Sulfisoxazole (BioDeep_00000002005)

 

Secondary id: BioDeep_00000398997

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


4-amino-N-(dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide

化学式: C11H13N3O3S (267.0678)
中文名称: 磺胺二甲异噁唑, 磺胺二甲异唑
谱图信息: 最多检出来源 Homo sapiens(blood) 20.95%

分子结构信息

SMILES: CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3

描述信息

Sulfisoxazole is only found in individuals that have used or taken this drug. It is a short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. [PubChem]Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3072; ORIGINAL_PRECURSOR_SCAN_NO 3068
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6520; ORIGINAL_PRECURSOR_SCAN_NO 6519
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3077; ORIGINAL_PRECURSOR_SCAN_NO 3073
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6493; ORIGINAL_PRECURSOR_SCAN_NO 6491
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6549; ORIGINAL_PRECURSOR_SCAN_NO 6547
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3096; ORIGINAL_PRECURSOR_SCAN_NO 3094
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3126; ORIGINAL_PRECURSOR_SCAN_NO 3125
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6542; ORIGINAL_PRECURSOR_SCAN_NO 6539
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6522; ORIGINAL_PRECURSOR_SCAN_NO 6521
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6555; ORIGINAL_PRECURSOR_SCAN_NO 6553
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3083; ORIGINAL_PRECURSOR_SCAN_NO 3080
CONFIDENCE standard compound; INTERNAL_ID 636; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3067; ORIGINAL_PRECURSOR_SCAN_NO 3065
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EB - Short-acting sulfonamides
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AB - Sulfonamides
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
CONFIDENCE standard compound; INTERNAL_ID 1013
Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].

同义名列表

75 个代谢物同义名

4-amino-N-(dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide; 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide; 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide; 5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole; 5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole; 5-(4-Aminophenylsulphonamido)-3,4-dimethylisoxazole; 5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole; N(1)-(3,4-Dimethyl-5-isoxazolyl)sulphanilamide; N(1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide; Sulfisoxazole, monosodium, monomesylate salt; N-(3,4)dimethylisoxazol-5-yl-sulphanilamide; N-(3,4)dimethylisoxazol-5-yl-sulfanilamide; 5-Sulphanilamido-3,4-dimethyl-isoxazole; 5-Sulfanilamido-3,4-dimethyl-isoxazole; 3,4-Dimethylisoxazole-5-sulphanilamide; 5-Sulphanilamido-3,4-dimethylisoxazole; Roche brand OF sulfisoxazole diolamine; 3,4-Dimethyl-5-sulphanilamidoisoxazole; 5-Sulfanilamido-3,4-dimethylisoxazole; 3,4-Dimethylisoxazole-5-sulfanilamide; 3,4-Dimethyl-5-sulfanilamidoisoxazole; Roche brand OF sulfisoxazole acetate; 3,4-Dimethyl-5-sulphonamidoisoxazole; 3,4-Dimethyl-5-sulfonamidoisoxazole; Sulfisoxazole, triammonium salt; Sulfisoxazole, monolithium salt; Vangard brand OF sulfisoxazole; Monolithium salt sulfisoxazole; Sulfisoxazole, monosodium salt; Triammonium salt sulfisoxazole; Monosodium salt sulfisoxazole; Zenith brand OF sulfisoxazole; Roche brand OF sulfisoxazole; Sulfisoxazole, ammonium salt; Ammonium salt sulfisoxazole; FNA brand OF sulfisoxazole; Sulfisoxazole roche brand; Diolamine, sulfisoxazole; Sulfisoxazole dialamine; Sulphadimethylisoxazole; Sulfisoxazole diolamine; Sulfadimethylisoxazole; Pediatric, gantrisin; Sulfadimethyloxazole; Gantrisin pediatric; Sulfafurazol fna; Sulphaisoxazole; Sulphafurazolum; Sulphisonazole; Sulphisoxazole; Sulfaisoxazole; Sulphofurazole; Sulphisoxasole; Sulfafurazolum; Sulphasoxazole; Sulphafurazole; Sulfisonazole; sulfisoxazole; Sulfasoxizole; Sulphafurazol; Sulfasoxazole; Sulfafurazole; Sulfofurazole; Sulphisoxazol; Sulfisoxasole; Sulfafurazol; Sulfisoxazol; Gantrisin; Neoxazoi; TL Azole; TL-Azole; ganda; V-Sul; V Sul; Sulfisoxazole



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AIDA, ALB, CDK2AP1, DHFR, ERBB2, IREB2, ODC1, SAT2, STH
Peripheral membrane protein 1 CYP27A1
Endosome membrane 1 ERBB2
Mitochondrion membrane 1 CYP27A1
Nucleus 5 ALB, CDK2AP1, ERBB2, SPI1, STH
cytosol 9 ALB, CDK2AP1, DHFR, ERBB2, IREB2, LIPE, ODC1, STH, STX1A
dendrite 2 PCDH8, SAT2
centrosome 1 ALB
nucleoplasm 4 CDK2AP1, ERBB2, SPI1, STH
Cell membrane 5 ERBB2, LIPE, PCDH8, SAT2, STX1A
lamellipodium 1 STX2
ruffle membrane 1 ERBB2
Multi-pass membrane protein 1 SAT2
glutamatergic synapse 1 PCDH8
Golgi apparatus 2 ALB, STH
mitochondrial inner membrane 1 CYP27A1
neuromuscular junction 1 ERBB2
neuronal cell body 1 SAT2
presynaptic membrane 2 ERBB2, PCDH8
sarcolemma 1 SAT2
synaptic vesicle 2 STX1A, STX2
Cytoplasm, cytosol 1 LIPE
plasma membrane 5 ERBB2, PCDH8, SAT2, STX1A, STX2
synaptic vesicle membrane 1 STX1A
Membrane 5 AIDA, ERBB2, LIPE, SPI1, STX2
apical plasma membrane 1 ERBB2
axon 2 SAT2, STX1A
basolateral plasma membrane 2 ERBB2, STX2
brush border 1 SAT2
caveola 1 LIPE
extracellular exosome 2 ALB, SAT2
endoplasmic reticulum 1 ALB
extracellular space 3 ALB, BMP8B, STX2
perinuclear region of cytoplasm 3 CDK2AP1, ERBB2, STH
Schaffer collateral - CA1 synapse 1 PCDH8
mitochondrion 3 CYP27A1, DHFR, IREB2
protein-containing complex 2 ALB, STX2
intracellular membrane-bounded organelle 1 STX2
Single-pass type I membrane protein 2 ERBB2, PCDH8
Secreted 3 ALB, BMP8B, PRB1
extracellular region 4 ALB, ERBB2, PRB1, STX1A
[Isoform 2]: Secreted 1 STX1A
mitochondrial matrix 1 CYP27A1
anchoring junction 1 ALB
transcription regulator complex 1 SPI1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 STX1A
nuclear membrane 1 STX1A
cytoplasmic vesicle 1 ERBB2
Early endosome 1 ERBB2
postsynaptic membrane 1 PCDH8
presynaptic active zone membrane 2 STX1A, STX2
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Mitochondrion inner membrane 1 CYP27A1
receptor complex 1 ERBB2
neuron projection 1 STX1A
ciliary basal body 1 ALB
chromatin 2 CDK2AP1, SPI1
Chromosome 1 CDK2AP1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Endomembrane system 2 STX1A, STX2
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cell projection, dendrite 1 PCDH8
myelin sheath 1 ERBB2
basal plasma membrane 1 ERBB2
SNARE complex 2 STX1A, STX2
endoplasmic reticulum lumen 1 ALB
platelet alpha granule lumen 1 ALB
NuRD complex 1 CDK2AP1
Single-pass type IV membrane protein 1 STX1A
semaphorin receptor complex 1 ERBB2
Synapse, synaptosome 1 STX1A
[Isoform 1]: Cell membrane 1 ERBB2
ERBB3:ERBB2 complex 1 ERBB2
ciliary transition fiber 1 ALB
synaptobrevin 2-SNAP-25-syntaxin-1a complex 1 STX1A


文献列表

  • Hyun-Ju Song, Dong Chan Moon, Su-Jeong Kim, Abraham Fikru Mechesso, Ji-Hyun Choi, Naila Boby, Hee Young Kang, Seok-Hyeon Na, Soon-Seek Yoon, Suk-Kyung Lim. Antimicrobial Resistance Profiles and Molecular Characteristics of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Healthy Cattle and Pigs in Korea. Foodborne pathogens and disease. 2023 01; 20(1):7-16. doi: 10.1089/fpd.2022.0051. [PMID: 36577050]
  • Biao Tang, Jiang Chang, Yifei Chen, Jiahui Lin, Xingning Xiao, Xiaodong Xia, Jun Lin, Hua Yang, Guoping Zhao. Escherichia fergusonii, an Underrated Repository for Antimicrobial Resistance in Food Animals. Microbiology spectrum. 2022 02; 10(1):e0161721. doi: 10.1128/spectrum.01617-21. [PMID: 35138151]
  • Bai Wei, Ke Shang, Se-Yeoun Cha, Jun-Feng Zhang, Hyung-Kwan Jang, Min Kang. Clonal dissemination of Salmonella enterica serovar albany with concurrent resistance to ampicillin, chloramphenicol, streptomycin, sulfisoxazole, tetracycline, and nalidixic acid in broiler chicken in Korea. Poultry science. 2021 Jul; 100(7):101141. doi: 10.1016/j.psj.2021.101141. [PMID: 34089935]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ayanna Glaize, Eduardo Gutierrez-Rodriguez, Irene Hanning, Sandra Díaz-Sánchez, Chris Gunter, Arnoud H M van Vliet, Wes Watson, Siddhartha Thakur. Transmission of antimicrobial resistant non-O157 Escherichia coli at the interface of animal-fresh produce in sustainable farming environments. International journal of food microbiology. 2020 Apr; 319(?):108472. doi: 10.1016/j.ijfoodmicro.2019.108472. [PMID: 31901751]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Cynthia N Schreiner, Charles E Ahlfors, Ronald J Wong, David K Stevenson, Diana F Clarke, Mark Mirochnick. In Vitro Study on the Effect of Maraviroc or Dolutegravir on Bilirubin to Albumin Binding. The Pediatric infectious disease journal. 2018 09; 37(9):908-909. doi: 10.1097/inf.0000000000002011. [PMID: 29561509]
  • Zuhal Alim, Deryanur Kilic, Zeynep Koksal, Sukru Beydemir, Hasan Ozdemir. Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1. Journal of biochemical and molecular toxicology. 2017 Oct; 31(10):. doi: 10.1002/jbt.21950. [PMID: 28665493]
  • Kyungsoo Oh, Moon-Chang Baek, Wonku Kang. Quantitative determination of sulfisoxazole and its three N-acetylated metabolites using HPLC-MS/MS, and the saturable pharmacokinetics of sulfisoxazole in mice. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 129(?):332-338. doi: 10.1016/j.jpba.2016.07.029. [PMID: 27454084]
  • Eunyoung Kim, Wonku Kang. Simultaneous determination of N(1)-acetyl sulfisoxazole and its metabolites, and relative bioavailability compare to sulfisoxazole in rats. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 129(?):117-120. doi: 10.1016/j.jpba.2016.06.055. [PMID: 27423008]
  • Janine T Bossé, Yanwen Li, Stephanie Walker, Tom Atherton, Roberto Fernandez Crespo, Susanna M Williamson, Jon Rogers, Roy R Chaudhuri, Lucy A Weinert, Olusegun Oshota, Matt T G Holden, Duncan J Maskell, Alexander W Tucker, Brendan W Wren, Andrew N Rycroft, Paul R Langford. Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae. The Journal of antimicrobial chemotherapy. 2015 Aug; 70(8):2217-22. doi: 10.1093/jac/dkv121. [PMID: 25957382]
  • Masahiro Sugino, Hitoshi Okada, Takashi Kusaka, Susumu Itoh. Evaluation of bilirubin displacement effect by acetaminophen in vitro. Annals of clinical biochemistry. 2015 Jul; 52(Pt 4):476-80. doi: 10.1177/0004563214567477. [PMID: 25525256]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Katherine F Smith, Michael J Yabsley, Susan Sanchez, Christine L Casey, Michael D Behrens, Sonia M Hernandez. Salmonella isolates from wild-caught Tokay geckos (Gekko gecko) imported to the U.S. from Indonesia. Vector borne and zoonotic diseases (Larchmont, N.Y.). 2012 Jul; 12(7):575-82. doi: 10.1089/vbz.2011.0899. [PMID: 22607081]
  • C A Haley, D A Dargatz, E J Bush, M M Erdman, P J Fedorka-Cray. Salmonella prevalence and antimicrobial susceptibility from the National Animal Health Monitoring System Swine 2000 and 2006 studies. Journal of food protection. 2012 Mar; 75(3):428-36. doi: 10.4315/0362-028x.jfp-11-363. [PMID: 22410214]
  • Collins Tabu, Robert F Breiman, Benjamin Ochieng, Barrack Aura, Leonard Cosmas, Allan Audi, Beatrice Olack, Godfrey Bigogo, Juliette R Ongus, Patricia Fields, Eric Mintz, Deron Burton, Joe Oundo, Daniel R Feikin. Differing burden and epidemiology of non-Typhi Salmonella bacteremia in rural and urban Kenya, 2006-2009. PloS one. 2012; 7(2):e31237. doi: 10.1371/journal.pone.0031237. [PMID: 22363591]
  • Philip Gardiner, Stuart W Paine. The impact of hepatic uptake on the pharmacokinetics of organic anions. Drug metabolism and disposition: the biological fate of chemicals. 2011 Oct; 39(10):1930-8. doi: 10.1124/dmd.111.039842. [PMID: 21778353]
  • Jin Hur, Ji Hee Kim, Jong Ho Park, Young-Ju Lee, John Hwa Lee. Molecular and virulence characteristics of multi-drug resistant Salmonella Enteritidis strains isolated from poultry. Veterinary journal (London, England : 1997). 2011 Sep; 189(3):306-11. doi: 10.1016/j.tvjl.2010.07.017. [PMID: 20822940]
  • Hanne Tegnander Soligard, Dag Bratlid, Chunyu Cao, Aihua Liang, Odd Georg Nilsen. Displacement of bilirubin from albumin in plasma from jaundiced newborns. An in vitro study of purified Chinese herbal constituents and sulfisoxazole. Phytotherapy research : PTR. 2011 Jul; 25(7):1068-72. doi: 10.1002/ptr.3402. [PMID: 21280114]
  • Jang-Gi Choi, Ok-Hwa Kang, Young-Seob Lee, Hee-Sung Chae, You-Chang Oh, Obiang-Obounou Brice, Min-San Kim, Dong-Hwan Sohn, Hun-Soo Kim, Hyun Park, Dong-Won Shin, Jung-Rae Rho, Dong-Yeul Kwon. In Vitro and In Vivo Antibacterial Activity of Punica granatum Peel Ethanol Extract against Salmonella. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):690518. doi: 10.1093/ecam/nep105. [PMID: 19687188]
  • S N Melendez, I Hanning, J Han, R Nayak, A R Clement, A Wooming, P Hererra, F T Jones, S L Foley, S C Ricke. Salmonella enterica isolates from pasture-raised poultry exhibit antimicrobial resistance and class I integrons. Journal of applied microbiology. 2010 Dec; 109(6):1957-66. doi: 10.1111/j.1365-2672.2010.04825.x. [PMID: 20722876]
  • NULL. Cholera outbreak --- Haiti, October 2010. MMWR. Morbidity and mortality weekly report. 2010 Nov; 59(43):1411. doi: NULL. [PMID: 21048563]
  • Paolo Ascenzi, Alessandro Bolli, Francesca Gullotta, Gabriella Fanali, Mauro Fasano. Drug binding to Sudlow's site I impairs allosterically human serum heme-albumin-catalyzed peroxynitrite detoxification. IUBMB life. 2010 Oct; 62(10):776-80. doi: 10.1002/iub.381. [PMID: 20979209]
  • Hanne T Soligard, Odd G Nilsen, Dag Bratlid. Displacement of bilirubin from albumin by ibuprofen in vitro. Pediatric research. 2010 Jun; 67(6):614-8. doi: 10.1203/pdr.0b013e3181da7578. [PMID: 20216106]
  • W Q Alali, H M Scott, B Norby. Assessing the similarity of antimicrobial resistance phenotypes among fecal Escherichia coli isolates from two aggregated occupational cohorts of humans versus swine using cluster analysis and multivariate statistics. Preventive veterinary medicine. 2010 Apr; 94(1-2):77-83. doi: 10.1016/j.prevetmed.2009.11.014. [PMID: 20022646]
  • M Aslam, K Stanford, T A McAllister. Characterization of antimicrobial resistance and seasonal prevalence of Escherichia coli O157:H7 recovered from commercial feedlots in Alberta, Canada. Letters in applied microbiology. 2010 Mar; 50(3):320-6. doi: 10.1111/j.1472-765x.2010.02798.x. [PMID: 20102509]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Yongli Zhang, Carl F Marrs, Carl Simon, Chuanwu Xi. Wastewater treatment contributes to selective increase of antibiotic resistance among Acinetobacter spp. The Science of the total environment. 2009 Jun; 407(12):3702-6. doi: 10.1016/j.scitotenv.2009.02.013. [PMID: 19321192]
  • Mohammad Jahangir Alam, David Renter, Ethel Taylor, Diana Mina, Rodney Moxley, David Smith. Antimicrobial susceptibility profiles of Salmonella enterica serotypes recovered from pens of commercial feedlot cattle using different types of composite samples. Current microbiology. 2009 Apr; 58(4):354-9. doi: 10.1007/s00284-008-9347-x. [PMID: 19219500]
  • Csaba Varga, Andrijana Rajić, Margaret E McFall, Richard J Reid-Smith, Anne E Deckert, Sylvia L Checkley, Scott A McEwen. Associations between reported on-farm antimicrobial use practices and observed antimicrobial resistance in generic fecal Escherichia coli isolated from Alberta finishing swine farms. Preventive veterinary medicine. 2009 Mar; 88(3):185-92. doi: 10.1016/j.prevetmed.2008.10.002. [PMID: 19041147]
  • Moussa S Diarra, Karine Giguère, François Malouin, Brigitte Lefebvre, Susan Bach, Pascal Delaquis, Mueen Aslam, Kim A Ziebell, Gabriel Roy. Genotype, serotype, and antibiotic resistance of sorbitol-negative Escherichia coli isolates from feedlot cattle. Journal of food protection. 2009 Jan; 72(1):28-36. doi: 10.4315/0362-028x-72.1.28. [PMID: 19205460]
  • Tomoko Uchino, Shamarendra N Sanyal, Motoko Yamabe, Toshihiko Kaku, Satoshi Takebayashi, Toru Shimaoka, Tatsuo Shimada, Takayuki Noguchi, Katsushige Ono. Rescue of pulmonary hypertension with an oral sulfonamide antibiotic sulfisoxazole by endothelin receptor antagonistic actions. Hypertension research : official journal of the Japanese Society of Hypertension. 2008 Sep; 31(9):1781-90. doi: 10.1291/hypres.31.1781. [PMID: 18971557]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Csaba Varga, Andrijana Rajić, Margaret E McFall, Brent P Avery, Richard J Reid-Smith, Anne Deckert, Sylvia L Checkley, Scott A McEwen. Antimicrobial resistance in generic Escherichia coli isolated from swine fecal samples in 90 Alberta finishing farms. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2008; 72(2):175-80. doi: . [PMID: 18505207]
  • Salina Parveen, Maryam Taabodi, Jurgen G Schwarz, Thomas P Oscar, Jeanine Harter-Dennis, David G White. Prevalence and antimicrobial resistance of Salmonella recovered from processed poultry. Journal of food protection. 2007 Nov; 70(11):2466-72. doi: 10.4315/0362-028x-70.11.2466. [PMID: 18044422]
  • F B O Santos, D H Dsouza, L Jaykus, P R Ferket, B W Sheldon. Genotypes, serotypes, and antibiotic resistance profiles of Salmonella isolated from commercial North Carolina turkey farms. Journal of food protection. 2007 Jun; 70(6):1328-33. doi: 10.4315/0362-028x-70.6.1328. [PMID: 17612059]
  • Charles E Ahlfors, Graham D Marshall, Duane K Wolcott, Don C Olson, Bart Van Overmeire. Measurement of unbound bilirubin by the peroxidase test using Zone Fluidics. Clinica chimica acta; international journal of clinical chemistry. 2006 Mar; 365(1-2):78-85. doi: 10.1016/j.cca.2005.07.030. [PMID: 16168977]
  • Ju-Yeon You, Bo-Mi Moon, In-Gyeong Oh, Byeong-Kirl Baek, Li-Guang Li, Byeong-Su Kim, Barry D Stein, John Hwa Lee. Antimicrobial resistance of Escherichia coli O157 from cattle in Korea. International journal of food microbiology. 2006 Jan; 106(1):74-8. doi: 10.1016/j.ijfoodmicro.2005.05.013. [PMID: 16300850]
  • Paolo Ascenzi, Alessio Bocedi, Stefania Notari, Enea Menegatti, Mauro Fasano. Heme impairs allosterically drug binding to human serum albumin Sudlow's site I. Biochemical and biophysical research communications. 2005 Aug; 334(2):481-6. doi: 10.1016/j.bbrc.2005.06.127. [PMID: 16004963]
  • V V Ebani, D Cerri, F Fratini, N Meille, P Valentini, E Andreani. Salmonella enterica isolates from faeces of domestic reptiles and a study of their antimicrobial in vitro sensitivity. Research in veterinary science. 2005 Apr; 78(2):117-21. doi: 10.1016/j.rvsc.2004.08.002. [PMID: 15563917]
  • Mark R Sannes, Michael A Kuskowski, James R Johnson. Antimicrobial resistance of Escherichia coli strains isolated from urine of women with cystitis or pyelonephritis and feces of dogs and healthy humans. Journal of the American Veterinary Medical Association. 2004 Aug; 225(3):368-73. doi: 10.2460/javma.2004.225.368. [PMID: 15328711]
  • Charles E Ahlfors. Effect of ibuprofen on bilirubin-albumin binding. The Journal of pediatrics. 2004 Mar; 144(3):386-8. doi: 10.1016/j.jpeds.2003.11.027. [PMID: 15001951]
  • Hisao Oka, Yuko Ito, Tomomi Goto, Tamae Minami, Isao Yamamoto, Hiroshi Matsumoto, Yoshihisa Mizuno, Masukiyo Tsuruta, Itsuki Hayashi. Survey of residual tetracycline antibiotics and sulfa drugs in kidneys of diseased animals in the Aichi Prefecture, Japan (1995-1999). Journal of AOAC International. 2003 May; 86(3):494-500. doi: 10.1093/jaoac/86.3.494. [PMID: 12852565]
  • J M McEvoy, A M Doherty, J J Sheridan, I S Blair, D A McDowell. The prevalence of Salmonella spp. in bovine faecal, rumen and carcass samples at a commercial abattoir. Journal of applied microbiology. 2003; 94(4):693-700. doi: 10.1046/j.1365-2672.2003.01898.x. [PMID: 12631205]
  • C Poppe, K Ziebell, L Martin, K Allen. Diversity in antimicrobial resistance and other characteristics among Salmonella typhimurium DT104 isolates. Microbial drug resistance (Larchmont, N.Y.). 2002; 8(2):107-22. doi: 10.1089/107662902760190653. [PMID: 12118515]
  • C E Ahlfors. Bilirubin-albumin binding and free bilirubin. Journal of perinatology : official journal of the California Perinatal Association. 2001 Dec; 21 Suppl 1(?):S40-2; discussion S59. doi: 10.1038/sj.jp.7210631. [PMID: 11803415]
  • C E Ahlfors. Unbound bilirubin associated with kernicterus: a historical approach. The Journal of pediatrics. 2000 Oct; 137(4):540-4. doi: 10.1067/mpd.2000.108566. [PMID: 11035835]
  • Rajiv Agarwal, J Christopher Gorski, Kimberly Sundblad, D Craig Brater. Urinary protein binding does not affect response to furosemide in patients with nephrotic syndrome. Journal of the American Society of Nephrology : JASN. 2000 Jun; 11(6):1100-1105. doi: 10.1681/asn.v1161100. [PMID: 10820174]
  • Y J Moon, S H Kim, C K Ryu, M G Lee. Factors influencing the protein binding of IQO4, a new isoquinolinedione derivative. Research communications in molecular pathology and pharmacology. 2000; 108(3-4):167-77. doi: NULL. [PMID: 11913709]
  • R H Dunlop, S A McEwen, A H Meek, R C Clarke, R M Friendship, W D Black, A N Sharpe. Measurement of antimicrobial-resistant Escherichia coli in pig feces with a hydrophobic grid membrane filter interpreter system. Applied and environmental microbiology. 1998 Jan; 64(1):366-9. doi: 10.1128/aem.64.1.366-369.1998. [PMID: 9435092]
  • D Brites, R Silva, A Brito. Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age. Scandinavian journal of clinical and laboratory investigation. 1997 Jul; 57(4):337-49. doi: 10.3109/00365519709099407. [PMID: 9249881]
  • J L Costela, R Carlos, M K Zamacona, R Jiménez, R Calvo. Interaction between propofol and sulfisoxazole in mice an in vivo and in vitro study. Research communications in molecular pathology and pharmacology. 1996 Jul; 93(1):89-100. doi: NULL. [PMID: 8865373]
  • H H Kim, M Samadpour, L Grimm, C R Clausen, T E Besser, M Baylor, J M Kobayashi, M A Neill, F D Schoenknecht, P I Tarr. Characteristics of antibiotic-resistant Escherichia coli O157:H7 in Washington State, 1984-1991. The Journal of infectious diseases. 1994 Dec; 170(6):1606-9. doi: 10.1093/infdis/170.6.1606. [PMID: 7996005]
  • B R Curtis, J G McFarland, G G Wu, G P Visentin, R H Aster. Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex. Blood. 1994 Jul; 84(1):176-83. doi: NULL. [PMID: 7517207]
  • W V Raszka, L P Skillman, P L McEvoy. In vitro susceptibility of clinical isolates of Mycobacterium avium and M. intracellulare to folate antagonists. Diagnostic microbiology and infectious disease. 1994 Mar; 18(3):201-4. doi: 10.1016/0732-8893(94)90092-2. [PMID: 7924214]
  • K A Kirchner, J R Voelker, D C Brater. Binding inhibitors restore furosemide potency in tubule fluid containing albumin. Kidney international. 1991 Sep; 40(3):418-24. doi: 10.1038/ki.1991.228. [PMID: 1724020]
  • M Bohdanecká, O Schück, V Reitschlägerová, J Sedivý. [Preclinical modeling of the possible effect of acute uremia on drug resorption in the gastrointestinal tract]. Casopis lekaru ceskych. 1990 Nov; 129(45):1431-3. doi: NULL. [PMID: 2249241]
  • P du Souich, R Calvo, S Erill. Effects of cefotaxime on the serum protein binding of sulfisoxazole. Biopharmaceutics & drug disposition. 1990 Jul; 11(5):371-9. doi: 10.1002/bdd.2510110502. [PMID: 2207291]
  • M Atef, S A Youssef, A Ramadan, M Issa. Ruminal excretion of sulfadimethoxine and sulfadimethyloxazole in goats and their influence on some enzyme activities and renal clearances. DTW. Deutsche tierarztliche Wochenschrift. 1990 May; 97(5):203-6. doi: NULL. [PMID: 2364891]
  • A Robertson, W Karp, R Brodersen. Comparison of the binding characteristics of serum albumins from various animal species. Developmental pharmacology and therapeutics. 1990; 15(2):106-11. doi: 10.1159/000457629. [PMID: 2078971]
  • M Bohdanecká, O Schück, V Reitschlägerová. [Preclinical possibilities of evaluating nonrenal elimination of drugs]. Ceskoslovenska fysiologie. 1990; 39(1):41-5. doi: NULL. [PMID: 2350796]
  • M Atef, S A Youssef, A Ramadan, M Issa. Kinetic disposition, systemic bioavailability, tissue levels and acetylation of some sulphonamides in goats. Archives internationales de pharmacodynamie et de therapie. 1989 Nov; 302(?):27-39. doi: NULL. [PMID: 2636822]
  • J P Kassirer, R I Kopelman. Interpreting negative test results. Hospital practice (Office ed.). 1989 Aug; 24(8):45, 48-9, 52 passim. doi: 10.1080/21548331.1989.11703761. [PMID: 2504740]
  • K Murata, K Tagawa, K Noda, M Samejima. Pharmacokinetic analysis of single- or multiple-dose plasma drug concentration data with a microcomputer using multi-fraction absorption models. Journal of pharmaceutical sciences. 1989 Feb; 78(2):154-9. doi: 10.1002/jps.2600780217. [PMID: 2715939]
  • T W Hansen, S Oyasaeter, T Stiris, D Bratlid. Effects of sulfisoxazole, hypercarbia, and hyperosmolality on entry of bilirubin and albumin into brain regions in young rats. Biology of the neonate. 1989; 56(1):22-30. doi: 10.1159/000242983. [PMID: 2503067]
  • D G Harle, B A Baldo, J V Wells. Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole. Molecular immunology. 1988 Dec; 25(12):1347-54. doi: 10.1016/0161-5890(88)90050-8. [PMID: 3237218]
  • K Hoppu, O Koskimies, J Vilska. Trimethoprim in the treatment of acute urinary tract infections in children. International journal of clinical pharmacology, therapy, and toxicology. 1988 Feb; 26(2):65-8. doi: NULL. [PMID: 3410587]
  • C A Gloff, R D Mamelok, L Z Benet. Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport. Pharmacology. 1988; 37(4):268-76. doi: 10.1159/000138476. [PMID: 3194444]
  • J Guerrero, M García-Morillas, B Gil-Extremera, S Erill. Serum protein binding of sulfisoxazole and diazepam in patients with chronic obstructive pulmonary disease. International journal of clinical pharmacology, therapy, and toxicology. 1987 May; 25(5):255-8. doi: NULL. [PMID: 3596851]
  • K Murata, K Noda, K Kohno, M Samejima. Pharmacokinetic analysis of concentration data of drugs with irregular absorption profiles using multi-fraction absorption models. Journal of pharmaceutical sciences. 1987 Feb; 76(2):109-13. doi: 10.1002/jps.2600760205. [PMID: 3572746]
  • B Irollo, B D Vu, D N Dai, J Yonger. Dissociation and association rate constants changes following bilirubin binding affinity decreases. Developmental pharmacology and therapeutics. 1987; 10(6):436-42. doi: 10.1159/000457775. [PMID: 3677971]
  • A Surjono, H Nakamura, T Matsuo. The effect of drugs on bilirubin-albumin binding capacity. The Kobe journal of medical sciences. 1986 Oct; 32(5):163-9. doi: NULL. [PMID: 3821018]
  • C E Ahlfors, S H Bennett, C T Shoemaker, W G Ellis, S L Davis, R P Wennberg, B W Goetzman. Changes in the auditory brainstem response associated with intravenous infusion of unconjugated bilirubin into infant rhesus monkeys. Pediatric research. 1986 Jun; 20(6):511-5. doi: 10.1203/00006450-198606000-00005. [PMID: 3714360]
  • F Ruiz-Cabello, S Erill. Serum protein binding of model acidic drugs in smokers and non-smokers. International journal of clinical pharmacology research. 1986; 6(3):177-9. doi: NULL. [PMID: 3744622]
  • M Shermantine, J Gambertoglio, W Amend, F Vincenti, S Oie. Pharmacokinetics of sulfisoxazole in renal transplant patients. Antimicrobial agents and chemotherapy. 1985 Oct; 28(4):535-9. doi: 10.1128/aac.28.4.535. [PMID: 3907496]
  • R J Wallace, J M Swenson, V A Silcox, M G Bullen. Treatment of nonpulmonary infections due to Mycobacterium fortuitum and Mycobacterium chelonei on the basis of in vitro susceptibilities. The Journal of infectious diseases. 1985 Sep; 152(3):500-14. doi: 10.1093/infdis/152.3.500. [PMID: 3875667]
  • C Dixon, R Bolivar, R Katz, M McMurtrey. Lipoid pneumonia and Mycobacterium fortuitum pulmonary infection: successful treatment with sulfisoxazole. Texas medicine. 1985 Mar; 81(3):57-60. doi: ". [PMID: 3983869]
  • P Ylitalo, M Janas, G Wilén, R Anttila. Sulfadiazine versus sulfafurazole excretion in urine and risk of crystallization in children with conventional dosage regimen. Arzneimittel-Forschung. 1985; 35(6):988-90. doi: . [PMID: 4026927]
  • N Kaniwa, N Aoyagi, H Ogata. Use of PKM-MULTI program for fitting discontinuous absorption profiles using a microcomputer. Journal of pharmacobio-dynamics. 1984 Dec; 7(12):900-9. doi: 10.1248/bpb1978.7.900. [PMID: 6549471]
  • F Ruiz-Cabello, S Erill. Abnormal serum protein binding of acidic drugs in diabetes mellitus. Clinical pharmacology and therapeutics. 1984 Nov; 36(5):691-5. doi: 10.1038/clpt.1984.241. [PMID: 6488690]
  • I Bekersky, A C Popick, W A Colburn. Influence of protein binding and metabolic interconversion on the disposition of sulfisoxazole and its N4-acetyl metabolite by the isolated perfused rat kidney. Drug metabolism and disposition: the biological fate of chemicals. 1984 Sep; 12(5):607-13. doi: NULL. [PMID: 6149912]
  • M García-Morillas, B Gil-Extremera, M D Caracuel-Ruiz. Differential effects of hepatic cirrhosis on the plasma protein binding of drugs. International journal of clinical pharmacology research. 1984; 4(5):327-33. doi: NULL. [PMID: 6519849]
  • A Boisvert, G Barbeau, P M Bélanger. Pharmacokinetics of sulfisoxazole in young and elderly subjects. Gerontology. 1984; 30(2):125-31. doi: 10.1159/000212618. [PMID: 6706125]
  • C Peters, P Peterson, P Marabella, R L Simmons, J S Najarian. Continuous sulfa prophylaxis for urinary tract infection in renal transplant recipients. American journal of surgery. 1983 Nov; 146(5):589-93. doi: 10.1016/0002-9610(83)90294-5. [PMID: 6356948]
  • A Iravani, N D Pryor, G A Richard. Treatment of urinary tract infections with varying regimens of sulfisoxazole. The Journal of urology. 1983 Sep; 130(3):484-7. doi: 10.1016/s0022-5347(17)51263-x. [PMID: 6887360]
  • L Wallen, W P Zeller, M Goessler, E Connor, R Yogev. Single-dose amikacin treatment of first childhood E. coli lower urinary tract infections. The Journal of pediatrics. 1983 Aug; 103(2):316-9. doi: 10.1016/s0022-3476(83)80376-x. [PMID: 6348227]
  • W J Cashore, W Oh, R Brodersen. Bilirubin-displacing effect of furosemide and sulfisoxazole. An in vitro and in vivo study in neonatal serum. Developmental pharmacology and therapeutics. 1983; 6(4):230-8. doi: 10.1159/000457309. [PMID: 6617404]
  • D E Smith, L Z Benet. Plasma protein binding of furosemide in kidney transplant patients. Journal of pharmacokinetics and biopharmaceutics. 1982 Dec; 10(6):663-74. doi: 10.1007/bf01062547. [PMID: 6763626]
  • H E Klintrup, V M Venho, A J Jounela, M Kairaluoma, M J Mattila, T K Larmi. Isoniazid, quinidine, and sulphafurazole absorption in patients with jejunum transposition 15 years earlier. Scandinavian journal of gastroenterology. 1982 Oct; 17(7):913-7. doi: 10.3109/00365528209181114. [PMID: 7156885]
  • F J Buckwold, P Ludwig, G K Harding, L Thompson, M Slutchuk, J Shaw, A R Ronald. Therapy for acute cystitis in adult women. Randomized comparison of single-dose sulfisoxazole vs trimethoprim-sulfamethoxazole. JAMA. 1982 Apr; 247(13):1839-42. doi: . [PMID: 7038165]
  • S Oie, J G Gambertoglio, L Fleckenstein. Comparison of the disposition of total and unbound sulfisoxazole after single and multiple dosing. Journal of pharmacokinetics and biopharmaceutics. 1982 Apr; 10(2):157-72. doi: 10.1007/bf01062333. [PMID: 7120046]
  • A Iravani, G A Richard, H Baer. Trimethoprim and sulfisoxazole in the treatment of urinary tract infections, with special reference to antibody-coated bacteria and fecal flora. Reviews of infectious diseases. 1982 Mar; 4(2):388-9. doi: 10.1093/clinids/4.2.388. [PMID: 7111961]
  • T M McCann, B M Churchill, B E Hardy, G S Arbus. Maintenance antimicrobials in high risk urologic pediatric patients. The International journal of pediatric nephrology. 1982 Mar; 3(1):29-32. doi: NULL. [PMID: 6980850]
  • R A Shastri. Plasma protein binding and half-life of sulphisoxazole (sulphafurazole). British journal of clinical pharmacology. 1982 Feb; 13(2):249-50. doi: 10.1111/j.1365-2125.1982.tb01371.x. [PMID: 7059428]
  • R L Suber, J C Gudat, G T Edds. Comparison of serum bilirubin levels in humans and two monogastric animal species after a single administration of sulfisoxazole. Journal of pharmaceutical sciences. 1982 Jan; 71(1):70-3. doi: 10.1002/jps.2600710118. [PMID: 7057385]
  • R Calvo, R Carlos, S Erill. Effects of carbamylation of plasma proteins and competitive displacers on drug binding in uremia. Pharmacology. 1982; 24(4):248-52. doi: 10.1159/000137603. [PMID: 7089046]
  • P Souney, B F Polk. Single-dose antimicrobial therapy for urinary tract infections in women. Reviews of infectious diseases. 1982 Jan; 4(1):29-34. doi: 10.1093/clinids/4.1.29. [PMID: 6918057]
  • E R Garrett, R S Süverkrup, K Eberst, R L Yost, J P O'Leary. Surgically affected sulfisoxazole pharmacokinetics in the morbidly obese. Biopharmaceutics & drug disposition. 1981 Oct; 2(4):329-65. doi: 10.1002/bdd.2510020405. [PMID: 7317572]
  • A Iravani, G A Richard, H Baer. Treatment of uncomplicated urinary tract infections with trimethoprim versus sulfisoxazole, with special reference to antibody-coated bacteria and fecal flora. Antimicrobial agents and chemotherapy. 1981 May; 19(5):842-50. doi: 10.1128/aac.19.5.842. [PMID: 7027925]