Carboxin (BioDeep_00000002334)

 

Secondary id: BioDeep_00000419514

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide

化学式: C12H13NO2S (235.0667)
中文名称: 甲醇中萎锈灵溶液
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 83.85%

分子结构信息

SMILES: CC1=C(C(=O)Nc2ccccc2)SCCO1
InChI: InChI=1S/C12H13NO2S/c1-9-11(16-8-7-15-9)12(14)13-10-5-3-2-4-6-10/h2-6H,7-8H2,1H3,(H,13,14)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 456; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8170; ORIGINAL_PRECURSOR_SCAN_NO 8169
CONFIDENCE standard compound; INTERNAL_ID 456; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8163; ORIGINAL_PRECURSOR_SCAN_NO 8162
CONFIDENCE standard compound; INTERNAL_ID 456; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8129; ORIGINAL_PRECURSOR_SCAN_NO 8127
CONFIDENCE standard compound; INTERNAL_ID 456; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8224; ORIGINAL_PRECURSOR_SCAN_NO 8222
CONFIDENCE standard compound; INTERNAL_ID 456; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8211; ORIGINAL_PRECURSOR_SCAN_NO 8210
CONFIDENCE standard compound; INTERNAL_ID 456; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8221; ORIGINAL_PRECURSOR_SCAN_NO 8218
D016573 - Agrochemicals
D010575 - Pesticides
Carboxin (Carboxine) is a systemic agricultural fungicide and seed protectant.

同义名列表

15 个代谢物同义名

2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide; 5,6-Dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide; 2,3-Dihydro-6-methyl-5-phenylcarbamoyl-1,4-oxathiin; 5,6-Dihydro-2-methyl-3-carboxanilido-1,4-oxathiin; 2,3-Dihydro-6-methyl-1,4-oxathiin-5-carboxanilide; 5-Carboxanilido-2,3-dihydro-6-methyl-1,4-oxathiin; 2,3-Dihydro-5-carboxanilido-6-methyl-1,4-oxathiin; 5,6-Dihydro-2-methyl-1,4-oxathiin-3-carboxanilide; Carbathiin; Carboxine; CARBOXIN; Vitavax; Oxatin; Fenoxan; Carboxin



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AXIN2, CAT, CDKN1A, CRYZ, GAPDH, NLRP7, NQO1, TUBB4B
Peripheral membrane protein 4 HSD17B6, NDUFA5, SDHA, SDHB
Endoplasmic reticulum membrane 1 HMGCR
Nucleus 6 AXIN2, CBX1, CDKN1A, GAPDH, NQO1, TUBB4B
cytosol 7 AXIN2, CAT, CDKN1A, CRYZ, GAPDH, NQO1, TUBB4B
dendrite 1 NQO1
mitochondrial membrane 1 SDHB
nuclear body 2 CBX1, CDKN1A
centrosome 1 AXIN2
nucleoplasm 5 ATP2B1, CBX1, CD2, CDKN1A, SDHB
Cell membrane 2 ATP2B1, CD2
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 5 ATP2B1, HMGCR, MT-CYB, SDHC, SDHD
Synapse 3 ATP2B1, NQO1, TAC1
cell surface 1 CD2
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 CD2
mitochondrial inner membrane 6 MT-CYB, NDUFA5, SDHA, SDHB, SDHC, SDHD
neuronal cell body 2 NQO1, TAC1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 2 GAPDH, NQO1
plasma membrane 5 ATP2B1, AXIN2, CD2, GAPDH, SDHB
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ATP2B1, CAT, GAPDH, HMGCR, MT-CYB, NQO1, SDHC
axon 1 TAC1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ATP2B1, CAT, CRYZ, GAPDH, TUBB4B
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HMGCR, HSD17B6
extracellular space 1 TAC1
perinuclear region of cytoplasm 2 CDKN1A, GAPDH
mitochondrion 8 CAT, CRYZ, MT-CYB, NDUFA5, SDHA, SDHB, SDHC, SDHD
protein-containing complex 3 CAT, CD2, CDKN1A
intracellular membrane-bounded organelle 5 ATP2B1, CAT, CBX1, GAPDH, HSD17B6
Microsome membrane 1 HSD17B6
pericentric heterochromatin 1 CBX1
Single-pass type I membrane protein 1 CD2
extracellular region 4 CAT, CD2, TAC1, TUBB4B
cytoplasmic side of plasma membrane 1 CD2
mitochondrial matrix 3 CAT, SDHA, SDHB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 GAPDH
external side of plasma membrane 1 CD2
Extracellular vesicle 1 TUBB4B
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 2 GAPDH, TUBB4B
nucleolus 2 CDKN1A, SDHA
cell-cell junction 1 CD2
vesicle 1 GAPDH
Cytoplasm, perinuclear region 1 GAPDH
Mitochondrion inner membrane 6 MT-CYB, NDUFA5, SDHA, SDHB, SDHC, SDHD
Matrix side 3 NDUFA5, SDHA, SDHB
heterochromatin 1 CBX1
Cytoplasm, cytoskeleton 2 GAPDH, TUBB4B
focal adhesion 1 CAT
microtubule 1 TUBB4B
spindle 1 CBX1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
lateral plasma membrane 1 ATP2B1
chromatin 1 CBX1
cell projection 1 ATP2B1
mitotic spindle 1 TUBB4B
cytoskeleton 2 GAPDH, TUBB4B
chromosome, telomeric region 1 CBX1
Basolateral cell membrane 1 ATP2B1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
Lipid droplet 1 GAPDH
axonemal microtubule 1 TUBB4B
Presynaptic cell membrane 1 ATP2B1
Peroxisome membrane 1 HMGCR
respiratory chain complex I 1 NDUFA5
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
azurophil granule lumen 1 TUBB4B
mitochondrial envelope 1 SDHD
respiratory chain complex II (succinate dehydrogenase) 4 SDHA, SDHB, SDHC, SDHD
immunological synapse 1 ATP2B1
chromosome, centromeric region 1 CBX1
respiratory chain complex III 1 MT-CYB
ribonucleoprotein complex 1 GAPDH
female pronucleus 1 CBX1
male pronucleus 1 CBX1
chromocenter 1 CBX1
GAIT complex 1 GAPDH
site of DNA damage 1 CBX1
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1
PCNA-p21 complex 1 CDKN1A


文献列表

  • Dongmei Wei, Xiaohu Wu, Mingshan Ji, Jun Xu, Fengshou Dong, Xingang Liu, Yongquan Zheng. Carboxin and its major metabolites residues in peanuts: Levels, dietary intake and chronic intake risk assessment. Food chemistry. 2019 Mar; 275(?):169-175. doi: 10.1016/j.foodchem.2018.09.087. [PMID: 30724184]
  • Zi-Li Ren, Hao Liu, Di Jiao, Hao-Tian Hu, Wei Wang, Jie-Xiu Gong, Ai-Li Wang, Hai-Qun Cao, Xian-Hai Lv. Design, synthesis, and antifungal activity of novel cinnamon-pyrazole carboxamide derivatives. Drug development research. 2018 09; 79(6):307-312. doi: 10.1002/ddr.21469. [PMID: 30256430]
  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • S V Vozniuk, L V Tytova, O V Ratushinska, G O Iutynska. [FORMATION AND FUNCTIONING OF SYMBIOTIC SYSTEMS AND RHIZOSPHERE MICROBIOCENISIS OF SOYBEAN UNDER VARIOUS FUNGICIDES APPLICATION]. Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993). 2016 Jul; 78(4):59-70. doi: 10.15407/microbiolj78.04.059. [PMID: 30653880]
  • Masayuki Kimura, Sayaka Mizukami, Yousuke Watanabe, Yasuko Hasegawa-Baba, Nobuhiko Onda, Toshinori Yoshida, Makoto Shibutani. Disruption of spindle checkpoint function in rats following 28 days of repeated administration of renal carcinogens. The Journal of toxicological sciences. 2016 Feb; 41(1):91-104. doi: 10.2131/jts.41.91. [PMID: 26763396]
  • Jiajia Yu, Yafen Zhang, Haifeng Cui, Peng Hu, Xiaoping Yu, Zihong Ye. An efficient genetic manipulation protocol for Ustilago esculenta. FEMS microbiology letters. 2015 Jun; 362(12):fnv087. doi: 10.1093/femsle/fnv087. [PMID: 26038251]
  • Md Asad-Uz-Zaman, Mohammad Rejwan Bhuiyan, Mohammad Ashik Iqbal Khan, Md Khurshed Alam Bhuiyan, Mohammad Abdul Latif. Integrated options for the management of black root rot of strawberry caused by Rhizoctonia solani Kuhn. Comptes rendus biologies. 2015 Feb; 338(2):112-20. doi: 10.1016/j.crvi.2014.11.006. [PMID: 25595298]
  • R B Singh, H K Singh, Arpita Parmar. Yield loss assessment due to Alternaria blight and its management in linseed. Pakistan journal of biological sciences : PJBS. 2014 Apr; 17(4):511-6. doi: 10.3923/pjbs.2014.511.516. [PMID: 25911838]
  • Pierre Leroux, Michel Gredt, Florent Remuson, Annie Micoud, Anne-Sophie Walker. Fungicide resistance status in French populations of the wheat eyespot fungi Oculimacula acuformis and Oculimacula yallundae. Pest management science. 2013 Jan; 69(1):15-26. doi: 10.1002/ps.3408. [PMID: 23073993]
  • Martin Schuster, Steffi Treitschke, Sreedhar Kilaru, Justin Molloy, Nicholas J Harmer, Gero Steinberg. Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase. The EMBO journal. 2012 Jan; 31(1):214-27. doi: 10.1038/emboj.2011.361. [PMID: 22027862]
  • Gabriel Scalliet, Judith Bowler, Torsten Luksch, Lucy Kirchhofer-Allan, Diana Steinhauer, Keith Ward, Michael Niklaus, Andreas Verras, Michael Csukai, Antoine Daina, Raymonde Fonné-Pfister. Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola. PloS one. 2012; 7(4):e35429. doi: 10.1371/journal.pone.0035429. [PMID: 22536383]
  • Gero Steinberg. Cytoplasmic fungal lipases release fungicides from ultra-deformable vesicular drug carriers. PloS one. 2012; 7(5):e38181. doi: 10.1371/journal.pone.0038181. [PMID: 22666476]
  • Alberto Elías-Villalobos, Alfonso Fernández-Álvarez, José I Ibeas. The general transcriptional repressor Tup1 is required for dimorphism and virulence in a fungal plant pathogen. PLoS pathogens. 2011 Sep; 7(9):e1002235. doi: 10.1371/journal.ppat.1002235. [PMID: 21909277]
  • Y N Yin, Y K Kim, C L Xiao. Molecular characterization of boscalid resistance in field isolates of Botrytis cinerea from apple. Phytopathology. 2011 Aug; 101(8):986-95. doi: 10.1094/phyto-01-11-0016. [PMID: 21469935]
  • Alma Djulic, Annette Schmid, Heike Lenz, Pia Sharma, Christin Koch, Stefan G R Wirsel, Ralf T Voegele. Transient transformation of the obligate biotrophic rust fungus Uromyces fabae using biolistics. Fungal biology. 2011 Jul; 115(7):633-42. doi: 10.1016/j.funbio.2011.03.007. [PMID: 21724169]
  • Jong H Kim, Kathleen L Chan, Noreen Mahoney, Bruce C Campbell. Antifungal activity of redox-active benzaldehydes that target cellular antioxidation. Annals of clinical microbiology and antimicrobials. 2011 May; 10(?):23. doi: 10.1186/1476-0711-10-23. [PMID: 21627838]
  • Claire J Knight, Andy M Bailey, Gary D Foster. Investigating Agrobacterium-mediated transformation of Verticillium albo-atrum on plant surfaces. PloS one. 2010 Oct; 5(10):e13684. doi: 10.1371/journal.pone.0013684. [PMID: 21060684]
  • Judith Bowler, Eileen Scott, Ravi Tailor, Gabriel Scalliet, John Ray, Michael Csukai. New capabilities for Mycosphaerella graminicola research. Molecular plant pathology. 2010 Sep; 11(5):691-704. doi: 10.1111/j.1364-3703.2010.00629.x. [PMID: 20696006]
  • Yun Mi Lee, Jae Sun Moon, Bong-Sik Yun, Ki Duk Park, Gyung Ja Choi, Jin-Cheol Kim, Sang Han Lee, Sung Uk Kim. Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi. Journal of agricultural and food chemistry. 2009 Jul; 57(13):5750-5. doi: 10.1021/jf900674y. [PMID: 19566082]
  • Gunther Doehlemann, Karina van der Linde, Daniela Assmann, Daniela Schwammbach, Alexander Hof, Amitabh Mohanty, David Jackson, Regine Kahmann. Pep1, a secreted effector protein of Ustilago maydis, is required for successful invasion of plant cells. PLoS pathogens. 2009 Feb; 5(2):e1000290. doi: 10.1371/journal.ppat.1000290. [PMID: 19197359]
  • Neil C Glynn, Martin C Hare, Simon G Edwards. Fungicide seed treatment efficacy against Microdochium nivale and M. majus in vitro and in vivo. Pest management science. 2008 Aug; 64(8):793-9. doi: 10.1002/ps.1558. [PMID: 18338339]
  • H F Avenot, A Sellam, G Karaoglanidis, T J Michailides. Characterization of mutations in the iron-sulphur subunit of succinate dehydrogenase correlating with Boscalid resistance in Alternaria alternata from California pistachio. Phytopathology. 2008 Jun; 98(6):736-42. doi: 10.1094/phyto-98-6-0736. [PMID: 18944299]
  • H Kurzawińska, S Mazur. The effect of Pythium oligandrum and chitosan used in control of potato against late blight and the occurrence of fungal diseases on tuber peel. Communications in agricultural and applied biological sciences. 2007; 72(4):967-71. doi: . [PMID: 18396836]
  • M Sajid Aqeel Ahmad, F Javed, M Ashraf, F Y Hafeez. Effect of fungicide seed treatments on N2-fixation and nodulation in pea, Pisum sativum L. Bulletin of environmental contamination and toxicology. 2006 Dec; 77(6):896-904. doi: 10.1007/s00128-006-1229-y. [PMID: 17219311]
  • J H Kim, B C Campbell, N Mahoney, K L Chan, G S May. Targeting antioxidative signal transduction and stress response system: control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function. Journal of applied microbiology. 2006 Jul; 101(1):181-9. doi: 10.1111/j.1365-2672.2006.02882.x. [PMID: 16834605]
  • Jong H Kim, Noreen Mahoney, Kathleen L Chan, Russell J Molyneux, Bruce C Campbell. Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds. Applied microbiology and biotechnology. 2006 May; 70(6):735-9. doi: 10.1007/s00253-005-0123-6. [PMID: 16463173]
  • Li-shar Huang, Gang Sun, David Cobessi, Andy C Wang, John T Shen, Eric Y Tung, Vernon E Anderson, Edward A Berry. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. The Journal of biological chemistry. 2006 Mar; 281(9):5965-72. doi: 10.1074/jbc.m511270200. [PMID: 16371358]
  • S M Fichtner, T Isakeit, T A Wheeler, H W Kaufman, J R Gannaway. Evaluation of Several Approaches to Manage Meloidogyne incognita and Cotton Seedling Disease Complexes in the High Plains of Texas. Journal of nematology. 2005 Mar; 37(1):66-70. doi: . [PMID: 19262844]
  • J Hysek, M Vach, M Javurek. Biological protection of the main cereals against fungal specific diseases. Communications in agricultural and applied biological sciences. 2005; 70(3):169-73. doi: . [PMID: 16637172]
  • Christopher N Topp, José Ruiz-Herrera, Alfredo D Martínez-Espinoza, Scott E Gold. Integration of the gene for carboxin resistance does not impact the Ustilago maydis-maize interaction. Current microbiology. 2002 Jan; 44(1):67-70. doi: 10.1007/s00284-001-0076-7. [PMID: 11727044]
  • M Henselová, D Hudecová. Differences in the microflora of scarified and unscarified seeds of Karwinskia humboldtiana (Rhamnaceae). Folia microbiologica. 2001; 46(6):543-8. doi: 10.1007/bf02818000. [PMID: 11898346]
  • M Kojic, W K Holloman. Shuttle vectors for genetic manipulations in Ustilago maydis. Canadian journal of microbiology. 2000 Apr; 46(4):333-8. doi: 10.1139/w00-002. [PMID: 10779869]
  • J P Keon, J W Owen, J A Hargreaves. Lack of evidence for antisense suppression in the fungal plant pathogen Ustilago maydis. Antisense & nucleic acid drug development. 1999 Feb; 9(1):101-4. doi: 10.1089/oli.1.1999.9.101. [PMID: 10192295]
  • A A Nomeir, M F McComish, N F Ferrala, D Silveira, J M Covey, M Chadwick. Liquid chromatographic analysis in mouse, dog and human plasma; stability, absorption, metabolism and pharmacokinetics of the anti-HIV agent 2-chloro-5-(2-methyl-5,6-dihydro-1,4-oxathiin-3-yl carboxamido) isopropylbenzoate (NSC 615985, UC84). Journal of pharmaceutical and biomedical analysis. 1998 May; 17(1):27-38. doi: 10.1016/s0731-7085(97)00159-3. [PMID: 9608423]
  • T Joseph-Horne, P M Wood, C K Wood, A L Moore, J Headrick, D Hollomon. Characterization of a split respiratory pathway in the wheat "take-all" fungus, Gaeumannomyces graminis var. tritici. The Journal of biological chemistry. 1998 May; 273(18):11127-33. doi: 10.1074/jbc.273.18.11127. [PMID: 9556599]
  • A C Udeogalanya. The rate of penetration of leaf tissues by the systemic fungicides benodanil (2-iodobenzanilide) and oxycarboxin (2,3-dihydro-6 methyl-5 phenylcarbamoyl-1,4-oxathin-4,4-dioxide). Beitrage zur tropischen Landwirtschaft und Veterinarmedizin. 1984; 22(1):91-4. doi: . [PMID: 6732737]
  • N Balicka, M Stankiewicz, Z Zukowska. Effect of oxafun on the antibiosis between Bacillus subtilis and Phoma betae. Acta microbiologica Polonica. 1983; 32(2):185-9. doi: ". [PMID: 6196950]
  • D A Day, G P Arron, G C Laties. The effect of carboxins on higher plant mitochondria. FEBS letters. 1978 Jan; 85(1):99-102. doi: 10.1016/0014-5793(78)81257-5. [PMID: 620796]
  • T Schewe, C Hiebsch. [Action of respiratory inhibitors on the electron transport system of Escherichia coli]. Acta biologica et medica Germanica. 1977; 36(7-8):961-6. doi: . [PMID: 347849]