1,10-Phenanthroline (BioDeep_00000003011)
Secondary id: BioDeep_00000400187
natural product human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
化学式: C12H8N2 (180.0687)
中文名称: 1,10-菲罗啉(无水), 1,10-菲罗啉, 1,10-菲啰啉
谱图信息:
最多检出来源 Homo sapiens(blood) 39.83%
分子结构信息
SMILES: c(c3)cc(c1)c(n3)c(n2)c(ccc2)c1
InChI: InChI=1/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H
描述信息
CONFIDENCE standard compound; INTERNAL_ID 1008; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5191; ORIGINAL_PRECURSOR_SCAN_NO 5190
CONFIDENCE standard compound; INTERNAL_ID 1008; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5188; ORIGINAL_PRECURSOR_SCAN_NO 5186
CONFIDENCE standard compound; INTERNAL_ID 1008; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5119; ORIGINAL_PRECURSOR_SCAN_NO 5117
CONFIDENCE standard compound; INTERNAL_ID 1008; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5135; ORIGINAL_PRECURSOR_SCAN_NO 5132
CONFIDENCE standard compound; INTERNAL_ID 1008; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5127; ORIGINAL_PRECURSOR_SCAN_NO 5126
CONFIDENCE standard compound; INTERNAL_ID 1008; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5090; ORIGINAL_PRECURSOR_SCAN_NO 5089
CONFIDENCE standard compound; INTERNAL_ID 176; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5120; ORIGINAL_PRECURSOR_SCAN_NO 5117
CONFIDENCE standard compound; INTERNAL_ID 176; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5192; ORIGINAL_PRECURSOR_SCAN_NO 5190
CONFIDENCE standard compound; INTERNAL_ID 176; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5090; ORIGINAL_PRECURSOR_SCAN_NO 5087
CONFIDENCE standard compound; INTERNAL_ID 176; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5117; ORIGINAL_PRECURSOR_SCAN_NO 5116
CONFIDENCE standard compound; INTERNAL_ID 176; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5141; ORIGINAL_PRECURSOR_SCAN_NO 5139
CONFIDENCE standard compound; INTERNAL_ID 176; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5194; ORIGINAL_PRECURSOR_SCAN_NO 5193
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D007364 - Intercalating Agents
D064449 - Sequestering Agents > D002614 - Chelating Agents > D007502 - Iron Chelating Agents
Acquisition and generation of the data is financially supported in part by CREST/JST.
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
KEIO_ID P057
同义名列表
17 个代谢物同义名
1,10-Phenanthroline monohydrochoride; 1,10-Phenanthroline monoperchlorate; 1,10-Phenanthroline hydrochoride; 5,6-Dihydro-1,10-phenanthroline; 1,10-Phenanthroline monohydrate; 1,10-Phenanthroline, zinc salt; 1,10-Phenanthroline hydrate; 4,5-Diazaphenanthrene; Copper phenanthroline; Orthophenanthroline; 1,10-phenanthroline; O-Phenanthroline; (OP)2Cu(I); O-PHE; Phen; 1,10-Phenanthroline; 1,10-Phenanthroline
数据库引用编号
40 个数据库交叉引用编号
- ChEBI: CHEBI:44975
- KEGG: C00604
- PubChem: 1318
- HMDB: HMDB0244053
- Metlin: METLIN65523
- DrugBank: DB02365
- ChEMBL: CHEMBL415879
- Wikipedia: Phenanthroline
- chemspider: 1278
- CAS: 66-71-7
- MoNA: PS002101
- MoNA: LU017602
- MoNA: LU100805
- MoNA: PS002102
- MoNA: PR100011
- MoNA: LU017605
- MoNA: LU017606
- MoNA: KO003776
- MoNA: KO003777
- MoNA: LU100804
- MoNA: PR100010
- MoNA: LU017603
- MoNA: KO003775
- MoNA: LU100802
- MoNA: LU100803
- MoNA: KO003773
- MoNA: LU017604
- MoNA: KO003774
- MoNA: PS002104
- MoNA: LU100801
- MoNA: LU017601
- MoNA: PS002103
- MoNA: LU100806
- MoNA: PS002105
- PMhub: MS000007714
- PubChem: 3879
- PDB-CCD: PHN
- NIKKAJI: J4.844E
- RefMet: 1,10-Phenanthroline
- KNApSAcK: 44975
分类词条
相关代谢途径
BioCyc(59)
- salvage pathways of pyrimidine ribonucleotides
- superpathway of pyrimidine deoxyribonucleoside salvage
- superpathway of pyrimidine ribonucleosides salvage
- pyrimidine ribonucleosides salvage I
- pyrimidine ribonucleosides salvage II
- pyrimidine deoxyribonucleosides salvage
- 4-hydroxyacetophenone degradation
- 4-aminophenol degradation
- alkylnitronates degradation
- patulin biosynthesis
- trans-4-hydroxy-L-proline degradation II
- indolmycin biosynthesis
- L-lysine biosynthesis II
- superpathway of fucose and rhamnose degradation
- formaldehyde oxidation I
- morphine biosynthesis
- formaldehyde assimilation II (assimilatory RuMP Cycle)
- superpathway of pentose and pentitol degradation
- superpathay of heme b biosynthesis from glutamate
- berberine biosynthesis
- aromatic biogenic amine degradation (bacteria)
- superpathway of microbial D-galacturonate and D-glucuronate degradation
- nicotinate degradation I
- superpathway of CMP-sialic acids biosynthesis
- tetrapyrrole biosynthesis I (from glutamate)
- superpathway of L-lysine degradation
- purine nucleotides degradation II (aerobic)
- L-lysine fermentation to acetate and butanoate
- NADH to cytochrome bo oxidase electron transfer I
- NADH to cytochrome bd oxidase electron transfer I
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation
- superpathway of Clostridium acetobutylicum solventogenic fermentation
- ammonia oxidation I (aerobic)
- L-rhamnose degradation I
- ppGpp biosynthesis
- ammonia oxidation III
- ammonia oxidation IV (autotrophic ammonia oxidizers)
- nitrifier denitrification
- superpathway of cholesterol degradation I (cholesterol oxidase)
- pyrimidine deoxyribonucleotides de novo biosynthesis I
- 4-amino-3-hydroxybenzoate degradation
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate
- mevalonate degradation
- L-leucine degradation I
- superpathway of penicillin, cephalosporin and cephamycin biosynthesis
- deacetylcephalosporin C biosynthesis
- superpathway of β-D-glucuronosides degradation
- flaviolin dimer and mompain biosynthesis
- guanosine nucleotides degradation III
- androstenedione degradation
- D-galacturonate degradation I
- D-fructuronate degradation
- superpathway of hexuronide and hexuronate degradation
- (S)-reticuline biosynthesis I
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
- superpathway of L-methionine salvage and degradation
- pyrimidine nucleobases salvage II
- tRNA charging
- ajmaline and sarpagine biosynthesis
PlantCyc(5)
代谢反应
3 个相关的代谢反应过程信息。
Reactome(3)
- Sensory Perception:
GTP + odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 ⟶ GDP + odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13
- Sensory perception of taste:
GTP + TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 ⟶ GDP + TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13
- Sensory perception of sweet, bitter, and umami (glutamate) taste:
GTP + TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 ⟶ GDP + TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yu Wang, Zhouhui Wu, Zhiwen Wang, Heng Du, Shuang Xiao, Lin Lu, Zhen Wang. Analyses of the Antibiofilm Activity of o-Phenanthroline Monohydrate against Enterococcus faecalis and Staphylococcus aureus and the Mechanisms Underlying These Effects.
ACS infectious diseases.
2024 Feb; 10(2):638-649. doi:
10.1021/acsinfecdis.3c00516
. [PMID: 38258383] - Anđela Bačinić, Sanja Frka, Marina Mlakar. A study of cobalt (II) complexes involved in marine biogeochemical processes: Co(II)-1,10-Phenanthroline and Co(II)-1,10-Phenanthroline-L-α-Phosphatidylcholine.
Bioelectrochemistry (Amsterdam, Netherlands).
2022 Apr; 144(?):108009. doi:
10.1016/j.bioelechem.2021.108009
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Cell reports.
2021 04; 35(4):109040. doi:
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Journal of inorganic biochemistry.
2020 10; 211(?):111206. doi:
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Metallomics : integrated biometal science.
2020 06; 12(6):891-901. doi:
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2020; 36(11):1345-1352. doi:
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2017 Sep; 174(?):35-43. doi:
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ChemMedChem.
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. [PMID: 27805201] - Shiori Nonaka, Tsutomu Katsuyama, Tatsuhiko Kondo, Yasuyuki Sasaki, Tadao Asami, Shunsuke Yajima, Shinsaku Ito. 1,10-Phenanthroline and its derivatives are novel hatching stimulants for soybean cyst nematodes.
Bioorganic & medicinal chemistry letters.
2016 11; 26(21):5240-5243. doi:
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2016 Aug; 161(?):355-67. doi:
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. [PMID: 27295415] - Ying Xiao, Qing Wang, Yanmei Huang, Xiangling Ma, Xinnuo Xiong, Hui Li. Synthesis, structure, and biological evaluation of a copper(ii) complex with fleroxacin and 1,10-phenanthroline.
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2016 Jun; 45(25):10466-79. doi:
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