Classification Term: 3180

Fluorenes (ontology term: CHEMONTID:0000020)

Compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene." []

found 40 associated metabolites at class metabolite taxonomy ontology rank level.

Ancestor: Benzenoids

Child Taxonomies: There is no child term of current ontology term.

Fluorene

2,2-Methylenebiphenyl

C13H10 (166.0782)


Fluorene, also known as diphenylenemethane or 9h-fluorene, is a member of the class of compounds known as fluorenes. Fluorenes are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene. Fluorene is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Fluorene can be found in corn, which makes fluorene a potential biomarker for the consumption of this food product. Fluorene is formally rated as an unfounded non-carcinogenic (IARC 3) potentially toxic compound. Fluorene , or 9H-fluorene, is a polycyclic aromatic hydrocarbon. It forms white crystals that exhibit a characteristic, aromatic odor similar to that of naphthalene. It is combustible. It has a violet fluorescence, hence its name. For commercial purposes it is obtained from coal tar. It is insoluble in water and soluble in many organic solvents . PAHs are carcinogens and have been associated with the increased risk of skin, respiratory tract, bladder, stomach, and kidney cancers. They may also cause reproductive effects and depress the immune system (L10) (T3DB). D009676 - Noxae > D002273 - Carcinogens

   

2-Acetylaminofluorene

N-(9H-fluoren-2-yl)ethanimidic acid

C15H13NO (223.0997)


D009676 - Noxae > D002273 - Carcinogens

   

N-Hydroxy-2-acetamidofluorene

N-(9H-fluoren-2-yl)-N-hydroxyacetamide

C15H13NO2 (239.0946)


   

9-Hydroxyfluorene

Diphenylene carbinol

C13H10O (182.0732)


This compound belongs to the family of Fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene. 9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 μM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo[1].

   

2-Nitrofluorene

2-Nitro-9H-fluorene

C13H9NO2 (211.0633)


D004785 - Environmental Pollutants > D000393 - Air Pollutants D009676 - Noxae > D009153 - Mutagens

   

2-Hydroxyfluorene

2-Hydroxy fluorene

C13H10O (182.0732)


2-Hydroxyfluorene (2-OHF) is a metabolite of fluorene. Fluorene is one of the most abundant polycyclic aromatic hydrocarbons (PAHs) throughout the gas phase in the environment, especially in tobacco smoke condensate. 2-OHF is an effective biomarker for evaluating the exposure to PAHs from smoking. It has been found in urine [HMDB] 2-Hydroxyfluorene (2-OHF) is a metabolite of fluorene. Fluorene is one of the most abundant polycyclic aromatic hydrocarbons (PAHs) throughout the gas phase in the environment, especially in tobacco smoke condensate. 2-OHF is an effective biomarker for evaluating the exposure to PAHs from smoking. It has been found in urine. CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4793; ORIGINAL_PRECURSOR_SCAN_NO 4790 CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4811; ORIGINAL_PRECURSOR_SCAN_NO 4806 CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4829; ORIGINAL_PRECURSOR_SCAN_NO 4826 CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4796; ORIGINAL_PRECURSOR_SCAN_NO 4793 CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4823; ORIGINAL_PRECURSOR_SCAN_NO 4821 CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4758; ORIGINAL_PRECURSOR_SCAN_NO 4754

   

3-Hydroxyfluorene

9H-fluoren-3-ol

C13H10O (182.0732)


This compound belongs to the family of Fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.

   

Indecainide

9-{3-[(propan-2-yl)amino]propyl}-9H-fluorene-9-carboximidate

C20H24N2O (308.1889)


Indecainide is only found in individuals that have used or taken this drug. It is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.Indecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent

   

Lumefantrine

2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]ethan-1-ol

C30H32Cl3NO (527.1549)


Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas. D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent

   

Bakers yeast extract

2-{tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁶]heptadeca-1(10),2,4,6,8,11,13,15-octaen-17-yl}acetic acid

C19H14O2 (274.0994)


Bakers yeast extract is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]")

   

desbutyl-lumefantrine

2-(butylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]ethan-1-ol

C26H24Cl3NO (471.0923)


desbutyl-lumefantrine is a metabolite of lumefantrine. Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. The term co-artemether is sometimes used to describe this combination. (Wikipedia)

   

(+)-1-(9-Fluorenyl)ethyl chloroformate

(+)-(3S,4S)-1-BENZYL-3-PYRROLIDINYLMETHYL1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE

C16H13ClO2 (272.0604)


   

(1-{3-[6-(9,9-Difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

methyl N-{1-[6-(5-{9,9-difluoro-7-[2-(2-{2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]heptan-3-yl)-1H-1,3-benzodiazol-6-yl]-9H-fluoren-2-yl}-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl}carbamate

C49H54F2N8O6 (888.4134)


   

1-Aminofluorene

9H-fluoren-1-amine

C13H11N (181.0891)


   

2-Aminofluorene

9H-fluoren-2-amine

C13H11N (181.0891)


D009676 - Noxae > D002273 - Carcinogens D009676 - Noxae > D009153 - Mutagens

   

2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate

(2,7-di-tert-butyl-9H-fluoren-9-yl)methyl chloroformate

C23H27ClO2 (370.1699)


   

2-(Dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol

2-(dibutylamino)-1-{2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl}ethan-1-ol

C30H32Cl3NO (527.1549)


   

9-Fluorenylmethyl chloroformate

(9H-fluoren-9-yl)methyl chloroformate

C15H11ClO2 (258.0448)


D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents

   

9-Fluorenylmethyl carbamate

(9H-fluoren-9-yl)methyl carbamate

C15H13NO2 (239.0946)


   

9-Fluorenylmethyl carbazate

9-Fluorenylmethyl chloroformate hydrazine

C15H14N2O2 (254.1055)


   

9H-Fluoren-9-ylmethyl Formate

9H-Fluoren-9-ylmethyl formic acid

C15H12O2 (224.0837)


   

Acetoxyacetylaminofluorene

Acetic acid, ester with N-(fluoren-2-yl)acetohydroxamic acid

C17H15NO3 (281.1052)


D009676 - Noxae > D000477 - Alkylating Agents

   

2,7-Difluoro-4-methoxyspiro[fluorene-9,5'-imidazolidine]-2',4'-dione

2,7-Difluoro-4-methoxyspiro-(9H-fluorene-9,4-imidazolidine)-2,5-dione

C16H10F2N2O3 (316.0659)


   

Alconil

Spiro(2-fluoro-9H-fluorene-9,4-imidazolidine)-2,5-dione

C15H9FN2O2 (268.0648)


   

Chlorflurenol-methyl

2-Chloro-9-hydroxyfluorene-9-carboxylic acid methyl ester

C15H11ClO3 (274.0397)


   

9H-Fluorene-9-carboxamide, 9-(3-aminopropyl)-

9-(3-aminopropyl)-9H-fluorene-9-carboxamide

C17H18N2O (266.1419)


   

Desbutyllumefantrine

2-(butylamino)-1-{2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl}ethan-1-ol

C26H24Cl3NO (471.0923)


   

Fluorenylmethyl chloroformate

Fluorenylmethyl chloroformic acid

C15H11ClO2 (258.0448)


   

Imirestat

Spiro(2,7-difluoro-9H-fluoren-9,4-imidazolidine)-2,5-dione

C15H8F2N2O2 (286.0554)


C471 - Enzyme Inhibitor > C72880 - Aldose Reductase Inhibitor

   

Lomitapide

N-(2,2,2-trifluoroethyl)-9-[4-(4-{2-[4-(trifluoromethyl)phenyl]benzamido}piperidin-1-yl)butyl]-9H-fluorene-9-carboxamide

C39H37F6N3O2 (693.279)


C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent

   

9-Acetylaminofluorene

N-(9H-Fluoren-9-yl)ethanimidate

C15H13NO (223.0997)


   

7-Acetamido-9-oxofluorene-4-carboxylic acid

7-[(1-Hydroxyethylidene)amino]-9-oxo-9H-fluorene-4-carboxylate

C16H11NO4 (281.0688)


   

2-(9H-Fluoren-1-yl)acetamide

2-(9H-Fluoren-1-yl)ethanimidate

C15H13NO (223.0997)


   

3a-Methyl-2,3,4,5,5a,10,10a,10b-octahydro-1H-cyclopenta[a]fluorene-2,3,7-triol

3a-methyl-1H,2H,3H,3aH,4H,5H,5aH,10H,10aH,10bH-cyclopenta[a]fluorene-2,3,7-triol

C17H22O3 (274.1569)


   

9-(Formyloxymethyl)-9H-fluorene-2-sulfonic acid

9-[(Formyloxy)methyl]-9H-fluorene-2-sulphonic acid

C15H12O5S (304.0405)


   

tilorone

2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one

C25H34N2O3 (410.2569)


   

2-((2-Methoxy-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl 4-(2-(2-(9H-fluoren-9-yl)acetamido)ethyl)benzoate

2-(9H-Fluoren-9-yl)-N-[2-(4-{[2-({2-methoxy-2-[3-(trifluoromethyl)phenyl]ethyl}amino)ethoxy]carbonyl}phenyl)ethyl]ethanimidate

C36H35F3N2O4 (616.2549)


   

VERATRAMINE

2-(1-{5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁶]heptadeca-7,11,13,15-tetraen-14-yl}ethyl)-5-methylpiperidin-3-ol

C27H39NO2 (409.2981)


   

1-Cycloheptyl-1-(9H-fluoren-2-ylmethyl)-3-(2,4,6-trimethylphenyl)urea

N-Cycloheptyl-N-[(9H-fluoren-2-yl)methyl]-n-(2,4,6-trimethylphenyl)carbamimidate

C31H36N2O (452.2827)


   

1,10-dihydro-1,10-dihydroxyfluoren-9-one

1,9a-dihydroxy-9,9a-dihydro-1H-fluoren-9-one

C13H10O3 (214.063)


1,10-dihydro-1,10-dihydroxyfluoren-9-one, also known as ddf or 1,10-dhfo, is a member of the class of compounds known as fluorenes. Fluorenes are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene. 1,10-dihydro-1,10-dihydroxyfluoren-9-one is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). 1,10-dihydro-1,10-dihydroxyfluoren-9-one can be found in a number of food items such as lichee, allium (onion), garden onion, and carrot, which makes 1,10-dihydro-1,10-dihydroxyfluoren-9-one a potential biomarker for the consumption of these food products.