Tolcapone (BioDeep_00000006636)
Secondary id: BioDeep_00000399159
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol
化学式: C14H11NO5 (273.0637)
中文名称: 托卡朋
谱图信息:
最多检出来源 Homo sapiens(blood) 35.23%
分子结构信息
SMILES: CC1=CC=C(C=C1)C(=O)C1=CC(=C(O)C(O)=C1)[N+]([O-])=O
InChI: InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
描述信息
Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinsons disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. [Wikipedia]
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D004791 - Enzyme Inhibitors > D065098 - Catechol O-Methyltransferase Inhibitors
N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
同义名列表
10 个代谢物同义名
5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol; 4-Methyl-3,4-dihydroxy-5-nitrobenzophenone; 3,4-Dihydroxy-5-nitro-4-methylbenzophenone; 3,4-Dihydroxy-4-methyl-5-nitrobenzophenone; 3,4 Dihydroxy 5 methyl 5 nitrobenzophenone; 3,4-Dihydroxy-5-methyl-5-nitrobenzophenone; Roche brand OF tolcapone; Tolcapone; Tasmar; Tolcapone
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:63630
- KEGG: C07949
- KEGGdrug: D00786
- PubChem: 4659569
- HMDB: HMDB0014468
- Metlin: METLIN43355
- DrugBank: DB00323
- ChEMBL: CHEMBL1324
- Wikipedia: Tolcapone
- MeSH: Tolcapone
- chemspider: 3848682
- CAS: 134308-13-7
- PMhub: MS000019707
- PubChem: 10150
- PDB-CCD: TCW
- NIKKAJI: J459.846F
- RefMet: Tolcapone
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Joana Rebouta, Luísa Dória, Ana Coelho, Miguel M Fonseca, Guillermo Castilla-Fernández, Nuno M Pires, M A Vieira-Coelho, Ana I Loureiro. HR/MS-based lipidome analysis of rat brain modulated by tolcapone.
Journal of pharmaceutical and biomedical analysis.
2024 Jan; 241(?):115971. doi:
10.1016/j.jpba.2024.115971. [PMID: 38266454] - Luke T Nelson, Ryan J Paxman, Jin Xu, Bill Webb, Evan T Powers, Jeffery W Kelly. Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma.
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2021 Mar; 28(1):24-29. doi:
10.1080/13506129.2020.1808783. [PMID: 32811187] - Aaro Jalkanen, Veera Lassheikki, Tommi Torsti, Elham Gharib, Marko Lehtonen, Risto O Juvonen. Tissue and interspecies comparison of catechol-O-methyltransferase mediated catalysis of 6-O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Mar; 51(3):268-278. doi:
10.1080/00498254.2020.1853850. [PMID: 33289420] - Carlos G Moreira, Marta M Morawska, Aron Baumann, Sophie Masneuf, Michael Linnebank, Michael Sommerauer, Hans-Peter Landolt, Daniela Noain, Christian R Baumann. Improved functional and histochemical outcomes in l-DOPA plus tolcapone treated VMAT2-deficient mice.
Neuropharmacology.
2020 12; 181(?):108353. doi:
10.1016/j.neuropharm.2020.108353. [PMID: 33038358] - Valentina Loconte, Michele Cianci, Ilaria Menozzi, Davide Sbravati, Francesco Sansone, Alessandro Casnati, Rodolfo Berni. Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin.
Bioorganic chemistry.
2020 10; 103(?):104144. doi:
10.1016/j.bioorg.2020.104144. [PMID: 32791384] - Xin Wang, Murat Cirit, John S Wishnok, Linda G Griffith, Steven R Tannenbaum. Analysis of an Integrated Human Multiorgan Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics.
Analytical chemistry.
2019 07; 91(13):8667-8675. doi:
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