Pyridine (BioDeep_00000003037)

 

Secondary id: BioDeep_00000405403, BioDeep_00000869536

human metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


Pyridine perbromate, 82BR-labeled

化学式: C5H5N (79.042197)
中文名称: 吡啶
谱图信息: 最多检出来源 Homo sapiens(plant) 13.48%

分子结构信息

SMILES: C(C1)CCNC1
InChI: InChI=1S/C5H5N/c1-2-4-6-5-3-1/h1-5H

描述信息

Pyridine is a clear liquid with an odor that is sour, putrid, and fish-like. It is a relatively simple heterocyclic aromatic organic compound that is structurally related to benzene, with one CH group in the six-membered ring replaced by a nitrogen atom. Pyridine is obtained from crude coal tar or is synthesized from acetaldehyde, formaldehyde and ammonia. Pyridine is often used as a denaturant for antifreeze mixtures, for ethyl alcohol, for fungicides, and as a dyeing aid for textiles. It is a harmful substance if inhaled, ingested or absorbed through the skin. In particular, it is known to reduce male fertility and is considered carcinogenic. Common symptoms of acute exposure to pyridine include: headache, coughing, asthmatic breathing, laryngitis, nausea and vomiting. -- Wikipedia.
Flavouring ingredient. Pyridine is found in many foods, some of which are kohlrabi, red bell pepper, green bell pepper, and papaya.
CONFIDENCE standard compound; INTERNAL_ID 8135
KEIO_ID P041

同义名列表

37 个代谢物同义名

Pyridine perbromate, 82BR-labeled; Pyridine ion (1-), potassium salt; Pyridine perchlorate, 2H-labeled; Pyridine ion (1-), lithium salt; Pyridine ion (1-), sodium salt; Pyridine, hydrogen fluoride; Pyridine ion (1-), hydrogen; Pyridine, hydrogen bromide; Pyridine, hydrogen iodide; Pyridine phosphate (2:1); Pyridine monophosphate; Pyridine hydride (2:1); Monopyridine phosphate; Pyridine hydrochloride; Pyridine sulfate (2:1); Pyridine monosulfate; Pyridine perchlorate; Pyridine diphosphate; Pyridine monohydrate; Pyridine disulfate; Pyridine dinitrate; Pyridine phosphate; Pyridine ion (2+); Pyridine nitrate; Pyridine hydride; Pyridine cyanate; Pyridine sulfate; Azabenzene; PYRIDINE; Tritisan; Pirydyna; Piridina; Pyridin; Azine; py; Pyridine; Pyridine



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(1)

PlantCyc(0)

代谢反应

36 个相关的代谢反应过程信息。

Reactome(36)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

73 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Etify A Bakhite, Suzan Abuelhassan, Mohamed A Gad, Abdu E Abdel-Rahman, Omaima F Ibrahim, Islam S Marae, Shaaban K Mohamed, Joel T Mague, Ayman Nafady. Pyridine Derivatives as Insecticides─Part 4: Synthesis, Crystal Structure, and Insecticidal Activity of Some New Thienylpyridines, Thienylthieno[2,3-b]pyridines, and Related Heterocyclic Derivatives. Journal of agricultural and food chemistry. 2023 Nov; ?(?):. doi: 10.1021/acs.jafc.3c01202. [PMID: 37941360]
  • Stone Woo, Ryan A Shenvi. Synthesis and target annotation of the alkaloid GB18. Nature. 2022 06; 606(7916):917-921. doi: 10.1038/s41586-022-04840-9. [PMID: 35551513]
  • Xiandeng Li, Tao Yang, Mengshi Hu, Yingxue Yang, Minghai Tang, Dexin Deng, Kongjun Liu, Suhong Fu, Yan Tan, Huan Wang, Yong Chen, Chufeng Zhang, Yong Guo, Bin Peng, Wenting Si, Zhuang Yang, Lijuan Chen. Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors. Bioorganic chemistry. 2022 04; 121(?):105669. doi: 10.1016/j.bioorg.2022.105669. [PMID: 35180490]
  • Takuji Oyama, Kazuki Takiguchi, Hiroyuki Miyachi. Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative. Acta crystallographica. Section F, Structural biology communications. 2022 Feb; 78(Pt 2):81-87. doi: 10.1107/s2053230x22000449. [PMID: 35102897]
  • Shamil N Galimov, Julia Y Gromenko, Kirill V Bulygin, Kamil Sh Galimov, Elmira F Galimova, Mikhail Y Sinelnikov. The level of secondary messengers and the redox state of NAD+/NADH are associated with sperm quality in infertility. Journal of reproductive immunology. 2021 11; 148(?):103383. doi: 10.1016/j.jri.2021.103383. [PMID: 34534880]
  • Arun K Ghosh, Jakka Raghavaiah, Dana Shahabi, Monika Yadav, Brandon J Anson, Emma K Lendy, Shin-Ichiro Hattori, Nobuyo Higashi-Kuwata, Hiroaki Mitsuya, Andrew D Mesecar. Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. Journal of medicinal chemistry. 2021 10; 64(19):14702-14714. doi: 10.1021/acs.jmedchem.1c01214. [PMID: 34528437]
  • Ranran Zhang, Junhong Liu, Hui Yan, Xingrong Peng, Ling Zhang, Minghua Qiu. Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.). Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26164934. [PMID: 34443522]
  • Snežana Jovanović-Stević, Snežana Radisavljević, Andreas Scheurer, Dušan Ćoćić, Biljana Šmit, Marijana Petković, Marko N Živanović, Katarina Virijević, Biljana Petrović. Bis(triazinyl)pyridine complexes of Pt(II) and Pd(II): studies of the nucleophilic substitution reactions, DNA/HSA interactions, molecular docking and biological activity. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2021 08; 26(5):625-637. doi: 10.1007/s00775-021-01879-3. [PMID: 34268603]
  • Xuan Zhang, Kyle G Nottingham, Chirag Patel, Juan V Alegre-Requena, Jeffrey N Levy, Robert S Paton, Andrew McNally. Phosphorus-mediated sp2-sp3 couplings for C-H fluoroalkylation of azines. Nature. 2021 06; 594(7862):217-222. doi: 10.1038/s41586-021-03567-3. [PMID: 33910228]
  • Lipiar K M O Goni, Mohammad A Jafar Mazumder, M A Quraishi, Mohammad Mizanur Rahman. Bioinspired Heterocyclic Compounds as Corrosion Inhibitors: A Comprehensive Review. Chemistry, an Asian journal. 2021 Jun; 16(11):1324-1364. doi: 10.1002/asia.202100201. [PMID: 33844882]
  • Jason M Meyer, Debra Crumrine, Holm Schneider, Angela Dick, Matthias Schmuth, Robert Gruber, Franz P W Radner, Susanne Grond, Joan S Wakefield, Theodora M Mauro, Peter M Elias. Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support a Specific Role in Lipid-Protein Cross-Linking. The American journal of pathology. 2021 05; 191(5):921-929. doi: 10.1016/j.ajpath.2021.02.005. [PMID: 33607042]
  • Iurii Galadzhun, Rafal Kulmaczewski, Namrah Shahid, Oscar Cespedes, Mark J Howard, Malcolm A Halcrow. The flexibility of long chain substituents influences spin-crossover in isomorphous lipid bilayer crystals. Chemical communications (Cambridge, England). 2021 Apr; 57(33):4039-4042. doi: 10.1039/d1cc01073e. [PMID: 33885699]
  • Diana Cosovanu, Montserrat Llovera, Gemma Villorbina, Ramon Canela-Garayoa, Jordi Eras. A simple and fast method for metabolomic analysis by gas liquid chromatography-mass spectrometry. Metabolomics : Official journal of the Metabolomic Society. 2021 02; 17(2):22. doi: 10.1007/s11306-021-01771-w. [PMID: 33547979]
  • Xicheng Liu, Mingxiao Shao, Congcong Liang, Jinghang Guo, Guangxuan Wang, Xiang-Ai Yuan, Zhihong Jing, Laijin Tian, Zhe Liu. Preparation and Bioactivity of Iridium(III) Phenanthroline Complexes with Halide Ions and Pyridine Leaving Groups. Chembiochem : a European journal of chemical biology. 2021 02; 22(3):557-564. doi: 10.1002/cbic.202000511. [PMID: 32964620]
  • Diana Berman, Yuchen Sha, Elena V Shevchenko. Effect of Polymer Removal on the Morphology and Phase of the Nanoparticles in All-Inorganic Heterostructures Synthesized via Two-Step Polymer Infiltration. Molecules (Basel, Switzerland). 2021 Jan; 26(3):. doi: 10.3390/molecules26030679. [PMID: 33525515]
  • Fang Yang, Xie-Er Jian, Peng-Cheng Diao, Xian-Sen Huo, Wen-Wei You, Pei-Liang Zhao. Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors. European journal of medicinal chemistry. 2020 Oct; 204(?):112625. doi: 10.1016/j.ejmech.2020.112625. [PMID: 32717486]
  • Maja Savic, Aleksandar Arsenijevic, Jelena Milovanovic, Bojana Stojanovic, Vesna Stankovic, Ana Rilak Simovic, Dejan Lazic, Nebojsa Arsenijevic, Marija Milovanovic. Antitumor Activity of Ruthenium(II) Terpyridine Complexes towards Colon Cancer Cells In Vitro and In Vivo. Molecules (Basel, Switzerland). 2020 Oct; 25(20):. doi: 10.3390/molecules25204699. [PMID: 33066568]
  • Gongquan Liu, Weiwei Wang, Fangyuan He, Peng Zhang, Ping Xu, Hongzhi Tang. Structural Insights into 6-Hydroxypseudooxynicotine Amine Oxidase from Pseudomonas geniculata N1, the Key Enzyme Involved in Nicotine Degradation. Applied and environmental microbiology. 2020 09; 86(19):. doi: 10.1128/aem.01559-20. [PMID: 32737127]
  • Yan Zheng, Fei He, Mingxu Chen, Jin Zhang, Guangzhi Hu, Delong Ma, Jinghua Guo, Huailin Fan, Wei Li, Xun Hu. Mimicking Hydrazine Dehydrogenase for Efficient Electrocatalytic Oxidation of N2H4 by Fe-NC. ACS applied materials & interfaces. 2020 Aug; 12(34):38183-38191. doi: 10.1021/acsami.0c10637. [PMID: 32799446]
  • Yongfu Liu, Jun Wu, Mingwei Zhou, Wenming Chen, Dongbo Li, Zhanguo Wang, Benoit Hornsperger, Johannes D Aebi, Hans-Peter Märki, Bernd Kuhn, Lisha Wang, Andreas Kuglstatter, Jörg Benz, Stephan Müller, Remo Hochstrasser, Giorgio Ottaviani, Jian Xin, Stephan Kirchner, Susanne Mohr, Philippe Verry, William Riboulet, Hong C Shen, Alexander V Mayweg, Kurt Amrein, Xuefei Tan. Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. Journal of medicinal chemistry. 2020 07; 63(13):6876-6897. doi: 10.1021/acs.jmedchem.0c00233. [PMID: 32530624]
  • Elias Feitosa-Araujo, Izabel de Souza Chaves, Alexandra Florian, Paula da Fonseca-Pereira, Jorge Alberto Condori Apfata, Elmien Heyneke, David Barbosa Medeiros, Marcel Viana Pires, Tabea Mettler-Altmann, H Ekkehard Neuhaus, Ferdinando Palmieri, Wagner L Araï Jo, Toshihiro Obata, Andreas P M Weber, Nicole Linka, Alisdair R Fernie, Adriano Nunes-Nesi. Downregulation of a Mitochondrial NAD+ Transporter (NDT2) Alters Seed Production and Germination in Arabidopsis. Plant & cell physiology. 2020 May; 61(5):897-908. doi: 10.1093/pcp/pcaa017. [PMID: 32065636]
  • Xiuqiang Yu, Xinyue Zhu, Yang Zhou, Qinglin Li, Zhan Hu, Ting Li, Jun Tao, Menglan Dou, Meng Zhang, Yu Shao, Ranfeng Sun. Discovery of N-Aryl-pyridine-4-ones as Novel Potential Agrochemical Fungicides and Bactericides. Journal of agricultural and food chemistry. 2019 Dec; 67(50):13904-13913. doi: 10.1021/acs.jafc.9b06296. [PMID: 31765135]
  • Yeheng Zhou, Wei Sun, Jiale Peng, Hui Yan, Li Zhang, Xingyong Liu, Zhili Zuo. Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments. Bioorganic chemistry. 2019 12; 93(?):103322. doi: 10.1016/j.bioorg.2019.103322. [PMID: 31585263]
  • Zhijiang Fan, Jun Shi, Na Luo, Muhan Ding, Xiaoping Bao. Synthesis, Crystal Structure, and Agricultural Antimicrobial Evaluation of Novel Quinazoline Thioether Derivatives Incorporating the 1,2,4-Triazolo[4,3-a]pyridine Moiety. Journal of agricultural and food chemistry. 2019 Oct; 67(42):11598-11606. doi: 10.1021/acs.jafc.9b04733. [PMID: 31560195]
  • Yaojie Shi, Qianqian Wang, Juan Rong, Jing Ren, Xuejiao Song, Xiaoli Fan, Mengyi Shen, Yong Xia, Ningyu Wang, Zhihao Liu, Quanfang Hu, Tinghong Ye, Luoting Yu. Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis. European journal of medicinal chemistry. 2019 Oct; 179(?):182-195. doi: 10.1016/j.ejmech.2019.06.025. [PMID: 31254920]
  • Marzieh Anjomshoa, Masoud Torkzadeh-Mahani, Mehdi Sahihi, Corrado Rizzoli, Mehdi Ansari, Jan Janczak, Sheila Sherafat Esfahani, Farangis Ataei, Monireh Dehkhodaei, Bagher Amirheidari. Tris-chelated complexes of nickel(II) with bipyridine derivatives: DNA binding and cleavage, BSA binding, molecular docking, and cytotoxicity. Journal of biomolecular structure & dynamics. 2019 09; 37(15):3887-3904. doi: 10.1080/07391102.2018.1534700. [PMID: 30309295]
  • Jing-Hui Zhu, Ben Zhong Tang, Kenneth Kam-Wing Lo. Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane (POSS) Core and Iridium(III) Polypyridine Arms: Synthesis, Aggregation Induced Emission, Cellular Uptake, and Bioimaging Studies. Chemistry (Weinheim an der Bergstrasse, Germany). 2019 Aug; 25(45):10633-10641. doi: 10.1002/chem.201901029. [PMID: 31025784]
  • Zhequan Fu, Qingyu Lin, Bingxin Hu, Yingying Zhang, Weijia Chen, Jing Zhu, Yanzhao Zhao, Hak Soo Choi, Hongcheng Shi, Dengfeng Cheng. P2X7 PET Radioligand 18F-PTTP for Differentiation of Lung Tumor from Inflammation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019 07; 60(7):930-936. doi: 10.2967/jnumed.118.222547. [PMID: 30655332]
  • Daniel Petinatti Pavarini, Denise Medeiros Selegato, Ian Castro-Gamboa, Luiz Vitor Silva do Sacramento, Maysa Furlan. Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection. Molecules (Basel, Switzerland). 2019 Mar; 24(6):. doi: 10.3390/molecules24061160. [PMID: 30909567]
  • Qinyuan Lu, Chenyuan Zhang, Wenyi Wang, Biyue Yuan, Yongming Zhang, Bruce E Rittmann. Bioavailable electron donors leached from leaves accelerate biodegradation of pyridine and quinoline. The Science of the total environment. 2019 Mar; 654(?):473-479. doi: 10.1016/j.scitotenv.2018.11.129. [PMID: 30447586]
  • Dongsheng Fan, Ting Li, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Zhi-Hong Jiang, Li-Ping Bai. Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii. Journal of natural medicines. 2019 Jan; 73(1):23-33. doi: 10.1007/s11418-018-1232-8. [PMID: 30105475]
  • María-José Dávila-Rodríguez, João Paulo Barolli, Katia Mara de Oliveira, Legna Colina-Vegas, Fábio da Silva Miranda, Eduardo Ernesto Castellano, Gustavo Von Poelhsitz, Alzir Azevedo Batista. Carbonyl-heterobimetallic Ru(II)/Fe(II)-complexes containing polypyridyl ligands: Synthesis, characterization, cellular viability assays and interactions with biomolecules. Archives of biochemistry and biophysics. 2018 12; 660(?):156-167. doi: 10.1016/j.abb.2018.10.020. [PMID: 30389443]
  • Fabio Henrique Silva, Kleber Yotsumoto Fertrin, Eduardo Costa Alexandre, Fabiano Beraldi Calmasini, Carla Fernanda Franco-Penteado, Fernando Ferreira Costa. Impairment of Nitric Oxide Pathway by Intravascular Hemolysis Plays a Major Role in Mice Esophageal Hypercontractility: Reversion by Soluble Guanylyl Cyclase Stimulator. The Journal of pharmacology and experimental therapeutics. 2018 11; 367(2):194-202. doi: 10.1124/jpet.118.249581. [PMID: 30108160]
  • Lijie Wei, Yuan Chen, Wenqiang Tan, Qing Li, Guodong Gu, Fang Dong, Zhanyong Guo. Synthesis, Characterization, and Antifungal Activity of Pyridine-Based Triple Quaternized Chitosan Derivatives. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102604. [PMID: 30314307]
  • Fang Cheng, Mingyang Li, Wei He, Bingbing Sun, Jinyan Qin, Jingping Qu. Activation of resin with controllable ligand density via catalytic oxa-Michael addition and application in antibody purification. Journal of chromatography. A. 2018 Oct; 1570(?):1-9. doi: 10.1016/j.chroma.2018.07.032. [PMID: 30153981]
  • Anna Podgórska, Monika Ostaszewska-Bugajska, Klaudia Borysiuk, Agata Tarnowska, Monika Jakubiak, Maria Burian, Allan G Rasmusson, Bożena Szal. Suppression of External NADPH Dehydrogenase-NDB1 in Arabidopsis thaliana Confers Improved Tolerance to Ammonium Toxicity via Efficient Glutathione/Redox Metabolism. International journal of molecular sciences. 2018 May; 19(5):. doi: 10.3390/ijms19051412. [PMID: 29747392]
  • B V Egorova, E V Matazova, A A Mitrofanov, G Yu Aleshin, A L Trigub, A D Zubenko, O A Fedorova, Yu V Fedorov, S N Kalmykov. Novel pyridine-containing azacrownethers for the chelation of therapeutic bismuth radioisotopes: Complexation study, radiolabeling, serum stability and biodistribution. Nuclear medicine and biology. 2018 05; 60(?):1-10. doi: 10.1016/j.nucmedbio.2018.01.005. [PMID: 29499420]
  • Sara Nourizadeh, Adeleh Divsalar, Mina Fekri, Behafarid Ghalandari, Mahbubeh Eslami-Moghadam, Ali Akbar Saboury, Saba Abbasi. Multiple Spectroscopic, Docking and Cytotoxic Study of a Synthesized 2,2' Bipyridin Phenyl Isopentylglycin Pt(II) Nitrate Complex: Human Serum Albumin and Breast Cancer Cell Line of MDA-MB231 as Targets. Journal of fluorescence. 2018 Mar; 28(2):551-559. doi: 10.1007/s10895-018-2216-5. [PMID: 29476398]
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