Pyrene (BioDeep_00000002811)

 

Secondary id: BioDeep_00001873555

human metabolite


代谢物信息卡片


Coal tar pitch volatiles:pyrene

化学式: C16H10 (202.0782)
中文名称: 芘-13C16,
谱图信息: 最多检出来源 Homo sapiens(blood) 20.47%

分子结构信息

SMILES: C1=CC2=C3C(=C1)C=CC4=CC=CC(=C43)C=C2
InChI: InChI=1S/C16H10/c1-3-11-7-9-13-5-2-6-14-10-8-12(4-1)15(11)16(13)14/h1-10H

描述信息

Pyrene is a polycyclic aromatic hydrocarbon (PAH) consisting of four fused benzene rings, resulting in a flat aromatic system. The chemical formula is C16H10. This colourless solid is the smallest peri-fused PAH (one where the rings are fused through more than one face). Pyrene forms during incomplete combustion of organic compounds.
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D004396 - Coloring Agents > D005456 - Fluorescent Dyes

同义名列表

12 个代谢物同义名

Coal tar pitch volatiles:pyrene; {Benzo[def]phenanthrene}; Benzo[def]phenanthrene; Pyrene (acd/name 4.0); beta-Pyrene; Benzpyrene; Β-pyrene; b-Pyrene; PYRENE; Pyren; Pyrene; Pyrene



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AHR, ALB, APOE, CAT, CYP1A1, HPGDS, MYLK, NR1I3, PLA2G12A, PMP2
Peripheral membrane protein 4 ACHE, ANOS1, CYP1A1, CYP1B1
Endoplasmic reticulum membrane 3 CYP1A1, CYP1A2, CYP1B1
Nucleus 6 ACHE, AHR, ALB, APOE, NR1I3, PMP2
cytosol 8 AHR, ALB, CAT, GPT, HPGDS, MYLK, NR1I3, PMP2
dendrite 1 APOE
centrosome 1 ALB
nucleoplasm 5 AHR, ATP2B1, CD2, HPGDS, NR1I3
Cell membrane 4 ACHE, ANOS1, ATP2B1, CD2
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 1 ATP2B1
Synapse 3 ACHE, ATP2B1, MYLK
cell surface 3 ACHE, ANOS1, CD2
glutamatergic synapse 2 APOE, ATP2B1
Golgi apparatus 5 ACHE, ALB, APOE, ATRN, CD2
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
neuronal cell body 1 APOE
presynaptic membrane 1 ATP2B1
plasma membrane 7 ACHE, ANOS1, APOE, ATP2B1, ATRN, CD2, MYLK
synaptic vesicle membrane 1 ATP2B1
Membrane 5 ACHE, APOE, ATP2B1, CAT, CYP1B1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 8 ALB, APOE, ATP2B1, ATRN, CAT, GPT, LYZ, PMP2
endoplasmic reticulum 2 ALB, APOE
extracellular space 6 ACHE, ALB, ANOS1, APOE, ATRN, LYZ
perinuclear region of cytoplasm 1 ACHE
mitochondrion 3 CAT, CYP1A1, CYP1B1
protein-containing complex 4 AHR, ALB, CAT, CD2
intracellular membrane-bounded organelle 6 ATP2B1, CAT, CYP1A1, CYP1A2, CYP1B1, HPGDS
Microsome membrane 3 CYP1A1, CYP1A2, CYP1B1
Single-pass type I membrane protein 2 ATRN, CD2
Secreted 5 ACHE, ALB, ANOS1, APOE, PLA2G12A
extracellular region 8 ACHE, ALB, ANOS1, APOE, CAT, CD2, LYZ, PLA2G12A
cytoplasmic side of plasma membrane 1 CD2
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
transcription regulator complex 1 AHR
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 CD2
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
actin cytoskeleton 1 MYLK
Early endosome 1 APOE
cell-cell junction 1 CD2
Cell projection, lamellipodium 1 MYLK
Mitochondrion inner membrane 1 CYP1A1
Cytoplasm, cytoskeleton 1 NR1I3
focal adhesion 1 CAT
extracellular matrix 2 ANOS1, APOE
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 APOE
lateral plasma membrane 1 ATP2B1
ciliary basal body 1 ALB
chromatin 2 AHR, NR1I3
cell projection 1 ATP2B1
cytoskeleton 1 NR1I3
centriole 1 ALB
Secreted, extracellular space 1 APOE
spindle pole 1 ALB
blood microparticle 2 ALB, APOE
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
aryl hydrocarbon receptor complex 1 AHR
Melanosome 1 APOE
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ACHE
myelin sheath 1 PMP2
stress fiber 1 MYLK
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 2 ALB, APOE
platelet alpha granule lumen 1 ALB
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
azurophil granule lumen 1 LYZ
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 APOE
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
synaptic cleft 2 ACHE, APOE
[Isoform 1]: Cell membrane 1 ATRN
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1
[Isoform H]: Cell membrane 1 ACHE
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
ciliary transition fiber 1 ALB


文献列表

  • Alison M Williams-Clayson, Christopher H Vane, Matthew D Jones, Russell Thomas, Christopher Taylor, Darren J Beriro. Dermal absorption of high molecular weight parent and alkylated polycyclic aromatic hydrocarbons from manufactured gas plant soils using in vitro assessment. Journal of hazardous materials. 2024 May; 469(?):133858. doi: 10.1016/j.jhazmat.2024.133858. [PMID: 38493626]
  • Jyoti Mathur, Ritu Panwar. Synergistic effect of pyrene and heavy metals (Zn, Pb, and Cd) on phytoremediation potential of Medicago sativa L. (alfalfa) in multi-contaminated soil. Environmental science and pollution research international. 2024 Mar; 31(14):21012-21027. doi: 10.1007/s11356-024-32499-4. [PMID: 38383928]
  • Jin A Kim, Young-Su Park, Jun-Hwan Kim, Cheol Young Choi. Toxic effects of polystyrene microbeads and benzo[α]pyrene on bioaccumulation, antioxidant response, and cell damage in goldfish Carassius auratus. Ecotoxicology and environmental safety. 2024 Jan; 270(?):115825. doi: 10.1016/j.ecoenv.2023.115825. [PMID: 38101975]
  • Jianjian Wu, Xinyue Liu, Fei Ge, Feng Li, Na Liu. Tolerance mechanism of rice (Oryza sativa L.) seedings towards polycyclic aromatic hydrocarbons toxicity: The activation of SPX-mediated signal transduction to maintain P homeostasis. Environmental pollution (Barking, Essex : 1987). 2024 Jan; 341(?):123009. doi: 10.1016/j.envpol.2023.123009. [PMID: 38006996]
  • L Paikhomba Singha, K Malabika Singha, Piyush Pandey. Functionally coherent transcriptional responses of Jatropha curcas and Pseudomonas fragi for rhizosphere mediated degradation of pyrene. Scientific reports. 2024 01; 14(1):1014. doi: 10.1038/s41598-024-51581-y. [PMID: 38200308]
  • Mohammad Ali Zazouli, Alireza Ala, Somayeh Asghari, Esmaeil Babanezhad. Evaluation of Azolla filiculoides potential in pyrene and phenanthrene accumulation and phytoremediation in contaminated waters. International journal of phytoremediation. 2023 Sep; ?(?):1-10. doi: 10.1080/15226514.2023.2257314. [PMID: 37705149]
  • Caixia Sun, Xiangbo Shen, Yulan Zhang, Tianshu Song, Lingjing Xu, Junyao Xiao. Molecular Defensive Mechanism of Echinacea purpurea (L.) Moench against PAH Contaminations. International journal of molecular sciences. 2023 Jul; 24(13):. doi: 10.3390/ijms241311020. [PMID: 37446196]
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  • Eliza Cwalina, Kristoffer Skovlund Kilpinen, Ingvild Ryde, Nikoline Juul Nielsen, Sigurd Christiansen, Jan H Christensen. Investigation of the spatial distribution of airborne polycyclic aromatic hydrocarbons using Rhytidiadelphus squarrosus in Tórshavn, Faroe Islands. Environmental science and pollution research international. 2023 Jun; ?(?):. doi: 10.1007/s11356-023-28423-x. [PMID: 37365368]
  • Shanshan Gao, Gege Yang, Xiaohui Zhang, Rui Shi, Rongrong Chen, Xin Zhang, Yuancheng Peng, Hua Yang, Ying Lu, Chunxia Song. β-Cyclodextrin Polymer-Based Fluorescence Enhancement Strategy via Host-Guest Interaction for Sensitive Assay of SARS-CoV-2. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087174. [PMID: 37108336]
  • José Carlos Castilla-Alcantara, Rosa Posada-Baquero, Maria Balseiro-Romero, Carmen Fernández-López, José Luis García, Alicia Fernandez-Vazquez, John R Parsons, Manuel Cantos, Jose Julio Ortega-Calvo. Risk reductions during pyrene biotransformation and mobilization in a model plant-bacteria-biochar system. The Science of the total environment. 2023 Apr; 868(?):161600. doi: 10.1016/j.scitotenv.2023.161600. [PMID: 36681341]
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  • Xia Li, Xiaofei Kang, Junzhu Zou, Jiahui Yin, Yuancheng Wang, Ao Li, Xiaodong Ma. Allochthonous arbuscular mycorrhizal fungi promote Salix viminalis L.-mediated phytoremediation of polycyclic aromatic hydrocarbons characterized by increasing the release of organic acids and enzymes in soils. Ecotoxicology and environmental safety. 2023 Jan; 249(?):114461. doi: 10.1016/j.ecoenv.2022.114461. [PMID: 38321680]
  • Wei Li, Wen-Bin Li, Li-Jun Xing, Shao-Xia Guo. Effect of arbuscular mycorrhizal fungi (AMF) and plant growth-promoting rhizobacteria (PGPR) on microorganism of phenanthrene and pyrene contaminated soils. International journal of phytoremediation. 2023; 25(2):240-251. doi: 10.1080/15226514.2022.2071832. [PMID: 35549569]
  • Kartik Dhar, Logeshwaran Panneerselvan, Kadiyala Venkateswarlu, Mallavarapu Megharaj. Efficient bioremediation of PAHs-contaminated soils by a methylotrophic enrichment culture. Biodegradation. 2022 12; 33(6):575-591. doi: 10.1007/s10532-022-09996-9. [PMID: 35976498]
  • Lakshmi Jain, Anjana Jajoo. Diminishing toxicity of pyrene on photosynthetic performance of soybean using Bacillus subtilis (NCIM 5594). Functional plant biology : FPB. 2022 Nov; ?(?):. doi: 10.1071/fp22172. [PMID: 36372780]
  • Ning Zhang, Fuwei Gao, Shiyi Cheng, Huijun Xie, Zhen Hu, Jian Zhang, Shuang Liang. Mn oxides enhanced pyrene removal with both rhizosphere and non-rhizosphere microorganisms in subsurface flow constructed wetlands. Chemosphere. 2022 Nov; 307(Pt 2):135821. doi: 10.1016/j.chemosphere.2022.135821. [PMID: 35944687]
  • Lili Tian, Li Ya Ma, Xiaolong Chen, Jing Ge, Yini Ma, Rong Ji, Xiangyang Yu. Insights into the accumulation, distribution and toxicity of pyrene associated with microplastics in rice (Oryza sativa L.) seedlings. Chemosphere. 2022 Oct; 311(Pt 2):136988. doi: 10.1016/j.chemosphere.2022.136988. [PMID: 36306968]
  • Xue Wang, Chao-Ba Lin, Dan-Qin Wang, Xue-Zhu Zhu, Hai-Yan Zhao, Bai-Tao Lyu. [Colonization performance and pyrene degradation characteristics of Stenotrophomonas maltophilia PX1]. Ying yong sheng tai xue bao = The journal of applied ecology. 2022 Sep; 33(9):2547-2556. doi: 10.13287/j.1001-9332.202209.033. [PMID: 36131672]
  • Kartik Dhar, Logeshwaran Panneerselvan, Suresh R Subashchandrabose, Kadiyala Venkateswarlu, Mallavarapu Megharaj. Anaerobic Degradation of Naphthalene and Pyrene by Sulfate-Reducing Cultures Enriched from Former Manufactured Gas Plant Soil. Microbial ecology. 2022 May; ?(?):. doi: 10.1007/s00248-022-02042-4. [PMID: 35610382]
  • Angela Capaccio, Antonio Sasso, Giulia Rusciano. Feasibility of SERS-Active Porous Ag Substrates for the Effective Detection of Pyrene in Water. Sensors (Basel, Switzerland). 2022 Apr; 22(7):. doi: 10.3390/s22072764. [PMID: 35408378]
  • Ismail Marzuki, Ruzkiah Asaf, Mudian Paena, Admi Athirah, Khairun Nisaa, Rasheed Ahmad, Mudyawati Kamaruddin. Anthracene and Pyrene Biodegradation Performance of Marine Sponge Symbiont Bacteria Consortium. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226851. [PMID: 34833943]
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  • Danielle M Smith, Carol Christensen, Dana van Bemmel, Nicolette Borek, Bridget Ambrose, Gladys Erives, Raymond Niaura, Kathryn C Edwards, Cassandra A Stanton, Benjamin C Blount, Lanqing Wang, Jun Feng, Jeffery M Jarrett, Cynthia D Ward, Dorothy Hatsukami, Stephen S Hecht, Heather L Kimmel, Mark Travers, Andrew Hyland, Maciej L Goniewicz. Exposure to Nicotine and Toxicants Among Dual Users of Tobacco Cigarettes and E-Cigarettes: Population Assessment of Tobacco and Health (PATH) Study, 2013-2014. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2021 05; 23(5):790-797. doi: 10.1093/ntr/ntaa252. [PMID: 33590857]
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  • Emelie Rietz Liljedahl, Gunnar Johanson, Helena Korres de Paula, Moosa Faniband, Eva Assarsson, Margareta Littorin, Malin Engfeldt, Carola Lidén, Anneli Julander, Karin Wahlberg, Christian Lindh, Karin Broberg. Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin-A Human Experimental Study. Environmental health perspectives. 2021 01; 129(1):17002. doi: 10.1289/ehp7310. [PMID: 33439052]
  • Jie Yang, Yujun Gu, Zhigao Chen, Yao Song, Fengfei Sun, Juan Liu, Michael Gatheru Waigi. Colonization and performance of a pyrene-degrading bacterium Mycolicibacterium sp. Pyr9 on root surfaces of white clover. Chemosphere. 2021 Jan; 263(?):127918. doi: 10.1016/j.chemosphere.2020.127918. [PMID: 32822944]
  • Süreyya Oğuz Tümay, Vildan Şanko, Erhan Demirbas, Ahmet Şenocak. Fluorescence determination of trace level of cadmium with pyrene modified nanocrystalline cellulose in food and soil samples. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Dec; 146(?):111847. doi: 10.1016/j.fct.2020.111847. [PMID: 33160013]
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  • Mónica Hernández, Randy Ortiz-Castro, Alberto Flores-Olivas, Ivana Moggio, Eduardo Arias, José Humberto Valenzuela-Soto. Fluorescence detection of pyrene-stained Bacillus subtilis LPM1 rhizobacteria from colonized patterns of tomato roots. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2020 Oct; 19(10):1423-1432. doi: 10.1039/d0pp00199f. [PMID: 32970082]
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