Amiloride (BioDeep_00000002543)

 

Secondary id: BioDeep_00000405754

human metabolite blood metabolite


代谢物信息卡片


3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide

化学式: C6H8ClN7O (229.0479)
中文名称: 阿米洛利
谱图信息: 最多检出来源 Mus musculus(blood) 7.87%

分子结构信息

SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
InChI: InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)

描述信息

A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilmans The Pharmacological Basis of Therapeutics, 9th ed, p705)
D049990 - Membrane Transport Modulators > D026941 - Sodium Channel Blockers > D062686 - Epithelial Sodium Channel Blockers
D049990 - Membrane Transport Modulators > D026941 - Sodium Channel Blockers > D062646 - Acid Sensing Ion Channel Blockers
C - Cardiovascular system > C03 - Diuretics > C03D - Aldosterone antagonists and other potassium-sparing agents
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49186 - Potassium-Sparing Diuretic
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
KEIO_ID A225; [MS2] KO008833
KEIO_ID A225

同义名列表

31 个代谢物同义名

3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Merck sharp and dohme brand OF amiloride hydrochloride; Cahill may roberts brand OF amiloride hydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; Trommsdorff brand OF amiloride hydrochloride; Alphapharm brand OF amiloride hydrochloride; Berolina brand OF amiloride hydrochloride; Douglas brand OF amiloride hydrochloride; Amrad brand OF amiloride hydrochloride; Merck brand OF amiloride hydrochloride; Hydrochloride, anhydrous amiloride; Amiloride hydrochloride, anhydrous; Anhydrous amiloride hydrochloride; Amiloride hydrochloride hydrate; Hydrochloride, amiloride; Amiloride hydrochloride; Trom, amiduret; Amiduret trom; Amiloridum; Amiloberag; Amyloride; AMILORIDE; Amilorida; Amiclaran; Modamide; Midoride; Kaluril; Midamor; Amidal; Amiloride



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AXIN2, NR3C2, SCNN1A, SGK1, SLC9A1
Golgi apparatus, trans-Golgi network membrane 1 AQP2
Endoplasmic reticulum membrane 2 NR3C2, SGK1
Nucleus 3 AXIN2, NR3C2, SGK1
cytosol 6 AVP, AXIN2, NR3C2, PRKCQ, SCNN1A, SGK1
dendrite 1 AVP
centrosome 1 AXIN2
nucleoplasm 4 ATP2B1, NR3C2, SGK1, SLC9A1
Cell membrane 7 AQP2, ASIC2, ATP2B1, SLC9A1, SLC9A3, TNF, TRPV1
lamellipodium 1 SLC9A1
Cytoplasmic granule 1 SCNN1A
Early endosome membrane 1 SLC9A3
Multi-pass membrane protein 11 AQP2, ASIC2, ATP2B1, CACNA1I, CATSPER3, SCNN1A, SLC9A1, SLC9A2, SLC9A3, SLC9C1, TRPV1
Synapse 1 ATP2B1
cell surface 4 PLAU, SLC9A1, SLC9A3, TNF
glutamatergic synapse 1 ATP2B1
Golgi apparatus 2 AQP2, TAS1R3
Golgi membrane 1 INS
neuronal cell body 3 ASIC2, TNF, TRPV1
presynaptic membrane 1 ATP2B1
acrosomal vesicle 2 CATSPER3, SCNN1A
plasma membrane 17 AQP2, ASIC2, ATP2B1, AXIN2, CACNA1I, CATSPER3, PLAU, PRKCQ, SCNN1A, SGK1, SLC9A1, SLC9A2, SLC9A3, SLC9C1, TAS1R3, TNF, TRPV1
synaptic vesicle membrane 1 ATP2B1
Membrane 9 AQP2, ATP2B1, CACNA1I, SCNN1A, SLC9A1, SLC9A2, SLC9C1, TAS1R3, TRPV1
apical plasma membrane 5 AQP2, SCNN1A, SLC9A1, SLC9A2, SLC9A3
basolateral plasma membrane 3 AQP2, ATP2B1, SLC9A1
brush border 1 SLC9A3
extracellular exosome 6 AQP2, ATP2B1, PLAU, SCNN1A, SLC9A1, SLC9A3
endoplasmic reticulum 2 CATSPER3, SGK1
extracellular space 4 AVP, INS, PLAU, TNF
perinuclear region of cytoplasm 2 AQP2, SLC9A1
intercalated disc 1 SLC9A1
mitochondrion 2 SGK1, SLC9A1
intracellular membrane-bounded organelle 1 ATP2B1
Secreted 3 AVP, INS, PLAU
extracellular region 4 AVP, INS, PLAU, TNF
Cell projection, cilium 1 SCNN1A
centriolar satellite 1 PRKCQ
ciliary membrane 1 SCNN1A
motile cilium 3 CATSPER3, SCNN1A, SLC9C1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 4 PLAU, SCNN1A, TNF, TRPV1
dendritic spine 1 ASIC2
T-tubule 1 SLC9A1
beta-catenin destruction complex 1 AXIN2
Early endosome 1 SLC9A3
recycling endosome 2 AQP2, TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 TRPV1
Apical cell membrane 4 AQP2, SCNN1A, SLC9A2, SLC9A3
Membrane raft 2 SLC9A1, TNF
focal adhesion 2 PLAU, SLC9A1
GABA-ergic synapse 1 TRPV1
secretory granule 1 AVP
lateral plasma membrane 2 AQP2, ATP2B1
nuclear speck 1 SGK1
Postsynaptic cell membrane 1 TRPV1
receptor complex 1 NR3C2
Cell projection, neuron projection 1 TRPV1
chromatin 1 NR3C2
cell projection 1 ATP2B1
phagocytic cup 1 TNF
brush border membrane 1 SLC9A3
Cytoplasmic vesicle, secretory vesicle, acrosome 1 SCNN1A
Cell projection, cilium, flagellum 1 SCNN1A
Basolateral cell membrane 3 AQP2, ATP2B1, SLC9A1
Recycling endosome membrane 1 SLC9A3
endosome lumen 1 INS
Cell projection, cilium, flagellum membrane 2 CATSPER3, SLC9C1
Cytoplasmic vesicle membrane 1 AQP2
sodium channel complex 1 SCNN1A
specific granule membrane 1 PLAU
tertiary granule membrane 1 PLAU
Presynaptic cell membrane 1 ATP2B1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
serine-type endopeptidase complex 1 PLAU
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 ASIC2
immunological synapse 2 ATP2B1, PRKCQ
neuronal dense core vesicle 1 AVP
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 AVP
serine protease inhibitor complex 1 PLAU
sperm principal piece 1 SCNN1A
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
protein complex involved in cell-matrix adhesion 1 PLAU
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
transport vesicle membrane 1 AQP2
photoreceptor ribbon synapse 1 ATP2B1
cation-transporting ATPase complex 1 SLC9A1
lumenal side of membrane 1 AQP2
CatSper complex 1 CATSPER3
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
sweet taste receptor complex 1 TAS1R3


文献列表

  • Noah H Somberg, João Medeiros-Silva, Hyunil Jo, Jun Wang, William F DeGrado, Mei Hong. Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface. Protein science : a publication of the Protein Society. 2023 10; 32(10):e4755. doi: 10.1002/pro.4755. [PMID: 37632140]
  • Kiem Vu, Benjamin J Buckley, Richard S Bujaroski, Eduardo Blumwald, Michael J Kelso, Angie Gelli. Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs. Frontiers in cellular and infection microbiology. 2023; 13(?):1101568. doi: 10.3389/fcimb.2023.1101568. [PMID: 36923593]
  • Juliana Pena Lopez, Mohammad-Zaman Nouri, Areej Ebrahim, Kevin M Chacko, Whitney C Schramm, Mohammed F Gholam, Tezcan Ozrazgat-Baslanti, Nancy D Denslow, Abdel A Alli. Lipid Profiles of Urinary Extracellular Vesicles Released during the Inactive and Active Phases of Aged Male Mice with Spontaneous Hypertension. International journal of molecular sciences. 2022 Dec; 23(23):. doi: 10.3390/ijms232315397. [PMID: 36499728]
  • Babar Shahzad, Lana Shabala, Meixue Zhou, Gayatri Venkataraman, Celymar Angela Solis, David Page, Zhong-Hua Chen, Sergey Shabala. Comparing Essentiality of SOS1-Mediated Na+ Exclusion in Salinity Tolerance between Cultivated and Wild Rice Species. International journal of molecular sciences. 2022 Aug; 23(17):. doi: 10.3390/ijms23179900. [PMID: 36077294]
  • ZhangFei Su, J Jay Leitch, Jacek Lipkowski. Effect of Lipid Composition on the Inhibition Mechanism of Amiloride on Alamethicin Ion Channels in Supported Phospholipid Bilayers. Langmuir : the ACS journal of surfaces and colloids. 2022 07; 38(27):8398-8406. doi: 10.1021/acs.langmuir.2c00953. [PMID: 35749587]
  • Bora Gulhan, Yağmur Ünsal, Demet Baltu, Nur Berna Çelik Ertaş, Gülşah Özdemir, Eda Utine, H Nursun Ozcan, Ali Duzova, Nazli Gönç. Apparent mineralocorticoid excess: A diagnosis beyond classical causes of severe hypertension in a child. Blood pressure monitoring. 2022 Jun; 27(3):208-211. doi: 10.1097/mbp.0000000000000583. [PMID: 35044984]
  • Mahmoud Azzeh, Marco Battaglia, Simon Davies, John Strauss, Prashant Dogra, Venkata Yellepeddi. Novel intranasal treatment for anxiety disorders using amiloride, an acid-sensing ion channel antagonist: Pharmacokinetic modeling and simulation. International journal of clinical pharmacology and therapeutics. 2022 Jun; 60(6):253-263. doi: 10.5414/cp204217. [PMID: 35445658]
  • Maria Mernea, Roxana Ștefania Ulăreanu, Dana Cucu, Jasim Hafedh Al-Saedi, Cristian-Emilian Pop, Sergiu Fendrihan, Giorgiana Diana Carmen Anghelescu, Dan Florin Mihăilescu. Epithelial Sodium Channel Inhibition by Amiloride Addressed with THz Spectroscopy and Molecular Modeling. Molecules (Basel, Switzerland). 2022 May; 27(10):. doi: 10.3390/molecules27103271. [PMID: 35630748]
  • Deepika Anand, Edith Hummler, Olivia J Rickman. ENaC activation by proteases. Acta physiologica (Oxford, England). 2022 05; 235(1):e13811. doi: 10.1111/apha.13811. [PMID: 35276025]
  • Stephanie M Mutchler, Thomas R Kleyman. Effects of amiloride on acetylcholine-dependent arterial vasodilation evolve over time in mice on a high salt diet. Physiological reports. 2022 04; 10(7):e15255. doi: 10.14814/phy2.15255. [PMID: 35384364]
  • Maria S Muntyan, Mikhail B Viryasov, Dimitry Y Sorokin, Vladimir P Skulachev. Sodium Energetic Cycle in the Natronophilic Bacterium Thioalkalivibrio versutus. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23041965. [PMID: 35216079]
  • Dusan Harmacek, Anne Blanchard, Gregoire Wuerzner, Marc Maillard, Xavier Jeunemaitre, Michel Azizi, Olivier Bonny. Acute decrease of urine calcium by amiloride in healthy volunteers under high-sodium diet. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2022 01; 37(2):298-303. doi: 10.1093/ndt/gfab159. [PMID: 33914065]
  • Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi, Xinling Liang. The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study. Renal failure. 2021 Dec; 43(1):452-459. doi: 10.1080/0886022x.2021.1892759. [PMID: 33657976]
  • Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde. Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2. Communications biology. 2021 12; 4(1):1347. doi: 10.1038/s42003-021-02866-9. [PMID: 34853399]
  • Marc Yeste, Sandra Recuero, Carolina Maside, Albert Salas-Huetos, Sergi Bonet, Elisabeth Pinart. Blocking NHE Channels Reduces the Ability of In Vitro Capacitated Mammalian Sperm to Respond to Progesterone Stimulus. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312646. [PMID: 34884450]
  • Akiko Hiramatsu, Yuichiro Izumi, Koji Eguchi, Naomi Matsuo, Qinyuan Deng, Hideki Inoue, Yushi Nakayama, Hiroshi Nonoguchi, Jose Aramburu, Cristina López-Rodríguez, Yutaka Kakizoe, Masataka Adachi, Takashige Kuwabara, Shokei Kim-Mitsuyama, Masashi Mukoyama. Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice. Hypertension (Dallas, Tex. : 1979). 2021 11; 78(5):1335-1346. doi: 10.1161/hypertensionaha.121.17435. [PMID: 34601973]
  • Liga Skarda, Julia Kowal, Kaspar P Locher. Structure of the Human Cholesterol Transporter ABCG1. Journal of molecular biology. 2021 10; 433(21):167218. doi: 10.1016/j.jmb.2021.167218. [PMID: 34461069]
  • Lin Zhou, Tong Zhang, Wei Shao, Ruohan Lu, Lin Wang, Haisheng Liu, Bin Jiang, Shiqin Li, Huiqin Zhuo, Suheng Wang, Qinxi Li, Caihua Huang, Donghai Lin. Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release. Skeletal muscle. 2021 07; 11(1):17. doi: 10.1186/s13395-021-00274-5. [PMID: 34229732]
  • Sagar S Manoli, Kyle Kisor, Bradley A Webb, Diane L Barber. Ethyl isopropyl amiloride decreases oxidative phosphorylation and increases mitochondrial fusion in clonal untransformed and cancer cells. American journal of physiology. Cell physiology. 2021 07; 321(1):C147-C157. doi: 10.1152/ajpcell.00001.2021. [PMID: 34038242]
  • A M Beal. The effect of acetazolamide, amiloride, bumetanide and SITS on secretion of fluid and electrolytes by the parotid gland of common wombats, Vombatus ursinus. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2021 07; 191(4):777-791. doi: 10.1007/s00360-021-01367-9. [PMID: 33877412]
  • Matthew A Sparks, Emre Dilmen, Donna L Ralph, Fitra Rianto, Thien A Hoang, Alison Hollis, Edward J Diaz, Rishav Adhikari, Gabriel Chew, Enrico G Petretto, Susan B Gurley, Alicia A McDonough, Thomas M Coffman. Vascular control of kidney epithelial transporters. American journal of physiology. Renal physiology. 2021 06; 320(6):F1080-F1092. doi: 10.1152/ajprenal.00084.2021. [PMID: 33969697]
  • Anett Hudák, Annamária Letoha, László Szilák, Tamás Letoha. Contribution of Syndecans to the Cellular Entry of SARS-CoV-2. International journal of molecular sciences. 2021 May; 22(10):. doi: 10.3390/ijms22105336. [PMID: 34069441]
  • Sang Ho Park, Haley Siddiqi, Daniela V Castro, Anna A De Angelis, Aaron L Oom, Charlotte A Stoneham, Mary K Lewinski, Alex E Clark, Ben A Croker, Aaron F Carlin, John Guatelli, Stanley J Opella. Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity. PLoS pathogens. 2021 05; 17(5):e1009519. doi: 10.1371/journal.ppat.1009519. [PMID: 34003853]
  • Benjamin J Buckley, Ashraf Aboelela, Hiwa Majed, Richard S Bujaroski, Karen L White, Andrew K Powell, Wen Wang, Kasiram Katneni, Jessica Saunders, David M Shackleford, Susan A Charman, Gregory M Cook, Michael J Kelso, Marie Ranson. Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride. Bioorganic & medicinal chemistry. 2021 05; 37(?):116116. doi: 10.1016/j.bmc.2021.116116. [PMID: 33799173]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Niklas Ayasse, Peder Berg, Jesper Frank Andersen, Samuel Levi Svendsen, Mads V Sørensen, Natalya U Fedosova, I Jeanette Lynch, Charles S Wingo, Jens Leipziger. Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases. American journal of physiology. Renal physiology. 2021 04; 320(4):F596-F607. doi: 10.1152/ajprenal.00444.2020. [PMID: 33554781]
  • Salvatore Blair, Xiuju Li, Debajyoti Dutta, Danuta Chamot, Larry Fliegel, Greg Goss. Rainbow Trout (Oncorhynchus mykiss) Na+/H+ Exchangers tNhe3a and tNhe3b Display Unique Inhibitory Profiles Dissimilar from Mammalian NHE Isoforms. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22042205. [PMID: 33672216]
  • Mandakini Shinde, Kishor Kale, Keshav Kumar, Divya Ottoor. Effect of quercetin on the amiloride-bovine serum albumin interaction using spectroscopic methods, molecular docking and chemometric approaches. Luminescence : the journal of biological and chemical luminescence. 2021 Feb; 36(1):129-141. doi: 10.1002/bio.3926. [PMID: 32725694]
  • Niklas Ayasse, Peder Berg, Jens Leipziger, Mads Vaarby Sørensen. ENaC expression correlates with the acute furosemide-induced K+ excretion. Physiological reports. 2021 01; 9(1):e14668. doi: 10.14814/phy2.14668. [PMID: 33410279]
  • Wen Shen, Mohammed Alshehri, Sameer Desale, Christopher Wilcox. The Effect of Amiloride on Proteinuria in Patients with Proteinuric Kidney Disease. American journal of nephrology. 2021; 52(5):368-377. doi: 10.1159/000515809. [PMID: 33957621]
  • Yi Xiao, Anja Rabien, René Buschow, Vyacheslav Amtislavskiy, Jonas Busch, Ergin Kilic, Sonia L Villegas, Bernd Timmermann, Moritz Schütte, Thorsten Mielke, Marie-Laure Yaspo, Klaus Jung, David Meierhofer. Endocytosis-Mediated Replenishment of Amino Acids Favors Cancer Cell Proliferation and Survival in Chromophobe Renal Cell Carcinoma. Cancer research. 2020 12; 80(24):5491-5501. doi: 10.1158/0008-5472.can-20-1998. [PMID: 33115803]
  • Francisca Crislândia Oliveira Silva, Jane Eire Silva Alencar de Menezes, Maria Kueirislene Amâncio Ferreira, Antonio Wlisses da Silva, Carlos Leone Alves Holanda, Joyce Dos Reis Lima, Adriana Rolim Campos, Francisco Flávio Vasconcelos Evaristo, Edson Holanda Teixeira, Francisco Ernani Alves Magalhães, Paulo Nogueira Bandeira, Hélcio Silva Dos Santos. Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio). Biochemical and biophysical research communications. 2020 12; 533(3):362-367. doi: 10.1016/j.bbrc.2020.07.107. [PMID: 32962857]
  • Marc A Egerman, Jenny S Wong, Tian Runxia, Gohar Mosoyan, Kinsuk Chauhan, Joselyn Reyes-Bahamonde, Nanditha Anandakrishnan, Nicholas J Wong, Emilia Bagiella, Fadi Salem, Kristin Meliambro, Hong Li, Evren U Azeloglu, Steven G Coca, Kirk N Campbell, Leopoldo Raij. Plasminogenuria is associated with podocyte injury, edema, and kidney dysfunction in incident glomerular disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 12; 34(12):16191-16204. doi: 10.1096/fj.202000413r. [PMID: 33070369]
  • Venkata S Mandala, Matthew J McKay, Alexander A Shcherbakov, Aurelio J Dregni, Antonios Kolocouris, Mei Hong. Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers. Nature structural & molecular biology. 2020 12; 27(12):1202-1208. doi: 10.1038/s41594-020-00536-8. [PMID: 33177698]
  • Henrik Andersen, Maria Høj Hansen, Kristian B Buhl, Mette Stæhr, Ulla G Friis, Camilla Enggaard, Shanya Supramaniyam, Ida K Lund, Per Svenningsen, Pernille B L Hansen, Boye L Jensen. Plasminogen Deficiency and Amiloride Mitigate Angiotensin II-Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel. Journal of the American Heart Association. 2020 12; 9(23):e016387. doi: 10.1161/jaha.120.016387. [PMID: 33215566]
  • Mir S Adil, S Priya Narayanan, Payaningal R Somanath. Is amiloride a promising cardiovascular medication to persist in the COVID-19 crisis?. Drug discoveries & therapeutics. 2020 Nov; 14(5):256-258. doi: 10.5582/ddt.2020.03070. [PMID: 33116037]
  • Anindit Mukherjee, Kelvin D MacDonald, Jeonghwan Kim, Michael I Henderson, Yulia Eygeris, Gaurav Sahay. Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis-based cell and mice models. Science advances. 2020 11; 6(47):. doi: 10.1126/sciadv.abc5911. [PMID: 33208364]
  • Caitlin Baumer-Harrison, Martin A Raymond, Thomas A Myers, Kolbe M Sussman, Spencer T Rynberg, Amanda P Ugartechea, Dean Lauterbach, Thomas G Mast, Joseph M Breza. Optogenetic Stimulation of Type I GAD65+ Cells in Taste Buds Activates Gustatory Neurons and Drives Appetitive Licking Behavior in Sodium-Depleted Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 10; 40(41):7795-7810. doi: 10.1523/jneurosci.0597-20.2020. [PMID: 32878902]
  • Luísa Nathália Bolda Mariano, Thaise Boeing, Valdir Cechinel-Filho, Rivaldo Niero, Luisa Mota da Silva, Priscila de Souza. The acute diuretic effects with low-doses of natural prenylated xanthones in rats. European journal of pharmacology. 2020 Oct; 884(?):173432. doi: 10.1016/j.ejphar.2020.173432. [PMID: 32745607]
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