Biguanide (BioDeep_00000006576)
Secondary id: BioDeep_00001868910
human metabolite blood metabolite
代谢物信息卡片
Human hepatitis b virus immune globulin
化学式: C2H7N5 (101.0701)
中文名称: 双胍
谱图信息:
最多检出来源 Rattus norvegicus(not specific) 2.31%
分子结构信息
SMILES: C(=NC(=N)N)(N)N
InChI: InChI=1S/C2H7N5/c3-1(4)7-2(5)6/h(H7,3,4,5,6,7)
描述信息
D007004 - Hypoglycemic Agents > D001645 - Biguanides
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:3095
- KEGG: C07672
- PubChem: 5939
- HMDB: HMDB0249203
- Metlin: METLIN66712
- DrugBank: DB13100
- ChEMBL: CHEMBL4297654
- Wikipedia: Biguanide
- MeSH: Biguanides
- chemspider: 5726
- CAS: 4911-98-2
- CAS: 56-03-1
- PMhub: MS000019638
- PubChem: 9874
- NIKKAJI: J4.565I
- KNApSAcK: 3095
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bao Tianshu, Zhang Lixuan, Wang Chunhong. The synthesis of thermostable, strongly basic Anion-Exchange resins using Cross-Linked biguanide and its application in the extraction of Sodium copper chlorophyllin.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Nov; 1211(?):123436. doi:
10.1016/j.jchromb.2022.123436. [PMID: 36252384] - Kampei Shimizu, Tomohiro Aoki, Nima Etminan, Katharina A M Hackenberg, Shoichi Tani, Hirotoshi Imamura, Hiroharu Kataoka, Nobuyuki Sakai. Associations Between Drug Treatments and the Risk of Aneurysmal Subarachnoid Hemorrhage: a Systematic Review and Meta-analysis.
Translational stroke research.
2022 Oct; ?(?):. doi:
10.1007/s12975-022-01097-2. [PMID: 36242746] - Chul-Min Park, Hyeon-Young Kim, Doin Jeon, Young-Jun Shin, In-Hyeon Kim, Seong-Jin Choi, Ki Cheon Kim, Kyuhong Lee, Sung-Hwan Kim, Min-Seok Kim. Anti-fibrotic effect of pycnogenol® in a polyhexamethylene guanidine-treated mouse model.
Respiratory physiology & neurobiology.
2022 02; 296(?):103802. doi:
10.1016/j.resp.2021.103802. [PMID: 34653662] - Yikelamu Alimu, Yoko Kusuya, Takako Yamamoto, Kana Arita, Naofumi Shigemune, Hiroki Takahashi, Takashi Yaguchi. Mechanism of Polyhexamethylene Biguanide Resistance in Purpureocillium lilacinum Strains.
Biocontrol science.
2022; 27(3):117-130. doi:
10.4265/bio.27.117. [PMID: 36216563] - Wahid M Basyouni, Samir Y Abbas, Khairy A M El-Bayouki, Eman A Younis, Sanaa A Ali, Hanan F Aly. Synthesis and hyperglycemic, biochemical and histopathological evaluation of novel sulfonylbiguanide and sulfonylurea derivatives as potent anti-diabetic agents.
Bioorganic chemistry.
2021 12; 117(?):105418. doi:
10.1016/j.bioorg.2021.105418. [PMID: 34736133] - Ying Xu, Yulong Liu, Taofeng He, Yaqi Zhang, Mingyun Wang, Huaqin Yuan, Mi Yang. Biguanides decorated albumin nanoparticles loading nintedanib for synergic enhanced hepatocellular carcinoma therapy.
Colloids and surfaces. B, Biointerfaces.
2021 Nov; 207(?):112020. doi:
10.1016/j.colsurfb.2021.112020. [PMID: 34403984] - Ryan Houston, Yusuke Sekine, Mads B Larsen, Kei Murakami, Steven J Mullett, Stacy G Wendell, Derek P Narendra, Bill B Chen, Shiori Sekine. Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Molecular biology of the cell.
2021 11; 32(21):ar32. doi:
10.1091/mbc.e21-04-0191. [PMID: 34495738] - Magdalena Markowicz-Piasecka, Karol Sadowski, Johanna Huttunen, Joanna Sikora, Kristiina M Huttunen. Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells.
International journal of molecular sciences.
2021 May; 22(11):. doi:
10.3390/ijms22115642. [PMID: 34073245] - Takako Yamamoto, Yikelamu Alimu, Hiroki Takahashi, Yoko Kusuya, Kouichi Hosoya, Naofumi Shigemune, Satoshi Nagai, Takashi Yaguchi. Isolation and Characterization of the Polyhexamethylene Biguanide Hydrochloride-Resistant Fungus, Purpureocillium lilacinum.
Biocontrol science.
2021; 26(3):157-166. doi:
10.4265/bio.26.157. [PMID: 34556618] - Jian-Ming Huang, Pin-Ju Ko, Chao-Li Huang, Po-Wei Wen, Chun-Hsien Chen, Min-Hsiu Shih, Wei-Chen Lin, Fu-Chin Huang. Cytochrome P450 monooxygenase of Acanthamoeba castellanii participates in resistance to polyhexamethylene biguanide treatment.
Parasite (Paris, France).
2021; 28(?):77. doi:
10.1051/parasite/2021074. [PMID: 34762043] - Maria Loose, Kurt G Naber, Larry Purcell, Manfred P Wirth, Florian M E Wagenlehner. Anti-Biofilm Effect of Octenidine and Polyhexanide on Uropathogenic Biofilm-Producing Bacteria.
Urologia internationalis.
2021; 105(3-4):278-284. doi:
10.1159/000512370. [PMID: 33401282] - Geetansh Sharma, Sonali K Kalra, Nidhi Tejan, Ujjala Ghoshal. Nanoparticles based therapeutic efficacy against Acanthamoeba: Updates and future prospect.
Experimental parasitology.
2020 Nov; 218(?):108008. doi:
10.1016/j.exppara.2020.108008. [PMID: 32979343] - Guang Xin, Yue Ming, Chengjie Ji, Zeliang Wei, Shiyi Li, Susan L Morris-Natschke, Xiaoyu Zhang, Kui Yu, Youping Li, Boli Zhang, Junhua Zhang, Zhihua Xing, Yarong He, Zhen Chen, Xijing Yang, Hai Niu, Kuo-Hsiung Lee, Wen Huang. Novel potent antiplatelet thrombotic agent derived from biguanide for ischemic stroke.
European journal of medicinal chemistry.
2020 Aug; 200(?):112462. doi:
10.1016/j.ejmech.2020.112462. [PMID: 32464472] - Melanie Hornschuh, Paula Zwicker, Thomas Schmidt, Birgit Finke, Axel Kramer, Gerald Müller. Poly (hexamethylene biguanide), adsorbed onto Ti-Al-V alloys, kills slime-producing Staphylococci and Pseudomonas aeruginosa without inhibiting SaOs-2 cell differentiation.
Journal of biomedical materials research. Part B, Applied biomaterials.
2020 07; 108(5):1801-1813. doi:
10.1002/jbm.b.34522. [PMID: 31774237] - M Besser, M Dietrich, L Weber, J D Rembe, E K Stuermer. Efficacy of antiseptics in a novel 3-dimensional human plasma biofilm model (hpBIOM).
Scientific reports.
2020 03; 10(1):4792. doi:
10.1038/s41598-020-61728-2. [PMID: 32179838] - Magdalena Markowicz-Piasecka, Joanna Sikora, Agnieszka Zajda, Kristiina M Huttunen. Novel halogenated sulfonamide biguanides with anti-coagulation properties.
Bioorganic chemistry.
2020 01; 94(?):103444. doi:
10.1016/j.bioorg.2019.103444. [PMID: 31776031] - George Sam Wang, Christopher Hoyte. Review of Biguanide (Metformin) Toxicity.
Journal of intensive care medicine.
2019 Nov; 34(11-12):863-876. doi:
10.1177/0885066618793385. [PMID: 30126348] - Haonan Xing, Lin Cheng, Mei Lu, Hui Liu, Lang Lang, Tianzhi Yang, Xiaoyun Zhao, Hui Xu, Li Yang, Pingtian Ding. A biodegradable poly(amido amine) based on the antimicrobial polymer polyhexamethylene biguanide for efficient and safe gene delivery.
Colloids and surfaces. B, Biointerfaces.
2019 Oct; 182(?):110355. doi:
10.1016/j.colsurfb.2019.110355. [PMID: 31306828] - Young-Suk Kim, Hyunju Cha, Hyo-Jin Kim, Joong-Myung Cho, Hak-Ryul Kim. The Anti-Fibrotic Effects of CG-745, an HDAC Inhibitor, in Bleomycin and PHMG-Induced Mouse Models.
Molecules (Basel, Switzerland).
2019 Jul; 24(15):. doi:
10.3390/molecules24152792. [PMID: 31370295] - M C Nolff, S Winter, S Reese, A Meyer-Lindenberg. Comparison of polyhexanide, cold atmospheric plasma and saline in the treatment of canine bite wounds.
The Journal of small animal practice.
2019 Jun; 60(6):348-355. doi:
10.1111/jsap.12971. [PMID: 30536970] - О А Safonova, T N Popova, T N Shestakova. Effect of 4-Methyl-Phenyl Biguanide on Free Radical Homeostasis and Activity of Oxidative Metabolism Enzymes in Rats with Cardiovascular Pathology Developing against the Background of Rheumatoid Arthritis.
Bulletin of experimental biology and medicine.
2019 Mar; 166(5):606-609. doi:
10.1007/s10517-019-04401-7. [PMID: 30903494] - Yong Joo Park, Mi Ho Jeong, In Jae Bang, Ha Ryong Kim, Kyu Hyuck Chung. Guanidine-based disinfectants, polyhexamethylene guanidine-phosphate (PHMG-P), polyhexamethylene biguanide (PHMB), and oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride (PGH) induced epithelial-mesenchymal transition in A549 alveolar epithelial cells.
Inhalation toxicology.
2019 03; 31(4):161-166. doi:
10.1080/08958378.2019.1624896. [PMID: 31179775] - Alina Yu Babenko, Daria A Savitskaya, Yulia A Kononova, Aleksandra Yu Trofimova, Anna V Simanenkova, Elena Yu Vasilyeva, Evgeny V Shlyakhto. Predictors of Effectiveness of Glucagon-Like Peptide-1 Receptor Agonist Therapy in Patients with Type 2 Diabetes and Obesity.
Journal of diabetes research.
2019; 2019(?):1365162. doi:
10.1155/2019/1365162. [PMID: 30944827] - S Hafner, M Ehrenfeld, A-C Neumann, Andreas Wieser. Comparison of the bactericidal effect of cold atmospheric pressure plasma (CAPP), antimicrobial photodynamic therapy (aPDT), and polihexanide (PHX) in a novel wet surface model to mimic oral cavity application.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.
2018 Dec; 46(12):2197-2202. doi:
10.1016/j.jcms.2018.09.006. [PMID: 30316654] - Peter Arner, Agné Kulyté, Kenneth Batchelor, Jurga Laurencikiene, James Livingston, Mikael Rydén. Mapping of biguanide transporters in human fat cells and their impact on lipolysis.
Diabetes, obesity & metabolism.
2018 10; 20(10):2416-2425. doi:
10.1111/dom.13395. [PMID: 29862627] - Kentaro Oh-Hashi, Shiori Matsumoto, Takayuki Sakai, Yuki Nomura, Kensuke Okuda, Hideko Nagasawa, Yoko Hirata. Elucidating the rapid action of 2-(2-chlorophenyl)ethylbiguanide on HT-29 cells under a serum- and glucose-deprived condition.
Cell biology and toxicology.
2018 08; 34(4):279-290. doi:
10.1007/s10565-017-9410-0. [PMID: 28871429] - Emily K Pugach, McKenna Feltes, Randal J Kaufman, Daniel S Ory, Anne G Bang. High-content screen for modifiers of Niemann-Pick type C disease in patient cells.
Human molecular genetics.
2018 06; 27(12):2101-2112. doi:
10.1093/hmg/ddy117. [PMID: 29659804] - E I Gorina, T N Popova, K K Shulgin, S S Popov, L F Panchenko, O A Safonova. [The effect of biguanide derivatives on oxidative stress in rats with hyperglycemia].
Biomeditsinskaia khimiia.
2018 Jun; 64(3):261-267. doi:
10.18097/pbmc20186403261. [PMID: 29964263] - Xiao-Bo Yu, Kai Hao, Jing Li, Xiao-Hui Chen, Gao-Xue Wang, Fei Ling. Effects of moroxydine hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation.
Research in veterinary science.
2018 Apr; 117(?):37-44. doi:
10.1016/j.rvsc.2017.11.007. [PMID: 29175011] - Selina Winter, Mirja Christine Nolff, Sven Reese, Andrea Meyer-Lindenberg. [Comparison of the antibacterial efficacy of polyhexanide, cold atmospheric argon plasma and saline in the treatment of canine bite wounds].
Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere.
2018 04; 46(2):73-82. doi:
10.15654/tpk-170713. [PMID: 29727894] - Aparajita Chowdhury, Lora L Arnold, Zemin Wang, Karen L Pennington, Puttappa Dodmane, Ana Paula Farragut-Cardoso, James E Klaunig, Daniel Cros, Edmond E Creppy, Samuel M Cohen. Effect of polyhexamethylene biguanide on rat liver.
Toxicology letters.
2018 Mar; 285(?):94-103. doi:
10.1016/j.toxlet.2017.12.032. [PMID: 29305328] - Anas Alshishani, Salizawati Muhamad Salhimi, Bahruddin Saad. Salting-out assisted liquid-liquid extraction coupled with hydrophilic interaction chromatography for the determination of biguanides in biological and environmental samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jan; 1073(?):51-59. doi:
10.1016/j.jchromb.2017.12.013. [PMID: 29241085] - Chensu Wang, Hanspeter Niederstrasser, Peter M Douglas, Rueyling Lin, Juan Jaramillo, Yang Li, Nathaniel W Oswald, Anwu Zhou, Elizabeth A McMillan, Saurabh Mendiratta, Zhaohui Wang, Tian Zhao, Zhiqaing Lin, Min Luo, Gang Huang, Rolf A Brekken, Bruce A Posner, John B MacMillan, Jinming Gao, Michael A White. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.
Nature communications.
2017 12; 8(1):2270. doi:
10.1038/s41467-017-02332-3. [PMID: 29273768] - Erika J Gutiérrez-Lara, Gabriel Navarrete-Vázquez, Araceli Sánchez-López, David Centurión. Pharmacological evaluation of metformin and N-benzylbiguanide, a novel analogue of metformin, on the vasopressor responses to adrenergic system stimulation in pithed rats with fructose-induced insulin resistance.
European journal of pharmacology.
2017 Nov; 814(?):313-323. doi:
10.1016/j.ejphar.2017.08.044. [PMID: 28870455] - Wahid M Basyouni, Samir Y Abbas, Mohamed F El Shehry, Khairy A M El-Bayouki, Hanan F Aly, Azza Arafa, Mahmoud S Soliman. New Biguanides as Anti-Diabetic Agents, Part II: Synthesis and Anti-Diabetic Properties Evaluation of 1-Arylamidebiguanide Derivatives as Agents of Insulin Resistant Type II Diabetes.
Archiv der Pharmazie.
2017 Nov; 350(11):. doi:
10.1002/ardp.201700183. [PMID: 29027251] - Samir Y Abbas, Wahid M Basyouni, Khairy A M El-Bayouk, Wael M Tohamy, Hanan F Aly, Azza Arafa, Mahmoud S Soliman. New Biguanides as Anti-Diabetic Agents Part I: Synthesis and Evaluation of 1-Substituted Biguanide Derivatives as Anti-Diabetic Agents of Type II Diabetes Insulin Resistant.
Drug research.
2017 Oct; 67(10):557-563. doi:
10.1055/s-0043-102692. [PMID: 28651259] - Angel S Galabov, Vesselina Vassileva, Vera Karabasheva. Inhibitory Effect of Abitylguanide on Adenovirus Replication.
Drug research.
2017 Oct; 67(10):583-590. doi:
10.1055/s-0043-111014. [PMID: 28586925] - Elizabeth Sanchez-Rangel, Silvio E Inzucchi. Metformin: clinical use in type 2 diabetes.
Diabetologia.
2017 09; 60(9):1586-1593. doi:
10.1007/s00125-017-4336-x. [PMID: 28770321] - Ane B Iversen, Michael R Horsman, Steen Jakobsen, Jonas B Jensen, Christian Garm, Niels Jessen, Peter Breining, Jørgen Frøkiær, Morten Busk. Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly.
Scientific reports.
2017 08; 7(1):9436. doi:
10.1038/s41598-017-10010-z. [PMID: 28842630] - Saeed Amiri Gheshlaghi, Razieh Mohammad Jafari, Mohammad Algazo, Nastaran Rahimi, Hussein Alshaib, Ahmad Reza Dehpour. Genistein modulation of seizure: involvement of estrogen and serotonin receptors.
Journal of natural medicines.
2017 Jul; 71(3):537-544. doi:
10.1007/s11418-017-1088-3. [PMID: 28439683] - Verena Christen, Susanne Faltermann, Nadja Rebecca Brun, Petra Y Kunz, Karl Fent. Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in vitro and in zebrafish eleuthero-embryos.
The Science of the total environment.
2017 May; 586(?):1204-1218. doi:
10.1016/j.scitotenv.2017.02.114. [PMID: 28236482] - Cornelia Wiegand, Thomas Eberlein, Anneke Andriessen. Antibacterial activity of polihexanide formulations in a co-culture of HaCaT keratinocytes and Staphylococcus aureus and at different pH levels.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
2017 05; 25(3):423-431. doi:
10.1111/wrr.12528. [PMID: 28370821] - N Kapalschinski, H M Seipp, M Kückelhaus, K K Harati, J J Kolbenschlag, A Daigeler, F Jacobsen, M Lehnhardt, T Hirsch. Albumin reduces the antibacterial efficacy of wound antiseptics against Staphylococcus aureus.
Journal of wound care.
2017 Apr; 26(4):184-187. doi:
10.12968/jowc.2017.26.4.184. [PMID: 28379100] - Daniela Knafl, Florian Thalhammer, Matthias G Vossen. In-vitro release pharmacokinetics of amikacin, teicoplanin and polyhexanide in a platelet rich fibrin-layer (PRF)-a laboratory evaluation of a modern, autologous wound treatment.
PloS one.
2017; 12(7):e0181090. doi:
10.1371/journal.pone.0181090. [PMID: 28686663] - N N Veselovskaya. [CHANGES OF LIFETIME MORPHOLOGICAL PARAMETERS OF THE RETINA ON THE BACKGROUND OF CORRECTION OF LIPID METABOLISM IN PATIENTSWITH TYPE 2 DIABETES MELLITUS].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994).
2017; 63(1):91-94. doi:
10.15407/fz63.01.091. [PMID: 29975833] - Cong Luo, Lei Miao, Yi Zhao, Sara Musetti, Yuhua Wang, Kai Shi, Leaf Huang. A novel cationic lipid with intrinsic antitumor activity to facilitate gene therapy of TRAIL DNA.
Biomaterials.
2016 09; 102(?):239-48. doi:
10.1016/j.biomaterials.2016.06.030. [PMID: 27344367] - W Liu, J Xu, Y Zhou, J Chen, J Ma, L Zeng. Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration.
Journal of veterinary pharmacology and therapeutics.
2016 Aug; 39(4):398-404. doi:
10.1111/jvp.12289. [PMID: 26763124] - Xiao-Bo Yu, Xiao-Hui Chen, Fei Ling, Kai Hao, Gao-Xue Wang, Bin Zhu. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells.
Antiviral research.
2016 07; 131(?):156-65. doi:
10.1016/j.antiviral.2016.05.008. [PMID: 27188236] - S Y Abbas, W M Basyouni, K A M El-Bayouki, R F Abdel-Rahman. Synthesis and Evaluation of 1-Substituted-Biguanide Derivatives as Anti-Diabetic Agents for Type II Diabetes Insulin Resistant.
Drug research.
2016 Jul; 66(7):377-83. doi:
10.1055/s-0042-107349. [PMID: 27191826] - Hao Cui, Peter Schröder. Uptake, translocation and possible biodegradation of the antidiabetic agent metformin by hydroponically grown Typha latifolia.
Journal of hazardous materials.
2016 May; 308(?):355-61. doi:
10.1016/j.jhazmat.2016.01.054. [PMID: 26852211] - Alexander А Gusev, Alexey A Kudrinsky, Olga V Zakharova, Alexey I Klimov, Pavel M Zherebin, George V Lisichkin, Inna A Vasyukova, Albert N Denisov, Yurii A Krutyakov. Versatile synthesis of PHMB-stabilized silver nanoparticles and their significant stimulating effect on fodder beet (Beta vulgaris L.).
Materials science & engineering. C, Materials for biological applications.
2016 May; 62(?):152-9. doi:
10.1016/j.msec.2016.01.040. [PMID: 26952409] - Wenlei Xie, Libing Hu. Biguanide-functionalized mesoporous SBA-15 silica as an efficient solid catalyst for interesterification of vegetable oils.
Food chemistry.
2016 Apr; 197(Pt A):92-9. doi:
10.1016/j.foodchem.2015.10.103. [PMID: 26616928] - Steen Jakobsen, Morten Busk, Jonas Brorson Jensen, Ole Lajord Munk, Nora Elisabeth Zois, Aage K O Alstrup, Niels Jessen, Jørgen Frøkiær. A PET Tracer for Renal Organic Cation Transporters, ¹¹C-Metformin: Radiosynthesis and Preclinical Proof-of-Concept Studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2016 Apr; 57(4):615-21. doi:
10.2967/jnumed.115.169292. [PMID: 26769859] - Satya Sree N Kolar, Joseph C Manarang, Alan R Burns, William L Miller, Alison M McDermott, Jan P G Bergmanson. Contact lens care solution killing efficacy against Acanthamoeba castellanii by in vitro testing and live-imaging.
Contact lens & anterior eye : the journal of the British Contact Lens Association.
2015 Dec; 38(6):442-50. doi:
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Contact lens & anterior eye : the journal of the British Contact Lens Association.
2015 Dec; 38(6):435-41. doi:
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Journal of materials science. Materials in medicine.
2015 Oct; 26(10):245. doi:
10.1007/s10856-015-5571-7. [PMID: 26411441] - Girlandia Alexandre Brasil, Ewelyne Miranda de Lima, Andrews Marques do Nascimento, Izabela Facco Caliman, Ana Raquel Santos de Medeiros, Mauro Sérgio Batista Silva, Gláucia Rodrigues de Abreu, Adelina Martha dos Reis, Tadeu Uggere de Andrade, Nazaré Souza Bissoli. Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system.
Life sciences.
2015 Sep; 137(?):65-73. doi:
10.1016/j.lfs.2015.07.005. [PMID: 26165753] - Carlo Garofalo, Nicolangelo Iazzetta, Andrea Camocardi, Mario Pacilio, Carmela Iodice, Roberto Minutolo, Luca De Nicola, Giuseppe Conte. [Anti-diabetics and chronic kidney disease].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2015 Sep; 32(5):. doi:
. [PMID: 26480253] - Ian J Horner, Nadine D Kraut, Jerod J Hurst, Alyssa M Rook, Crystal M Collado, G Ekin Atilla-Gokcumen, E Peter Maziarz, X Michael Liu, Mohinder M Merchea, Frank V Bright. Effects of Polyhexamethylene Biguanide and Polyquaternium-1 on Phospholipid Bilayer Structure and Dynamics.
The journal of physical chemistry. B.
2015 Aug; 119(33):10531-42. doi:
10.1021/acs.jpcb.5b07162. [PMID: 26239890] - E Araki, Y Tanizawa, Y Tanaka, A Taniguchi, K Koiwai, G Kim, A Salsali, H J Woerle, U C Broedl. Long-term treatment with empagliflozin as add-on to oral antidiabetes therapy in Japanese patients with type 2 diabetes mellitus.
Diabetes, obesity & metabolism.
2015 Jul; 17(7):665-74. doi:
10.1111/dom.12464. [PMID: 25772548] - Raimo Mikkola, Maria A Andersson, Maria Hautaniemi, Mirja S Salkinoja-Salonen. Toxic indole alkaloids avrainvillamide and stephacidin B produced by a biocide tolerant indoor mold Aspergillus westerdijkiae.
Toxicon : official journal of the International Society on Toxinology.
2015 Jun; 99(?):58-67. doi:
10.1016/j.toxicon.2015.03.011. [PMID: 25804991] - Elena Llorens, Silvia Calderón, Luis J del Valle, Jordi Puiggalí. Polybiguanide (PHMB) loaded in PLA scaffolds displaying high hydrophobic, biocompatibility and antibacterial properties.
Materials science & engineering. C, Materials for biological applications.
2015 May; 50(?):74-84. doi:
10.1016/j.msec.2015.01.100. [PMID: 25746248] - Ahmadou M Jingi, Jobert Richie N Nansseu, Jean Jacques N Noubiap. Primary care physicians' practice regarding diabetes mellitus diagnosis, evaluation and management in the West region of Cameroon.
BMC endocrine disorders.
2015 Apr; 15(?):18. doi:
10.1186/s12902-015-0016-3. [PMID: 25881080] - Gerald Müller, Hicham Benkhai, Rutger Matthes, Birgit Finke, Wenke Friedrichs, Norman Geist, Walter Langel, Axel Kramer. Poly (hexamethylene biguanide) adsorption on hydrogen peroxide treated Ti-Al-V alloys and effects on wettability, antimicrobial efficacy, and cytotoxicity.
Biomaterials.
2014 Jul; 35(20):5261-5277. doi:
10.1016/j.biomaterials.2014.03.033. [PMID: 24703717] - M Núñez-Moral, E Sánchez-Álvarez, I González-Díaz, B Peláez-Requejo, A Fernández-Viña, A Quintana-Fernández, C Rodríguez-Suárez. Exit-site infection of peritoneal catheter is reduced by the use of polyhexanide. results of a prospective randomized trial.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2014 May; 34(3):271-7. doi:
10.3747/pdi.2012.00109. [PMID: 24497599] - Qingxia Zhu, Yongbing Cao, Yingying Cao, Yifeng Chai, Feng Lu. Rapid on-site TLC-SERS detection of four antidiabetes drugs used as adulterants in botanical dietary supplements.
Analytical and bioanalytical chemistry.
2014 Mar; 406(7):1877-84. doi:
10.1007/s00216-013-7605-7. [PMID: 24452744] - Zeljka Minic, Donal S O'Leary, Tadeusz J Scislo. Nucleus tractus solitarii A(2a) adenosine receptors inhibit cardiopulmonary chemoreflex control of sympathetic outputs.
Autonomic neuroscience : basic & clinical.
2014 Feb; 180(?):32-42. doi:
10.1016/j.autneu.2013.10.005. [PMID: 24216055] - Antonio Granata, Monica Insalaco, Pierpaolo Di Nicolò, Viviana R Scarfia, Leo Russo, Giuseppe D'anna, Paolo Lentini, Fulvio Fiorini, Pasquale Fatuzzo. [Oral hypoglycemic drugs in chronic kidney disease: which limitations in the clinical setting].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2014 Jan; 31(1):. doi:
NULL. [PMID: 24671840] - Joyce B Shepard, Royce A Wilkinson, Jean R Starkey, Martin Teintze. Novel guanide-substituted compounds bind to CXCR4 and inhibit breast cancer metastasis.
Anti-cancer drugs.
2014 Jan; 25(1):8-16. doi:
10.1097/cad.0000000000000019. [PMID: 24045366] - Z Drahota, E Palenickova, R Endlicher, M Milerova, J Brejchova, M Vosahlikova, P Svoboda, L Kazdova, M Kalous, Z Cervinkova, M Cahova. Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties.
Physiological research.
2014; 63(1):1-11. doi:
10.33549/physiolres.932600. [PMID: 24182344] - Qihai Gu, Zhanna V Vysotskaya, Charles R Moss, Martin K Kagira, Carolyn A Gilbert. Calcium-sensing receptor in rat vagal bronchopulmonary sensory neurons regulates the function of the capsaicin receptor TRPV1.
Experimental physiology.
2013 Nov; 98(11):1631-42. doi:
10.1113/expphysiol.2013.074633. [PMID: 23913765] - E S Tanygina, T N Popova, A V Semenikhina, L V Marasova, E D Kryl'skiĭ. [The dose-dependent influence of 3,5-dicarbometoxyphenylbiguanide on activity of the glutathione antioxidant system in heart and blood serum of rats with the experimental myocardial infarction].
Biomeditsinskaia khimiia.
2013 Nov; 59(6):655-61. doi:
10.18097/pbmc20135906655. [PMID: 24511677] - Iwao Ohno, Hiromitsu Hayashi, Kazutaka Aonuma, Masaru Horio, Naoki Kashihara, Hirokazu Okada, Yasuhiro Komatsu, Shozo Tamura, Kazuo Awai, Yasuyuki Yamashita, Ryohei Kuwatsuru, Atsushi Hirayama, Yoshihiko Saito, Toyoaki Murohara, Nagara Tamaki, Akira Sato, Tadateru Takayama, Enyu Imai, Yoshinari Yasuda, Daisuke Koya, Yoshiharu Tsubakihara, Shigeo Horie, Yukunori Korogi, Yoshifumi Narumi, Katsumi Hayakawa, Hiroyuki Daida, Koichi Node, Isao Kubota. Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version : JSN, JRS, and JCS Joint Working Group.
Clinical and experimental nephrology.
2013 Aug; 17(4):441-79. doi:
10.1007/s10157-013-0843-3. [PMID: 23896863] - Iwao Ohno, Hiromitsu Hayashi, Kazutaka Aonuma, Masaru Horio, Naoki Kashihara, Hirokazu Okada, Yasuhiro Komatsu, Shozo Tamura, Kazuo Awai, Yasuyuki Yamashita, Ryohei Kuwatsuru, Atsushi Hirayama, Yoshihiko Saito, Toyoaki Murohara, Nagara Tamaki, Akira Sato, Tadateru Takayama, Enyu Imai, Yoshinari Yasuda, Daisuke Koya, Yoshiharu Tsubakihara, Shigeo Horie, Yukunori Korogi, Yoshifumi Narumi, Katsumi Hayakawa, Hiroyuki Daida, Koichi Node, Isao Kubota. Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version. JSN, JRS, and JCS Joint Working Group.
Japanese journal of radiology.
2013 Aug; 31(8):546-84. doi:
10.1007/s11604-013-0226-4. [PMID: 23884513] - Venu Perla, Sastry S Jayanty. Biguanide related compounds in traditional antidiabetic functional foods.
Food chemistry.
2013 Jun; 138(2-3):1574-80. doi:
10.1016/j.foodchem.2012.09.125. [PMID: 23411283] - Grit Baier, Alex Cavallaro, Krasimir Vasilev, Volker Mailänder, Anna Musyanovych, Katharina Landfester. Enzyme responsive hyaluronic acid nanocapsules containing polyhexanide and their exposure to bacteria to prevent infection.
Biomacromolecules.
2013 Apr; 14(4):1103-12. doi:
10.1021/bm302003m. [PMID: 23448580] - Colleen Flynn, George L Bakris. Noninsulin glucose-lowering agents for the treatment of patients on dialysis.
Nature reviews. Nephrology.
2013 Mar; 9(3):147-53. doi:
10.1038/nrneph.2013.12. [PMID: 23358424] - M Rosiak, M Postula, A Kaplon-Cieslicka, E Trzepla, A Czlonkowski, K J Filipiak, G Opolski. Metformin treatment may be associated with decreased levels of NT-proBNP in patients with type 2 diabetes.
Advances in medical sciences.
2013; 58(2):362-8. doi:
10.2478/ams-2013-0009. [PMID: 24327531] - NULL. Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version.
Circulation journal : official journal of the Japanese Circulation Society.
2013; 77(7):1883-914. doi:
10.1253/circj.cj-66-0069. [PMID: 23803256] - E S Tanigina, A V Semenikhina, T N Popova, L V Matasova, E D Kryl'skiy. Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis.
Bulletin of experimental biology and medicine.
2012 Dec; 154(2):192-5. doi:
10.1007/s10517-012-1909-z. [PMID: 23330122] - Elise Chadeau, Emilie Dumas, Isabelle Adt, Pascal Degraeve, Claude Noël, Christophe Girodet, Nadia Oulahal. Assessment of the mode of action of polyhexamethylene biguanide against Listeria innocua by Fourier transformed infrared spectroscopy and fluorescence anisotropy analysis.
Canadian journal of microbiology.
2012 Dec; 58(12):1353-61. doi:
10.1139/w2012-113. [PMID: 23210992] - Zhong-Yang Shen, Wei-Ping Zheng, Yong-Lin Deng, Hong-Li Song. Variations in the S and P regions of the hepatitis B virus genome under immunosuppression in vitro and in vivo.
Viral immunology.
2012 Oct; 25(5):368-78. doi:
10.1089/vim.2012.0008. [PMID: 22946668] - E Cholongitas, T Vasiliadis, N Antoniadis, I Goulis, V Papanikolaou, E Akriviadis. Hepatitis B prophylaxis post liver transplantation with newer nucleos(t)ide analogues after hepatitis B immunoglobulin discontinuation.
Transplant infectious disease : an official journal of the Transplantation Society.
2012 Oct; 14(5):479-87. doi:
10.1111/j.1399-3062.2012.00741.x. [PMID: 22624695] - Kui-Xia Sun, Jie Li, Feng-Cai Zhu, Jian-Xun Liu, Rong-Cheng Li, Xiang-Jun Zhai, Yan-Ping Li, Zhan-Jun Chang, Jing-Jing Nie, Hui Zhuang. A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women.
Vaccine.
2012 Aug; 30(36):5335-40. doi:
10.1016/j.vaccine.2012.06.036. [PMID: 22749833] - Sh Shokuhi, L Gachkar, I Alavi-Darazam, P Yuhanaee, M Sajadi. Occupational Exposure to Blood and Body Fluids among Health Care Workers in Teaching Hospitals in Tehran, Iran.
Iranian Red Crescent medical journal.
2012 Jul; 14(7):402-7. doi:
NULL. [PMID: 22997555] - Xiaoqing Li, Yingjun Zheng, Adrian Liau, Biao Cai, Dongqing Ye, Feng Huang, Xiaorong Sheng, Fuyang Ge, Liu Xuan, Shun Li, Jing Li. Hepatitis B virus infections and risk factors among the general population in Anhui Province, China: an epidemiological study.
BMC public health.
2012 Apr; 12(?):272. doi:
10.1186/1471-2458-12-272. [PMID: 22475135] - Jianbo Li, Ming Shi, Hongman Zhang, Lingfei Yan, Ming Xie, Lei Zhuang, Yun Zhu, Jiawei Chen. Relation of homocysteine to early nephropathy in patients with Type 2 diabetes.
Clinical nephrology.
2012 Apr; 77(4):305-10. doi:
10.5414/cn107296. [PMID: 22445474] - Tamio Teramoto, Kohji Shirai, Hiroyuki Daida, Nobuhiro Yamada. Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study.
Cardiovascular diabetology.
2012 Mar; 11(?):29. doi:
10.1186/1475-2840-11-29. [PMID: 22439599] - Guo-rong Han, Hong-xiu Jiang, Geng-ju Wang, Xin Yue, Cui-min Wang, Nan-ying Kan, Min-min Wu. [Efficacy and safety of telbivudine in pregnant women to prevent perinatal transmission of hepatitis B virus].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2012 Mar; 20(3):201-5. doi:
10.3760/cma.j.issn.1007-3418.2012.03.013. [PMID: 22475140] - Ayumu Hirata, Ken Kishida, Hideaki Nakatsuji, Kana Inoue, Aki Hiuge-Shimizu, Tohru Funahashi, Iichiro Shimomura. High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome.
Nutrition & metabolism.
2012 Jan; 9(1):4. doi:
10.1186/1743-7075-9-4. [PMID: 22277344] - Man-Wo Tsang. The management of type 2 diabetic patients with hypoglycaemic agents.
ISRN endocrinology.
2012; 2012(?):478120. doi:
10.5402/2012/478120. [PMID: 22645689] - Edson Abdala, Luis Sérgio Fonseca de Azevedo, Vivian Iida Avelino-Silva, Sílvia Figueiredo Costa, Marlova Luzzi Caramori, Tania Mara Varejão Strabelli, Lígia Camera Pierrotti, Heloisa Helena de Souza Marques, Heloisa Helena Marques da Silva, Marta Heloisa Lopes, Glaucia Fernanda Varkulja, Vera Aparecida Santos, Maria Aparecida Shikanai-Yasuda. Assessment of organ transplants from donors with markers of hepatitis B.
Clinics (Sao Paulo, Brazil).
2012; 67(4):399-404. doi:
10.6061/clinics/2012(04)15. [PMID: 22522767] - Hirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, Yumie Takeshita, Tsuguhito Ota, Yoshiro Saito, Kazuhiko Takahashi, Shuichi Kaneko, Toshinari Takamura. Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.
PloS one.
2012; 7(4):e34952. doi:
10.1371/journal.pone.0034952. [PMID: 22496878] - Cathy Slack, Andrea Foley, Linda Partridge. Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila.
PloS one.
2012; 7(10):e47699. doi:
10.1371/journal.pone.0047699. [PMID: 23077661] - Gabriella Garruti, Helen H Wang, Leonilde Bonfrate, Ornella de Bari, David Q-H Wang, Piero Portincasa. A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.
Journal of lipids.
2012; 2012(?):304292. doi:
10.1155/2012/304292. [PMID: 22577560] - Ting-Jung Wu, Tse-Ching Chen, Frank Wang, Kun-Ming Chan, Ruey-Shyang Soong, Hong-Shiue Chou, Wei-Chen Lee, Chau-Ting Yeh. Large fragment pre-S deletion and high viral load independently predict hepatitis B relapse after liver transplantation.
PloS one.
2012; 7(2):e32189. doi:
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International journal of peptides.
2012; 2012(?):349427. doi:
10.1155/2012/349427. [PMID: 22319541] - Shinya Furukawa, Teru Kumagi, Teruki Miyake, Teruhisa Ueda, Tetsuji Niiya, Keiichiro Nishino, Shigeto Murakami, Masato Murakami, Bunzo Matsuura, Morikazu Onji. Suicide attempt by an overdose of sitagliptin, an oral hypoglycemic agent: a case report and a review of the literature.
Endocrine journal.
2012; 59(4):329-33. doi:
10.1507/endocrj.ej11-0390. [PMID: 22277726] - H-J Kim, K-H Yoon, M-J Kang, H-W Yim, K-S Lee, V Vuksan, M-K Sung. A six-month supplementation of mulberry, korean red ginseng, and banaba decreases biomarkers of systemic low-grade inflammation in subjects with impaired glucose tolerance and type 2 diabetes.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):735191. doi:
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