Tetrachlorohydroquinone (BioDeep_00000005207)
Secondary id: BioDeep_00001868393
human metabolite blood metabolite
代谢物信息卡片
2,3,5,6-Tetrachloro-1,4-benzenediol
化学式: C6H2Cl4O2 (245.8809)
中文名称: 四氯氢醌
谱图信息:
最多检出来源 Macaca mulatta(otcml) 43.33%
分子结构信息
SMILES: C1(=C(C(=C(C(=C1Cl)Cl)O)Cl)Cl)O
InChI: InChI=1S/C6H2Cl4O2/c7-1-2(8)6(12)4(10)3(9)5(1)11/h11-12H
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:17042
- KEGG: C03434
- PubChem: 66603
- HMDB: HMDB0258872
- Metlin: METLIN65979
- ChEMBL: CHEMBL2074639
- KNApSAcK: C00007485
- chemspider: 59970
- CAS: 87-87-6
- PMhub: MS000017937
- PubChem: 6261
- 3DMET: B00583
- NIKKAJI: J54.019F
- RefMet: Tetrachlorohydroquinone
- KNApSAcK: 17042
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tie Cheng Wang, Na Lu, Jie Li, Yan Wu. Degradation of pentachlorophenol in soil by pulsed corona discharge plasma.
Journal of hazardous materials.
2010 Aug; 180(1-3):436-41. doi:
10.1016/j.jhazmat.2010.04.049. [PMID: 20452725] - Tie Cheng Wang, Na Lu, Jie Li, Yan Wu. Evaluation of the potential of pentachlorophenol degradation in soil by pulsed corona discharge plasma from soil characteristics.
Environmental science & technology.
2010 Apr; 44(8):3105-10. doi:
10.1021/es903527w. [PMID: 20218544] - Ben-Zhan Zhu, Guo-Qiang Shan. Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals.
Chemical research in toxicology.
2009 Jun; 22(6):969-77. doi:
10.1021/tx900030v. [PMID: 19408893] - Wen-Ching Chang, Jiiang-Huei Jeng, Chi-Chang Shieh, Yi-Chang Tsai, Yuan-Soon Ho, How-Ran Guo, Hsin-I Liu, Ching-Chang Lee, Sheng-Yow Ho, Ying-Jan Wang. Skin tumor-promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD-1 Mice.
Molecular carcinogenesis.
2003 Apr; 36(4):161-70. doi:
10.1002/mc.10113. [PMID: 12669308] - Y J Wang, C C Lee, W C Chang, H B Liou, Y S Ho. Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone.
Toxicology letters.
2001 Jun; 122(2):157-69. doi:
10.1016/s0378-4274(01)00361-7. [PMID: 11439222] - K Sai, B L Upham, K S Kang, R Hasegawa, T Inoue, J E Trosko. Inhibitory effect of pentachlorophenol on gap junctional intercellular communication in rat liver epithelial cells in vitro.
Cancer letters.
1998 Aug; 130(1-2):9-17. doi:
10.1016/s0304-3835(98)00082-2. [PMID: 9751251] - M Dahlhaus, E Almstadt, P Henschke, S Lüttgert, K E Appel. Oxidative DNA lesions in V79 cells mediated by pentachlorophenol metabolites.
Archives of toxicology.
1996; 70(7):457-60. doi:
10.1007/s002040050299. [PMID: 8740541] - M Dahlhaus, E Almstadt, P Henschke, S Lüttgert, K E Appel. Induction of 8-hydroxy-2-deoxyguanosine and single-strand breaks in DNA of V79 cells by tetrachloro-p-hydroquinone.
Mutation research.
1995 Jun; 329(1):29-36. doi:
10.1016/0027-5107(95)00014-a. [PMID: 7770074] - G J Ikeda, P P Sapienza, P I Warr. Disposition and metabolism of radiolabelled pentachloroanisole in rats and rabbits.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1994 Dec; 32(12):1137-46. doi:
10.1016/0278-6915(94)90129-5. [PMID: 7813985] - K Randerath, B Moorthy, N Mabon, P Sriram. Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite.
Carcinogenesis.
1994 Oct; 15(10):2087-94. doi:
10.1093/carcin/15.10.2087. [PMID: 7955037] - C S Orser, J Dutton, C Lange, P Jablonski, L Xun, M Hargis. Characterization of a Flavobacterium glutathione S-transferase gene involved reductive dechlorination.
Journal of bacteriology.
1993 May; 175(9):2640-4. doi:
10.1128/jb.175.9.2640-2644.1993. [PMID: 8478329] - B G Reigner, J F Rigod, T N Tozer. Disposition, bioavailability, and serum protein binding of pentachlorophenol in the B6C3F1 mouse.
Pharmaceutical research.
1992 Aug; 9(8):1053-7. doi:
10.1023/a:1015810629245. [PMID: 1409377] - J A van Raaij, K J van den Berg, W R Notten. Hexachlorobenzene and its metabolites pentachlorophenol and tetrachlorohydroquinone: interaction with thyroxine binding sites of rat thyroid hormone carriers ex vivo and in vitro.
Toxicology letters.
1991 Dec; 59(1-3):101-7. doi:
10.1016/0378-4274(91)90060-j. [PMID: 1755017] - J A van Raaij, K J van den Berg, R Engel, P C Bragt, W R Notten. Effects of hexachlorobenzene and its metabolites pentachlorophenol and tetrachlorohydroquinone on serum thyroid hormone levels in rats.
Toxicology.
1991 Mar; 67(1):107-16. doi:
10.1016/0300-483x(91)90168-z. [PMID: 2017761] - K J Van den Berg, J A van Raaij, P C Bragt, W R Notten. Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo.
Archives of toxicology.
1991; 65(1):15-9. doi:
10.1007/bf01973497. [PMID: 2043046] - B G Reigner, J F Rigod, T N Tozer. Simultaneous assay of pentachlorophenol and its metabolite, tetrachlorohydroquinone, by gas chromatography without derivatization.
Journal of chromatography.
1990 Nov; 533(?):111-24. doi:
10.1016/s0378-4347(00)82191-x. [PMID: 2081757]
