Skullcapflavone II (BioDeep_00000002777)

Main id: BioDeep_00000017598

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-chromen-4-one

化学式: C19H18O8 (374.1001628)
中文名称: 黄芩新素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1OC)oc(cc2=O)c1c(cccc1O)OC)O)OC)OC
InChI: InChI=1S/C19H18O8/c1-23-11-7-5-6-9(20)13(11)12-8-10(21)14-15(22)17(24-2)19(26-4)18(25-3)16(14)27-12/h5-8,20,22H,1-4H3

描述信息

Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].

同义名列表

7 个代谢物同义名

5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-chromen-4-one; 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one; 5,2-dihydroxy-6,7,8,6-tetramethoxy-flavone; 5,2-Dihydroxy-6,7,8,6-tetramethoxyflavone; Skullcapflavone II; Scullcapflavone II; Neobaicalein



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Soha Parsafar, Farhang Aliakbari, Sepideh Sadat Seyedfatemi, Zahra Najarzadeh, Hamdam Hourfar, Hassan Bardania, Mohsen Farhadpour, Mehdi Mohammadi, Dina Morshedi. Insights into the inhibitory mechanism of skullcapflavone II against α-synuclein aggregation and its mediated cytotoxicity. International journal of biological macromolecules. 2022 Jun; 209(Pt A):426-440. doi: 10.1016/j.ijbiomac.2022.03.092. [PMID: 35398391]
  • Julia Solnier, Liam Martin, Sanjib Bhakta, Franz Bucar. Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species. Molecules (Basel, Switzerland). 2020 Feb; 25(3):. doi: 10.3390/molecules25030734. [PMID: 32046221]
  • Young Hun Lee, Eun Kyoung Seo, Seung-Taek Lee. Skullcapflavone II Inhibits Degradation of Type I Collagen by Suppressing MMP-1 Transcription in Human Skin Fibroblasts. International journal of molecular sciences. 2019 Jun; 20(11):. doi: 10.3390/ijms20112734. [PMID: 31167359]
  • Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Ok Hee Chai. Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release. International immunopharmacology. 2017 Nov; 52(?):77-84. doi: 10.1016/j.intimp.2017.08.029. [PMID: 28886581]
  • Qing-wei Yan, Rui-jian Zhong, Guo-ping Zhou, Hui-zheng Fu, Tian-xiao Zhang. [Chemical Constituents from Camellia oleifera Stem]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Oct; 38(10):2102-4. doi: . [PMID: 27254924]
  • Motahareh Boozari, Ameneh Mohammadi, Javad Asili, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. Environmental toxicology and pharmacology. 2015 Jan; 39(1):307-12. doi: 10.1016/j.etap.2014.12.002. [PMID: 25546119]
  • Ha-Young Jang, Kyung-Seop Ahn, Mi-Jeong Park, Ok-Kyoung Kwon, Hyeong-Kyu Lee, Sei-Ryang Oh. Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma. International immunopharmacology. 2012 Apr; 12(4):666-74. doi: 10.1016/j.intimp.2012.01.010. [PMID: 22314230]
  • Harendra S Parekh, Gang Liu, Ming Q Wei. A new dawn for the use of traditional Chinese medicine in cancer therapy. Molecular cancer. 2009 Mar; 8(?):21. doi: 10.1186/1476-4598-8-21. [PMID: 19298677]
  • Zhao-Tang Ma, Xiu-Wei Yang. [Studies on ethyl acetate soluble constituents of Huanglian Jiedutang]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Sep; 33(18):2080-6. doi: . [PMID: 19160789]
  • Michael Bonham, Jeff Posakony, Ilsa Coleman, Bruce Montgomery, Julian Simon, Peter S Nelson. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 May; 11(10):3905-14. doi: 10.1158/1078-0432.ccr-04-1974. [PMID: 15897592]
  • Li-xin Yang, Dai Liu, Xue-feng Feng, Shu-lian Cui, Jing-yu Yang, Xiao-jun Tang, Xi-rong He, Ju-fu Liu, Shi-lin Hu. [Determination of flavone for Scutellaria baicalensis from different areas by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2002 Mar; 27(3):166-70. doi: . [PMID: 12774393]