.jep.2009.12.001. [PMID: 19969059] - Ahmad Rajaei, Mohsen Barzegar, Ashraf Mohabati Mobarez, Mohammad Ali Sahari, Zohre Hamidi Esfahani. Antioxidant, anti-microbial and antimutagenicity activities of pistachio (Pistachia vera) green hull extract.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Jan; 48(1):107-12. doi:
10.1016/j.fct.2009.09.023. [PMID: 19781589] - Daphne Sue Yen Loh, Hui Meng Er, Yu Sui Chen. Mutagenic and antimutagenic activities of aqueous and methanol extracts of Euphorbia hirta.
Journal of ethnopharmacology.
2009 Dec; 126(3):406-14. doi:
10.1016/j.jep.2009.09.025. [PMID: 19778596] - Kwanghee Koh Park, Joon Woo Park, Andrew D Hamilton. Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin.
Organic & biomolecular chemistry.
2009 Oct; 7(20):4225-32. doi:
10.1039/b911605b. [PMID: 19795061] - Annamaria Buschini, Lisa Ferrarini, Susanna Franzoni, Serena Galati, Mirca Lazzaretti, Francesca Mussi, Cristina Northfleet de Albuquerque, Tânia Maria Araújo Domingues Zucchi, Paola Poli. Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.
Journal of parasitology research.
2009; 2009(?):463575. doi:
10.1155/2009/463575. [PMID: 20981287] - Renato Bruni, Damiano Rossi, Mariavittoria Muzzoli, Carlo Romagnoli, Guglielmo Paganetto, Elena Besco, Fritz Choquecillo, Katia Peralta, William Schmitt Lora, Gianni Sacchetti. Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark.
Fitoterapia.
2006 Dec; 77(7-8):538-45. doi:
10.1016/j.fitote.2006.06.009. [PMID: 16963198] - Kari Kreander, Anna Galkin, Satu Vuorela, Päivi Tammela, Leena Laitinen, Marina Heinonen, Pia Vuorela. In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions.
The Journal of pharmacy and pharmacology.
2006 Nov; 58(11):1545-52. doi:
10.1211/jpp.58.11.0016. [PMID: 17132218] - D Rossi, R Bruni, N Bianchi, C Chiarabelli, R Gambari, A Medici, A Lista, G Paganetto. Evaluation of the mutagenic, antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2003 Mar; 10(2-3):139-44. doi:
10.1078/094471103321659843. [PMID: 12725567] - B Sripanidkulchai, U Tattawasart, P Laupatarakasem, U Vinitketkumneun, K Sripanidkulchai, C Furihata, T Matsushima. Antimutagenic and anticarcinogenic effects of Phyllanthus amarus.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2002 Jan; 9(1):26-32. doi:
10.1078/0944-7113-00092. [PMID: 11924760] - T Ohe, K Marutani, S Nakase. Catechins are not major components responsible for anti-genotoxic effects of tea extracts against nitroarenes.
Mutation research.
2001 Sep; 496(1-2):75-81. doi:
10.1016/s1383-5718(01)00220-0. [PMID: 11551482] - B E Butterworth, O B Mathre, K Ballinger. The preparation of anthraquinone used in the National Toxicology Program cancer bioassay was contaminated with the mutagen 9-nitroanthracene.
Mutagenesis.
2001 Mar; 16(2):169-77. doi:
10.1093/mutage/16.2.169. [PMID: 11230561] - K Hirayama, P Baranczewski, J E Akerlund, T Midtvedt, L Möller, J Rafter. Effects of human intestinal flora on mutagenicity of and DNA adduct formation from food and environmental mutagens.
Carcinogenesis.
2000 Nov; 21(11):2105-11. doi:
10.1093/carcin/21.11.2105. [PMID: 11062175] - X S Cui, L C Eriksson, L Möller. Formation and persistence of DNA adducts during and after a long-term administration of 2-nitrofluorene.
Mutation research.
1999 Jun; 442(1):9-18. doi:
10.1016/s1383-5718(99)00053-4. [PMID: 10366768] - G Umbuzeiro-Valent, D A Roubicek, E M Haebisch. Mutagenic and antimutagenic evaluation of the juice of the leaves of Bryophyllum calycinum (Kalanchoe pinnata), a plant with antihistamine activity.
Environmental and molecular mutagenesis.
1999; 33(4):325-7. doi:
10.1002/(sici)1098-2280(1999)33:4<325::aid-em10>3.0.co;2-e. [PMID: 10398381] - R Edenharder, X Tang. Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1997 Mar; 35(3-4):357-72. doi:
10.1016/s0278-6915(97)00125-7. [PMID: 9207898] - D J Doolittle, R Winegar, C K Lee, W S Caldwell, A W Hayes, J D de Bethizy. The genotoxic potential of nicotine and its major metabolites.
Mutation research.
1995 Oct; 344(3-4):95-102. doi:
10.1016/0165-1218(95)00037-2. [PMID: 7491133] - X S Cui, U B Torndal, L C Eriksson, L Möller. Early formation of DNA adducts compared with tumor formation in a long-term tumor study in rats after administration of 2-nitrofluorene.
Carcinogenesis.
1995 Sep; 16(9):2135-41. doi:
10.1093/carcin/16.9.2135. [PMID: 7554066] - L Möller, M Zeisig, T Midtvedt, J A Gustafsson. Intestinal microflora enhances formation of DNA adducts following administration of 2-NF and 2-AAF.
Carcinogenesis.
1994 May; 15(5):857-61. doi:
10.1093/carcin/15.5.857. [PMID: 8200087] - P T Scheepers, J L Theuws, R P Bos. Mutagenicity of urine from rats after 1-nitropyrene and 2-nitrofluorene administration using new sensitive Salmonella typhimurium strains YG1012 and YG1024.
Mutation research.
1991 Aug; 260(4):393-9. doi:
10.1016/0165-1218(91)90025-h. [PMID: 1870628] - J Suzuki, S Meguro, O Morita, S Hirayama, S Suzuki. Comparison of in vivo binding of aromatic nitro and amino compounds to rat hemoglobin.
Biochemical pharmacology.
1989 Oct; 38(20):3511-9. doi:
10.1016/0006-2952(89)90122-6. [PMID: 2818643] - B Beije, L Möller. Correlation between induction of unscheduled DNA synthesis in the liver and excretion of mutagenic metabolites in the urine of rats exposed to the carcinogenic air pollutant 2-nitrofluorene.
Carcinogenesis.
1988 Aug; 9(8):1465-70. doi:
10.1093/carcin/9.8.1465. [PMID: 3402043] - L Möller, M Corrie, T Midtvedt, J Rafter, J A Gustafsson. The role of the intestinal microflora in the formation of mutagenic metabolites from the carcinogenic air pollutant 2-nitrofluorene.
Carcinogenesis.
1988 May; 9(5):823-30. doi:
10.1093/carcin/9.5.823. [PMID: 3365841] - L Möller, J Rafter, J A Gustafsson. Metabolism of the carcinogenic air pollutant 2-nitrofluorene in the rat.
Carcinogenesis.
1987 May; 8(5):637-45. doi:
10.1093/carcin/8.5.637. [PMID: 3581422] - M Wilpart, M Roberfroid. Effects of secondary biliary acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine, 2-acetylaminofluorene and 2-nitrofluorene towards Salmonella typhimurium strains.
Carcinogenesis.
1986 May; 7(5):703-6. doi:
10.1093/carcin/7.5.703. [PMID: 3516434] - R Shaw, A W Andrews, C W Riggs. Assay of mutagens in aqueous fecal extracts with a modified ames Salmonella test.
Teratogenesis, carcinogenesis, and mutagenesis.
1985; 5(1):15-27. doi:
10.1002/tcm.1770050104. [PMID: 2859658] - C Wei, O G Raabe, L S Rosenblatt. Microbial detection of mutagenic nitro-organic compounds in filtrates of coal fly ash.
Environmental mutagenesis.
1982; 4(3):249-58. doi:
10.1002/em.2860040307. [PMID: 7047159]
