Hexylamine (BioDeep_00000003527)

 

Secondary id: BioDeep_00000400202

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


Hexylamine hydrochloride

化学式: C6H15N (101.1204)
中文名称: 正己胺, 己胺
谱图信息: 最多检出来源 Homo sapiens(plant) 8.57%

分子结构信息

SMILES: CCCCCCN
InChI: InChI=1/C6H15N/c1-2-3-4-5-6-7/h2-7H2,1H3

描述信息

Hexylamine is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]")
Acquisition and generation of the data is financially supported in part by CREST/JST.
It is used as a food additive .

同义名列表

12 个代谢物同义名

Hexylamine hydrochloride; Hexylamine hydrobromide; mono-N-Hexylamine; hexan-1-amine; Hexyl amine-1; 1-Aminohexane; N-Hexylamine; 1-Hexanamine; 1-Hexylamine; Hexylamine; Hexylamine; Hexylamine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AOC3, AXIN2, CNR2, KRT10, MITF, PFDN5, PYGB
Endosome membrane 1 TF
Mitochondrion membrane 1 MAOA
Nucleus 5 AXIN2, KRT10, MITF, NCL, PFDN5
cytosol 5 AXIN2, KRT10, MAOA, MITF, PFDN5
dendrite 2 CNR2, DRD2
centrosome 1 AXIN2
nucleoplasm 2 MITF, NCL
Cell membrane 3 AOC3, DRD2, SLC38A5
Cytoplasmic side 1 MAOA
Multi-pass membrane protein 2 DRD2, SLC38A5
Golgi apparatus membrane 1 DRD2
Synapse 1 DRD2
cell cortex 1 NCL
cell surface 5 AOC3, EPCAM, KRT10, PLG, TF
glutamatergic synapse 2 DRD2, PLG
Golgi apparatus 2 AOC3, ATRN
Golgi membrane 1 DRD2
lysosomal membrane 1 MITF
presynaptic membrane 1 DRD2
Lysosome 1 IL4I1
acrosomal vesicle 2 DRD2, IL4I1
plasma membrane 10 AOC3, ATRN, AXIN2, CNR2, DRD2, EPCAM, NCL, PLG, SLC38A5, TF
synaptic vesicle membrane 1 DRD2
Membrane 6 AOC3, KRT10, MAOA, NCL, PYGB, SLC38A5
apical plasma membrane 2 EPCAM, TF
axon 1 DRD2
basolateral plasma membrane 1 EPCAM
extracellular exosome 9 ATRN, CFH, EPCAM, KRT10, LYZ, NCL, PLG, PYGB, TF
Lysosome membrane 1 MITF
endoplasmic reticulum 2 AOC3, CNR2
extracellular space 8 ATRN, CFH, IL3, KRT10, LOX, LYZ, PLG, TF
perinuclear region of cytoplasm 1 TF
Schaffer collateral - CA1 synapse 1 PLG
Cell junction, tight junction 1 EPCAM
bicellular tight junction 1 EPCAM
mitochondrion 1 MAOA
protein-containing complex 1 MITF
Single-pass type I membrane protein 2 ATRN, EPCAM
Secreted 6 CFH, IL3, IL4I1, LOX, PLG, TF
extracellular region 9 CFH, IL3, IL4I1, KRT10, LOX, LYZ, PLG, PYGB, TF
Mitochondrion outer membrane 1 MAOA
Single-pass membrane protein 1 MAOA
mitochondrial outer membrane 1 MAOA
basal part of cell 1 TF
[Isoform 2]: Secreted 1 ATRN
ciliary membrane 1 DRD2
external side of plasma membrane 1 PLG
dendritic spine 1 DRD2
perikaryon 2 CNR2, DRD2
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 TF
nucleolus 1 NCL
Early endosome 2 AOC3, TF
clathrin-coated pit 1 TF
recycling endosome 1 TF
Single-pass type II membrane protein 1 AOC3
vesicle 1 TF
postsynaptic membrane 2 CNR2, DRD2
GABA-ergic synapse 1 DRD2
extracellular matrix 1 LOX
collagen trimer 1 LOX
collagen-containing extracellular matrix 2 LOX, PLG
intermediate filament 1 KRT10
lateral plasma membrane 2 DRD2, EPCAM
Late endosome 1 TF
cilium 1 DRD2
chromatin 1 MITF
Chromosome 1 NCL
cytoskeleton 1 KRT10
cytoplasmic ribonucleoprotein granule 1 NCL
Secreted, extracellular space 2 KRT10, LOX
Nucleus, nucleolus 1 NCL
Cytoplasmic vesicle, secretory vesicle, acrosome 1 IL4I1
blood microparticle 3 CFH, PLG, TF
non-motile cilium 1 DRD2
sperm midpiece 1 IL4I1
spliceosomal complex 1 NCL
[Isoform 3]: Secreted 1 ATRN
sperm flagellum 1 DRD2
microvillus 1 AOC3
Cornified envelope 2 KRT10, NCL
Cell projection, dendrite 1 CNR2
intermediate filament cytoskeleton 1 PFDN5
basal plasma membrane 1 TF
secretory granule lumen 1 TF
HFE-transferrin receptor complex 1 TF
endoplasmic reticulum lumen 1 TF
platelet alpha granule lumen 1 PLG
axon terminus 1 DRD2
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
endocytic vesicle 2 DRD2, TF
azurophil granule lumen 2 LYZ, PYGB
serine-type endopeptidase complex 1 CFH
immunological synapse 1 IL4I1
Single-pass type IV membrane protein 1 MAOA
clathrin-coated endocytic vesicle membrane 1 TF
ribonucleoprotein complex 1 NCL
extrinsic component of cytoplasmic side of plasma membrane 1 CNR2
prefoldin complex 1 PFDN5
Lateral cell membrane 1 EPCAM
[Isoform 1]: Cell membrane 1 ATRN
dopaminergic synapse 1 DRD2
keratin filament 1 KRT10
vesicle coat 1 TF
symbiont cell surface 1 CFH
G protein-coupled receptor complex 1 DRD2
macropinosome membrane 1 NCL
dense body 1 TF


文献列表

  • Arun Govind G, Agamudi Shivasankaran Kamalanathan, Mookambeswaran Arunachalam Vijayalakshmi, Krishnan Venkataraman. Efficient purification of Apolipoprotein A1 (ApoA1) from plasma by HEA HyperCel™: An alternative approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jan; 1073(?):104-109. doi: 10.1016/j.jchromb.2017.12.016. [PMID: 29248767]
  • Sylwia Studzińska, Rafał Rola, Bogusław Buszewski. The impact of ion-pairing reagents on the selectivity and sensitivity in the analysis of modified oligonucleotides in serum samples by liquid chromatography coupled with tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2017 May; 138(?):146-152. doi: 10.1016/j.jpba.2017.02.014. [PMID: 28208106]
  • Satu Hyvärinen, Koji Uchida, Markku Varjosalo, Reija Jokela, T Sakari Jokiranta. Recognition of malondialdehyde-modified proteins by the C terminus of complement factor H is mediated via the polyanion binding site and impaired by mutations found in atypical hemolytic uremic syndrome. The Journal of biological chemistry. 2014 Feb; 289(7):4295-306. doi: 10.1074/jbc.m113.527416. [PMID: 24344133]
  • Ju He, Joanna Gajewiak, Jordan L Scott, Denghuang Gong, Muzaffar Ali, Michael D Best, Glenn D Prestwich, Robert V Stahelin, Tatiana G Kutateladze. Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications. Chemistry & biology. 2011 Oct; 18(10):1312-9. doi: 10.1016/j.chembiol.2011.07.022. [PMID: 22035800]
  • W Walter Lorenz, Rob Alba, Yuan-Sheng Yu, John M Bordeaux, Marta Simões, Jeffrey F D Dean. Microarray analysis and scale-free gene networks identify candidate regulators in drought-stressed roots of loblolly pine (P. taeda L.). BMC genomics. 2011 May; 12(?):264. doi: 10.1186/1471-2164-12-264. [PMID: 21609476]
  • Yuko Rönquist-Nii, Staffan Eksborg, Magnus Axelson, Johan Harmenberg, Simon Ekman, Michael Bergqvist, Olof Beck. Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Feb; 879(5-6):326-34. doi: 10.1016/j.jchromb.2010.12.017. [PMID: 21251888]
  • Anne-Sylvie Fabiano-Tixier, Abdelhakim Elomri, Axelle Blanckaert, Elisabeth Seguin, Emmanuel Petitcolas, Farid Chemat. Rapid and green analytical method for the determination of quinoline alkaloids from Cinchona succirubra based on Microwave-Integrated Extraction and Leaching (MIEL) prior to high performance liquid chromatography. International journal of molecular sciences. 2011; 12(11):7846-60. doi: 10.3390/ijms12117846. [PMID: 22174637]
  • Hao Chen, Baichen Zhang, Leslie M Hicks, Liming Xiong. A nucleotide metabolite controls stress-responsive gene expression and plant development. PloS one. 2011; 6(10):e26661. doi: 10.1371/journal.pone.0026661. [PMID: 22028934]
  • Shannen Lau, Bim Graham, Ben J Boyd, Colin W Pouton, Paul J White. Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds. Journal of nucleic acids. 2011; 2011(?):154609. doi: 10.4061/2011/154609. [PMID: 21772990]
  • Michiro Susa, Arun K Iyer, Keinosuke Ryu, Edwin Choy, Francis J Hornicek, Henry Mankin, Lara Milane, Mansoor M Amiji, Zhenfeng Duan. Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PloS one. 2010 May; 5(5):e10764. doi: 10.1371/journal.pone.0010764. [PMID: 20520719]
  • Maria Cristiane Martins de Souza, Igor Tadeu Lazzarotto Bresolin, Sonia Maria Alves Bueno. Purification of human IgG by negative chromatography on omega-aminohexyl-agarose. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Feb; 878(5-6):557-66. doi: 10.1016/j.jchromb.2009.12.034. [PMID: 20079697]
  • M Schroeder, E Fatarella, J Kovac, G M Guebitz, V Kokol. Laccase-induced grafting on plasma-pretreated polypropylene. Biomacromolecules. 2008 Oct; 9(10):2735-41. doi: 10.1021/bm800450b. [PMID: 18771316]
  • Isa S Duarte, Ricardo L Zollner, Sonia M A Bueno. In vitro evaluation of biospecific and pseudobiospecific ligands aimed at extracorporeal treatment for immunoglobulin E removal. Artificial organs. 2006 Aug; 30(8):606-14. doi: 10.1111/j.1525-1594.2006.00269.x. [PMID: 16911314]
  • S Collaud, P Jichlinski, A Marti, D Aymon, R Gurny, N Lange. An open pharmacokinetic study of hexylaminolevulinate-induced photodiagnosis after intravesical administration. Drugs in R&D. 2006; 7(3):173-86. doi: 10.2165/00126839-200607030-00005. [PMID: 16752943]
  • A Ahmed-Ouameur, S Diamantoglou, M R Sedaghat-Herati, Sh Nafisi, R Carpentier, H A Tajmir-Riahi. The effects of drug complexation on the stability and conformation of human serum albumin: protein unfolding. Cell biochemistry and biophysics. 2006; 45(2):203-13. doi: 10.1385/cbb:45:2:203. [PMID: 16757821]
  • Hong Zhao, Richard B Greenwald, Prasanna Reddy, Jing Xia, Ping Peng. A new platform for oligonucleotide delivery utilizing the PEG prodrug approach. Bioconjugate chemistry. 2005 Jul; 16(4):758-66. doi: 10.1021/bc049804k. [PMID: 16029016]
  • Ann Huygens, Appolinary R Kamuhabwa, Peter A M de Witte. Stability of different formulations and ion pairs of hypericin. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2005 Apr; 59(3):461-8. doi: 10.1016/j.ejpb.2004.09.014. [PMID: 15760726]
  • Ann Huygens, Appolinary R Kamuhabwa, Ben van Cleynenbreugel, Hendrik van Poppel, Tania Roskams, Peter A M de Witte. In vivo accumulation of different hypericin ion pairs in the urothelium of the rat bladder. BJU international. 2005 Feb; 95(3):436-41. doi: 10.1111/j.1464-410x.2005.05316.x. [PMID: 15679810]
  • Titus A M Msagati, Mathew Muzi Nindi. Multiresidue determination of sulfonamides in a variety of biological matrices by supported liquid membrane with high pressure liquid chromatography-electrospray mass spectrometry detection. Talanta. 2004 Sep; 64(1):87-100. doi: 10.1016/j.talanta.2004.02.038. [PMID: 18969572]
  • Alexander R Ivanov, Csaba Horváth, Barry L Karger. High-efficiency peptide analysis on monolithic multimode capillary columns: Pressure-assisted capillary electrochromatography/capillary electrophoresis coupled to UV and electrospray ionization-mass spectrometry. Electrophoresis. 2003 Nov; 24(21):3663-73. doi: 10.1002/elps.200305620. [PMID: 14613191]
  • Koichiro Teshima, Takahiro Kondo, Chie Maeda, Tsuneo Oda, Toshiaki Hagimoto, Ryoichi Tsukuda, Yoshinobu Yoshimura. Application of 1-alkylamines to a liquid chromatographic/turbo ionspray tandem mass spectrometric method for quantifying metabolites of a new bone anabolic agent, TAK-778, in human serum. Journal of mass spectrometry : JMS. 2002 Jun; 37(6):631-8. doi: 10.1002/jms.324. [PMID: 12112746]
  • G Houen. Aminoalkyl affinity matrices. Journal of biochemical and biophysical methods. 2001 Oct; 49(1-3):189-97. doi: 10.1016/s0165-022x(01)00199-3. [PMID: 11694280]
  • W Wang, M Maniar, R Jain, J Jacobs, J Trias, Z Yuan. A fluorescence-based homogeneous assay for measuring activity of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase. Analytical biochemistry. 2001 Mar; 290(2):338-46. doi: 10.1006/abio.2000.4973. [PMID: 11237337]
  • P Chen, D Wiesler, J Chmelik, M Novotny. Substituted 2-hydroxy-1,2-dihydropyrrol-3-ones: fluorescent markers pertaining to oxidative stress and aging. Chemical research in toxicology. 1996 Sep; 9(6):970-9. doi: 10.1021/tx960040+. [PMID: 8870984]
  • L Luhová, L Slavík, I Frébort, M Sebela, L Zajoncová, P Pec. Comparison of kinetic properties between plant and fungal amine oxidases. Journal of enzyme inhibition. 1996; 10(4):251-262. doi: 10.3109/14756369609036532. [PMID: 8872745]
  • T Ohya. Formation of a new 1,1,1 adduct in the reaction of malondialdehyde, n-hexylamine and alkanal under neutral conditions. Biological & pharmaceutical bulletin. 1993 Feb; 16(2):137-41. doi: 10.1248/bpb.16.137. [PMID: 8364449]
  • E Yano. Increased activity of monoamine oxidase by epoxy resin hardeners. Toxicology letters. 1987 Jun; 37(1):27-32. doi: 10.1016/0378-4274(87)90163-9. [PMID: 3590227]
  • R H Raja, M Herzig, M Grissom, P H Weigel. Preparation and use of synthetic cell culture surfaces. A new reagent for the covalent immobilization of proteins and glycoproteins on a nonionic inert matrix. The Journal of biological chemistry. 1986 Jun; 261(18):8505-13. doi: NULL. [PMID: 3522570]
  • V V Vorontsov. [Effect of some phenothiazine derivatives on kidney function]. Farmakologiia i toksikologiia. 1975 May; 38(3):313-6. doi: NULL. [PMID: 6306]