Trypanothione disulfide (BioDeep_00000005117)
Secondary id: BioDeep_00001869819
human metabolite
代谢物信息卡片
化学式: C27H47N9O10S2 (721.2887)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(natural_products) 3.67%
分子结构信息
SMILES: C1CCNC(=O)CNC(=O)C(CSSCC(C(=O)NCC(=O)NCCCNC1)NC(=O)CCC(C(=O)O)N)NC(=O)CCC(C(=O)O)N
InChI: InChI=1S/C27H47N9O10S2/c28-16(26(43)44)4-6-20(37)35-18-14-47-48-15-19(36-21(38)7-5-17(29)27(45)46)25(42)34-13-23(40)32-11-3-9-30-8-1-2-10-31-22(39)12-33-24(18)41/h16-19,30H,1-15,28-29H2,(H,31,39)(H,32,40)(H,33,41)(H,34,42)(H,35,37)(H,36,38)(H,43,44)(H,45,46)/t16-,17-,18-,19-/m0/s1
描述信息
This compound belongs to the family of Cyclic Peptides. These are compounds containing a cyclic moiety bearing a peptide backbone
同义名列表
15 个代谢物同义名
(2S)-2-amino-4-{[(4R,23R)-23-{[(4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino}-5,8,19,22-tetrahydroxy-1,2-dithia-6,9,13,18,21-pentaazacyclotetracosa-5,8,18,21-tetraen-4-yl]-C-hydroxycarbonimidoyl}butanoic acid; 2-AMINO-4-[4-(4-amino-4-carboxy-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyrIC ACID; 2-AMINO-4-[4-(4-amino-4-carboxy-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyrate; N(1),N(8)-Bis(gamma-glutamyl-hemicystinyl-glycyl)spermidine; N(1),N(8)-Bis(gamma-glu-hemi-cys-gly)sperimidine; Trypanothione disulphide; Trypanothione disulfide; Oxidized trypanothione; Trypanothiondisulphid; Trypanothiondisulfid; Dethiotrypanothione; Trypanothione; CHEMBL84760; TSST; Trypanothione disulfide
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:35490
- KEGG: C03170
- PubChem: 4632404
- PubChem: 115098
- HMDB: HMDB0060521
- Metlin: METLIN63641
- chemspider: 102998
- CAS: 96304-42-6
- PMhub: MS000017825
- PubChem: 6053
- PDB-CCD: TS2
- NIKKAJI: J634.980C
- RefMet: Trypanothione disulfide
- KNApSAcK: 35490
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(1)
- trypanothione redox reactions:
NADP+ + trypanothione ⟶ H+ + NADPH + trypanothione disulfide
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michael Diechtierow, R Luise Krauth-Siegel. A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage.
Free radical biology & medicine.
2011 Aug; 51(4):856-68. doi:
10.1016/j.freeradbiomed.2011.05.014. [PMID: 21640819] - Anil Kumar Shukla, Sanjukta Patra, Vikash Kumar Dubey. Deciphering molecular mechanism underlying antileishmanial activity of Nyctanthes arbortristis, an Indian medicinal plant.
Journal of ethnopharmacology.
2011 Apr; 134(3):996-8. doi:
10.1016/j.jep.2011.01.044. [PMID: 21291983] - Matthew Berriman, Elodie Ghedin, Christiane Hertz-Fowler, Gaëlle Blandin, Hubert Renauld, Daniella C Bartholomeu, Nicola J Lennard, Elisabet Caler, Nancy E Hamlin, Brian Haas, Ulrike Böhme, Linda Hannick, Martin A Aslett, Joshua Shallom, Lucio Marcello, Lihua Hou, Bill Wickstead, U Cecilia M Alsmark, Claire Arrowsmith, Rebecca J Atkin, Andrew J Barron, Frederic Bringaud, Karen Brooks, Mark Carrington, Inna Cherevach, Tracey-Jane Chillingworth, Carol Churcher, Louise N Clark, Craig H Corton, Ann Cronin, Rob M Davies, Jonathon Doggett, Appolinaire Djikeng, Tamara Feldblyum, Mark C Field, Audrey Fraser, Ian Goodhead, Zahra Hance, David Harper, Barbara R Harris, Heidi Hauser, Jessica Hostetler, Al Ivens, Kay Jagels, David Johnson, Justin Johnson, Kristine Jones, Arnaud X Kerhornou, Hean Koo, Natasha Larke, Scott Landfear, Christopher Larkin, Vanessa Leech, Alexandra Line, Angela Lord, Annette Macleod, Paul J Mooney, Sharon Moule, David M A Martin, Gareth W Morgan, Karen Mungall, Halina Norbertczak, Doug Ormond, Grace Pai, Chris S Peacock, Jeremy Peterson, Michael A Quail, Ester Rabbinowitsch, Marie-Adele Rajandream, Chris Reitter, Steven L Salzberg, Mandy Sanders, Seth Schobel, Sarah Sharp, Mark Simmonds, Anjana J Simpson, Luke Tallon, C Michael R Turner, Andrew Tait, Adrian R Tivey, Susan Van Aken, Danielle Walker, David Wanless, Shiliang Wang, Brian White, Owen White, Sally Whitehead, John Woodward, Jennifer Wortman, Mark D Adams, T Martin Embley, Keith Gull, Elisabetta Ullu, J David Barry, Alan H Fairlamb, Fred Opperdoes, Barclay G Barrell, John E Donelson, Neil Hall, Claire M Fraser, Sara E Melville, Najib M El-Sayed. The genome of the African trypanosome Trypanosoma brucei.
Science (New York, N.Y.).
2005 Jul; 309(5733):416-22. doi:
10.1126/science.1112642. [PMID: 16020726] - M R Ariyanayagam, A H Fairlamb. Ovothiol and trypanothione as antioxidants in trypanosomatids.
Molecular and biochemical parasitology.
2001 Jul; 115(2):189-98. doi:
10.1016/s0166-6851(01)00285-7. [PMID: 11420105] - S R Wilkinson, D J Meyer, J M Kelly. Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity.
The Biochemical journal.
2000 Dec; 352 Pt 3(?):755-61. doi:
10.1042/bj3520755. [PMID: 11104683] - R Mukhopadhyay, S Dey, N Xu, D Gage, J Lightbody, M Ouellette, B P Rosen. Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.
Proceedings of the National Academy of Sciences of the United States of America.
1996 Sep; 93(19):10383-7. doi:
10.1073/pnas.93.19.10383. [PMID: 8816809] - A H Fairlamb, G B Henderson, C J Bacchi, A Cerami. In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.
Molecular and biochemical parasitology.
1987 Jun; 24(2):185-91. doi:
10.1016/0166-6851(87)90105-8. [PMID: 3114634]
